FXR
Le récepteur X des farnésoïdes (FXR) est un récepteur nucléaire qui joue un rôle clé dans la régulation de l'homéostasie des acides biliaires, du métabolisme des lipides et de la régulation du glucose. FXR est une cible thérapeutique potentielle pour le traitement des maladies du foie, des troubles métaboliques et des maladies cardiovasculaires. Les inhibiteurs de FXR peuvent moduler ces voies, offrant des perspectives sur les mécanismes des maladies et les stratégies thérapeutiques. Chez CymitQuimica, nous proposons une gamme d'inhibiteurs de FXR pour soutenir vos recherches en hépatologie, métabolisme et développement de médicaments.
Produits appartenant à la catégorie "FXR"
Trier par
43 produits dans cette catégorie.
Tropifexor
CAS :Tropifexor (LJN452) is a novel and highly potent agonist of FXR with an EC50 of 0.2 nM.Formule :C29H25F4N3O5SDegré de pureté :99.1% - 99.85%Couleur et forme :SolidMasse moléculaire :603.58Ref: TM-T4379
1mg87,00€5mg166,00€10mg248,00€25mg437,00€50mg665,00€100mg1.008,00€200mg1.520,00€500mg2.252,00€1mL*10mM (DMSO)213,00€T0901317
CAS :T0901317 is a potent and selective agonist for both LXR and FXR, with EC50 of ~50 nM and 5 μM, respectively; it inhibits nuclear factor/κB (NF/κB).Formule :C17H12F9NO3SDegré de pureté :98% - 99.58%Couleur et forme :SolidMasse moléculaire :481.33Guggulsterone
CAS :Guggulsterone (Guggulsterone E&Z) E&Z is a 3-hydroxy steroid. It has a role as an androgen.Formule :C21H28O2Degré de pureté :99.40% - 99.8%Couleur et forme :Light Yellow PowderMasse moléculaire :312.45Ref: TM-T5574
1mg35,00€5mg55,00€10mg93,00€25mg178,00€50mg245,00€100mg360,00€200mg532,00€1mL*10mM (DMSO)60,00€FXR agonist 10
FXR agonist10 (Compound 27) acts as an agonist for FXR with an EC50 of 14.26 μM. It increases the expression of SHP and BSEP proteins while decreasing the expression of NTCP and CYP7A1 proteins. Additionally, FXR agonist10 has been shown to ameliorate ANIT-induced cholestasis in mouse models.Formule :C15H22O4Couleur et forme :SolidMasse moléculaire :266.33Forskolin
CAS :Forskolin (Coleonol) is a natural product, an adenylate cyclase activator (EC50=0.5 μM).Formule :C22H34O7Degré de pureté :98.83% - 99.86%Couleur et forme :Less Crystalline Solid Colorless Crystalline SolidMasse moléculaire :410.5Ref: TM-T2939
5mg43,00€10mg56,00€25mg86,00€50mg96,00€100mg144,00€200mg182,00€500mg306,00€1mL*10mM (DMSO)56,00€LZ-007
CAS :LZ-007 is an agonist of the Farnesoid X receptor (FXR), with an EC50 of 51 nM as determined by TR-FRET assay, and an EC50 of 76 nM in HepG2 cells. It exhibits favorable pharmacokinetic properties in SD rats and can improve metabolic dysfunction-associated steatohepatitis induced by high-fat diets and CCl4 in mice.Formule :C27H29F3N2O5Couleur et forme :SolidMasse moléculaire :518.53LY2562175
CAS :LY2562175 is an effective and selective FXR agonist (EC50: 193 nM).Formule :C28H27Cl2N3O4Degré de pureté :99.16% - 99.78%Couleur et forme :SolidMasse moléculaire :540.44Ref: TM-T15806
1mg104,00€5mg227,00€10mg369,00€25mg740,00€50mg1.169,00€100mg1.568,00€200mg2.118,00€1mL*10mM (DMSO)269,00€Lecufexor
CAS :Lecufexor is an agonist of the farnesoid X receptor (FXR).Formule :C32H21Cl3N2O5Couleur et forme :SolidMasse moléculaire :619.88FXR agonist 11
CAS :FXR agonist11 (Compound 14) is an FXR activator with an EC50 of 1.2 μM and a maximal effect of 73.7%. It significantly increases GSH levels in the liver and is used to study drug-induced liver injury.Formule :C18H16N2O5Couleur et forme :SolidMasse moléculaire :340.33FXR agonist 9
CAS :FXR agonist9 (compound 26) is a selective, orally active partial agonist of FXR with an EC50 of 0.09 µM (maximum efficacy of 75.13%). It ameliorates the pathological features of fatty liver disease in mice induced by HFD and CCl4-related metabolic dysfunction.Formule :C28H30N2O5Couleur et forme :SolidMasse moléculaire :474.55Vonafexor
CAS :Vonafexor (EYP001) is a farnesoid X receptor (FXR, NR1H4) agonist, with anti-HBV effectsFormule :C19H15Cl3N2O5SDegré de pureté :98.74%Couleur et forme :SolidMasse moléculaire :489.76Ursodeoxycholic acid
CAS :Ursodeoxycholic acid (UDCA) can be used to dissolve gallstones and reduce cholesterol absorption.Formule :C24H40O4Degré de pureté :99.74% - ≥95%Couleur et forme :White - Almost White Solid PowderMasse moléculaire :392.57Ursodeoxycholic acid sodium
CAS :Ursodeoxycholic acid sodium (Sodium Ursodeoxycholate) is a naturally occurring secondary bile acid with anti-inflammatory and cytoprotective activities.Formule :C24H40NaO4Degré de pureté :98% - 98.55%Couleur et forme :SolidMasse moléculaire :415.56NR1H4 Protein, Mouse, Recombinant (His)
NR1H4 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 27.80 kDa.Couleur et forme :Lyophilized PowderMasse moléculaire :27.80 kDa (predicted)Sevelamer hydrochloride
CAS :Sevelamer hydrochloride (Sevelamer HCl) is a phosphate binding drug used to treat hyperphosphatemia via binding to dietary phosphate and prevents its absorptionFormule :(C3H7N·C3H5ClO·HCl)xDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :186.08BAR-2227
CAS :BAR-2227 (compound 3a) functions as an FXR agonist and a LIFR inhibitor. It is utilized in the study of liver fibrosis and inflammation.Formule :C24H17Cl2NO4Couleur et forme :SolidMasse moléculaire :454.30INT-767
CAS :INT-767 is a highly potent farneson X receptor (FXR)/TGR5 dual agonist that prevents NASH and promotes visceral fat brown lipogenesis and mitochondrial functionFormule :C25H43NaO6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :494.66Obeticholic Acid
CAS :Obeticholic Acid (6-ECDCA, INT-747) is a high-affinity, semisynthetic, bile acid-derived FXR agonist.Cost-effective and quality-assured.Formule :C26H44O4Degré de pureté :99.88% - 99.97%Couleur et forme :SolidMasse moléculaire :420.63Ref: TM-T1789
5mg48,00€10mg52,00€25mg82,00€50mg99,00€100mg163,00€200mg274,00€500mg505,00€1mL*10mM (DMSO)49,00€Vidofludimus
CAS :Vidofludimus (SC12267) (4SC-101, SC12267) is a novel small molecule inhibitor of dihydroorotate dehydrogenase (DHODH).Formule :C20H18FNO4Degré de pureté :98.83% - 99.58%Couleur et forme :SolidMasse moléculaire :355.36Cilofexor
CAS :Cilofexor inhibits binding of a synthetic peptide, Cilofexor is a farnesoid X receptor (FXR) agonist.Formule :C28H22Cl3N3O5Degré de pureté :99.32% - ≥95%Couleur et forme :SolidMasse moléculaire :586.85Ref: TM-T7436
1mg50,00€2mg73,00€5mg124,00€10mg188,00€25mg380,00€50mg567,00€100mg807,00€500mg1.644,00€1mL*10mM (DMSO)158,00€BAR502
CAS :BAR502 is a dual GPBAR1 and FXR agonist (IC50s: 0.4 μM and 2 μM).Formule :C25H44O3Degré de pureté :99.95%Couleur et forme :SolidMasse moléculaire :392.62Chenodeoxycholic acid
CAS :Chenodeoxycholic acid (CDCA), a bile acid, usually conjugated with either glycine or taurine, acts as a detergent to solubilize fats for intestinal absorption.Formule :C24H40O4Degré de pureté :99.70% - 99.72%Couleur et forme :White - Almost White Solid PowderMasse moléculaire :392.57FXR agonist 5
CAS :FXR agonist 5 is an FXR agonist used in the study of liver diseases or diseases mediated by metabolic inflammation.Formule :C40H53N5O5Degré de pureté :99.74%Couleur et forme :SolidMasse moléculaire :683.88Nidufexor
CAS :Nidufexor is an agonist for the farnesoid X receptor (FXR).Formule :C27H22ClN3O4Degré de pureté :98.67%Couleur et forme :SolidMasse moléculaire :487.93GW 4064
CAS :GW 4064 is an effective farnesoid X receptor (FXR) agonist (EC50 =65 nM).Formule :C28H22Cl3NO4Degré de pureté :97.47% - 99.94%Couleur et forme :SolidMasse moléculaire :542.84Ref: TM-T2233
5mg50,00€10mg84,00€25mg139,00€50mg235,00€100mg424,00€200mg640,00€500mg1.008,00€1mL*10mM (DMSO)63,00€LH10
LH10 is an FXR agonist based on fexaramine, with an EC50 of 0.14 μM. It offers hepatoprotective effects, mitigating conditions such as cholestasis induced by alpha naphthylisothiocyanate (ANIT), acute liver injury caused by APAP, and non-alcoholic steatohepatitis (NASH).Formule :C34H33N3O2Couleur et forme :SolidMasse moléculaire :515.64Gly-β-MCA
CAS :Gly-β-MCA is an orally bioactive, entero inhibitor of the farnesoid X receptor (FXR), a bile acid, used in the study of obesity and diabetes.Formule :C26H43NO6Degré de pureté :≥98.0%Couleur et forme :SolidMasse moléculaire :465.62LY367385
CAS :LY367385 is a highly effective and selective mGluR1a antagonist.Formule :C10H11NO4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :209.2ZLY28
ZLY28 is a novel, first-in-class compound with specific intestinal restriction and oral activity, serving as a dual modulator of FXR and FABP1.Formule :C29H23Cl2NO4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :520.4FXR/CES2 modulator 1
CAS :Compound LE-77, known as FXR/CES2 modulator 1, functions as a dual regulator that activates FXR and inhibits CES2. It effectively mitigates the intestinal toxicity of irinotecan.Formule :C27H21Cl2NO5Couleur et forme :SolidMasse moléculaire :510.36NR1H4 Protein, Human, Recombinant (His)
NR1H4 Protein, Human, Recombinant (His) is expressed in E.Couleur et forme :Lyophilized PowderMasse moléculaire :27.83 kDa (predicted)Glyco-Obeticholic acid
CAS :Glyco-Obeticholic acid is an active metabolite of Obeticholic acid. Obeticholic acid is an agonist of the farnesoid X receptor (FXR).Formule :C28H47NO5Degré de pureté :99.77% - 99.95%Couleur et forme :SolidMasse moléculaire :477.68Fexaramine
CAS :Fexaramine is a small molecule farnesoid X receptor (FXR) agonist with 100-fold increased affinity compared to natural compounds.Formule :C32H36N2O3Degré de pureté :98.87% - 99.61%Couleur et forme :SolidMasse moléculaire :496.64Osocimab
CAS :Osocimab (BAY 1213790) is a strong FXIa inhibitor, Ki 2.4 nM, EC50 0.2 nM, and reduces thrombosis in research.Degré de pureté :> 95% - > 95%Couleur et forme :LiquidMasse moléculaire :144.46 kDaFXR agonist 12
CAS :FXR agonist12 (Compound C7) is an orally active FXR agonist. It downregulates bile acid synthesis-related genes and upregulates bile acid transport-related genes in HepG2 cells. FXR agonist12 alleviates ANIT-induced cholestasis and reduces liver damage and fibrosis in a mouse model of NASH.Formule :C26H44O3Couleur et forme :SolidMasse moléculaire :404.626GSK2324
CAS :GSK2324 is a potent FXR agonist for the treatment of NAFLD by controlling hepatic lipids through reduced uptake and selective reduction of fatty acid synthesis.Formule :C29H22Cl2N2O4Degré de pureté :100% - 98.50%Couleur et forme :SolidMasse moléculaire :533.4NDB
CAS :NDB is a hFXRα antagonist that inhibits GW4064-stimulated FXR/RXR interactions in primary mouse hepatocytes.NDB is used in the study of diabetes.Formule :C26H28Cl2N2O2Degré de pureté :98.94%Couleur et forme :SolidMasse moléculaire :471.42Tauro-β-muricholic acid sodium
CAS :Tauro-β-muricholic Acid sodium is a endogenous metabolite, is a competitive and reversible antagonist of farnesoid X receptor (FXR)(IC50 of 40 μM).Formule :C26H44NNaO7SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :537.69Tauro-β-muricholic acid
CAS :Tauro-β-muricholic acid (TβMCA), a trihydroxylated bile acid, acts as a competitive and reversible FXR antagonist (IC 50 = 40 μM) and exhibits antiapoptoticFormule :C26H45NO7SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :515.7Chenodeoxycholic Acid sodium salt
CAS :Chenodeoxycholic Acid sodium salt (CDCA sodium salt) is a bile acid in humans that activates the nuclear receptor FXR, rescues axonal degeneration of induced pluripotent stem cell-derived neurons in patients with spastic paraplegia type 5 and cerebral xanthomatosis, and can be used to study pancreatic necrosis.Formule :C24H39NaO4Degré de pureté :99.68% - 99.72%Couleur et forme :SolidMasse moléculaire :414.55Tauro-Obeticholic acid
CAS :Tauro-Obeticholic acid is an active Obeticholic acid metabolite. Obeticholic acid is an orally bioavailable agonist of farnesoid-X receptor (FXR).Formule :C28H49NO6SDegré de pureté :99.82% - 99.82%Couleur et forme :SolidMasse moléculaire :527.76Ref: TM-T13092
1mg117,00€5mg274,00€10mg414,00€25mg685,00€50mg938,00€100mg1.311,00€1mL*10mM (DMSO)349,00€Turofexorate Isopropyl
CAS :Turofexorate Isopropyl (XL335) is a potent, selective, and orally bioavailable FXR agonist with EC50 of 4 nMFormule :C25H24F2N2O3Degré de pureté :99.33% - 99.73%Couleur et forme :SolidMasse moléculaire :438.47DY268
CAS :DY268 is a compound based on trisubstituted pyrazolamide without any FXR agonist activity and cytotoxicity and can be used as an effective FXR antagonist.Formule :C30H32N4O5SDegré de pureté :98.48% - 99.43%Couleur et forme :SolidMasse moléculaire :560.66Ref: TM-T31587
1mg40,00€5mg88,00€10mg126,00€25mg245,00€50mg454,00€100mg655,00€500mg1.406,00€1mL*10mM (DMSO)87,00€
