Canal chlorure
Les canaux chlorure sont des protéines membranaires qui contrôlent le mouvement des ions chlorure à travers les membranes cellulaires, jouant un rôle essentiel dans le maintien du volume cellulaire, de l'excitabilité électrique et de l'équilibre acido-basique. La dysrégulation des canaux chlorure est liée à des maladies telles que la mucoviscidose, l'épilepsie et les troubles rénaux. Chez CymitQuimica, nous proposons une variété de modulateurs des canaux chlorure pour soutenir vos recherches sur le transport des ions, l'homéostasie cellulaire et les mécanismes des maladies.
Produits appartenant à la catégorie "Canal chlorure"
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T16Ainh-A01
CAS :T16Ainh-A01 is a potent TMEM16A chloride channel inhibitor with a 1 μM IC50, targeting CaCC.Formule :C19H20N4O3S2Degré de pureté :97.18% - 98.15%Couleur et forme :SolidMasse moléculaire :416.52MONNA
CAS :MONNA is a potent TMEM16A (Anoctamin-1) blocker (IC50 : 80 nM). It induces vasorelaxation of rodent resistance arteries in presence or absence of chloride ions.Formule :C18H14N2O5Degré de pureté :98.29%Couleur et forme :SolidMasse moléculaire :338.31CaCCinh-A01
CAS :CaCCinh-A01 is an inhibitor of the calcium-activated chloride channel (CaCC, 10 μM) and TMEM16A (IC50: 2.1 μM).Formule :C18H21NO4SDegré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :347.43Picrotoxinin
CAS :Picrotoxinin blocks chloride channels, antagonizes GABAA noncompetitively (IC50: 1.15 μM, α1β2γ2L), and induces convulsions.Formule :C15H16O6Degré de pureté :98.07%Couleur et forme :SolidMasse moléculaire :292.28Niflumic acid
CAS :Niflumic acid (Nifluril) is a Ca2+-activated Cl- channel blocker and an analgesic and anti-inflammatory agent used in the therapy of rheumatoid arthritis.Formule :C13H9F3N2O2Degré de pureté :99.47%Couleur et forme :SolidMasse moléculaire :282.22Irisolidone
CAS :Irisolidone is a potent volume-regulated anion channel (VRAC) current inhibitor, it exhibits high efficacy for VRAC blockade with IC50s of 5-13 μM.Formule :C17H14O6Degré de pureté :99.41% - 99.46%Couleur et forme :SolidMasse moléculaire :314.29Afoxolaner
CAS :Afoxolaner is an isoxazoline insecticide/acaricide against Ixodes scapularis in dogs.Formule :C26H17ClF9N3O3Degré de pureté :99.10% - 99.38%Couleur et forme :SolidMasse moléculaire :625.87NS1652
CAS :NS1652 is an anion conductance inhibitor. NS1652 blocks chloride channel has an IC50 of 1.6 μM in human and mouse red blood cells.Formule :C15H11F3N2O3Degré de pureté :99.62%Couleur et forme :SolidMasse moléculaire :324.25Org 25543
CAS :Org 25543 is the development of an N-Acyl amino acid that selectively inhibits the glycine transporter 2 to produce analgesia in a rat model of chronic pain.Formule :C24H32N2O4Degré de pureté :99.13%Couleur et forme :SolidMasse moléculaire :412.52Ref: TM-T50082
1mg84,00€5mg167,00€10mg250,00€25mg414,00€50mg562,00€100mg787,00€200mg1.035,00€1mL*10mM (DMSO)187,00€Eact
CAS :Eact is a potent TMEM16A activator that also triggers TRPV1, causing itch, pain, and heat sensitivity.Formule :C22H24N2O5SDegré de pureté :97.01%Couleur et forme :SolidMasse moléculaire :428.5Ref: TM-T15192
1mg37,00€2mg50,00€5mg79,00€10mg126,00€25mg254,00€50mg429,00€100mg632,00€200mg899,00€1mL*10mM (DMSO)87,00€Talniflumate
CAS :Talniflumate (Somalgen) is a calcium-activated chloride channel (hCLCA1/mCLCA3) blocker that reduces mucin synthesis and releases in animal models and cellFormule :C21H13F3N2O4Degré de pureté :98% - 99.81%Couleur et forme :White To Pale Yellow Crystalline PowderMasse moléculaire :414.33Ref: TM-T4503
1mg37,00€2mg52,00€5mg77,00€10mg97,00€25mg182,00€50mg300,00€100mg449,00€1mL*10mM (DMSO)85,00€Fenamic acid
CAS :Fenamic acid (N-Phenylanthranilic acid) is a chloride channel blocker that causes renal papillary necrosis in rats.Formule :C13H11NO2Degré de pureté :99.60%Couleur et forme :White To Off-White Crystalline PowderMasse moléculaire :213.2319ANO1-IN-4
CAS :ANO1-IN-4 (Compound 10bm) is a reversible inhibitor of the calcium-activated chloride channel transmembrane protein 16A (TMEM16A, also known as ANO1), with an IC50 of 0.030 µM. It demonstrates good metabolic stability in rat liver microsomes and can inhibit spontaneous contractions in isolated mouse ileum.Formule :C19H19BrF2N2O2SCouleur et forme :SolidMasse moléculaire :457.33Meticrane
CAS :Meticrane (Arresten) is a sulphonamide-derivative with thiazide-like diuretic activity.Formule :C10H13NO4S2Degré de pureté :99.16%Couleur et forme :SolidMasse moléculaire :275.34Flufenamic acid
CAS :Flufenamic acid (Arlef) is an anthranilic acid derivative with analgesic, anti-inflammatory, and antipyretic properties.Formule :C14H10F3NO2Degré de pureté :98.68%Couleur et forme :White To Light Yellow Crystalline PowderMasse moléculaire :281.23Shikonin
CAS :Shikonin: TMEM16A inhibitor (IC50: 6.5μM), targets PKM2, suppresses NF-κB, inhibits TNF-α, and reduces exosome secretion.Formule :C16H16O5Degré de pureté :98.13% - 99.9%Couleur et forme :SolidMasse moléculaire :288.3Ref: TM-T1125
5mg34,00€10mg52,00€25mg87,00€50mg140,00€100mg215,00€200mg319,00€500mg533,00€1mL*10mM (DMSO)52,00€DCPIB
CAS :DCPIB, a known specific and potent inhibitor of volume-regulated anion channels (VRAC),DCPIB displayed superior selectivity toward TRESK with an IC50 of 0.14 μMFormule :C22H28Cl2O4Degré de pureté :99.79% - 99.87%Couleur et forme :SolidMasse moléculaire :427.36Ref: TM-T10979
1mg35,00€5mg74,00€10mg114,00€25mg235,00€50mg465,00€100mg605,00€200mg852,00€1mL*10mM (DMSO)84,00€Ani9
CAS :Ani9 selectively blocks ANO1/TMEM16A with a 77 nM IC50, useful for ANO1 research and treating cancer, hypertension, pain, diarrhea, asthma.Formule :C17H17ClN2O3Degré de pureté :98.72%Couleur et forme :SolidMasse moléculaire :332.78Ref: TM-T26630
1mg39,00€5mg84,00€10mg131,00€25mg269,00€50mg454,00€100mg655,00€500mg1.406,00€1mL*10mM (DMSO)92,00€Picrotin
CAS :Picrotin is an inhibitor of glycine receptors. Picrotin blocks α2 GlyR, α1 GlyR, and α3 GlyR and can be used in studies about neurotransmission.Formule :C15H18O7Degré de pureté :97.11%Couleur et forme :SolidMasse moléculaire :310.3ANO1-IN-1
CAS :ANO1-IN-1 blocks ANO1/2 channels (IC50: 2.56/15.43 μM) and hinders glioma cell growth.Formule :C18H28N2O2SDegré de pureté :99.66%Couleur et forme :SolidMasse moléculaire :336.49
