Lipoxygénase
Les lipoxygénases sont une famille d'enzymes qui catalysent l'oxygénation des acides gras polyinsaturés, conduisant à la production de médiateurs lipidiques bioactifs tels que les leucotriènes et les lipoxines. Ces médiateurs jouent un rôle crucial dans l'inflammation, les réponses immunitaires et le cancer. Les inhibiteurs de la lipoxygénase sont utilisés pour étudier leur rôle dans les maladies inflammatoires, l'asthme et le cancer. Chez CymitQuimica, nous proposons une variété d'inhibiteurs de la lipoxygénase pour soutenir vos recherches en inflammation, oncologie et métabolisme lipidique.
Produits appartenant à la catégorie "Lipoxygénase"
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6-Hydroxyflavanone
CAS :6-Hydroxyflavanone from Acorus calamus leaves targets COX-2, 5-LOX, opioid, and GABA-A receptors, reducing inflammation and neuropathic pain.Formule :C15H12O3Degré de pureté :99.91%Couleur et forme :Slightly Yellow-Cream PowderMasse moléculaire :240.255-LOX-IN-5
Compound 29, also known as 5-LOX-IN-5, is a 5-lipoxygenase (5-LOX) inhibitor with an inhibitory concentration 50 (IC50) of 56 nM, utilized in researchFormule :C19H18BrN3O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :432.33Zileuton
CAS :Zileuton (A 64077) inhibits 5-lipoxygenase, reduces leukotrienes, aids bronchodilation, lessens mucus/edema, and helps manage asthma symptoms.Formule :C11H12N2O2SDegré de pureté :98.72% - 99.43%Couleur et forme :Crystalline SolidMasse moléculaire :236.29Nordihydroguaiaretic acid
CAS :Nordihydroguaiaretic acid (NDGA) is a natural lipoxygenase (5-LOX) inhibitor. Nordihydroguaiaretic acid has antioxidant effect. Cost-effective and quality-assured.Formule :C18H22O4Degré de pureté :97.82% - 99.91%Couleur et forme :SolidMasse moléculaire :302.36A-69412
CAS :A-69412 is a reversible 5-lipoxygenase inhibitor, potentially treating ulcerative colitis and asthma.Formule :C7H10N2O3Degré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :170.17Ref: TM-T10208
1mg115,00€5mg255,00€10mg375,00€25mg562,00€50mg792,00€100mg1.064,00€500mg2.147,00€1mL*10mM (DMSO)188,00€KKII5
CAS :KKII5 is a potent inhibitor of the lipoxygenase LOX-1 with an IC50 of 19 μM.KKII5 inhibits lipid peroxidation and enhances the ability of the active centers ofFormule :C16H14N2SDegré de pureté :97.44%Couleur et forme :SolidMasse moléculaire :266.36Ref: TM-T77288
2mg37,00€5mg56,00€10mg84,00€25mg126,00€50mg197,00€100mg330,00€200mg472,00€1mL*10mM (DMSO)138,00€5-Lipoxygenase-In-1
CAS :5-Lipoxygenase-In-1 (compound example 4.10) is a 5-Lipoxygenase inhibitor.Formule :C23H28N4O2SCouleur et forme :SolidMasse moléculaire :424.56ThioLox
CAS :ThioLox, a 15-LOX-1 inhibitor (IC50: 12 μM), has anti-inflammatory, neuroprotective benefits, and guards against glutamate toxicity.Formule :C15H18N2OSDegré de pureté :100%Couleur et forme :SoildMasse moléculaire :274.38Ref: TM-T67908
5mg35,00€10mg52,00€25mg105,00€50mg170,00€100mg295,00€200mg419,00€1mL*10mM (DMSO)47,00€Wedelolactone
CAS :Wedelolactone (IKK Inhibitor II) inhibits NF-κB-mediated gene transcription in cells by blocking the phosphorylation and degradation of IκBα.Formule :C16H10O7Degré de pureté :98.07% - 99.76%Couleur et forme :SolidMasse moléculaire :314.25Ref: TM-T3384
1mg35,00€5mg74,00€10mg115,00€25mg185,00€50mg331,00€100mg437,00€500mg1.008,00€1mL*10mM (DMSO)52,00€Acetone 2,4-Dinitrophenylhydrazone-13C3
CAS :Produit contrôléApplications Isotope labelled Acetone 2,4-Dinitrophenylhydrazone is a dinitrophenylhydrazone (DNPH) derivative of an aliphatic ketone found in mainstream cigarette smoke. Acetone 2,4-Dinitrophenylhydrazone showed inhibitory activity towards soybean lipoxygenase and renal prostaglandin synthetase. References Delgado, B. et al.: J. Liq. Chrom. Rel Technol., 31, 361 (2008); Miller, J.H. et al.: J. Chrom. Sci., 48, 12 (2010); Baumann, J. et al.: Agents Act., 12, 360 (1982);Formule :C613C3H10N4O4Couleur et forme :NeatMasse moléculaire :241.18Belamcandol B (contains up to 20% trans isomer)
CAS :Produit contrôléApplications Belamcandol B is a compound isolated from the seeds of B. Chinensis. and known to be an starting compound in the synthesis of 5-lipoxygenase inhibitors. References Fukuyama, Y., et al.: Chem. Pharma. Bull., 39, 1877 (1991); Fukuyama, Y., et al.: Chem. Pharma. Bull., 41, 561 (1993);Formule :C22H36O2Couleur et forme :NeatMasse moléculaire :332.52Psoralidin
CAS :Psoralidin inhibits Akt phosphorylation and phosphatidylinositol 3-kinase activation and transcriptionally.Formule :C20H16O5Degré de pureté :98% - 98.75%Couleur et forme :SolidMasse moléculaire :336.34ZD-2138
CAS :ZD-2138: Selective 5-LOX inhibitor, eases allergen-induced asthma attacks and airway constriction in guinea pigs.Formule :C23H24FNO4Degré de pureté :100% - 100%Couleur et forme :SolidMasse moléculaire :397.44Phenethyl ferulate
CAS :Phenethyl ferulate is a chemopreventive against colon cancer, enhancing apoptosis in tumors and inhibiting COX/5-LOX (IC50: 4.35/5.75 μM).Formule :C18H18O4Degré de pureté :99.58% - 99.91%Couleur et forme :SolidMasse moléculaire :298.33PGS-IN-1
CAS :PGS-IN-1 (KME-4) is a potent inhibitor of prostaglandin synthetase (PGS, IC50: 0.28 μM) and 5-lipoxygenase (IC50: 1.05 μM).Formule :C19H26O3Degré de pureté :99.67%Couleur et forme :SolidMasse moléculaire :302.41Ref: TM-T10098
1mg52,00€2mg67,00€5mg97,00€10mg170,00€25mg369,00€50mg540,00€100mg772,00€500mg1.549,00€1mL*10mM (DMSO)133,00€Phenidone
CAS :Phenidone inhibits COX/LOX, reducing rat autoimmune paralysis and lowering blood pressure in hypertensive rats.Formule :C9H10N2ODegré de pureté :99.34%Couleur et forme :White Solid Solid CrystallineMasse moléculaire :162.19h15-LOX-2 inhibitor 1
CAS :Compound 105 (h15-LOX-2 inhibitor 1) is a potent inhibitor of human epithelial 15-lipoxygenase-2 (h15-LOX-2), exhibiting an IC50 of 0.34 μM [1].Formule :C17H13F3N2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :334.36Ketoconazole-d8
CAS :Produit contrôléApplications Deuterated Ketoconazole, an inhibitor of cytochrome P-450 dependent steps in the biosynthesis of steroid hormones in vivo. Antimetastatic and antineoplastic activity. Orally active 5-lipoxygenase and thromboxane synthase inhibitor. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Lambert, A., et al.: Biochem. Pharmacol., 35, 3999 (1986), Van Wauwe, J.P. and Janssen, P.A.J., J. Med. Chem., 32, 2231 (1989), Nardone, P.A., et al.: . Surg. Res., 44, 425 (1988), Tucker, W.F.G., et al.: Br. Med. J., 293, 882 (1986)Formule :C26H20D8Cl2N4O4Couleur et forme :White To BeigeMasse moléculaire :539.48PXS-6302 hydrochloride
CAS :PXS-6302 hydrochloride is a potent irreversible lysine oxidase (LOX) inhibitor, inhibiting Bovine LOX, rh LOXL1, rh LOXL2, rh LOXL3, and rh LOXL4 with IC50 of 3Formule :C10H11ClF3NO2SDegré de pureté :99.89%Couleur et forme :SoildMasse moléculaire :301.71Meclofenoxate hydrochloride
CAS :Meclofenoxate HCl (Lucidril) boosts memory and cognition; it's a DIMETHYLAMINOETHANOL and p-chlorophenoxyacetic acid ester.Formule :C12H16ClNO3·HClDegré de pureté :99.04%Couleur et forme :White Crystal PowderMasse moléculaire :294.17
