Canal TRP/TRPV
Les canaux TRP (récepteur potentiel transitoire), y compris la sous-famille TRPV, sont un groupe de canaux ioniques impliqués dans divers processus sensoriels, tels que la sensation de température, la perception de la douleur et l'osmorégulation. Les canaux TRP sont largement exprimés dans différents tissus et jouent un rôle dans les réponses physiologiques aux stimuli environnementaux. Les canaux TRPV, en particulier, sont impliqués dans la détection des changements de température et sont associés à des conditions telles que la douleur chronique, l'inflammation et le cancer. Chez CymitQuimica, nous proposons une gamme complète de modulateurs de canaux TRP/TRPV pour soutenir vos recherches en biologie sensorielle, gestion de la douleur et transduction du signal.
Produits appartenant à la catégorie "Canal TRP/TRPV"
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M8-B Hydrochloride
CAS :M8-B Hydrochloride is a selective transient receptor potential melastatin-8 (TRPM8) channel antagonist.Formule :C22H25ClN2O3SDegré de pureté :99.33%Couleur et forme :SolidMasse moléculaire :432.96Ref: TM-T8442
2mg35,00€5mg52,00€10mg74,00€25mg145,00€50mg226,00€100mg335,00€200mg469,00€1mL*10mM (DMSO)64,00€ML329
CAS :ML329 is a small molecule inhibitor of MITF, inhibiting TRPM-1 promoter activity.Formule :C16H12N2O4SDegré de pureté :98.96%Couleur et forme :SolidMasse moléculaire :328.34Ref: TM-T4028
1mg52,00€2mg73,00€5mg115,00€10mg187,00€25mg424,00€50mg627,00€100mg893,00€1mL*10mM (DMSO)118,00€TRPM4-IN-1
CAS :TRPM4-IN-1 (4-chloro-2-(2-(2-chlorophenoxy)acetamido)benzoic acid) is a potent and selective inhibitor of TRPM4 with an IC50 of 1.5 μM.Formule :C15H11Cl2NO4Degré de pureté :97.22%Couleur et forme :SolidMasse moléculaire :340.16TRPM8 antagonist 3
CAS :TRPM8 antagonist 3 is a blocker of TRPM8 (IC50 = 11 nM).Formule :C13H12N2O4SDegré de pureté :99.25%Couleur et forme :SolidMasse moléculaire :292.31Ref: TM-T9709
1mg62,00€5mg135,00€10mg202,00€25mg335,00€50mg490,00€100mg672,00€200mg905,00€1mL*10mM (DMSO)149,00€A-1165442
CAS :A-1165442 is a competitive TRPV1 antagonist. For human TRPV, the IC50 values is 9 nM.Formule :C22H20ClF2N3O2Couleur et forme :SolidMasse moléculaire :431.86ML204 hydrochloride
CAS :ML204 hydrochloride (ML204 HCl) is a TRPC4/TRPC5 channel antagonist.Formule :C15H19ClN2Couleur et forme :SolidMasse moléculaire :262.78HC-030031
CAS :HC-030031 (TOSLAB 829227) is a potent TRPA1 inhibitor, which antagonizes AITC- and formalin-evoked calcium influx with IC50s of 6.2 and 5.3 μM, respectively.Formule :C18H21N5O3Degré de pureté :99.69% - ≥95%Couleur et forme :SolidMasse moléculaire :355.39Optovin
CAS :Optovin is a TRPA1 activator, which is reversibly photoactivated.Formule :C15H13N3OS2Degré de pureté :100.00% - 99.16%Couleur et forme :SolidMasse moléculaire :315.41Ref: TM-T6617
1mg40,00€2mg51,00€5mg81,00€10mg97,00€25mg188,00€50mg314,00€100mg563,00€200mg687,00€1mL*10mM (DMSO)86,00€TRPM4-IN-2
CAS :NBA, or TRPM4-IN-2, is a potent TRPM4 inhibitor with IC50 of 0.16 μM, used in prostate and colorectal cancer research.Formule :C19H14ClNO4Degré de pureté :99.21%Couleur et forme :SolidMasse moléculaire :355.77(S)-ABT 102
CAS :N-[(1S)-1H-inden-1-yl]-N'-indazol-4-ylurea is a strong TRPV1 blocker with a 123 nM IC50 against capsaicin.Formule :C21H24N4ODegré de pureté :99.41% - 99.78%Couleur et forme :SoildMasse moléculaire :348.44Ref: TM-T29522L
1mg77,00€5mg158,00€10mg225,00€25mg338,00€50mg472,00€100mg645,00€200mg868,00€1mL*10mM (DMSO)162,00€PF-05105679
CAS :PF-05105679 is a selective TRPM8 antagonist (IC50 = 103 nM). PF-05105679 can be used in research on cold-related pain.Formule :C26H21FN2O3Degré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :428.45Ref: TM-T16483
1mg48,00€2mg65,00€5mg96,00€10mg160,00€25mg305,00€50mg472,00€100mg710,00€200mg938,00€500mg1.444,00€1mL*10mM (DMSO)96,00€Pyr10
CAS :Pyr10, a pyrazole derivative, selectively inhibits TRPC3, not STIM1/Orai1, with IC50 of 0.72 μM in TRPC3-HEK293, and 13.08 μM in BRL-2H3 cells.Formule :C18H13F6N3O2SDegré de pureté :99.69% - 99.70%Couleur et forme :SolidMasse moléculaire :449.37IA-Alkyne
CAS :IA-Alkyne: TRPC agonist, cysteine-reactivity probe, potential in respiratory infection study.Formule :C8H12INODegré de pureté :99.76%Couleur et forme :SolidMasse moléculaire :265.09Ref: TM-T15543
1mg59,00€5mg126,00€10mg187,00€25mg264,00€50mg329,00€100mg455,00€1mL*10mM (DMSO)120,00€TRPC6-PAM-C20
CAS :TRPC6-PAM-C20, a selective enhancer for TRPC6, boosts calcium in HEK cells and OAG-related platelet clumping, EC50: 2.37μM.Formule :C22H21NO4Degré de pureté :98.16%Couleur et forme :SolidMasse moléculaire :363.41Pyr3
CAS :Pyr3 selectively blocks TRPC3 channels, reducing Ca2+ influx; it's effective at 700 nM.Formule :C16H11Cl3F3N3O3Degré de pureté :99.47%Couleur et forme :SolidMasse moléculaire :456.63Ref: TM-T16687
1mg35,00€2mg52,00€5mg77,00€10mg97,00€25mg215,00€50mg363,00€100mg512,00€200mg738,00€500mg1.121,00€1mL*10mM (DMSO)86,00€RN-1734
CAS :RN-1734 is selective TRPV4 channel antagonist(IC50 of 2.3 μM,5.9 μM,3.2 μM for hTRPV4, mTRPV4 and rTRPV4,respectively)Formule :C14H22Cl2N2O2SDegré de pureté :99.1% - 99.30%Couleur et forme :SolidMasse moléculaire :353.31SB-366791
CAS :SB-366791 is a new and selective cinnamide TRPV1 antagonist.Formule :C16H14ClNO2Degré de pureté :99.12%Couleur et forme :SolidMasse moléculaire :287.74TRPM8 antagonist 2
CAS :TRPM8 antagonist 2 is a potent and selective TRPM8 antagonist with an IC50 of 0.2 nM. TRPM8 antagonist 2 is used in the research of neuropathic pain syndromes.Formule :C26H26N2O2Degré de pureté :98.10%Couleur et forme :SolidMasse moléculaire :398.5Ref: TM-T5698
1mg35,00€5mg70,00€10mg104,00€25mg170,00€50mg274,00€100mg439,00€200mg632,00€1mL*10mM (DMSO)78,00€NGD-8243
CAS :NGD-8243 (N-[4-(trifluoromethyl)phenyl]-7-[3-(trifluoromethyl)pyridin-2-yl]quinazolin-4-amine) is a TRPV1 inhibitor and can be used in studies for preventionFormule :C21H12F6N4Degré de pureté :95.26%Couleur et forme :SolidMasse moléculaire :434.34Vocacapsaicin hydrochloride
CAS :Vocacapsaicin hydrochloride (CA-008 hydrochloride) is a non-opioid TRPV1 agonist, a raw material for capsaicin, and is used for pain relief.Formule :C26H42ClN3O4Degré de pureté :98.51% - 99.94%Couleur et forme :SolidMasse moléculaire :496.08HC-067047
CAS :HC-067047 is a potent and selective TRPV4 antagonist.Also inhibits the endogenous TRPV4-mediated response to 4α-PDH .Formule :C26H28F3N3O2Degré de pureté :99.45% - 99.79%Couleur et forme :SolidMasse moléculaire :471.51SAR7334
CAS :SAR7334 (TRCP6-IN-1) is a potent and specific inhibitor of TRPC6(IC50 of 7.9 nM).Formule :C21H22ClN3ODegré de pureté :99.62% - 99.71%Couleur et forme :SolidMasse moléculaire :367.87Ref: TM-T12849
1mg71,00€5mg160,00€10mg250,00€25mg401,00€50mg567,00€100mg707,00€200mg938,00€1mL*10mM (DMSO)170,00€Asivatrep
CAS :Asivatrep (PAC14028) is a selective and potent antagonist of transient receptor potential vanilloid subtype 1 (TRPV1) for the study of atopic dermatitis.Formule :C21H22F5N3O3SDegré de pureté :95.13%Couleur et forme :SolidMasse moléculaire :491.48WS-12
CAS :WS-12 is a potent TRPM8 agonist that acts as a cooling agent (EC50 : 193 nM)Formule :C18H27NO2Degré de pureté :99.99%Couleur et forme :Whitish To White Solid CrystallineMasse moléculaire :289.41ABT-239
CAS :ABT-239 is a novel, highly efficacious antagonist belonging to the non-imidazole class of histamine H3 receptor (H3R) antagonists.Formule :C22H22N2ODegré de pureté :100%Couleur et forme :SolidMasse moléculaire :330.42Ref: TM-T14087
1mg48,00€5mg96,00€10mg160,00€25mg313,00€50mg470,00€100mg660,00€200mg917,00€1mL*10mM (DMSO)96,00€JNJ-28583113
CAS :JNJ-28583113 is a TRPM2 antagonist, inducing phosphorylation of GSK3α and β subunits, protecting cells from oxidative stress-induced cell death.Formule :C19H21F3N2O2Degré de pureté :98.57%Couleur et forme :SolidMasse moléculaire :366.38Ref: TM-T74779
1mg92,00€5mg215,00€10mg321,00€25mg494,00€50mg856,00€100mg1.478,00€200mg1.931,00€1mL*10mM (DMSO)225,00€PF-04745637
CAS :PF-04745637 is a potent and selective TRPA1 antagonist with an IC50 of 17 nM[1].Formule :C27H32ClF3N2O2Degré de pureté :97.91% - 99.3%Couleur et forme :SolidMasse moléculaire :509Ref: TM-T64337
1mg73,00€5mg145,00€10mg197,00€25mg333,00€50mg475,00€100mg655,00€200mg882,00€1mL*10mM (DMSO)163,00€MSP3
CAS :MSP3 is an agonist of TRPV1 (EC50 = 0.87 μM) and shows antinociceptive and neuroprotective effects.Formule :C16H19NO3SDegré de pureté :99.46%Couleur et forme :SolidMasse moléculaire :305.39Ref: TM-T28118
2mg34,00€5mg52,00€10mg85,00€25mg170,00€50mg255,00€100mg378,00€200mg533,00€1mL*10mM (DMSO)74,00€M084
CAS :M084 (N-Butyl-1H-benzimidazol-2-amine) is a blocker of TRPC4/5 channel, with antidepressant and anxiolytic effects.Formule :C11H15N3Degré de pureté :98.13%Couleur et forme :SolidMasse moléculaire :189.26Ref: TM-T8607
1mg88,00€5mg170,00€10mg259,00€25mg425,00€50mg598,00€100mg810,00€200mg1.074,00€1mL*10mM (DMSO)145,00€MDR-652
CAS :MDR-652 is a highly specific and efficacious agonist of nonpungent transient receptor potential vanilloid 1 (TRPV1) with Ki value of 11.4 nM and 23.8 nM forFormule :C22H23ClFN3O2SDegré de pureté :99.96%Couleur et forme :SolidMasse moléculaire :447.95Ref: TM-T22360
1mg66,00€5mg144,00€10mg205,00€25mg369,00€50mg558,00€100mg800,00€200mg1.074,00€1mL*10mM (DMSO)157,00€BI-749327
CAS :BI-749327 is a high selectivity and orally bioavailable antagonist of TRPC6 (IC50s: 13 nM, 19 nM and 15 nM for mouse, human and guinea pig TRPC6).Formule :C23H21F3N4O2Degré de pureté :99.68%Couleur et forme :SolidMasse moléculaire :442.43Ref: TM-T10537
1mg133,00€2mg177,00€5mg274,00€10mg432,00€25mg630,00€50mg825,00€100mg1.103,00€500mg2.205,00€1mL*10mM (DMSO)301,00€AM12
CAS :AM12 inhibits Lanthanide-evoked TRPC5 activity (IC50: 0.28 μM).Formule :C15H9BrO5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :349.13BTD
CAS :BTD is a TRPC5 activator that activates heteromeric channel complexes composed of TRPC5 and its closest relatives TRPC1 or TRPC4.Formule :C24H33N3O4SCouleur et forme :SolidMasse moléculaire :459.6TRPM4 inhibitor 8
CAS :TRPM4 inhibitor 8 is an inhibitor of Transient receptor potential melastatin 4(TRPM4) which contributes to viability, migration, cell cycle shift, and adhesion.Formule :C11H17BrN2Degré de pureté :97%Couleur et forme :SolidMasse moléculaire :257.17Ref: TM-T9776
5mg47,00€10mg65,00€25mg96,00€50mg180,00€100mg283,00€200mg424,00€500mg697,00€1mL*10mM (DMSO)50,00€AC1903
CAS :AC1903 is a specific inhibitor of TRPC5 channel, and has been shown to suppress severe proteinuria and prevent podocyte loss.Formule :C19H17N3ODegré de pureté :98.45%Couleur et forme :SolidMasse moléculaire :303.36Linoleoyl Ethanolamide
CAS :Linoleoyl Ethanolamide is an endocannabinoid agent.Formule :C20H37NO2Degré de pureté :99.97%Couleur et forme :SolidMasse moléculaire :323.51Ref: TM-T8425
1mg35,00€5mg67,00€10mg90,00€25mg164,00€50mg239,00€100mg348,00€200mg522,00€1mL*10mM (DMSO)85,00€BCTC
CAS :BCTC is a potent TRPV1 antagonist that inhibits capsaicin-induced and acid-induced activation of rat TRPV1 (IC50 of 35 and 6 nM, respectively)Formule :C20H25ClN4ODegré de pureté :99.21%Couleur et forme :SolidMasse moléculaire :372.89N4-benzyl-N2-methylquinazoline-2,4-diamine hydrochloride
CAS :N4-benzyl-N2-methylquinazoline-2,4-diamine hydrochloride is an inhibitor of TRPC4.Formule :C16H17ClN4Degré de pureté :99.25%Couleur et forme :SolidMasse moléculaire :300.79Ref: TM-T8565
1mg88,00€5mg170,00€10mg259,00€25mg425,00€50mg598,00€100mg810,00€200mg1.074,00€1mL*10mM (DMSO)170,00€RQ-00203078
CAS :RQ-00203078 is a highly selective, potent and orally available TRPM8 antagonist.Formule :C21H13ClF6N2O5SDegré de pureté :98% - 99.17%Couleur et forme :SolidMasse moléculaire :554.85cim0216
CAS :CIM0216 is a synthetic TRPM3 activator whose potency and apparent affinity greatly exceeds that of the canonical TRPM3 agonist.Formule :C21H21N3O2Degré de pureté :99.87%Couleur et forme :SolidMasse moléculaire :347.41Ref: TM-T9263
1mg47,00€2mg59,00€5mg92,00€10mg145,00€25mg298,00€50mg465,00€100mg702,00€500mg1.454,00€1mL*10mM (DMSO)92,00€AMG 517
CAS :AMG 517 is an effective and specific TRPV1 antagonist, antagonizes proton (IC50: 0.76 nM), capsaicin (IC50: 0.62 nM) and heat activation (IC50: 1.3 nM) of TRPV1Formule :C20H13F3N4O2SDegré de pureté :99.77% - 99.85%Couleur et forme :SolidMasse moléculaire :430.4GSK2798745
CAS :GSK2798745 is an orally active transient receptor potential vanilloid 4 (TRPV4) ion channel blocker (IC50s: 1.8 and 1.6 nM for hTRPV4 and rTRPV4).Formule :C25H28N6O3Couleur et forme :SolidMasse moléculaire :460.53MK6-83
CAS :MK6-83 is the transient receptor potential channel ML3 agonist.Formule :C16H20N2O2S2Degré de pureté :99.71%Couleur et forme :SolidMasse moléculaire :336.47TRPV4 agonist-1 free base
CAS :TRPV4 agonist-1 free base (OUN67600) is an agonist of transient receptor potential vanilloid 4 (TRPV4;EC50 of 60 nM, in the hTRPV4 Ca2+ assay).Formule :C25H22F2N4O2Degré de pureté :99.79%Couleur et forme :SolidMasse moléculaire :448.46ABT 102
CAS :ABT 102 (CHEMBL398338) is a selective antagonist of transient receptor potential vanilloid 1 (TRPV1) receptor.Formule :C21H24N4ODegré de pureté :98.38% - 99.72%Couleur et forme :SolidMasse moléculaire :348.44Ref: TM-T29522
1mg115,00€5mg249,00€10mg369,00€25mg562,00€50mg787,00€100mg1.054,00€200mg1.406,00€1mL*10mM (DMSO)259,00€(Z)-Capsaicin
CAS :(Z)-Capsaicin (Zucapsaicin) is a medication used to treat osteoarthritis of the knee and Others neuropathic pain.(Z)-Capsaicin is a synthetic cis isomer ofFormule :C18H27NO3Degré de pureté :97.33% - 99.67%Couleur et forme :SolidMasse moléculaire :305.41Resolvin D2
CAS :Resolvin D2 (RvD2) is a TRPV1 inhibitor and pro-ablative mediator with anti-inflammatory, anti-infective and pro-ablative effects.Formule :C22H32O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :376.49JNJ-17203212
CAS :JNJ-17203212 is a potent and selective antagonist of TRPV1 (human TRPV1 and rat TRPV1, IC50 of 65 nM and 102 nM).Formule :C17H15F6N5ODegré de pureté :99.18%Couleur et forme :SolidMasse moléculaire :419.32AP 18
CAS :AP-18 is a potent and selective TRPA1 inhibitor.Formule :C11H12ClNODegré de pureté :99.85% - 99.87%Couleur et forme :SolidMasse moléculaire :209.67Ref: TM-T21543
2mg35,00€5mg50,00€10mg73,00€25mg140,00€50mg215,00€100mg338,00€500mg723,00€1mL*10mM (DMSO)50,00€TRPM8 antagonist WS-3
CAS :TRPM8 antagonist WS-3 (Cyclohexanecarboxamide) is an agonist of TRPM8( EC50 : 3.7 μM).Formule :C13H25NODegré de pureté :97.64%Couleur et forme :DrypowderMasse moléculaire :211.34
