Prolyl-Hydroxylase de HIF/HIF
Le facteur inductible par l'hypoxie (HIF) est un facteur de transcription qui joue un rôle crucial dans les réponses cellulaires aux faibles niveaux d'oxygène (hypoxie). L'activité de HIF est étroitement régulée par les prolyl-hydroxylases de HIF, qui ciblent HIF pour sa dégradation dans des conditions normoxiques. Les inhibiteurs de la prolyl-hydroxylase de HIF peuvent stabiliser HIF, favorisant l'expression de gènes impliqués dans l'angiogenèse, l'érythropoïèse et le métabolisme. Ces inhibiteurs sont d'un grand intérêt pour le traitement de conditions telles que l'anémie, les maladies ischémiques et le cancer. Chez CymitQuimica, nous proposons des inhibiteurs de HIF/prolyl-hydroxylase HIF pour soutenir vos recherches en biologie de l'hypoxie, en thérapie anticancéreuse et en régulation métabolique.
Produits appartenant à la catégorie "Prolyl-Hydroxylase de HIF/HIF"
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M1001
CAS :M1001 is a HIF-2α agonist.Formule :C17H17N3O2SDegré de pureté :98.83%Couleur et forme :SolidMasse moléculaire :327.4FM19G11
CAS :FM19G11 is an inhibitor of hypoxia inducible factor (HIF) α-subunit (IC50 = 80 nM in hypoxia induced luciferase assay).Formule :C23H17N3O8Degré de pureté :97.28%Couleur et forme :SolidMasse moléculaire :463.4Acriflavine Hydrochloride
CAS :Acriflavine HCl is a HIF-1α inhibitor reducing PGK1, VEGF, and HIF-1α levels both in vitro and in vivo.Formule :C14H14ClN3Degré de pureté :99.69%Couleur et forme :SolidMasse moléculaire :259.73PT-2385
CAS :PT-2385 is a selective HIF-2α inhibitor (Kd<50 nM).Formule :C17H12F3NO4SDegré de pureté :98.69% - 99.55%Couleur et forme :SolidMasse moléculaire :383.34Ref: TM-T7848
1mg66,00€2mg87,00€5mg153,00€10mg258,00€25mg411,00€50mg610,00€100mg868,00€1mL*10mM (DMSO)126,00€MK-8617
CAS :MK-8617 is an orally available HIF PHD1 3 pan-inhibitor, inhibiting PHD1/2/3 (IC50: 1.0/1.0/14 nM).Formule :C24H21N5O4Degré de pureté :100% - 99.38%Couleur et forme :SolidMasse moléculaire :443.45Chloramphenicol
CAS :Chloramphenicol (Chloromycetin) is a broad-spectrum antibiotic that inhibits the biosynthesis of bacterial proteins. Cost-effective and quality-assured.Formule :C11H12Cl2N2O5Degré de pureté :99.6% - 99.84%Couleur et forme :Needles Or Elongated Plates From Water Or Ethylene Dichloride SolidMasse moléculaire :323.13AKB-6899
CAS :AKB-6899 is an inhibitor of prolyl hydroxylase domain 3 (PHD3) and increases the soluble form of the VEGF receptor (sVEGFR-1) production from GM-CSF-treatedFormule :C14H11FN2O4Degré de pureté :97.11%Couleur et forme :SolidMasse moléculaire :290.25Ref: TM-T29797
1mg74,00€5mg169,00€10mg263,00€25mg455,00€50mg652,00€100mg929,00€1mL*10mM (DMSO)178,00€DMOG
CAS :DMOG (Dimethyloxalylglycine), an antagonist of the α-ketoglutarate cofactor, is an inhibitor for HIF prolyl hydroxylase.Formule :C6H9NO5Degré de pureté :80.23% - 99.98%Couleur et forme :SolidMasse moléculaire :175.14(Rac)-PT2399
CAS :(Rac)-PT2399 is a potent and specific inhibitor of hypoxia-inducible factor 2a (HIF-2α)(IC50 of 0.01 μM).Formule :C17H10F5NO4SCouleur et forme :SolidMasse moléculaire :419.32HIF1-IN-3
CAS :HIF1-IN-3 (Benzenepropanamide, N-[(8-hydroxy-7-quinolinyl)(4-methoxyphenyl)methyl]-) is an effective inhibitor of HIF-1 (EC50 = 0.9 μM) and can be used inFormule :C26H24N2O3Degré de pureté :99.48%Couleur et forme :SolidMasse moléculaire :412.48KRH102140
CAS :KRH102140 is a PHD2 activator that reduces angiogenesis by inhibiting HIF-1alpha, used in cardiovascular disease research.Formule :C25H24FNODegré de pureté :98.31% - 99.61%Couleur et forme :SolidMasse moléculaire :373.46Glucosamine
CAS :Glucosamine (Chitosamine) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids.Formule :C6H13NO5Degré de pureté :99.80% - 99.80%Couleur et forme :CoaMasse moléculaire :179.17Vadadustat
CAS :Vadadustat is a novel, titratable, oral hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor in development for the treatment of anemia.Formule :C14H11ClN2O4Degré de pureté :99.09% - 99.4%Couleur et forme :SolidMasse moléculaire :306.7ZG-2033
CAS :ZG-2033 (Compound 26) is an orally active HIF-2α agonist that exhibits nanomolar activity (EC50 = 490 nM) in a luciferase reporter assay. It demonstrates an anti-anemic effect and shows synergistic effects with AKB-6548 in anemia, making it useful for the study of renal anemia.Formule :C15H14N2O2SCouleur et forme :SolidMasse moléculaire :286.35Sirtuin modulator 2
CAS :Sirtuin modulator 2 (N-(3-(imidazo[2,1-b]thiazol-6-yl)phenyl)-2-methoxybenzamide) exhibits antidiabetic, anti-inflammatory and antitumor activities.Formule :C19H15N3O2SDegré de pureté :99.47%Couleur et forme :SolidMasse moléculaire :349.41Glucosamine hydrochloride
CAS :Glucosamine hydrochloride (Chitosamine hydrochloride) is commonly used as a treatment for osteoarthritis, although its acceptance as a medical therapy varies.Formule :C6H13NO5·HClDegré de pureté :99.77%Couleur et forme :White Solid CrystallineMasse moléculaire :215.63Deoxyshikonin
CAS :1.Formule :C16H16O4Degré de pureté :99.36% - ≥95%Couleur et forme :SolidMasse moléculaire :272.3HIF-1α-IN-6
HIF-1α-IN-6 (compound 3s) is a potent inhibitor of HIF-1α, demonstrating IC50 values of 0.6 nM and 53.3 nM in MiaPaCa-2 and MDA-MB-231 cells, respectively.Degré de pureté :98%Couleur et forme :Odour SolidAmifostine
CAS :Amifostine (Ethyol) anhydrous is a cytoprotective agent, acts as a free radical scavenging activity.Formule :C5H15N2O3PSDegré de pureté :99.88%Couleur et forme :White SolidMasse moléculaire :214.22BAY 87-2243
CAS :BAY 87-2243 is a potent and selective inhibitor of hypoxia-inducible factor-1 (HIF-1).Formule :C26H26F3N7O2Degré de pureté :98% - 99.77%Couleur et forme :SolidMasse moléculaire :525.53M1002
CAS :M1002, a HIF-2 agonist, boosts HIF-2alpha/ARNT activation and alters HIF-281alpha PAS-B, working with PHD inhibitors.Formule :C15H8F6N2O2SDegré de pureté :99.73%Couleur et forme :SolidMasse moléculaire :394.29Ref: TM-T61822
1mg52,00€5mg97,00€10mg153,00€25mg249,00€50mg369,00€100mg545,00€500mg1.130,00€1mL*10mM (DMSO)114,00€ZINC13466751
CAS :ZINC13466751 is a potent HIF-1α/von Hippel-Lindau interaction inhibitor(IC50 = 2.0 µM).Formule :C20H21N5O2Degré de pureté :99.94%Couleur et forme :SolidMasse moléculaire :363.41Ref: TM-T13398
1mg48,00€5mg97,00€10mg160,00€25mg255,00€50mg353,00€100mg452,00€200mg630,00€1mL*10mM (DMSO)105,00€HIF-2α-IN-4
CAS :HIF-2a translation inhibitor is a compound used as a molecular building block.Formule :C9H9N3O4S2Degré de pureté :≥98%Couleur et forme :SolidMasse moléculaire :287.32ZG-2305
ZG-2305 is an effective, selective, and orally active inhibitor of FIH (factor inhibiting hypoxia-inducible factor (FIH)), with Ki values of 79.6 nM for FIH and 2786 nM for PHD2. This compound enhances the expression of the EGLN3 gene, reduces cellular triglyceride levels, and decreases lipid accumulation. ZG-2305 holds potential for research into obesity and fatty liver disease.Formule :C17H11Cl2N3O5Couleur et forme :SolidMasse moléculaire :408.19HIF-IN-1
CAS :HIF-IN-1 is a inhibitor of hypoxia-inducible factor, which is associated with tumor and cancer cell proliferation and inhibits HIF-1α protein aggregation.Formule :C17H12N2ODegré de pureté :99.48%Couleur et forme :SolidMasse moléculaire :260.29ENMD-1198
CAS :ENMD-119 is a 2-methoxyestradiol analog with antiproliferative and antiangiogenic activity. It is suitable for inhibiting HIF-1α and STAT3 in human HCC cells.Formule :C20H25NO2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :311.42HIF-1α-IN-2 hydrochloride
HIF-1α-IN-2 hydrochloride is a potent HIF-1α inhibitor exhibiting anticancer activity, demonstrated by IC50 values of 28 nM in MDA-MB-231 cells and 15 nM inFormule :C21H20ClN3OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :397.92E3330
CAS :E3330 is a potent and selective APE1(Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity.Formule :C21H30O6Degré de pureté :98.83%Couleur et forme :SolidMasse moléculaire :378.46Ref: TM-T6823
1mg50,00€2mg72,00€5mg107,00€10mg167,00€25mg304,00€50mg500,00€100mg725,00€200mg1.017,00€500mg1.510,00€1mL*10mM (DMSO)88,00€IMM-H007
CAS :IMM-H007 is a novel lipid-lowering agent, increasing abca1 protein expressionFormule :C22H23N5O8Degré de pureté :97.73%Couleur et forme :SolidMasse moléculaire :485.45Ref: TM-T9010
1mg40,00€5mg96,00€10mg135,00€25mg226,00€50mg320,00€100mg434,00€200mg602,00€1mL*10mM (DMSO)131,00€PHD2-IN-1
CAS :PHD2-IN-1, a potent and orally active HIF prolyl hydroxylase 2 (PHD2) inhibitor, exhibits an IC50 of 22.53 nM and is applicable in anemia research [1].Formule :C21H23ClN4O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :446.88KC7F2
CAS :KC7F2 is a potent HIF-1 pathway inhibitor with potential anti-cancer activity.Formule :C16H16Cl4N2O4S4Degré de pureté :98% - 99.11%Couleur et forme :SolidMasse moléculaire :570.38Angiogenesis agent 1
CAS :Compound C-31, a salidroside-based glycoside, activates HIF-1α and may aid in diabetic limb ischemia studies.Formule :C20H24O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :376.4(-)-Hydroxycitric acid lactone
CAS :(-)-Hydroxycitric acid lactone (Garcinia lactone) is an anti-obesity agent.(-)-Hydroxycitric acid lactone was a potent inhibitor of ATP citrate lyase, whichFormule :C6H6O7Degré de pureté :99.91%Couleur et forme :SolidMasse moléculaire :190.11AKBA
CAS :AKBA (3-O-Acetyl-11-keto-beta-boswellic acid), a natural component from frankincense, is a novel activator of Nrf2.Formule :C32H48O5Degré de pureté :97.85% - 99.77%Couleur et forme :SolidMasse moléculaire :512.72Ref: TM-T5S1569
1g1.863,00€1mg43,00€5mg88,00€10mg117,00€25mg187,00€50mg279,00€100mg439,00€500mg1.188,00€1mL*10mM (DMSO)143,00€Adaptaquin
CAS :Adaptaquin is an inhibitor of the hypoxia-inducing factor prolyl hydroxylase (HIF-PH) [1] [2].Formule :C21H16ClN3O2Degré de pureté :98.35%Couleur et forme :SolidMasse moléculaire :377.82PHD2-IN-4
CAS :PHD2-IN-4 (compound 1) is an inhibitor of PHD2, with an IC50 of 4 nM. It is utilized in research related to chronic kidney disease.Formule :C21H19N5O3Couleur et forme :SolidMasse moléculaire :389.407TM6089
CAS :TM6089 is an inhibitor of Prolyl Hydroxylase that stimulates HIF activity without iron chelation, induces angiogenesis, and protects organ against ischemia.Formule :C13H14N4O3SDegré de pureté :99.07%Couleur et forme :SolidMasse moléculaire :306.34Ref: TM-T17105
1mg74,00€5mg164,00€10mg239,00€25mg430,00€50mg645,00€100mg940,00€200mg1.264,00€1mL*10mM (DMSO)170,00€Oltipraz
CAS :Oltipraz (RP 35972) is a synthetic dithiolethione with potential chemopreventive and anti-angiogenic properties.Formule :C8H6N2S3Degré de pureté :100% - 99.56%Couleur et forme :SolidMasse moléculaire :226.34UNC6934
CAS :UNC6934 is a chemical probe targeting the N-terminal PWWP (PWWP1) domain of NSD2.Formule :C24H21N5O4Degré de pureté :99.81%Couleur et forme :SolidMasse moléculaire :443.45Ref: TM-T9584
1mg86,00€2mg111,00€5mg180,00€10mg283,00€25mg455,00€50mg645,00€100mg882,00€500mg1.758,00€1mL*10mM (DMSO)188,00€Annaosanchun
CAS :Annaosanchun (YC-6) is potentially for the treatment of acute ischemic stroke (AIS).Formule :C19H32O3Degré de pureté :99.58%Couleur et forme :SolidMasse moléculaire :308.46AFP464 free base
CAS :AFP464 (NSC710464) free base is an active HIF-1α inhibitor (IC50: 0.25 μM) and a potent aryl hydrocarbon receptor (AhR) activator.Formule :C22H23F3N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :448.44PHD-1-IN-1
CAS :PHD-1-IN-1 is a potent inhibitor of hypoxia-inducible factor prolylhydroxylase domain-1 (PHD-1) enzyme(IC50 = 0.034 μM).Formule :C13H8N4Degré de pureté :99.78%Couleur et forme :SolidMasse moléculaire :220.23Daprodustat
CAS :Daprodustat (GSK1278863) is a HIF-prolyl hydroxylase inhibitor.Formule :C19H27N3O6Degré de pureté :97% - 99.82%Couleur et forme :SolidMasse moléculaire :393.43Ref: TM-T3197
1mg39,00€5mg75,00€10mg111,00€25mg177,00€50mg296,00€100mg439,00€200mg645,00€1mL*10mM (DMSO)90,00€B2
CAS :B2 (Linazolamide intermediate B impurity 2) promotes inclusion formation in cellular models of Huntington's disease and Parkinson's diseaseFormule :C20H17ClN4O3Degré de pureté :99.14%Couleur et forme :SolidMasse moléculaire :396.83PX-478
CAS :PX-478 is a HIF-1α inhibitor with selectivity, oral activity, and blood-brain barrier permeability.Formule :C13H20Cl4N2O3Degré de pureté :97% - ≥98%Couleur et forme :SolidMasse moléculaire :394.12FG-2216
CAS :FG-2216 (YM-311) is a HIF-prolyl hydroxylase inhibitor for the PDH2 enzyme; orally bioavailable and induced reversible and significant Epo induction in vivo.Formule :C12H9ClN2O4Degré de pureté :100% - 99%Couleur et forme :SolidMasse moléculaire :280.66
