P-gp
La P-glycoprotéine est une pompe d'efflux dépendante de l'ATP qui transporte une grande variété de substrats, y compris des médicaments, des toxines et des lipides, hors des cellules. Elle joue un rôle crucial dans la résistance aux médicaments, en particulier dans le cancer, en réduisant la concentration intracellulaire des agents chimiothérapeutiques. La P-gp est également impliquée dans la barrière hémato-encéphalique, influençant l'exposition du système nerveux central à divers composés. Chez CymitQuimica, nous proposons une gamme de modulateurs de la P-gp pour soutenir vos recherches en résistance aux médicaments, pharmacocinétique et développement thérapeutique.
Produits appartenant à la catégorie "P-gp"
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49 produits dans cette catégorie.
Encequidar
CAS :Encequidar (HM30181A) is a potent and selective P-glycoprotein inhibitor.Formule :C38H36N6O7Degré de pureté :99.93%Couleur et forme :SolidMasse moléculaire :688.73Ref: TM-T8426
1mg48,00€2mg65,00€5mg96,00€10mg144,00€25mg246,00€50mg380,00€100mg557,00€1mL*10mM (DMSO)134,00€Phellamurin
CAS :Phellamurin blocks intestinal P-glycoprotein dose-dependently and it seriously interacts with cyclosporin; coadministration should be avoided.Formule :C26H30O11Degré de pureté :93.19% - 93.19%Couleur et forme :SolidMasse moléculaire :518.51Ref: TM-TN4761
1mg163,00€5mg320,00€10mg472,00€25mg753,00€50mg1.074,00€100mg1.444,00€1mL*10mM (DMSO)410,00€HM-30181 mesylate monohydrate
CAS :HM-30181 mesylate monohydrate is an oral P-glycoprotein (P-gp) inhibitor, used to enhance the oral bioavailability of P-gp substrate drugs.Formule :C39H42N6O11SDegré de pureté :99.37%Couleur et forme :SolidMasse moléculaire :802.85Ref: TM-T9173
1mg69,00€2mg88,00€5mg126,00€10mg195,00€25mg325,00€50mg467,00€100mg680,00€200mg882,00€500mg1.320,00€1mL*10mM (DMSO)187,00€Elacridar
CAS :Elacridar (GG918) is a potent inhibitor of P-glycoprotein and BCRP.Cost-effective and quality-assured.Formule :C34H33N3O5Degré de pureté :100% - 99.62%Couleur et forme :SolidMasse moléculaire :563.64Ref: TM-T2657
5mg42,00€10mg63,00€25mg107,00€50mg188,00€100mg283,00€200mg472,00€500mg753,00€1mL*10mM (DMSO)57,00€Tariquidar methanesulfonate hydrate
CAS :m-PEG8-Ms is a PROTAC linker belonging to the PEG class and can be used to synthesize PROTAC compounds.Formule :C40H58N4O18S2Degré de pureté :98.13%Couleur et forme :SolidMasse moléculaire :947.04Solamargine
CAS :Solamargine, a steroidal alkaloid from Solanum nigrum, inhibits cancer cell growth and induces apoptosis.Formule :C45H73NO15Degré de pureté :99.17% - 99.88%Couleur et forme :SolidMasse moléculaire :868.06Norverapamil hydrochloride
CAS :Norverapamil HCl, a Verapamil metabolite, blocks L-type calcium channels and inhibits P-gp function.Formule :C26H37ClN2O4Degré de pureté :99.47%Couleur et forme :SolidMasse moléculaire :477.04Ref: TM-T16339
1mg37,00€5mg111,00€10mg187,00€25mg315,00€50mg472,00€100mg658,00€500mg1.378,00€1mL*10mM (DMSO)116,00€HTT-D3
CAS :HTT-D3 is a Huntington splicing regulator that induces HTT mRNA degradation, leading to a reduction in HTT protein levels.Formule :C23H25FN6Degré de pureté :99.31%Couleur et forme :SolidMasse moléculaire :404.48coniferyl ferulate
CAS :Coniferyl ferulate is a strong inhibitor of glutathione S-transferase (GST) isolated from Radix Angelicae sinensis.Formule :C20H20O6Degré de pureté :97.09%Couleur et forme :SolidMasse moléculaire :356.37MCI826
CAS :MCI826 is a potent and selective antagonist of P-glycoprotein (P-gp) and peptide leukotrienes (p-LTs), showing anti-asthmatic activity in a guinea pig model ofFormule :C22H28N2O3SDegré de pureté :98.73%Couleur et forme :SolidMasse moléculaire :400.53Paris saponin VII
CAS :Paris saponin VII (Dioscini) shows inhibitory effects on cell proliferation.Formule :C51H82O21Degré de pureté :99.51% - 99.63%Couleur et forme :SolidMasse moléculaire :1031.18Valspodar
CAS :Valspodar (PSC 833) is a specific P-glycoprotein inhibitor and MDR regulator often used as a chemical sensitizer to study advanced epithelial ovarian cancer.Formule :C63H111N11O12Degré de pureté :100% - 95%Couleur et forme :SolidMasse moléculaire :1214.62Hypophyllanthin
CAS :Hypophyllanthin and phyllanthin have antitumour effects against Ehrlich Ascites Carcinoma in mice.Formule :C24H30O7Degré de pureté :98.39%Couleur et forme :SolidMasse moléculaire :430.49Polyoxyethylene stearate
CAS :Polyoxyethylene stearate (POES) is an agent of non-ionic emulsifying.Formule :C20H40O3Degré de pureté :n~9-10Couleur et forme :Light Amber SemisolidMasse moléculaire :328.29775Risperidone
CAS :Risperidone (R 64 766) is a selective blocker of dopamine D2 receptors and serotonin 5-HT2 receptors that act as an atypical antipsychotic agent.Formule :C23H27FN4O2Degré de pureté :99.73%Couleur et forme :Crystalline SolidMasse moléculaire :410.48Sinapine thiocyanate
CAS :Sinapine Thiocyanate, is a derivative of Sinapine (S486605), an alkaloidal amine found in black mustard seeds.Formule :C16H24NO5·CNSDegré de pureté :98.19% - ≥95%Couleur et forme :SolidMasse moléculaire :368.45Glibenclamide
CAS :Glibenclamide (Glyburide) is an antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide.Formule :C23H28ClN3O5SDegré de pureté :99.05% - 99.75%Couleur et forme :SolidMasse moléculaire :494P-gp inhibitor 1
CAS :P-gp inhibitor 1 inhibits reversing P-glycoprotein-mediated multidrug resistance with an EC50 of 57.9 nM (K562/A02 cells).Formule :C32H31N5O2Degré de pureté :98.65%Couleur et forme :SolidMasse moléculaire :517.62Ref: TM-T12341
5mg50,00€10mg84,00€25mg150,00€50mg219,00€100mg304,00€200mg419,00€1mL*10mM (DMSO)58,00€Piperine
CAS :Piperine (Bioperine) , a alkaloid, has been used in trials studying the treatment of multiple myeloma and deglutition disorders.Formule :C17H19NO3Degré de pureté :100% - 97.79%Couleur et forme :SolidMasse moléculaire :285.34γ-Tocotrienol
CAS :γ-Tocotrienol (Plastochromanol) is one of the four types of tocotrienol, a type of vitamin E.Formule :C28H42O2Degré de pureté :97.27% - 98.13%Couleur et forme :SolidMasse moléculaire :410.63Ref: TM-T19768
1mg47,00€2mg62,00€5mg92,00€10mg144,00€25mg235,00€50mg350,00€100mg515,00€200mg743,00€1mL*10mM (DMSO)97,00€Zosuquidar
CAS :Zosuquidar (RS 33295-198) is a potent P-glycoprotein inhibitor with antitumor activity that inhibits tumor growth.Formule :C32H31F2N3O2Couleur et forme :SolidMasse moléculaire :527.6Evodine
CAS :1. Evodine has antinociceptive activity.Formule :C18H19NO5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :329.35Chrysosplenetin
CAS :Chrysosplenetin is a metabolic inhibitor of artemisinin.Formule :C19H18O8Degré de pureté :97.43% - 98.53%Couleur et forme :SolidMasse moléculaire :374.34Ref: TM-TJS1159
1mg60,00€5mg127,00€10mg188,00€25mg348,00€50mg512,00€100mg730,00€500mg1.483,00€1mL*10mM (DMSO)226,00€Zosuquidar trihydrochloride
CAS :Zosuquidar trihydrochloride (LY-335979 trihydrochloride) is a potent modulator of P-glycoprotein-mediated multi-drug resistance with Ki of 60 nM. Phase 3.Formule :C32H31F2N3O2·3HClDegré de pureté :100% - 99.55%Couleur et forme :SolidMasse moléculaire :636.99PGP-4008
CAS :PGP-4008 is a selective and potent P-glycoprotein (Pgp) inhibitor that inhibits tumor growth by co-administration with Doxorubicin.Formule :C26H23N3ODegré de pureté :98% - 98.53%Couleur et forme :SolidMasse moléculaire :393.48Zamicastat
CAS :Zamicastat (BIA 5-1058) inhibits DBH, P-gp (IC50=73.8μM), and BCRP (IC50=17.0μM).Formule :C21H21F2N3OSDegré de pureté :99.58%Couleur et forme :SolidMasse moléculaire :401.47Ref: TM-T13383
1mg96,00€5mg205,00€10mg309,00€25mg557,00€50mg838,00€100mg1.216,00€1mL*10mM (DMSO)221,00€Trifluoperazine
CAS :Trifluoperazine (trifluoroperazine) is a Dopamine D2 receptor inhibitor(IC50 : 1.2 nM), and Treatment of schizophrenia.Formule :C21H24F3N3SDegré de pureté :98.3% - 99.46%Couleur et forme :White To Yellowish Crystalline PowderMasse moléculaire :407.5Ceefourin 1
CAS :Ceefourin 1 is a highly selective multidrug resistance protein 4 (MRP4) inhibitor.Formule :C11H10N4S3Degré de pureté :99.15%Couleur et forme :SolidMasse moléculaire :294.42Ref: TM-T8596
1mg43,00€5mg88,00€10mg119,00€25mg250,00€50mg389,00€100mg550,00€200mg785,00€1mL*10mM (DMSO)87,00€Voacamine
CAS :Voacamine: an indole alkaloid, CB1 antagonist, inhibits P-gp, may affect rhythm.Formule :C43H52N4O5Degré de pureté :98.54%Couleur et forme :SolidMasse moléculaire :704.9Laniquidar TFA
Laniquidar TFA (R101933), a non-competitive P-gp inhibitor, has an IC50 of 0.51 μM; used to study AML and MDS, but with limited bioavailability.Formule :C39H37F3N4O5Degré de pureté :98.74%Couleur et forme :SoildMasse moléculaire :698.73YS-370
CAS :YS-370 orally blocks P-gp, moderately inhibits CYP3A4, reverses drug resistance, and enhances paclitaxel's anticancer effects.Formule :C37H35BrN4O3Degré de pureté :97.50%Couleur et forme :SolidMasse moléculaire :663.6Tariquidar
CAS :Tariquidar (XR9576)(Kd=5.1 nM) is a specific and effective non-competitive inhibitor of P-glycoprotein. It can reverse drug resistance in MDR cell Lines.Formule :C38H38N4O6Degré de pureté :98.07% - 99.17%Couleur et forme :SolidMasse moléculaire :646.73Larotaxel
CAS :Larotaxel (XRP9881), a taxane with anticancer properties, stabilizes microtubules, induces apoptosis, and is researched in breast and bladder cancer.Formule :C45H53NO14Degré de pureté :99.22%Couleur et forme :SolidMasse moléculaire :831.9Encequidar mesylate
CAS :Encequidar mesylate (HM30181A mesylate) is a competitive P-glycoprotein inhibitor.Formule :C39H40N6O10SDegré de pureté :99.84%Couleur et forme :SolidMasse moléculaire :784.83Ref: TM-T11578L
2mg42,00€5mg62,00€10mg88,00€25mg155,00€50mg250,00€100mg393,00€500mg893,00€1mL*10mM (DMSO)74,00€Verapamil hydrochloride
CAS :Verapamil hydrochloride (Verapamil HCl) is a calcium channel blocker that is a class IV anti-arrhythmia agent.Formule :C27H39ClN2O4Degré de pureté :98.7% - 99.98%Couleur et forme :White To Off-White PowderMasse moléculaire :491.06Atazanavir
CAS :Atazanavir (BMS-232632)(BMS-232632) is an highly effective HIV-1 protease inhibitor.Formule :C38H52N6O7Degré de pureté :98% - 99.95%Couleur et forme :Crystalline SolidMasse moléculaire :704.86Atazanavir sulfate
CAS :Atazanavir sulfate, an azapeptide HIV-protease inhibitor, treats HIV/AIDS alongside other anti-HIV drugs.Formule :C38H52N6O7·H2SO4Degré de pureté :99.31% - 99.40%Couleur et forme :SolidMasse moléculaire :802.93Ref: TM-T0100
5mg47,00€10mg62,00€25mg95,00€50mg120,00€100mg180,00€200mg264,00€500mg449,00€1mL*10mM (DMSO)52,00€Sinapine
CAS :Sinapine: an alkaloid with chemo-resistance, antioxidant, and radioprotective properties from cruciferous seeds.Formule :C16H24NO5Degré de pureté :98% - 99.85%Couleur et forme :White Or Light-Tan SolidMasse moléculaire :310.37Selamectin
CAS :Selamectin (UK-124114) is a macrocyclic lactone derivative of ivermectin, an anthelmintic that potentiates glutamate- and GABA-gated chloride channel opening inFormule :C43H63NO11Degré de pureté :99.84%Couleur et forme :SolidMasse moléculaire :769.96ONT-093
CAS :ONT-093 (OC-144-093) is an oral P-glycoprotein (P-gp) inhibitor with potential anti-cancer activity, used in the study of myelodysplastic syndromes.Formule :C32H38N4ODegré de pureté :98.86%Couleur et forme :SolidMasse moléculaire :494.67Dofequidar fumarate
CAS :Dofequidar fumarate (MS-209)(MS-209 fumarate), a quinoline-based compound administered orally, is known for counteracting multidrug resistance (MDR) through theFormule :C34H35N3O7Degré de pureté :99.43%Couleur et forme :SolidMasse moléculaire :597.66Ref: TM-T11071
1mg39,00€2mg50,00€5mg85,00€10mg125,00€25mg245,00€50mg472,00€100mg687,00€500mg1.444,00€1mL*10mM (DMSO)96,00€Isosinensetin
CAS :1. Isosinensetin (6-Demethoxynobiletin) shows antioxidant and HIV-1 protease inhibiting activities.Formule :C20H20O7Degré de pureté :99.05% - ≥95%Couleur et forme :SolidMasse moléculaire :372.37P-gb-IN-1
CAS :P-gb-IN-1 is a potent P-glycoprotein (P-gp) inhibitor that exhibits reverse activity by inhibiting P-gp outflow.Formule :C30H28N2O6Degré de pureté :99.58%Couleur et forme :SoildMasse moléculaire :512.55FM04
CAS :FM04 is a potent oral P-gp inhibitor (EC50: 83 nM), disrupting human P-gp NBD2 to enhance cancer treatment.Formule :C26H25NO4Degré de pureté :99.84%Couleur et forme :SolidMasse moléculaire :415.48Talinolol
CAS :(±)-Talinolol is a selective β1 adrenoceptor antagonist well known for its cardioprotective and antihypertensive activity.Formule :C20H33N3O3Degré de pureté :98.80%Couleur et forme :SolidMasse moléculaire :363.49Ref: TM-T21640
2mg35,00€5mg50,00€10mg96,00€25mg188,00€50mg329,00€100mg565,00€200mg818,00€1mL*10mM (DMSO)55,00€Verapamil
CAS :Verapamil (CP-16533-1), an oral calcium channel blocker, inhibits P-gp and CYP3A4, used for hypertension, arrhythmias, and angina research.Formule :C27H38N2O4Degré de pureté :99.53%Couleur et forme :OilMasse moléculaire :454.6Ref: TM-T20656
10mg35,00€25mg51,00€50mg73,00€100mg96,00€200mg143,00€500mg230,00€1mL*10mM (DMSO)55,00€(20S)-Protopanaxadiol
CAS :(20S)-Protopanaxadiol (20-Epiprotopanaxadiol) (20-Epiprotopanaxadiol), an apoptosis inducer, is an aglycon metabolic derivative of the protopanaxadiol-typeFormule :C30H52O3Degré de pureté :98.03% - 98.91%Couleur et forme :SolidMasse moléculaire :460.73Convallatoxin
CAS :Convallatoxin is a natural product.Formule :C29H42O10Degré de pureté :99.27%Couleur et forme :Prisms From Methanol + Ether SolidMasse moléculaire :550.64Trifluoperazine dihydrochloride
CAS :Trifluoperazine dihydrochloride (SKF5019) is a potent dopamine D2 receptor inhibitor used as an antipsychotic and an antiemetic.Formule :C21H26Cl2F3N3SDegré de pureté :99.57% - 99.96%Couleur et forme :Cream Fine PowderMasse moléculaire :480.43
