récepteur 5-HT
Les récepteurs 5-HT, également connus sous le nom de récepteurs de la sérotonine, sont un groupe de récepteurs couplés aux protéines G (GPCR) qui médiatisent les effets de la sérotonine, un neurotransmetteur impliqué dans la régulation de l'humeur, l'anxiété, le sommeil, l'appétit et d'autres processus physiologiques. Ces récepteurs sont divisés en plusieurs sous-types, chacun ayant des fonctions et des propriétés pharmacologiques distinctes. Les modulateurs des récepteurs 5-HT sont largement étudiés pour leurs rôles dans le traitement de la dépression, des troubles anxieux et d'autres affections neuropsychiatriques. Chez CymitQuimica, nous offrons une gamme de modulateurs des récepteurs 5-HT de haute qualité pour soutenir vos recherches en neuropharmacologie, troubles de l'humeur et signalisation GPCR.
Produits appartenant à la catégorie "récepteur 5-HT"
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Arotinolol
CAS :Arotinolol is a nonselective α/β-adrenergic receptor blocker and a vasodilating β-blocker. Arotinolol also shows potency for inhibiting the binding of the radioligand [125I-ICYP] to [5HT1B-serotonergic] receptor sites. It is an antihypertensive agent.Formule :C15H21N3O2S3Couleur et forme :White SolidMasse moléculaire :371.54Wf-516
CAS :Wf-516 is a 5-HT reuptake inhibitor (Kis: 5 nM and 40 nM for 5-HT1A receptor and 5-HT2A receptor in humans, respectively), and with potent antidepressantFormule :C25H25Cl2N3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :502.395-HT2C agonist-3
CAS :5-HT2C agonist-3 ((+)-19), a selective 5-HT2C agonist (EC 50: 24 nM, Ki: 78 nM), exhibits antipsychotic-like activity by blocking amphetamine-inducedFormule :C19H23ClFNO2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :351.84Puerarin
CAS :Puerarin (Kakonein), also known as Kakonein, is a member of the class of compounds known as isoflavonoid C-glycosides. It is a 5-HT2C receptor antagonist.Formule :C21H20O9Degré de pureté :98.90% - 99.21%Couleur et forme :Yellow Brown Fine PowderMasse moléculaire :416.38Cilansetron
CAS :Cilansetron is an effective and selective 5-HT3 receptor antagonist that can be used for related diseases caused by colitis.Formule :C20H21N3ODegré de pureté :99.77% - 99.85%Couleur et forme :SolidMasse moléculaire :319.4Clothiapine
CAS :Clothiapine is an atypical antipsychotic of the dibenzothiazepine chemical class.Formule :C18H18ClN3SDegré de pureté :99.93%Couleur et forme :SolidMasse moléculaire :343.87GSK163090
CAS :GSK163090 is a specific and orally active 5-HT1A/B/D receptor antagonist (pKis: 9.4/8.5/9.7, and 6.3/6.7 for 5-HT1A/B/D, and dopamine D2/D3).Formule :C25H29N5ODegré de pureté :99.20%Couleur et forme :SolidMasse moléculaire :415.53Ref: TM-TQ0311
1mg37,00€2mg52,00€5mg80,00€10mg125,00€25mgÀ demander50mgÀ demander1mL*10mM (DMSO)87,00€JPC0323
JPC0323 is a dual positive allosteric modulator of the 5-HT2C and 5-HT2A receptors, featuring on-target properties, acceptable plasma exposure, and adequateFormule :C22H43NO4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :385.585-HT2C agonist-4
CAS :Compound 3i, a 5-HT2C agonist-4, acts as an agonist for the 5-HT2C receptor with an EC50 of 5.7 nM. It is capable of reducing locomotor activity in zebrafish larvae.Formule :C24H25N5OCouleur et forme :SolidMasse moléculaire :399.49Risperidone
CAS :Risperidone (R 64 766) is a selective blocker of dopamine D2 receptors and serotonin 5-HT2 receptors that act as an atypical antipsychotic agent.Formule :C23H27FN4O2Degré de pureté :99.73%Couleur et forme :Crystalline SolidMasse moléculaire :410.48MRS7925
MRS7925 (Compound 43) serves as a potent antagonist of the 5-HT2B receptor, with an inhibition constant (Ki) of 17 nM, and is utilized in the study of fibrosisFormule :C20H26IN5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :511.36Escin IB
CAS :Escin Ib inhibits gastric emptying, at least in part, mediated by capsaicin-sensitive sensory nerves, to stimulate the synthesis and/or release of dopamine, toFormule :C55H86O24Degré de pureté :99.09% - 99.81%Couleur et forme :SolidMasse moléculaire :1131.26Indophagolin
CAS :Indophagolin: autophagy inhibitor, IC50 140 nM; blocks P2X4, P2X1, P2X3 receptors, IC50s 2.71, 2.40, 3.49 μM.Formule :C19H15BrClF3N2O3SDegré de pureté :99.76%Couleur et forme :SolidMasse moléculaire :523.75Ref: TM-T8946
1mg58,00€5mg111,00€10mg170,00€25mg284,00€50mg393,00€100mg552,00€200mg748,00€1mL*10mM (DMSO)129,00€Pipamperone
CAS :Pipamperone (McN-JR 3345) binds 5-HT2A closely as receptor.Formule :C21H30FN3O2Degré de pureté :99.94%Couleur et forme :White PowderMasse moléculaire :375.48Ref: TM-T12480
1mg62,00€2mg85,00€5mg119,00€10mg170,00€25mg283,00€50mg430,00€100mg622,00€1mL*10mM (DMSO)131,00€WAY208466 dihydrochloride
CAS :WAY208466 dihydrochloride is a 5-HT6 receptor agonist (EC50=7.3 nM) with antidepressant and anxiolytic activity.Formule :C17H20Cl2FN3O2SDegré de pureté :98.43%Couleur et forme :SolidMasse moléculaire :420.33WAY-100635 maleate
CAS :WAY-100635 Maleate is a specific and effective 5-HT receptor antagonist (IC50=0.95 nM).Formule :C25H34N4O2·xC4H4O4Degré de pureté :100%Couleur et forme :White SolidMasse moléculaire :538.645Ref: TM-T3453
2mg46,00€5mg66,00€10mg95,00€25mg159,00€50mg226,00€100mg334,00€500mg807,00€1mL*10mM (DMSO)79,00€5-HT2A receptor agonist-6
CAS :5-HT2A receptor agonist-6 (compound 47) is a selective agonist of the 5-HT2A receptor with a pEC50 value of 6.58.Formule :C18H19N3O3Couleur et forme :SolidMasse moléculaire :325.36Niaprazine
CAS :Niaprazine is a histamine H1-receptor antagonist with marked sedative properties.Formule :C20H25FN4ODegré de pureté :99.5%Couleur et forme :SolidMasse moléculaire :356.44Ref: TM-T36949
2mg40,00€5mg58,00€10mg96,00€25mg144,00€50mg210,00€100mg309,00€200mg444,00€1mL*10mM (DMSO)64,00€Brexpiprazole
CAS :Brexpiprazole (OPC-34712) is a partial agonist of human 5-hydroxytryptamine (5-HT) 5-HT1A and dopamine D2 receptors.Formule :C25H27N3O2SDegré de pureté :99.06% - 99.96%Couleur et forme :SolidMasse moléculaire :433.57SB 243213
CAS :SB 243213 is a 5-HT2C receptor antagonist with anxiolytic and antidepressant activity used in schizophrenia and movement disorders.Formule :C22H19F3N4O2Degré de pureté :100% - 100%Couleur et forme :SolidMasse moléculaire :428.41Bemesetron
CAS :Bemesetron (MDL 72222) is a selective antagonist of 5-HT3 (IC50 = 0.33 nM) with neuroprotective effects.Formule :C15H17Cl2NO2Degré de pureté :97.37%Couleur et forme :SolidMasse moléculaire :314.21Prucalopride
CAS :Prucalopride (R-93877), a selective 5-HT4A/4B agonist (Ki: 2.5/8 nM), is >290x more specific for these receptors.Formule :C18H26ClN3O3Degré de pureté :100%Couleur et forme :SolidMasse moléculaire :367.87Ro4368554
CAS :Ro4368554 is a selective 5-HT6 antagonist capable of crossing the blood-brain barrier. It can reverse memory deficits caused by scopolamine and tryptophan depletion. Ro4368554 is applicable for research related to memory impairments.Formule :C19H21N3O2SCouleur et forme :SolidMasse moléculaire :355.454lumateperone Tosylate
CAS :lumateperone Tosylate (ITI-007) is a 5-HT2A receptor antagonist, a partial agonist of presynaptic D2 receptors and an antagonist of postsynaptic D2 receptors.Formule :C31H36FN3O4SDegré de pureté :95.83% - 98.57%Couleur et forme :SolidMasse moléculaire :565.7F 14679
CAS :F 14679 is a potent 5-HT1A agonist (pKi=10.23) with a maximum Ca2t response similar to 5-HT.Formule :C21H25ClF2N4ODegré de pureté :99.09%Couleur et forme :SolidMasse moléculaire :422.9FFN246
CAS :FFN246, a fluorescent probe, concurrently targets the serotonin transporter (SERT) and vesicular monoamine transporter 2 (VMAT2), exhibiting excitation andFormule :C15H13FN2ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :256.27SB 242084
CAS :SB 242084 dihydrochloride hydrate is a psychoactive drug and research chemical which acts as a selective antagonist for the 5HT2C receptor.Formule :C21H19ClN4O2Degré de pureté :99.77% - ≥98%Couleur et forme :SolidMasse moléculaire :394.85Ref: TM-T7277
1mg42,00€2mg55,00€5mg90,00€10mg115,00€25mg246,00€50mg472,00€100mg720,00€1mL*10mM (DMSO)89,00€Cisapride
CAS :Cisapride (R 51619), a 5-HT4 agonist, enhances gut peristalsis and gastric emptying, reduces reflux.Formule :C23H29ClFN3O4Degré de pureté :99.77%Couleur et forme :White To Slightly Biege Powder SolidMasse moléculaire :465.95Ref: TM-T1291
5mg47,00€10mg59,00€25mg77,00€50mg99,00€100mg135,00€200mg235,00€500mg394,00€1mL*10mM (DMSO)55,00€(S)-Bexicaserin
CAS :(S)-Bexcaserin (compound 2) serves as a 5-HT2C receptor agonist, presenting research possibilities in obesity and psychiatric disorders [1].Formule :C15H19F2N3ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :295.33Frovatriptan succinate hydrate
CAS :Frovatriptan treats all migraine types, nausea, vomiting, light/sound sensitivity, and prevents menstrual migraines; it targets 5-HT1B/D and 5-HT7 receptors.Formule :C18H25N3O6Degré de pureté :99.95%Couleur et forme :SolidMasse moléculaire :379.41Hypidone hydrochloride
CAS :Hypidone hydrochloride (YL0919) is a novel antidepressant candidate with dual activity as a 5-HT1A receptor agonist and a selective serotonin reuptake inhibitorFormule :C18H23ClN2O2Degré de pureté :99.82% - 99.93%Couleur et forme :SolidMasse moléculaire :334.84Aripiprazole
CAS :Aripiprazole (OPC-14597) is a piperazine/quinolone antipsychotic, partial agonist at 5-HT1A/D2, and antagonist at 5-HT2A.Formule :C23H27Cl2N3O2Degré de pureté :99.43% - 99.62%Couleur et forme :Colourless Flake Crystalline SolidMasse moléculaire :448.39Naratriptan
CAS :Naratriptan is a selective agonist of 5-HT1 receptor and is is used for the treatment of migraine headaches.Formule :C17H25N3O2SDegré de pureté :99.08%Couleur et forme :SolidMasse moléculaire :335.47Metoclopramide hydrochloride
CAS :Metoclopramide hydrochloride (Metoclopramide HCl) is a selective dopamine D2 receptor antagonist, used as an antiemetic.Formule :C14H22ClN3O2·HClDegré de pureté :99.99%Couleur et forme :White To Off-White PowderMasse moléculaire :336.26Tiflucarbine
CAS :Tiflucarbine is a potential non-selective 5-HT agonist with antidepressant activity.Tiflucarbine dose-dependently increased the specific activity of solubleFormule :C16H17FN2SDegré de pureté :100%Couleur et forme :SolidMasse moléculaire :288.38pCPA methyl ester hydrochloride
CAS :pCPA methyl ester HCl inhibits tryptophan hydroxylase, 5-HT synthesis, crosses blood-brain barrier, lowers central 5-HT.Formule :C10H13Cl2NO2Degré de pureté :99.08% - 99.88%Couleur et forme :SolidMasse moléculaire :250.12Loxapine
CAS :Loxapine, a dibenzoxazepine antipsychotic, treats schizophrenia by blocking D2/D4 and serotonin receptors. Related to clozapine.Formule :C18H18ClN3ODegré de pureté :99.88%Couleur et forme :Pale Yellowish Crystals From Petroleum Ether SolidMasse moléculaire :327.815-HT2 agonist-1
CAS :Compound 24, a 5-HT2 agonist-1, selectively activates 5-HT2A, 5-HT2B, and 5-HT2C receptors with IC50 values of 10 nM, 8.3 nM, and 1.6 nM, respectively.Formule :C19H23ClN2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :346.85Gevotroline
CAS :Gevotroline, a chemical in palm wine that can be used to treat psychosis, is a 5-HT2 receptor antagonist that can be used to study behavioral disorders.Formule :C19H20FN3Degré de pureté :98.79%Couleur et forme :SolidMasse moléculaire :309.385-HT1AR/5-HT6R ligand-1
5-HT1AR/5-HT6R ligand-1 (Compound PP13) functions as a ligand for the 5-HT receptor, demonstrating high affinity for 5-HT1AR, 5-HT6R, and 5-HT7R with Ki values of 19, 69, and 198 nM, respectively. In HEK293 cells, it inhibits cAMP production with EC50 values of 1535, 488, and 53 nM for these receptors. Additionally, 5-HT1AR/5-HT6R ligand-1 exhibits antiproliferative effects on several cancer cell lines, including 1321N1, U87MG, MCF7, and AsPC-1, with IC50 values of 9.6, 13.6, 19.3, and 14.6 μM, respectively. The compound also shows antagonistic activity towards the dopamine receptor D2R, with a Ki of 1903 nM.Formule :C25H29ClN4O2SCouleur et forme :SolidMasse moléculaire :485.04GTS-21 dihydrochloride
CAS :GTS-21 dihydrochloride (DMBX-anabaseine) is a nAChRs agonist. nAChRs are neuron receptor proteins that activated by the binding of the neurotransmitter ACh.Formule :C19H20N2O2·2HClDegré de pureté :100% - 99.62%Couleur et forme :SolidMasse moléculaire :381.3Ref: TM-T2663
5mg51,00€10mg85,00€25mg115,00€50mg144,00€100mg216,00€200mg325,00€500mg545,00€1mL*10mM (DMSO)57,00€4-Iodoamphetamine hydrochloride
CAS :4-Iodoamphetamine (p-Iodoamphetamine) hydrochloride is a halogenated phenethylamine characterized by the presence of an iodine atom at the para position of the phenyl group. It selectively induces serotonin release and inhibits reuptake in rat brain synaptosomes.Formule :C9H13ClINCouleur et forme :SolidMasse moléculaire :297.56Citalopram hydrobromide
CAS :Citalopram hydrobromide (XU-62-320) , a selective serotonin reuptake inhibitor (SSRI), selectively inhibits the CNS neuronal reuptake of serotonin, therebyFormule :C20H22BrFN2ODegré de pureté :99.81%Couleur et forme :White Crystalline PowderMasse moléculaire :405.304SB 204741
CAS :SB 204741 is a selective 5-HT2B antagonist with high affinity and pKi value of 7.1.Formule :C14H14N4OSDegré de pureté :99.83%Couleur et forme :SolidMasse moléculaire :286.35Eletriptan hydrobromide
CAS :Eletriptan hydrobromide (Eletriptan HBr) is an orally active agonist with specific affinity for the 5-hydroxytriptamine1B/1D receptor.Formule :C22H27BrN2O2SDegré de pureté :100% - 99.69%Couleur et forme :Tan SolidMasse moléculaire :463.43Ref: TM-T0216
2mg39,00€5mg57,00€10mg70,00€25mg134,00€50mg230,00€100mg373,00€200mg555,00€1mL*10mM (DMSO)63,00€Cinitapride Hydrogen Tartrate
CAS :Cinitapride Hydrogen Tartrate is a gastroprokinetic agent that acts as an antagonist of the 5-HT2 receptors and as an agonist of the 5-HT1 and 5-HT4 receptorsFormule :C25H36N4O10Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :552.5812-Methyl-5-HT maleate
CAS :2-Methyl-5-HT maleate, a selective 5-HT3 agonist, shows anti-depressive effects.Formule :C15H18N2O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :306.31WAY-607695
CAS :WAY-607695 is a potential 5-HT1A receptor agonist.Formule :C13H12FNO2Degré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :233.24Rotigotine Hydrochloride
CAS :Rotigotine HCl, D3-preferential dopamine agonist, is 50x stronger than quinpirole in anti-Parkinson's efficacy.Formule :C19H26ClNOSDegré de pureté :99.53% - 99.56%Couleur et forme :Almost White To White Crystalline PowderMasse moléculaire :351.93D3/5-HT receptor modulator-1
CAS :D3/5-HT receptor modulator-1 (compound 5i) is a selective antagonist of the dopamine D3 and 5-HT2A receptors, and a partial agonist at the 5-HT1A receptor. It exhibits Ki values of 4.5 nM, 11.9 nM, and 15.3 nM for the dopamine D3, 5-HT2A, and 5-HT1A receptors respectively. The compound shows lower affinity for the dopamine D2 receptor, 5-HT2C receptor, and hERG channel. D3/5-HT receptor modulator-1 possesses atypical antipsychotic properties.Formule :C24H29N3O2Couleur et forme :SolidMasse moléculaire :391.506
