Lipoxygénase
Les lipoxygénases sont une famille d'enzymes qui catalysent l'oxygénation des acides gras polyinsaturés, conduisant à la production de médiateurs lipidiques bioactifs tels que les leucotriènes et les lipoxines. Ces médiateurs jouent un rôle crucial dans l'inflammation, les réponses immunitaires et le cancer. Les inhibiteurs de la lipoxygénase sont utilisés pour étudier leur rôle dans les maladies inflammatoires, l'asthme et le cancer. Chez CymitQuimica, nous proposons une variété d'inhibiteurs de la lipoxygénase pour soutenir vos recherches en inflammation, oncologie et métabolisme lipidique.
Produits appartenant à la catégorie "Lipoxygénase"
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BI-0115
CAS :BI-0115 inhibits LOX-1, preventing oxLDL uptake by triggering receptor inhibition and dimer formation.Formule :C15H14ClN3ODegré de pureté :99.34%Couleur et forme :SolidMasse moléculaire :287.74p-Hexylresorcinol
CAS :Produit contrôléApplications p-Hexylresorcinol shows antiimnflammatory activity acting on the human 5-LO (5-Lipoxygenase) proinflammatory enzyme Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Filosa, R. et al.: Eur. j. Med. Chem., 67, 269 (2013);Formule :C12H18O2Couleur et forme :White To Light BrownMasse moléculaire :194.27LOX-IN-3 dihydrochloride
CAS :LOX-IN-3 dihydrochloride is an inhibitor of lysyl oxidase (LOX).Formule :C13H15Cl2FN2O2SDegré de pureté :99.86%Couleur et forme :SolidMasse moléculaire :353.24Ref: TM-T39986
1mg57,00€5mg120,00€10mg188,00€25mg354,00€50mg588,00€100mg938,00€200mg1.320,00€1mL*10mM (DMSO)127,00€CBS-1114 HCl
CAS :CBS-1114 HCl: 5-lipoxygenase inhibitor, anti-inflammatory, improves heart function, reduces heart's fat.Formule :C13H14ClN3Degré de pureté :99.53%Couleur et forme :SoildMasse moléculaire :247.722,4-Dichlorobenzoyl Chloride
CAS :Produit contrôléApplications 2,4-Dichlorobenzoyl Chloride is a reactant used in the synthesis of aroyl(sulfamoylphenyl)thiourea derivatives as 15-lipoxygenase inhibitors. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Mahdavi, M., et. al.: Eur. J. Med. Chem., 82, 308 (2014)Formule :C7H3Cl3OCouleur et forme :NeatMasse moléculaire :209.462,5-Di-tert-butylhydroquinone
CAS :2,5-Di-tert-butylhydroquinone (BHQ) is an effective and selective endoplasmic reticulum Ca2+-ATPase inhibitor.Formule :C14H22O2Degré de pureté :97.11%Couleur et forme :PelletslargecrystalsMasse moléculaire :222.321-Naphthyl 3,5-dinitrobenzoate
CAS :1-Naphthyl 3,5-dinitrobenzoate (JMC-4) is an inhibitor of 5-LOX can be used in studies about inflammatory therapy.Formule :C17H10N2O6Degré de pureté :97.42%Couleur et forme :SolidMasse moléculaire :338.27Nordihydro Guaiaretic Acid (mixture of diastereomers)
CAS :Produit contrôléApplications Nordihydro Guaiaretic Acid is a lipoxygenase inhibitor; polyphenol-bearing o-dihydroxy (catechol) structure. Inhibitor of broad bean lipoxygenase. The oxidation product from Resveratrol (R150000) showed a high inhibitory activity, whereas Resveratrol itself had no activity and its oxidation efficiency was low. References Brash, A., et al.: J. Biol. Chem., 274, 23679 (1999), Fujimoto, A., et al.: Bioorg. Med. Chem. Lett., 20, 7393 (2010), Ridolfi, M., et al.: J. Agric. Food Chem., 50, 835 (2002),Formule :C18H22O4Couleur et forme :White To BrownMasse moléculaire :302.36MK-886
CAS :Produit contrôléApplications MK-886 is a potent and selective inhibitor of FLAP and Cox-1. References Gillard, J., et al.: Can. J. Physiol. Pharmacol., 67, 456-464 (1989);Formule :C27H34ClNO2SCouleur et forme :NeatMasse moléculaire :472.084',5-Dihydroxyflavone
CAS :4',5-Dihydroxyflavone is a soybean LOX-1(Ki: 102.6 μM) and yeast α-Glucosidase inhibitor (IC50: 66 μM).Formule :C15H10O4Degré de pureté :95.38%Couleur et forme :SolidMasse moléculaire :254.24RWJ 63556
CAS :RWJ 63556 is an orally active inhibitor of COX-2 selective/5-lipoxygenase, shows anti-inflammatory activities.Formule :C11H10FNO3S2Degré de pureté :98.91%Couleur et forme :SolidMasse moléculaire :287.33Ref: TM-T12784
1mg52,00€5mg93,00€10mg145,00€25mg279,00€50mg424,00€100mg562,00€200mg743,00€1mL*10mM (DMSO)87,00€Caffeic Acid
CAS :Caffeic Acid is an orally bioavailable, hydroxycinnamic acid derivative and polyphenol, with potential anti-oxidant, anti-inflammatory, and antineoplasticFormule :C9H8O4Degré de pureté :98.89% - 99.3%Couleur et forme :Yellow Crystals From Concentrated Aqueous Solutions Alkaline Solns Turn From Yellow To Orange Alkaline Solutions Turn From Yellow To Orange (Ntp 1992)Masse moléculaire :180.16Dimethyl (2-Oxoheptyl)phosphonate
CAS :Produit contrôléApplications Dimethyl (2-Oxoheptyl)phosphonate is a useful synthetic intermediate, and is used as a reagent to synthesize Caffeic acid (C080000) derivatives, which function as 5-lipoxygenase, 12-lipoxygenase, and prostaglandin synthase inhibitors. References Sugiura, M., et al.: Chem. Pharm. Bull., 37, 1039 (1989)Formule :C9H19O4PCouleur et forme :YellowMasse moléculaire :222.22E 6080 HCl
CAS :E 6080 HCl is a 5-lipoxygenase inhibitor and can be used to study bronchial diseases.Formule :C17H20ClN3O3S2Degré de pureté :99.59%Couleur et forme :SoildMasse moléculaire :413.94U-73122
CAS :U-73122 (U73122) , an effective PLC inhibitor, reduces agonist-induced Ca2+ increases in platelets and PMN.Formule :C29H40N2O3Degré de pureté :97.50%Couleur et forme :Solid Off-WhiteMasse moléculaire :464.64COX-2/15-LOX-IN-2
COX-2/15-LOX-IN-2 is a potent inhibitor of both COX-2 and 15-LOX, demonstrating IC50 values of 0.065 μM for COX-2 and 1.86 μM for 15-LOX.Formule :C27H26N6OS2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :514.66Chebulagic acid
CAS :Chebulagic acid, isolated from the Terminalia chebula Retz, is a COX-LOX dual inhibitor.Formule :C41H30O27Degré de pureté :100% - 99.8%Couleur et forme :SolidMasse moléculaire :954.66Ref: TM-TQ0180
1mg79,00€5mg165,00€10mg238,00€25mg398,00€50mg592,00€100mg842,00€1mL*10mM (DMSO)256,00€Setileuton
CAS :Setileuton (MK0633) is a specific 5-LOX inhibitor and can be used in research on asthma and atherosclerosis.Formule :C22H17F4N3O4Degré de pureté :100% - 99.31%Couleur et forme :SolidMasse moléculaire :463.38Oleoyl coenzyme A lithium
CAS :Oleoyl coenzyme A lithium (Oleoyl-CoA lithium) is a thioester of oleic acid and coenzyme A, acting as an allosteric inhibitor of h15-LOX-2.Formule :C39H67LiN7O17P3SCouleur et forme :SolidMasse moléculaire :1037.913-Hydroxycoumarin
CAS :3-Hydroxycoumarin is a natural compound, and is human 15-LOX-1 inhibitorsFormule :C9H6O3Degré de pureté :98.32% - 99.5%Couleur et forme :SolidMasse moléculaire :162.14
