Prolyl-Hydroxylase de HIF/HIF
Le facteur inductible par l'hypoxie (HIF) est un facteur de transcription qui joue un rôle crucial dans les réponses cellulaires aux faibles niveaux d'oxygène (hypoxie). L'activité de HIF est étroitement régulée par les prolyl-hydroxylases de HIF, qui ciblent HIF pour sa dégradation dans des conditions normoxiques. Les inhibiteurs de la prolyl-hydroxylase de HIF peuvent stabiliser HIF, favorisant l'expression de gènes impliqués dans l'angiogenèse, l'érythropoïèse et le métabolisme. Ces inhibiteurs sont d'un grand intérêt pour le traitement de conditions telles que l'anémie, les maladies ischémiques et le cancer. Chez CymitQuimica, nous proposons des inhibiteurs de HIF/prolyl-hydroxylase HIF pour soutenir vos recherches en biologie de l'hypoxie, en thérapie anticancéreuse et en régulation métabolique.
Produits appartenant à la catégorie "Prolyl-Hydroxylase de HIF/HIF"
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TC-S 7009
CAS :TC-S 7009: Strong HIF-2α inhibitor (Kd 81 nM), weak for HIF-1α; disrupts dimerization & gene expression.Formule :C12H6ClFN4O3Degré de pureté :100% - 99.71%Couleur et forme :SolidMasse moléculaire :308.65PHD-IN-2
CAS :PHD-IN-2 (Compound 91), a potent PHD antagonist with an IC50 of less than 5 nM, effectively stimulates erythropoietin synthesis in HEP3B cells with an EC50 ofFormule :C26H27N7O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :501.54Tilorone dihydrochloride
CAS :Tilorone dihydrochloride is an orally active interferon inducer, and has antineoplastic and anti-inflammatory actions.Formule :C25H36Cl2N2O3Degré de pureté :98% - 99.86%Couleur et forme :Orange Yellow Crystal PowderMasse moléculaire :483.47SYP-5
CAS :SYP-5 is a novel inhibitor of HIF-1, suppresses tumor cells invasion and angiogenesis.Formule :C18H16O3SDegré de pureté :98.31%Couleur et forme :SolidMasse moléculaire :312.38Enarodustat
CAS :Enarodustat (JTZ-951) is an orally active factor inhibitor of prolyl hydroxylase (EC50: 0.22 μM) and has the potential for renal anemia treatment.Formule :C17H16N4O4Degré de pureté :99.14% - 99.61%Couleur et forme :SolidMasse moléculaire :340.33Ref: TM-T15219
1mg39,00€2mg50,00€5mg79,00€10mg115,00€25mg188,00€50mg311,00€100mg462,00€1mL*10mM (DMSO)90,00€HIF-2α-IN-9
CAS :HIF-2α-IN-9 (compound 35r) serves as an HIF-2α inhibitor, effectively suppressing VEGF-A with an IC50 of 305 nM, and modulating growth-promoting genes withinFormule :C12H13F5O4S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :380.35GN44028
CAS :GN44028 is a HIF-1 inhibitor with an IC50 of 14 nM, stopping HIF-1α activity but not mRNA or protein levels, or dimerization.Formule :C18H15N3O2Degré de pureté :98.20%Couleur et forme :SolidMasse moléculaire :305.33Ref: TM-T15396
1mg70,00€5mg135,00€10mg188,00€25mg325,00€50mg465,00€100mg615,00€200mg830,00€1mL*10mM (DMSO)149,00€2,4-DPD
CAS :2,4-DPD is competitive inhibitor of the oxygen-sensing enzyme HIF-α prolyl hydroxylase (HIF-PH)Formule :C11H13NO4Degré de pureté :99.74%Couleur et forme :Yellow Solid CrystallineMasse moléculaire :223.23Ethyl 3,4-dihydroxybenzoate
CAS :Ethyl 3,4-dihydroxybenzoate (EDHB): a prolyl hydroxylase inhibitor attenuates acute hypobaric hypoxia mediated vascular leakage in brain.Formule :C9H10O4Degré de pureté :99.88%Couleur et forme :White Crystal Or PowderMasse moléculaire :182.17ZK-261991
CAS :ZK-261991 is an orally active inhibitor of VEGFR tyrosine kinase(IC50 of 5 nM, VEGFR2).Formule :C24H25N7O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :443.5Desidustat
CAS :Desidustat is an inhibitor of HIF hydroxylase.Formule :C16H16N2O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :332.31Ref: TM-T5176
1mg35,00€2mg52,00€5mg94,00€10mg167,00€25mg300,00€50mg516,00€100mg732,00€1ml*10 (DMSO)112,00€Belzutifan
CAS :"Belzutifan (MK-6482) is an oral HIF-2α inhibitor for ccRCC, with enhanced potency (IC50: 9 nM)."Formule :C17H12F3NO4SDegré de pureté :99.34% - 99.41%Couleur et forme :SolidMasse moléculaire :383.34Ref: TM-T16679
1mg70,00€5mg153,00€10mg216,00€25mg411,00€50mg660,00€100mg938,00€200mg1.264,00€1mL*10mM (DMSO)166,00€DDO-3055
CAS :DDO-3055 is an orally active PHD2 inhibitor utilized in studies related to anemia associated with chronic kidney disease.Formule :C17H13ClN2O5Couleur et forme :SolidMasse moléculaire :360.749HIF-1 inhibitor-4
CAS :HIF-1 inhibitor-4 (HIF-1 inhibitor-4) is a HIF-1 inhibitor with IC50 of 560 nM.Formule :C18H19IN2O2Degré de pureté :99.17%Couleur et forme :SolidMasse moléculaire :422.26Ref: TM-T67767
1mg48,00€5mg96,00€10mg157,00€25mg281,00€50mg454,00€100mg702,00€200mg938,00€1mL*10mM (DMSO)116,00€IDF-11774
CAS :IDF-11774 is a HIF-1 inhibitor.It reduces hif-1α HRE luciferase activity (IC50 = 3.65 μM).Formule :C23H32N2O2Degré de pureté :98.05%Couleur et forme :SolidMasse moléculaire :368.51Citric acid trilithium salt tetrahydrate
CAS :Citric acid trilithium salt tetrahydrate (Lithium citrate tribasic tetrahydrate) , the active component of Lithium, is a medicine used in the therapy ofFormule :C6H13Li3O11Degré de pureté :≥95%Couleur et forme :White Crystalline PowderMasse moléculaire :281.98IOX2
CAS :IOX2 is a selective HIF PHD inhibitor, active in cells with 21 nM IC50 for PHD2/ELGN-1, not inhibiting FIH at 20uM.Formule :C19H16N2O5Degré de pureté :98% - 99.59%Couleur et forme :SolidMasse moléculaire :352.34Fenbendazole
CAS :Fenbendazole (Fenbendazol) is an antinematodal benzimidazole used in veterinary medicine.Formule :C15H13N3O2SDegré de pureté :99.74%Couleur et forme :White To Yellowish PowderMasse moléculaire :299.35Izilendustat
CAS :Tert-butyl compound inhibits human EGLN-1; confirmed by spectrometry after 20 mins.Formule :C22H28ClN3O4Degré de pureté :99.95%Couleur et forme :SolidMasse moléculaire :433.93Ref: TM-T64336
5mg46,00€10mg64,00€25mg109,00€50mg170,00€100mg273,00€200mg399,00€1mL*10mM (DMSO)49,00€HIV-IN-7
Axl-IN-16 (Compound 4), an Axl inhibitor, not only suppresses Axl expression and HIF activity but also triggers fruiting body formation in Flammulina velutipes.Formule :C32H61N3O10P2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :709.79HIF-2α-IN-2
CAS :HIF-2α-IN-2 is a hypoxia-inducible factor (HIF-2α) inhibitor (IC50: 16 nM in scintillation proximity assay).Formule :C17H13F2NO4SDegré de pureté :99.24%Couleur et forme :SolidMasse moléculaire :365.35Ref: TM-T11561
1mg71,00€5mg135,00€10mg178,00€25mg309,00€50mg447,00€100mg620,00€200mg835,00€1mL*10mM (DMSO)149,00€JPHM-2-167
CAS :PHM-2-167 (Compound 11) is a selective inhibitor of the prolyl hydroxylase domain enzyme (PHD). It inhibits PHD2 and PHD3 with IC50 values of 0.253 μM and 3.95 μM, respectively. PHM-2-167 is applicable for research in chronic kidney disease.Formule :C30H28N6O2Couleur et forme :SolidMasse moléculaire :504.582PHD-IN-1
CAS :PHD-IN-1 (compound 80) serves as a potent PHD2 inhibitor, exhibiting an IC50 value of ≤5 nM.Formule :C24H23N7O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :441.49HIF-2α-IN-3
CAS :HIF-2α-IN-3 is an allosteric inhibitor of HIF-2α (IC50: 0.4 μM; KD: 1.1 μM) with anticancer activity.Formule :C12H6ClN5O5Degré de pureté :98.11%Couleur et forme :SolidMasse moléculaire :335.66Ref: TM-T11562
1mg115,00€5mg274,00€10mg432,00€25mg845,00€50mg1.293,00€100mg1.768,00€1mL*10mM (DMSO)303,00€HNHA
CAS :HNHA is an inhibitor of HDAC.Formule :C17H21NO2SDegré de pureté :98.04%Couleur et forme :SolidMasse moléculaire :303.42Ref: TM-T21806
1mg44,00€5mg84,00€10mg135,00€25mg279,00€50mg445,00€100mg640,00€200mg879,00€1mL*10mM (DMSO)90,00€Panaxadiol
CAS :Panaxadiol (20(R)-Panaxadiol) is a novel antitumor agent extracted from the Chinese medical herb Panax ginseng.Formule :C30H52O3Degré de pureté :98% - 99.9%Couleur et forme :SolidMasse moléculaire :460.73HIF-1α-IN-2
CAS :HIF-1α-IN-2 is a HIF-1α inhibitor with anticancer activity that inhibits the expression of HIF-1α and VEGF, and inhibits cell migration.Formule :C21H19N3OSDegré de pureté :98.45%Couleur et forme :SolidMasse moléculaire :361.46HIF-2α agonist 2
CAS :HIF-2α agonist 2 is an HIF-2α agonist with an EC50 value of 1.68 μM for HIF-2α.Formule :C13H8Br2N2O2SDegré de pureté :98.32%Couleur et forme :SoildMasse moléculaire :416.09Albendazole
CAS :Albendazole (SKF-62979) is used as a drug indicated for the treatment of a variety of worm infestations.Formule :C12H15N3O2SDegré de pureté :98.21% - 98.76%Couleur et forme :Colorless Crystals SolidMasse moléculaire :265.33JNJ-42041935
CAS :JNJ-42041935 (HIF-PHD Inhibitor II) is a potent (pKi = 7.3-7.9), 2-oxoglutarate competitive, reversible, and selective inhibitor of PHD enzymes.Formule :C12H6ClF3N4O3Degré de pureté :99.58% - ≥95%Couleur et forme :SolidMasse moléculaire :346.65Ref: TM-T3180
1mg40,00€2mg52,00€5mg88,00€10mg119,00€25mg210,00€50mg354,00€100mg567,00€500mg1.198,00€1mL*10mM (DMSO)87,00€Oroxylin A
CAS :Oroxylin A fights tumors, aids RAS therapy, promotes CaCo-2 cell apoptosis, blocks MCF-7 cell invasion and enhances leukemia treatment.Formule :C16H12O5Degré de pureté :98.72% - 99.55%Couleur et forme :SolidMasse moléculaire :284.26PT2399
CAS :PT2399, an oral HIF-2 inhibitor, blocks HIF-2α/1β dimerization, showing strong in vivo antitumor effects.Formule :C17H10F5NO4SDegré de pureté :98.8% - 99.07%Couleur et forme :SolidMasse moléculaire :419.32Ref: TM-T12675L
1mg99,00€5mg235,00€10mg354,00€25mg640,00€50mg944,00€100mg1.320,00€1mL*10mM (DMSO)259,00€ML228
CAS :ML228 activates HIF pathway and VEGF, with EC50 of 1μM, effective in vitro.Formule :C27H21N5Degré de pureté :99.03%Couleur et forme :SolidMasse moléculaire :415.49VHL-IN-1
VHL-IN-1 (compound 30), a ubiquitin E3 ligase von Hippel-Lindau (VHL) inhibitor with a dissociation constant (Kd) of 37 nM, potently stabilizes HIF-1α andFormule :C28H37FN4O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :544.68Deferoxamine Mesylate
CAS :Deferoxamine Mesylate (DFOM) is an iron chelator and iron death inhibitor.Formule :C26H52N6O11SDegré de pureté :94.68% - 99.80%Couleur et forme :SolidMasse moléculaire :656.79Chlorogenic Acid
CAS :Chlorogenic acid is a natural phenol. Chlorogenic acid has anti-inflammatory, antitumor, and antimicrobial effects. Cost-effective and quality-assured.Formule :C16H18O9Degré de pureté :98.76% - 99.67%Couleur et forme :SolidMasse moléculaire :354.31Minocycline hydrochloride
CAS :Minocycline HCl: tetracycline antibiotic, treats bacterial infections and acne, may cause acute or chronic hepatitis.Formule :C23H28ClN3O7Degré de pureté :100% - 99.89%Couleur et forme :Bright Yellow-Orange Amorphous Solid Crystalline YellowMasse moléculaire :493.94Glucosamine sulfate
CAS :Glucosamine sulfate (D-Glucosaminesulfate) was extracted from synthetic product;Store the product in sealed, cool and dry condition.Formule :C6H13NO5·H2SO4Degré de pureté :99.64%Couleur et forme :White CrystalMasse moléculaire :277.25HIF-2α-IN-1
CAS :HIF-2α-IN-1 is a potent HIF-2α inhibitor with IC50 values less than 500 nM.Formule :C16H8F5NO4SDegré de pureté :97.99%Couleur et forme :SolidMasse moléculaire :405.3Roxadustat
CAS :Roxadustat (FG-4592) is an orally bioavailable, hypoxia-inducible factor prolyl hydroxylase inhibitor (HIF-PHI), with potential anti-anemic activity.Formule :C19H16N2O5Degré de pureté :99% - 99.82%Couleur et forme :SolidMasse moléculaire :352.34Hydroxycitric acid tripotassium hydrate
CAS :Hydroxycitric acid tripotassium hydrate (Potassium citrate monohydrate) effectively inhibits HIF, has antioxidation, anti-inflammation, and anti-tumor effects.Formule :C6H7K3O8Degré de pureté :95%Couleur et forme :White Solid CrystallineMasse moléculaire :324.41THS-044
CAS :THS-044 (N-[2-Nitro-4-(Trifluoromethyl)phenyl]morpholin-4-Amine) binding stabilizes the HIF2α PAS-B folded state with a kd of 2 μM and regulates HIF2 activityFormule :C11H12F3N3O3Degré de pureté :100%Couleur et forme :SolidMasse moléculaire :291.23dencichine
CAS :Dencichine (ODAP) is a neurotoxic agent and a haemostatic agent, which relates to modulation of the coagulation system, and fibrinolytic system.Formule :C5H8N2O5Degré de pureté :≥95%Couleur et forme :SolidMasse moléculaire :176.13Ref: TM-TL0001
1mg49,00€5mg97,00€10mg169,00€25mg349,00€50mg520,00€100mg748,00€200mg1.026,00€1mL*10mM (DMSO)106,00€Amifostine trihydrate
CAS :Amifostine trihydrate (WR2721) is the first approved radioprotective drug, used to decrease the risk of kidney problems caused by treatment with cisplatin.Formule :C5H15N2O3PS·3H2ODegré de pureté :99.71% - 99.80%Couleur et forme :SolidMasse moléculaire :268.27EHP-101
CAS :EHP-101 is a PPARγ/CB2 dual agonist with anti-inflammatory properties, inhibits fat formation, and combats diet-related obesity.Formule :C28H35NO3Degré de pureté :99.22%Couleur et forme :SolidMasse moléculaire :433.58Ref: TM-T13289
1mg107,00€5mg227,00€10mg378,00€25mg620,00€50mg868,00€100mg1.169,00€1mL*10mM (DMSO)250,00€IOX4
CAS :IOX4 is a potent PHD2 inhibitor (IC50 = 1.6 nM)Formule :C15H16N6O3Degré de pureté :99.97%Couleur et forme :SolidMasse moléculaire :328.33LW6
CAS :LW6 (HIF-1α inhibitor) is a novel HIF-1 inhibitor.Formule :C26H29NO5Degré de pureté :98.1% - 99.10%Couleur et forme :SolidMasse moléculaire :435.51Ref: TM-T3494
2mg47,00€5mg69,00€10mg89,00€25mg183,00€50mg298,00€100mg449,00€500mg938,00€1mL*10mM (DMSO)69,00€Fraxinellone
CAS :1.Formule :C14H16O3Degré de pureté :99.35%Couleur et forme :SolidMasse moléculaire :232.271,4-DPCA
CAS :1,4-DPCA is an inhibitor of prolyl-hydroxylase with an IC50 of 2.4 µM for collagen hydroxylation in human foreskin fibroblasts and 60 μM for factor inhibitingFormule :C13H8N2O3Degré de pureté :97.75%Couleur et forme :SolidMasse moléculaire :240.21Ref: TM-T21653
5mg51,00€10mg84,00€25mg153,00€50mg235,00€100mg376,00€200mg553,00€500mg883,00€1mL*10mM (DMSO)57,00€Hydralazine hydrochloride
CAS :Hydralazine hydrochloride, an antihypertensive phthalazine, induces vasodilation and may inhibit tumor DNA methylation.Formule :C8H9ClN4Degré de pureté :99.1% - 99.86%Couleur et forme :Yellow Crystals White Crystalline SolidMasse moléculaire :196.64
