Canal calcique
Les canaux calciques sont des protéines membranaires qui régulent le flux d'ions calcium dans et hors des cellules, ce qui est essentiel pour diverses fonctions cellulaires, y compris la contraction musculaire, la libération de neurotransmetteurs et l'expression génique. La dysrégulation de l'activité des canaux calciques est associée à des conditions telles que l'hypertension, les arythmies cardiaques et les troubles neurologiques. Chez CymitQuimica, nous proposons une large sélection de modulateurs des canaux calciques pour soutenir vos recherches en santé cardiovasculaire, neurobiologie et transduction du signal.
Produits appartenant à la catégorie "Canal calcique"
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DS16570511
CAS :DS16570511 is a novel, cell-permeable inhibitor targeting the mitochondrial calcium uniporter.Formule :C30H25Cl2N3O4Degré de pureté :98.45% - ≥98%Couleur et forme :SolidMasse moléculaire :562.44SERCA2a activator 1
CAS :SERCA2a activator 1 boosts heart function by reducing phospholamban restraint and enhancing cardiac contraction-relaxation cycles.Formule :C32H29N3O4SDegré de pureté :99.52%Couleur et forme :SolidMasse moléculaire :551.66Ref: TM-T16873
1mg187,00€5mg472,00€10mg660,00€25mg1.035,00€50mg1.483,00€100mg2.072,00€1mL*10mM (DMSO)563,00€PD 0299685
CAS :PD 0299685 is a potent α2δ ligand of the Ca2+ channel for the treatment of interstitial cystitis.Formule :C10H21NO2Degré de pureté :97.20%Couleur et forme :SoildMasse moléculaire :187.28Drotaverine hydrochloride
CAS :Drotaverine hydrochloride is a type 4 cyclic nucleotide phosphodiesterase (PDE4) inhibitor,and is an antispasmodic drug, used to enhance cervical dilationFormule :C24H32ClNO4Degré de pureté :99.81%Couleur et forme :Pale-Yellow Crystalline SolidMasse moléculaire :433.968PD173212
CAS :PD 173212 is a blocker that blocks N-type voltage sensitive calcium channel (Cav2.2).Formule :C38H53N3O3Degré de pureté :99.54%Couleur et forme :SolidMasse moléculaire :599.85Ref: TM-T16448
2mg46,00€5mg80,00€10mg116,00€25mg190,00€50mg284,00€100mg395,00€200mg560,00€1mL*10mM (DMSO)96,00€Jamaicin
CAS :Jamaicin (AnCoA4), an isoflavone derived from the chickweed plant, is an inhibitor of the STIM1-Orai1 channel that blocks calcium ion influx.Formule :C22H18O6Degré de pureté :99.32%Couleur et forme :SolidMasse moléculaire :378.37SR33805
CAS :SR33805 is a potent antagonist of Ca2+ channel(EC50s of 4.1 nM and 33 nM in depolarized and polarized conditions, respectively)Formule :C32H40N2O5SDegré de pureté :99.15%Couleur et forme :SolidMasse moléculaire :564.74Ref: TM-T8674
1mg48,00€5mg96,00€10mg145,00€25mg255,00€50mg375,00€100mg535,00€200mg728,00€1mL*10mM (DMSO)108,00€MRS1845
CAS :MRS1845 is a selective inhibitor of store-operated calcium (SOC) channel (IC50 of 1.7 μM).Formule :C21H22N2O6Degré de pureté :99.69%Couleur et forme :SolidMasse moléculaire :398.41GSK205
CAS :GSK205 is a selective TRPV4 antagonist (IC50: 4.19 μM) for inhibiting TRPV4-mediated Ca2+ influx.Formule :C24H25BrN4SDegré de pureté :99.46%Couleur et forme :SolidMasse moléculaire :481.45Ref: TM-T11480
1mg70,00€5mg154,00€10mg246,00€25mg545,00€50mg909,00€100mg1.406,00€200mg1.882,00€1mL*10mM (DMSO)162,00€Fasudil hydrochloride
CAS :Fasudil hydrochloride (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK with Ki of 0.33 μM, 1.0 μM, 9.3 μM and 55 μM, respectively.Formule :C14H18ClN3O2SDegré de pureté :100% - ≥95%Couleur et forme :White SolidMasse moléculaire :327.83(Z)-Methyl 2-(3-Nitrobenzylidene)-3-oxobutanoate
CAS :Produit contrôléApplications (Z)-Methyl 2-(3-Nitrobenzylidene)-3-oxobutanoate is an intermediate in the synthesis of Lercanidipine-d3 Hydrochloride (L179002), a labelled dihydropyridine calcium channel blocker. References Bianchi, G., et al.: Pharmacol. Res., 21, 193 (1989); Rimoldi, E., et al.: Acta Therap., 200, 23 (1994)Formule :C12H11NO5Couleur et forme :NeatMasse moléculaire :249.22rac Atomoxetine-d5 Hydrochloride
CAS :Produit contrôléApplications rac Atomoxetine-d5 Hydrochloride is labelled rac Atomoxetine Hydrochloride (A791390) which is a compound active at novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases. References Farid, N.A., et al.: J. Clin. Pharmacol., 25, 296 (1985), Gehlert, D.R., et al.: J. Neurochem., 64, 2792 (1995), Hwamg. et al.: Neurosci. Lett., 265, 151 (1999), Ring, B.J., et al.: Drug Metab. Dispos., 30, 319 (2002),Formule :C17D5H16NO·ClHCouleur et forme :NeatMasse moléculaire :296.85CDN1163
CAS :CDN1163 is a small molecule activator of sarco/endoplasmic reticulum Ca2+-ATPase (SERCA).Formule :C20H20N2O2Degré de pureté :99.83% - ≥95%Couleur et forme :SolidMasse moléculaire :320.39Ref: TM-T7373
2mg43,00€5mg64,00€10mg87,00€25mg163,00€50mg264,00€100mg426,00€200mg617,00€1mL*10mM (DMSO)70,00€Suvecaltamide
CAS :Suvecaltamide (MK-8998) as potent inhibitors of T-type calcium channels.Formule :C20H23F3N2O2Degré de pureté :98.79% - 99.29%Couleur et forme :SolidMasse moléculaire :380.4LY393615
LY393615 (NCC1048) is a novel blocker of both neuronal Ca²⁺ (calcium) and Na⁺ (sodium) channels, exhibiting half-maximal inhibitory concentrations (IC₅₀) of 1.9Degré de pureté :98%Couleur et forme :Odour SolidVerapamil-d3 Hydrochloride
CAS :Produit contrôléApplications Verapamil-d3 Hydrochloride is the labeled analogue of Verapamil Hydrochloride (V125000), which is a calcium channel blocker, antihypertensive, antianginal, and antiarrhythmic (class IV). Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Atlas, D, and Adler, M.: Proc. Natl. Acad. Sci. USA, 78, 1237 (1981); Janis, R., et al.: Adv. Drug. Res., 16, 309 (1987)Formule :C27D3H35N2O4·ClHCouleur et forme :NeatMasse moléculaire :457.633646Paxilline
CAS :Produit contrôléApplications Paxilline is a indole-diterpenes and a potent inhibitor of large conductance Ca2+-activated K+ currents in vascular smooth muscle cells Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Tagami, K., et al.: J. Am. Chem. Soc. 35, 260 (2013); Li, G. and Cheung, W. Eur. J. Pharmacol 372, 103 (1999);Formule :C27H33NO4Couleur et forme :NeatMasse moléculaire :435.56Desacetyl Diltiazem Hydrochloride
CAS :Applications Desacetyl Diltiazem Hydrochloride is a metabolite of Diltiazem Hydrochloride (D460620), a calcium channel blocher with vasodilating activity. Antianginal; antihypertensive; antiarrhythmic (class IV). References Shallcross, H., et al.: Br. Med. J., 295, 1236 (1987); Yeung, P.K.F., et al.: Drug Metab. Dispos., 18, 1055 (1990); Cashman, J.R., et al.: J. Med. Chem., 34,2049 (1991); Sato, et al.: Arzneim.-Forsch., 21, 1338 (1971); Smirnov, S.R.: Eur. J. Pharmacol., 360, 81 (1998); Hansson, L., et al.: Lancet, 356, 359 (2000)Formule :C20H24N2O3S·ClHCouleur et forme :NeatMasse moléculaire :408.94Ruthenium Red
CAS :Ruthenium Red (Ammoniated ruthenium oxychloride) is a polycationic dye widely used for electron microscopy (EM) of cells, tissues and vegetative bacteria.Formule :Cl6H42N14O2Ru3Degré de pureté :95%Couleur et forme :Purple PowderMasse moléculaire :786.34Defluoro Flunarizine Dihydrochloride
CAS :Produit contrôléImpurity Flumazenil EP Impurity B Stability Hygroscopic Applications Defluoro Flunarizine (Flumazenil EP Impurity B) Dihydrochloride, is an impurity of Flunarizine(F455200, Dihydrochloride), which is a calcium channel blocker. Flunarizine is a fluorinated derivative of Cinnarizine and a vasodilator (cerebral and peripheral). References Desmedt, L.K., et al.: Arzneim.-Forsch., 25, 1408 (1975), Godfraind, T., et al.: Eur. J. Pharmacol., 53, 273 (1979), Nihard, P., et al.: Angiology, 33, 37 (1982), Holmes, B., et al.: Drugs, 27, 6 (1984)Formule :C26H27FN2·2ClHCouleur et forme :NeatMasse moléculaire :459.43
