CFTR
Le CFTR est une protéine canal chlorure qui régule le transport des ions chlorure et bicarbonate à travers les membranes des cellules épithéliales, jouant un rôle crucial dans le maintien de l'équilibre hydrique dans les tissus. Les mutations du gène CFTR entraînent la mucoviscidose, une maladie génétique caractérisée par la production de mucus épais pouvant obstruer les voies respiratoires et causer de graves problèmes respiratoires et digestifs. Chez CymitQuimica, nous proposons une sélection de modulateurs CFTR pour soutenir vos recherches sur la mucoviscidose, le transport des ions et les troubles génétiques.
Produits appartenant à la catégorie "CFTR"
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CFTR corrector 12
CAS :CFTR corrector 12 is a CFTR corrector that rescues all mutant proteins except M760R ABCA3 and can be used to study cystic fibrosis.Formule :C19H21ClN4O2S2Degré de pureté :99.78%Couleur et forme :SolidMasse moléculaire :436.98(R)-Elexacaftor
CAS :(R)-Elexacaftor, an enantiomer of Elexacaftor, functions as a modulator of the cystic fibrosis transmembrane conductance regulator (CFTR).Formule :C26H34F3N7O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :597.65IOWH-032
CAS :IOWH-032 (IOWH032) , a synthetic CFTR inhibitor, has been investigated for the treatment of cholera, diarrhea, and secretory diarrhea.Formule :C22H15Br2N3O4Degré de pureté :100% - ≥95%Couleur et forme :SolidMasse moléculaire :545.18Glibenclamide
CAS :Glibenclamide (Glyburide) is an antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide.Formule :C23H28ClN3O5SDegré de pureté :99.05% - 99.75%Couleur et forme :SolidMasse moléculaire :494Steviol
CAS :1.Formule :C20H30O3Degré de pureté :98% - 99.92%Couleur et forme :SolidMasse moléculaire :318.45Ref: TM-T2S1837
1mg52,00€5mg95,00€10mg162,00€25mg264,00€50mg393,00€100mg582,00€200mg830,00€1mL*10mM (DMSO)77,00€Elexacaftor
CAS :Elexacaftor (VX-445) is a cystic fibrosis transmembrane conductance regulator (CFTR) corrector.Cost-effective and quality-assured.Formule :C26H34F3N7O4SDegré de pureté :98.87% - 99.87%Couleur et forme :SolidMasse moléculaire :597.65Ref: TM-T14935
1mg87,00€2mg137,00€5mg243,00€10mg393,00€25mg772,00€50mg1.074,00€100mg1.444,00€1mL*10mM (DMSO)320,00€CFTR corrector 9
CAS :CFTR corrector 9 is a CF modulator used to research cystic fibrosis and related disorders.Formule :C16H14N2O4Degré de pureté :98.24%Couleur et forme :SolidMasse moléculaire :298.29Ref: TM-T60653
2mg42,00€5mg64,00€10mg92,00€25mg178,00€50mg266,00€100mg383,00€200mg537,00€1mL*10mM (DMSO)62,00€Ataluren
CAS :Ataluren (PTC124) is a novel, orally administered drug that targets nonsense mutations.Formule :C15H9FN2O3Degré de pureté :99.16% - 99.84%Couleur et forme :SolidMasse moléculaire :284.24Ref: TM-T1805
5mg38,00€10mg57,00€25mg93,00€50mg124,00€100mg188,00€200mg225,00€500mg379,00€1mL*10mM (DMSO)48,00€Icenticaftor
CAS :Icenticaftor (QBW251) is an orally active potentiator of CFTR channel.Formule :C12H13F6N3O3Degré de pureté :98.39%Couleur et forme :SolidMasse moléculaire :361.24Ref: TM-T9499
1mg160,00€5mg329,00€10mg495,00€25mg792,00€50mg1.111,00€100mg1.578,00€200mg2.137,00€1mL*10mM (DMSO)261,00€CFTR corrector 17
CAS :CFTRcorrector 17 (example 17) is a regulator of the cystic fibrosis transmembrane conductance regulator (CFTR). It is utilized in the study of diseases mediated by CFTR.Formule :C18H15FN2O2Couleur et forme :SolidMasse moléculaire :310.32GlyH-101
CAS :GlyH-101 is a cell-permeable glycinyl hydrazone compound that blocks CFTR with Ki of 1.4 uM.Formule :C19H15Br2N3O3Degré de pureté :98.71% - 98.78%Couleur et forme :SolidMasse moléculaire :493.15Ref: TM-T2451
1mg40,00€2mg51,00€5mg85,00€10mg119,00€25mg246,00€50mg492,00€100mg688,00€200mg908,00€1mL*10mM (DMSO)93,00€GLPG1837
CAS :GLPG1837 (ABBV-974) is an effective CFTR potentiator, with EC50s of 3 nM and 339 nM for F508del and G551D CFTR, respectively.Formule :C16H20N4O3SDegré de pureté :98.75% - 99.73%Couleur et forme :SolidMasse moléculaire :348.42Ref: TM-T7083
1mg35,00€5mg80,00€10mg120,00€25mg188,00€50mg354,00€100mg537,00€200mg750,00€1mL*10mM (DMSO)88,00€(R)-BPO-27
CAS :(R)-BPO-27 is an orally active and potent ATP-competitive CFTR inhibitor (IC50: 4 nM) for the study of diarrhoea and polycystic kidney.Formule :C26H18BrN3O6Degré de pureté :99.1%Couleur et forme :SolidMasse moléculaire :548.34Bamocaftor
CAS :Bamocaftor corrects CFTR in CF, restoring F508del-CFTR function, used with tezacaftor and VX-561 for F508del/MF patients.Formule :C28H32F3N5O4SDegré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :591.65Ref: TM-T30293
1mg354,00€5mg847,00€10mg1.159,00€25mg1.700,00€50mg2.308,00€100mg3.117,00€1mL*10mM (DMSO)1.225,00€CFTR(inh)-172
CAS :CFTR(inh)-172 (CFTR Inhibitor-172) is a voltage-independent, selective CFTR inhibitor.Formule :C18H10F3NO3S2Degré de pureté :98% - 99.72%Couleur et forme :SolidMasse moléculaire :409.4Ref: TM-T2355
1mg35,00€2mg46,00€5mg66,00€10mg97,00€25mg188,00€50mg359,00€100mg530,00€1mL*10mM (DMSO)69,00€BPO-27 racemate
CAS :BPO-27 racemate (BPO-27 (racemate)) is an effective CFTR inhibitor with IC50 of 8 nM.Formule :C26H18BrN3O6Degré de pureté :98.19%Couleur et forme :SolidMasse moléculaire :548.34Ref: TM-T10591
1mg47,00€5mg117,00€10mg170,00€25mg280,00€50mg409,00€100mg565,00€200mg758,00€1mL*10mM (DMSO)135,00€VRT-532
CAS :VRT-532 (CFpot-532) is an effective modulator of CFTR and is commonly used in studies of cystic fibrosis (CF) caused by CFTR defects.Formule :C16H14N2ODegré de pureté :100% - 99.89%Couleur et forme :SolidMasse moléculaire :250.3CFTR corrector 15
CAS :CFTR Corrector 15 (Compound 4172) serves as a corrector for cystic fibrosis transmembrane conductance regulator (CFTR). When used in combination with VX-809, it addresses the folding defects of F508del-CFTR. CFTR Corrector 15 is also applicable in the research of cystic fibrosis.Formule :C24H22ClN5O2SCouleur et forme :SolidMasse moléculaire :479.98
