Cellules souche et Dérivés
Les inhibiteurs de cellules souches sont des composés qui ciblent spécifiquement les voies de signalisation et les protéines impliquées dans le maintien, la différenciation et la prolifération des cellules souches. Ces inhibiteurs sont cruciaux pour comprendre la biologie des cellules souches et pour développer des stratégies visant à manipuler les cellules souches à des fins thérapeutiques, telles que la médecine régénérative et le traitement du cancer. En contrôlant le destin des cellules souches, ces inhibiteurs peuvent aider à orienter la différenciation des cellules souches en types cellulaires spécifiques ou à prévenir une croissance cellulaire indésirable. Chez CymitQuimica, nous offrons une sélection d'inhibiteurs de cellules souches de haute qualité pour soutenir vos recherches en biologie des cellules souches, biologie du développement et médecine régénérative.
Sous-catégories appartenant à la catégorie "Cellules souche et Dérivés"
- Gamma-sécrétase
- Hérisson/Smoothened
- Voie de signalisation Hippo
- JAK
- Porc-épic
- ROCK
- STAT
- Cellules souches
- TGF-beta/Smad
- Wnt/beta-caténine
Affichez 2 plus de sous-catégories
Produits appartenant à la catégorie "Cellules souche et Dérivés"
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IWP-O1
CAS :IWP-O1 is a highly potent Porcupine (Porcn) inhibitor (EC50: 80 pM), effectively suppresses the phosphorylation of Dvl2/3 and LRP6 in HeLa cells.Formule :C26H20N6ODegré de pureté :99.12%Couleur et forme :SolidMasse moléculaire :432.48Ref: TM-T5342
2mg39,00€5mg64,00€10mg101,00€25mg163,00€50mg226,00€100mg320,00€200mg459,00€1mL*10mM (DMSO)70,00€Ac-VDVAD-CHO
CAS :Ac-VDVAD-CHO is an inhibitor of caspase-2 and caspase-3 (IC50: 46 nM for caspase-2 and 15 nM for caspase-3) [1].Formule :C23H37N5O10Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :543.57Dynarrestin
CAS :Dynarrestin inhibits cytoplasmic dynein 1/2, preventing microtubule sliding without affecting ATP hydrolysis or ciliogenesis.Formule :C22H23F2N3O2SDegré de pureté :99.49%Couleur et forme :SolidMasse moléculaire :431.5Povorcitinib phosphate
CAS :Povorcitinib phosphate is a selective JAK1 inhibitor and can be used in studies about the treatment of cutaneous lupus erythematosus and Lichen planus.Formule :C23H25F5N7O5PDegré de pureté :97.71%Couleur et forme :SolidMasse moléculaire :605.45Ref: TM-T39113L
1mg65,00€2mg95,00€5mg145,00€10mg212,00€25mg359,00€50mg512,00€100mg695,00€200mg937,00€SANT 2
CAS :SANT 2 is a Hedgehog (Hh) signaling pathway antagonist with potential anti-inflammatory and anti-cancer activities.Formule :C26H26ClN3O4Degré de pureté :99.23%Couleur et forme :SolidMasse moléculaire :479.96Wnt pathway inhibitor 3
CAS :Wnt pathway inhibitor 3 is a potent AC1 inhibitor with an IC50 value of 45 nM.Wnt pathway inhibitor 3 has antiproliferative activity and can be used in studiesFormule :C21H17BrN2O5Degré de pureté :99.69%Couleur et forme :SoildMasse moléculaire :457.27E 2012
CAS :E2012 is a γ-secretase modulator (GSM).Formule :C25H26FN3O2Degré de pureté :99.18%Couleur et forme :SolidMasse moléculaire :419.49AT13148
CAS :AT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II.Formule :C17H16ClN3ODegré de pureté :98.04% - ≥95%Couleur et forme :SolidMasse moléculaire :313.78NRX-103095
CAS :NRX-103095 increases β-catenin binding to SCFβ-TrCP E3 ligase; EC50 is 163 nM for pSer33/Ser37 affinity boost.Formule :C22H16Cl2F3N3O3SDegré de pureté :99.16% - 99.60%Couleur et forme :SolidMasse moléculaire :530.35Ref: TM-T63730
1mg150,00€5mg364,00€10mg588,00€25mg1.169,00€50mg1.882,00€100mg2.822,00€1mL*10mM (DMSO)426,00€IMR-1A
CAS :IMR-1A is the metabolite of IMR-1 which is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 μMol/L.Formule :C13H11NO5S2Degré de pureté :97.1% - 99.06%Couleur et forme :SolidMasse moléculaire :325.36GSK-3β inhibitor 21
GSK-3β Inhibitor21 (compound 44) is an ATP-competitive inhibitor of GSK-3β with an IC50 value of 6.06 µM, characterized by its ability to inhibit tau phosphorylation and prevent amyloid protein aggregation. This compound is utilized in the research of Alzheimer's disease.Couleur et forme :Odour SolidSTAT3-IN-31
STAT3-IN-31 (compound K2071), derived from STATtic, acts as an inhibitor of both STAT3 and mitotic processes. This compound interrupts mitotic progression and impacts the formation of the mitotic spindle. Additionally, STAT3-IN-31 hampers migration in glioblastoma cells, suppresses cellular proliferation within tumor spheroids, induces senescence in glioblastoma, and inhibits the growth of Temozolomide-resistant cells while reducing the secretion of the pro-inflammatory cytokine monocyte chemoattractant protein (MCP-1).Formule :C16H15NO3SCouleur et forme :SolidMasse moléculaire :301.36JAK-IN-33
JAK-IN-33 (Compound 3 (R)) is a selective inhibitor of the Janus kinase (JAK) family [1].Degré de pureté :98%Couleur et forme :Odour SolidCDK8-IN-12
CAS :CDK8-IN-12: selective CDK8 inhibitor (Ki 14 nM), oral anticancer, blocks GSK-3α/β, PCK-θ, halts MV4-11 cell growth.Formule :C21H20ClN3O2Degré de pureté :98.97% - 99.83%Couleur et forme :SoildMasse moléculaire :381.86Ref: TM-T72048
1mg52,00€5mg101,00€10mg150,00€25mg250,00€50mg363,00€100mg509,00€200mg695,00€1mL*10mM (DMSO)116,00€KY-05009
CAS :KY-05009 blocks TGF-β1 EMT in lung cancer cells, inhibits TNIK, Wnt genes, induces apoptosis, and is an ATP-competitive TNIK inhibitor (Ki = 100 nM).Formule :C18H16N4O2SDegré de pureté :98.06%Couleur et forme :SolidMasse moléculaire :352.41Ref: TM-T11793
5mg50,00€10mg71,00€25mg117,00€50mg170,00€100mg245,00€200mg354,00€1mL*10mM (DMSO)51,00€Neocucurbitacin A
CAS :Neocucurbitacin A (compound 7), a STAT3 inhibitor extracted from the pericarp of Aquilaria crassna, serves as a potential agent for anticancer research [1].Formule :C31H42O8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :542.66RGB-286638 free base
CAS :RGB-286638 free base inhibits CDKs (1-5 nM), weaker on CDK7/6.Formule :C29H35N7O4Degré de pureté :97.29% - 99.91%Couleur et forme :SolidMasse moléculaire :545.63Peficitinib
CAS :Peficitinib (ASP015K) (ASP015K, JNJ-54781532) is an orally bioavailable JAK inhibitor. Phase 3.Formule :C18H22N4O2Degré de pureté :98.67% - 99.4%Couleur et forme :SolidMasse moléculaire :326.39Ref: TM-T6933
2mg40,00€5mg66,00€10mg104,00€25mg182,00€50mg283,00€100mg439,00€200mg645,00€1mL*10mM (DMSO)73,00€LGK974
CAS :LGK974 (NVP-LGK974) is a selective PORCN inhibitor that blocks Wnt signaling, used in metastatic colorectal and head/neck cancer trials. IC50: 0.4 nM.Formule :C23H20N6ODegré de pureté :100% - ≥98%Couleur et forme :SolidMasse moléculaire :396.44Ref: TM-T2618
1mg48,00€2mg65,00€5mg96,00€10mg164,00€25mg304,00€50mg545,00€100mg778,00€1mL*10mM (DMSO)96,00€FLLL32
CAS :FLLL32 is an effective JAK2/STAT3 inhibitor (IC50 of <5 μM).Formule :C28H32O6Degré de pureté :96.39% - 97.90%Couleur et forme :SolidMasse moléculaire :464.55Ref: TM-T6838
2mg46,00€5mg66,00€10mg93,00€25mg124,00€50mg197,00€100mg350,00€500mg840,00€1mL*10mM (DMSO)72,00€AZD2858
CAS :AZD2858 is a selective GSK-3 inhibitor, inhibiting tau phosphorylation at the S396 site and activating Wnt signaling pathway.Formule :C21H23N7O3SDegré de pureté :98% - 99.25%Couleur et forme :SolidMasse moléculaire :453.52Ref: TM-T1957
1mg38,00€2mg49,00€5mg79,00€10mg106,00€25mg198,00€50mg374,00€100mg555,00€500mg1.206,00€1mL*10mM (DMSO)108,00€RU-SKI 43
CAS :RU-SKI 43: Potent, selective Hhat inhibitor, IC50 850 nM. Anticancer; potential lung adenocarcinoma treatment. Inhibits Gli-1, Akt, mTOR pathways.Formule :C22H30N2O2SDegré de pureté :99.78%Couleur et forme :SolidMasse moléculaire :386.55Epiblastin A
CAS :Epiblastin A inhibits CK1, targets its isoenzymes, and converts EpiSCs to cESCs.Formule :C12H10ClN7Degré de pureté :99.45%Couleur et forme :SolidMasse moléculaire :287.71Cerdulatinib hydrochloride
CAS :Cerdulatinib hydrochloride is an oral tyrosine kinase inhibitor targeting JAK1/2/3, TYK2, Syk, and 19 others with IC50 < 200 nM.Formule :C20H28ClN7O3SDegré de pureté :99.23%Couleur et forme :SolidMasse moléculaire :482SMANT hydrochloride
CAS :SMANT hydrochloride (N-(4-bromophenyl)-3-(3,5-dimethylpiperidin-1-yl)propanamide hydrochloride) is an antagonist of Smoothened accumulation.Formule :C16H24BrClN2ODegré de pureté :100%Couleur et forme :SolidMasse moléculaire :375.73Disitertide acetate
Disitertide acetate: a TGF-β1 and PI3K blocker, promotes apoptosis; inhibits receptor interaction.Formule :C70H113N17O24S2Degré de pureté :95.11%Couleur et forme :SoildMasse moléculaire :1640.88IWP-3
CAS :IWP-3 is a potent inhibitor of Wnt production with an IC50 of 40 nM. It inhibits Porcupine (Porcn), blocking the palmitoylation of Wnt proteins, and moderately inhibits CK1γ3 and CK1ε, but does not inhibit CK1α [1] [2].Formule :C22H17FN4O2S3Degré de pureté :98.38%Couleur et forme :SolidMasse moléculaire :484.59GSK180736A
CAS :GSK180736A: GRK2 inhibitor (IC50 0.77µM), >100x selectivity vs GRKs, weak at PKA (IC50 30µM), strong vs ROCK1 (IC50 100nM).Formule :C19H16FN5O2Degré de pureté :98.16% - 98.44%Couleur et forme :SolidMasse moléculaire :365.36Ref: TM-T3513
1mg42,00€2mg52,00€5mg73,00€10mg88,00€25mg170,00€50mg306,00€100mg568,00€500mg1.225,00€1mL*10mM (DMSO)65,00€Tolnaftate
CAS :Tolnaftate (NP-27) is a synthetic antifungal agent.Formule :C19H17NOSDegré de pureté :98.85%Couleur et forme :White PowderMasse moléculaire :307.41MSC-4106
CAS :MSC-4106, an oral YAP/TAZ-TEAD inhibitor, blocks TEAD1/3 auto-palmitoylation and suppresses NCI-H226 tumors.Formule :C18H12F3N3O2Degré de pureté :100%Couleur et forme :SoildMasse moléculaire :359.3Ref: TM-T60148
1mg96,00€5mg235,00€10mg378,00€25mg630,00€50mg898,00€100mg1.216,00€200mg1.634,00€1mL*10mM (DMSO)271,00€Cerdulatinib
CAS :Cerdulatinib (PRT2070) is an novel oral dual Syk/JAK inhibitor.Formule :C20H27N7O3SDegré de pureté :98.74% - 99.49%Couleur et forme :SolidMasse moléculaire :445.54Ref: TM-T2487
1mg44,00€2mg55,00€5mg79,00€10mg106,00€25mg185,00€50mg283,00€100mg432,00€200mg605,00€500mg938,00€1mL*10mM (DMSO)86,00€Tofacitinib Citrate
CAS :Tofacitinib Citrate (CP-690550 citrate) is a a potent, cell-permeable inhibitor of JAK1/2/3 (IC50s: 1/20/112 nM).Formule :C22H28N6O8Degré de pureté :99.19% - 99.75%Couleur et forme :SolidMasse moléculaire :504.49TAK-901
CAS :TAK-901 has been used in trials studying the treatment of Lymphoma, Myelofibrosis, Multiple Myeloma, Myeloid Metaplasia, and Advanced Solid Tumors, among othersFormule :C28H32N4O3SDegré de pureté :97.38% - 99.1%Couleur et forme :SolidMasse moléculaire :504.64AR-A014418
CAS :AR-A014418 (GSK 3β inhibitor VIII) is an ATP-competitive, and selective GSK3β inhibitor.Formule :C12H12N4O4SDegré de pureté :99.94% - ≥95%Couleur et forme :SolidMasse moléculaire :308.31Aloisine B
CAS :Aloisine B (AloisineB) inhibited cyclin-dependent kinase and glycogen synthase kinase with IC50 values of 0.85 µM and 0.75 µM, respectively.Formule :C15H14ClN3Degré de pureté :95.15%Couleur et forme :SolidMasse moléculaire :271.74Tubastatin
CAS :Tubastatin inhibits TGF-β1-induced S6K phosphorylation, HIF-1α expression and VEG F expression.Formule :C21H22N2O2Degré de pureté :98.23%Couleur et forme :SolidMasse moléculaire :334.41Brevilin A
CAS :Brevilin A, a sesquiterpene from Centipeda minima, hinders JAK and blocks STAT3 (IC50=10.6μM), inducing apoptosis and autophagy in cancer cells.Formule :C20H26O5Degré de pureté :100% - 99.74%Couleur et forme :SolidMasse moléculaire :346.42Ref: TM-T4672
1mg96,00€5mg215,00€10mg369,00€25mg610,00€50mg840,00€100mg1.130,00€500mg2.308,00€1mL*10mM (DMSO)235,00€PIMPC
CAS :PIMPC, a compound endowed with antioxidant and metal-chelating properties, acts as a novel inhibitor of glycogen synthase kinase 3 (GSK-3), and exhibitsFormule :C21H19N5ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :357.41Rhodblock 6
CAS :Rhodblock 6 is a Rho kinase inhibitor, blocking phosphorylated MRLC localization by targeting ROCK activity.Formule :C12H13N3ODegré de pureté :98.27%Couleur et forme :SolidMasse moléculaire :215.25Wnt/β-catenin agonist 2
CAS :Wnt/β-catenin agonist 2 activates Wnt/β-catenin signaling and is an effective Wnt agonist.Formule :C13H12N4O3Degré de pureté :99.58%Couleur et forme :SolidMasse moléculaire :272.26Ref: TM-T41094
1mg54,00€5mg116,00€10mg187,00€25mg318,00€50mg449,00€100mg638,00€500mg1.264,00€1mL*10mM (DMSO)111,00€Ilginatinib hydrochloride
CAS :Ilginatinib hydrochloride (NS-018 hydrochloride) is a highly active and orally bioavailable inhibitor of JAK2.Formule :C21H21ClFN7Degré de pureté :99.55%Couleur et forme :SolidMasse moléculaire :425.89Ref: TM-T12266L2
1mg77,00€5mg165,00€10mg240,00€25mg408,00€50mg562,00€100mg800,00€200mg1.074,00€1mL*10mM (DMSO)177,00€CUR61414
CAS :CUR61414 is a cell-permeable inhibitor of Hedgehog signaling pathway (IC50 =100-200 nM) and selectively binds to smoothened (Ki = 44 nM).Formule :C31H42N4O5Degré de pureté :97.34% - 98.00%Couleur et forme :SolidMasse moléculaire :550.69Ref: TM-T15019
1mg52,00€5mg111,00€10mg180,00€25mg359,00€50mg550,00€100mg787,00€1mL*10mM (DMSO)123,00€LSKL TFA
CAS :LSKL TFA (H-Leu-Ser-Lys-Leu-NH2 TFA) is a TGF-尾1 antagonist that inhibits TSP-1 binding to LAP and reduces renal interstitial fibrosis and liver fibrosis.Formule :C23H43F3N6O7Degré de pureté :99.33%Couleur et forme :SolidMasse moléculaire :572.62CCG 203769
CAS :CCG 203769 (Thiadiazolidinone (TDZD) deriv. 6) is a selective inhibitor of RGS4 with an IC50 of 17 nM for the RGS4-Gαo protein-protein interaction.Formule :C8H14N2O2SDegré de pureté :99.46%Couleur et forme :SolidMasse moléculaire :202.27Ref: TM-T10705
1mg88,00€5mg187,00€10mg264,00€25mg469,00€50mg657,00€100mg944,00€500mg1.882,00€1mL*10mM (DMSO)207,00€DIF-3
CAS :DIF-3 activates GSK-3β, degrades cyclin D1/c-Myc, and inhibits Wnt/β-catenin in DLD-1 cells, curbing HeLa cell proliferation.Formule :C13H17ClO4Degré de pureté :99.57%Couleur et forme :SolidMasse moléculaire :272.72Ref: TM-T60485
1mg92,00€5mg235,00€10mg350,00€25mg588,00€50mg838,00€100mg1.130,00€500mg2.308,00€1mL*10mM (DMSO)215,00€2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide
CAS :2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide (GDC046), a potent lead analog, has good kinase selectivity and physicochemical properties.Formule :C16H13Cl2N3O2Degré de pureté :98.77%Couleur et forme :SolidMasse moléculaire :350.2SAG 21k
CAS :SAG 21k is an orally bioactive and potent Hedgehog signaling activator that crosses the blood-brain barrier for the study of cartilage regeneration.Formule :C29H28ClF2N3O2SDegré de pureté :99.51%Couleur et forme :SolidMasse moléculaire :556.07BMP signaling agonist sb4
CAS :BMP signaling agonist sb4 (SB 4) is an agonist of benzoxazole bone morphogenetic protein (BMP) signaling (EC50 :74 nM)Formule :C14H10BrNOSDegré de pureté :99.48% - 99.94%Couleur et forme :SolidMasse moléculaire :320.2Ref: TM-T7799
5mg47,00€10mg60,00€25mg88,00€50mg126,00€100mg187,00€200mg283,00€500mg490,00€1mL*10mM (DMSO)50,00€β-catenin modulator IIa-661
CAS :β-catenin modulator IIa-661 is a small molecule inhibitor of the Wnt pathway with antitumour activity.Formule :C19H23ClN2O3SDegré de pureté :99.53%Couleur et forme :SoildMasse moléculaire :394.92JAK3-IN-6
CAS :JAK3-IN-6 is irreversible Janus Associated Kinase 3 (JAK3) inhibitor, with an IC50 of 0.15 nMFormule :C19H18N4O3Degré de pureté :97.46% - 99.94%Couleur et forme :SolidMasse moléculaire :350.37Cenacitinib
CAS :Cenacitinib is an effective inhibitor of Janus kinase (Janus kinase) and possesses anti-inflammatory activity.Formule :C19H19F2N7O3Couleur et forme :SolidMasse moléculaire :431.40JAK/HDAC-IN-2
JAK/HDAC-IN-2, a potent 2-amino-4-phenylaminopyrimidine dual-target inhibitor, effectively suppresses JAK1/2 and HDAC3/6 at nanomolar concentrations.Formule :C28H38N6O5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :570.7ARN25068
CAS :ARN25068 inhibits GSK-3β, FYN, DYRK1A kinases; acts in sub-micromolar range; combats tau hyperphosphorylation.Formule :C19H18N6SDegré de pureté :99.71%Couleur et forme :SolidMasse moléculaire :362.45ELN318463 racemate
CAS :ELN318463 racemate (ELN 318463 racemate) is the racemate of ELN318463 which is an amyloid precursor protein (APP) selective γ-secretase inhibitor.Formule :C19H20BrClN2O3SDegré de pureté :99.73%Couleur et forme :SolidMasse moléculaire :471.8Ref: TM-T11178L
1mg162,00€5mg391,00€10mg615,00€25mg907,00€50mg1.235,00€100mg1.663,00€1mL*10mM (DMSO)447,00€JAK2-IN-6
CAS :JAK2-IN-6: A potent JAK2-specific inhibitor (IC50=22.86μg/mL), blocks JAK2 signaling, has anticancer properties, and is inactive against JAK1/3.Formule :C14H10ClN3OS2Degré de pureté :99.38%Couleur et forme :SolidMasse moléculaire :335.83SRI-011381
CAS :SRI-011381, a new-type agonist of the TGF-beta signaling pathway, is utilized in the treatment of Alzheimer's disease.Formule :C20H31N3ODegré de pureté :98.64%Couleur et forme :SolidMasse moléculaire :329.48Ref: TM-T4283
1mg35,00€2mg48,00€5mg70,00€10mg111,00€25mg227,00€50mg378,00€100mg622,00€200mg873,00€500mg1.293,00€1mL*10mM (DMSO)49,00€Wnt pathway activator 1
CAS :Wnt pathway activator 1 is a potent Wnt activator with an IC50 of 28-29 nM.Formule :C18H16O4Degré de pureté :99.94%Couleur et forme :SolidMasse moléculaire :296.32Ref: TM-T17256
2mg34,00€5mg52,00€10mg80,00€25mg131,00€50mg212,00€100mg316,00€200mg454,00€1mL*10mM (DMSO)52,00€Izencitinib
CAS :Izencitinib (JNJ-8398) is a JAK inhibitor with potential anti-inflammatory activity for the study of ulcerative colitis and Crohn;s disease.Formule :C22H26N8Degré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :402.50Ref: TM-T35898
1mg88,00€5mg187,00€10mg298,00€25mg597,00€50mg938,00€100mg1.510,00€200mg2.072,00€1mL*10mM (DMSO)207,00€NSC 370284
CAS :NSC 370284 inhibits STAT3/5, reducing AML cell viability with TET1 overexpression in vitro/in vivo.Formule :C21H25NO6Degré de pureté :96.16%Couleur et forme :SolidMasse moléculaire :387.43Ref: TM-T9949
5mg70,00€10mg119,00€25mg250,00€50mg424,00€100mg627,00€500mg1.320,00€1mL*10mM (DMSO)77,00€JNJ-1289
CAS :JNJ-1289: potent hSMOX inhibitor, IC50 50 nM, potential for anticancer/anti-inflammatory research.Formule :C16H12N4OSDegré de pureté :98.16%Couleur et forme :SolidMasse moléculaire :308.36GKI-1 HCl
GKI-1 HCl is a Greatwall (GWL) kinase inhibitor that inhibits hGWLFL and hGWL-KinDom.The inhibitory effect of GKI-1 HCl on ROCK1 is more significant.Formule :C15H13Cl2N3Degré de pureté :98.44%Couleur et forme :SoildMasse moléculaire :306.19Ref: TM-T11402L
1mg96,00€5mg225,00€10mg334,00€25mg533,00€50mg750,00€100mg1.064,00€200mg1.415,00€1mL*10mM (DMSO)251,00€TBB
CAS :TBB (NSC-231634)(NSC-231634) is a highly selective, ATP/GTP-competitive inhibitor of casein kinase-2 (CK2).Formule :C6HBr4N3Degré de pureté :98.51% - 99.45%Couleur et forme :Off-White SolidMasse moléculaire :434.71Dog sCD14(SolubleCluster of Differentiation 14) ELISA Kit
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Dog sCD14. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Dog sCD14. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Dog sCD14, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Dog sCD14 in the samples is then determined by comparing the OD of the samples to the standard curve.Couleur et forme :Colourless Transparentliquidpan-TEAD-IN-1
CAS :pan-TEAD-IN-1 (Compound 3) is an orally active pan-inhibitor of TEAD, disrupting its interaction with coactivators YAP/TAZ by targeting the palmitoylation site of TEAD. This inhibition leads to the downregulation of oncogene transcription, such as Ctgf and Cyr61, within the Hippo signaling pathway. Demonstrating outstanding efficacy, pan-TEAD-IN-1 has an IC50 of 0.36 nM for luciferase and 1.52 nM for H226 cells, along with favorable pharmacokinetic properties (AUC0-∞= 228.7 μg/mL·min, T1/2= 183.9 min). The compound significantly inhibits tumor growth in xenograft models of TEAD-dependent cancers, indicating its potential for research in these cancer types.Formule :C19H16F3NOCouleur et forme :SolidMasse moléculaire :331.33IHR-1
CAS :IHR-1, a Smo inhibitor (IC50 7.6 nM), blocks Hedgehog pathway, not Wnt/Notch, and prevents Smo in primary cilium.Formule :C20H12Cl4N2O2Degré de pureté :97.02%Couleur et forme :SolidMasse moléculaire :454.13Ref: TM-T24159
2mg34,00€5mg52,00€10mg85,00€25mg138,00€50mg205,00€100mg306,00€200mg439,00€1mL*10mM (DMSO)58,00€PROTAC YAP degrader-1
PROTAC YAP degrader-1, a targeted proteolysis promoting chimeric molecule, both degrades the YAP protein and inhibits its nuclear localization. This compound is formulated with Demethyl-NSC682769 as the target protein ligand, and utilizes (R,S,R)-AHPC-PEG2-C2-boc, which is the E3 ubiquitin ligase ligand + Linker conjugate. The linker incorporated in the design is Acid-PEG2-C2-Boc.Formule :C56H62N6O9SCouleur et forme :SolidMasse moléculaire :995.19FH535
CAS :FH535, a Wnt/β-catenin signaling and PPAR inhibitor, exhibits anti-tumor activities.Formule :C13H10Cl2N2O4SDegré de pureté :98.25% - 99.5%Couleur et forme :SolidMasse moléculaire :361.2Ref: TM-T2413
5mg38,00€10mg57,00€25mg94,00€50mg164,00€100mg274,00€200mg404,00€500mg653,00€1mL*10mM (DMSO)64,00€BI-1408
CAS :BI-1408 is a modulator potent of γ secretase (IC50: 0.04 μM for Aβ42).Formule :C22H23FN6Degré de pureté :99%Couleur et forme :SolidMasse moléculaire :390.46JAK-IN-30
CAS :JAK-IN-30 (compound 31) is a water-soluble inhibitor of Janus kinases (JAKs), demonstrating inhibitory potency with half-maximal inhibitory concentration (IC50Formule :C19H26N8SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :398.53CID-5056270
CAS :CID-5056270 has anticancer activity and can inhibit lung cancer, anal cancer, bladder cancer, cervical cancer, vulvar cancer, penile cancer, Burkitt's lymphomaFormule :C17H13N3O3SDegré de pureté :99.57%Couleur et forme :SolidMasse moléculaire :339.37GS-829845
CAS :GS-829845 is a JAK1 inhibitor, the main component of the active metabolite of Filgotinib, which is approximately 10-fold less potent and has a longer half-lifeFormule :C17H19N5O2SDegré de pureté :99.78%Couleur et forme :SolidMasse moléculaire :357.43Brepocitinib P-Tosylate
CAS :Brepocitinib P-Tosylate (PF-06700841 P-Tosylate) is a potent dual inhibitor of Janus kinase 1 (JAK1) and TYK2 (IC50s of 17 nM and 23 nM, respectively).Formule :C25H29F2N7O4SDegré de pureté :99.82% - 99.97%Couleur et forme :SolidMasse moléculaire :561.6HPI 1
CAS :HPI 1 suppresses Hh pathway: IC50 = 1.5 μM (Shh, SAG), 4 μM (Gli2), 6 μM (Gli1) in Shh-LIGHT2 cells.Formule :C27H29NO6Degré de pureté :94.4%Couleur et forme :SolidMasse moléculaire :463.52Ref: TM-T22089
1mg47,00€2mg60,00€5mg92,00€10mg135,00€25mg217,00€50mg324,00€100mg472,00€500mg1.026,00€1mL*10mM (DMSO)107,00€JAK-IN-25
CAS :JAK-IN-25 (compound 19), a potent JAK inhibitor, exhibits IC50 values of 6 nM for TYK2, 21 nM for JAK1, 8 nM for JAK2, and 1051 nM for JAK3.Formule :C19H17N5O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :379.37FzM1
CAS :FzM1, a negative allosteric modulator (NAM) of the Frizzled receptor FZD4, diminishes WNT5A-dependent WNT responsive element (WRE) activity (log EC50inh=−6.2)Formule :C21H16N2O2SDegré de pureté :99.37% - 99.89%Couleur et forme :SolidMasse moléculaire :360.43Ref: TM-T24076
1mg42,00€5mg64,00€10mg99,00€25mg188,00€50mg328,00€100mg528,00€500mg1.130,00€1mL*10mM (DMSO)62,00€Cyanoacetohydrazide
CAS :Cyanoacetohydrazide (Cyanoacetic hydrazide) is an anti-TB drug. It has also been used to derive compounds that may have antitumor properties.Formule :C3H5N3ODegré de pureté :99.78%Couleur et forme :Stout Prisms From Alcohol Slightly Brown PowderMasse moléculaire :99.09Porcn-IN-1
CAS :Porcn-IN-1 (Porcupine-IN-1) is an effective porcupine inhibitor (IC50: 0.5±0.2 nM).Formule :C25H19FN4ODegré de pureté :99.15%Couleur et forme :SolidMasse moléculaire :410.44Toxoflavin
CAS :Toxoflavin (Xanthothricin) is an antagonist of transcription factor 4 (TCF4)/β-catenin complex. Toxoflavin also acts as an inhibitor of KDM4A.Formule :C7H7N5O2Degré de pureté :98.24% - 99.7%Couleur et forme :SolidMasse moléculaire :193.16STAT3-IN-39
CAS :STAT3-IN-39 (compound 10K) is an orally active inhibitor of STAT3, demonstrating effective inhibition of STAT3 phosphorylation with an IC50 of 0.47 μM in NIH-3T3 cells. It hinders TGF-β1-induced fibrotic responses and prevents epithelial-mesenchymal transition in A549 cells. STAT3-IN-39 is applicable for research related to idiopathic pulmonary fibrosis.Formule :C20H17F3N2O3SCouleur et forme :SolidMasse moléculaire :422.42TNIK-IN-2
CAS :TNIK-IN-2 is an inhibitor Traf2- and Nck-interacting protein kinase (TNIK, IC50 = 1.33 μM)) which is a downstream signal protein of the Wnt/β-catenin pathway.Formule :C22H19N3O3Degré de pureté :98.09%Couleur et forme :SolidMasse moléculaire :373.4PF-4800567
CAS :PF-4800567 is a selective inhibitor of casein kinase 1ε (CK1ε; IC50 = 32 nM) with greater than 20-fold selectivity over CK1δ.Formule :C17H18ClN5O2Degré de pureté :98.23%Couleur et forme :SolidMasse moléculaire :359.81ABC99
CAS :ABC99 irreversibly inhibits wnt-deacylating enzyme NOTUM (IC50: 13 nM) with high serine hydrolase family selectivity.Formule :C22H21ClN4O5Degré de pureté :98.65%Couleur et forme :SoildMasse moléculaire :456.88Ref: TM-T23602
1mg172,00€5mg354,00€10mg528,00€25mg852,00€50mg1.159,00€100mg1.568,00€1mL*10mM (DMSO)354,00€Ellagic acid
CAS :Ellagic acid (Gallogen), a thickened tetracyclic natural product, is a potent CK2 inhibitor. Ellagic acid is an antioxidant. Cost-effective and quality-assured.Formule :C14H6O8Degré de pureté :97.11% - 99.75%Couleur et forme :Cream Colored Needles From Pyridine 1992)Masse moléculaire :302.19DMAT
CAS :DMAT (Casein kinase II Inhibitor) is a potent and specific inhibitor of CK2(IC50 value of 130 nM).Formule :C9H7Br4N3Degré de pureté :99.48%Couleur et forme :SolidMasse moléculaire :476.79Hh-Ag1.5
CAS :Hh-Ag1.5 is a dual Hedgehog/Smo agonist (EC50/Ki: 0.5-2.3 nM), reprograms hepatic stem cells, and differentiates hiPSCs into neural/skin cells.Formule :C28H26ClF2N3OSDegré de pureté :98.61%Couleur et forme :SolidMasse moléculaire :526.04Ref: TM-T24754
1mg127,00€5mg305,00€10mg472,00€25mg782,00€50mg1.103,00€100mg1.539,00€1mL*10mM (DMSO)354,00€GSK-25
CAS :GSK-25 maintains good selectivity against a panel of 31 kinases, as well as RSK1 and p70S6K, and a dramatically improved P450 profile.Formule :C24H16Cl2F2N6ODegré de pureté :98.59%Couleur et forme :SolidMasse moléculaire :513.33Ref: TM-T4488
1mg47,00€2mg59,00€5mg92,00€10mg117,00€25mg172,00€50mg271,00€100mg454,00€1mL*10mM (DMSO)95,00€Wnt/β-catenin agonist 3
CAS :Wnt/β-catenin agonist 3 is a Wnt/beta-catenin agonist.Formule :C16H15ClN4O2Degré de pureté :99.39%Couleur et forme :SolidMasse moléculaire :330.77Ref: TM-T9988
5mg74,00€10mg107,00€25mg216,00€50mg354,00€100mg567,00€200mg800,00€500mg1.198,00€1mL*10mM (DMSO)81,00€MF-Human cTnT/TNNT2(Troponin T Type 2, Cardiac) ELISA Kit
This ELISA kit uses the Sandwich-ELISA principle. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to Human cTnT/TNNT2. Samples (or Standards) are added to the micro ELISA plate wells and combined with the specific antibody and biotinylated detection antibody specific for Human cTnT/TNNT2. Then Avidin-Horseradish Peroxidase (HRP) conjugate are added successively to each micro plate well and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain Human cTnT/TNNT2, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of stop solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm. The OD value is proportional to the concentration of Human cTnT/TNNT2. You can calculate the concentration of Human cTnT/TNNT2 in the samples by comparing the OD of the samples to the standard curve.inS3-54A18
CAS :inS3-54A18 is an effective inhibitor of STAT3. inS3-54A18 has anticancer effects.Formule :C23H16ClNO2Degré de pureté :99.54%Couleur et forme :SolidMasse moléculaire :373.83Ref: TM-T15582
2mg42,00€5mg65,00€10mg93,00€25mg160,00€50mg226,00€100mg320,00€200mg452,00€1mL*10mM (DMSO)71,00€SH5-07
CAS :SH5-07 is a hydroxamic acid-based Stat3 inhibitor (IC50: 3.9 μM).Formule :C29H28F5N3O5SDegré de pureté :95.54%Couleur et forme :SolidMasse moléculaire :625.61Ref: TM-TQ0052
1mg37,00€5mg80,00€10mg117,00€25mg197,00€50mg294,00€100mg425,00€200mg602,00€1mL*10mM (DMSO)99,00€Jaspamycin
CAS :Jaspamycin (7-CN-7-C-Ino) does not bind with purified human PKARIα.Formule :C12H12N4O5Couleur et forme :SolidMasse moléculaire :292.25Fasudil hydrochloride
CAS :Fasudil hydrochloride (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK with Ki of 0.33 μM, 1.0 μM, 9.3 μM and 55 μM, respectively.Formule :C14H18ClN3O2SDegré de pureté :100% - ≥95%Couleur et forme :White SolidMasse moléculaire :327.83Ginsenoside Rk1
CAS :Ginsenoside Rk1 is a component created by processing the ginseng plant at high temperatures.Formule :C42H70O12Degré de pureté :99.13%Couleur et forme :SolidMasse moléculaire :767FPFT-2216
CAS :FPFT-2216 is a "molecular glue" compound with potential anti-tumor activity that degrades IKZF6, IKZF1, DE1D and can be used to study immune system diseases.Formule :C12H12N4O3SDegré de pureté :99.35% - 99.62%Couleur et forme :SolidMasse moléculaire :292.31Ref: TM-T60608
1mg97,00€5mg246,00€10mg369,00€25mg785,00€50mg1.169,00€100mg1.882,00€200mg2.547,00€1mL*10mM (DMSO)250,00€CMD178 TFA
CMD178 (TFA) is a lead peptide that consistently reduces the expression of Foxp3 and STAT5 induced by IL-2/s IL-2Rα signaling.Formule :C48H60F3N9O9Degré de pureté :100%Couleur et forme :SolidMasse moléculaire :964.05Ref: TM-TP1433
1mg48,00€5mg97,00€10mg160,00€25mg263,00€50mg378,00€100mg568,00€200mg805,00€1mL*10mM (DMSO)170,00€MF-Mouse cTnT/TNNT2(Troponin T Type 2, Cardiac) ELISA Kit
This ELISA kit uses the Sandwich-ELISA principle. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to Mouse cTnT/TNNT2. Samples (or Standards) are added to the micro ELISA plate wells and combined with the specific antibody and biotinylated detection antibody specific for Mouse cTnT/TNNT2. Then Avidin-Horseradish Peroxidase (HRP) conjugate are added successively to each micro plate well and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain Mouse cTnT/TNNT2, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of stop solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm. The OD value is proportional to the concentration of Mouse cTnT/TNNT2. You can calculate the concentration of Mouse cTnT/TNNT2 in the samples by comparing the OD of the samples to the standard curve.AT9283
CAS :AT9283 (J-504568) is an effective multi-targeted inhibitor of JAK2(IC50=1.2 nM) and JAK3(IC50=1.1 nM), Aurora A, Aurora B and Abl(T315I).Formule :C19H23N7O2Degré de pureté :99.83% - 99.98%Couleur et forme :SolidMasse moléculaire :381.43Ref: TM-T3068
1mg47,00€2mg60,00€5mg95,00€10mg170,00€25mg299,00€50mg499,00€100mg723,00€1mL*10mM (DMSO)97,00€NCC007
CAS :NCC007 is a novel CKIα and CKIδ dual inhibitors by structural modification of N9 and C2 position of longdaysin.Formule :C22H28F3N7Degré de pureté :98.88%Couleur et forme :SolidMasse moléculaire :447.5LEQ506
CAS :LEQ506 is a Smo inhibitor with IC50s of 2 nM and 4 nM for hSmo and mSmo, respectively.Formule :C25H32N6ODegré de pureté :98.53%Couleur et forme :SolidMasse moléculaire :432.56Ref: TM-T11838
1mg64,00€5mg145,00€10mg210,00€25mg338,00€50mg455,00€100mg610,00€200mg823,00€1mL*10mM (DMSO)160,00€Pacritinib
CAS :Pacritinib (SB1518) (SB1518) is an effective and specific inhibitor of JAK2 and FLT3 (IC50: 23/22 nM, in cell-free assays).Formule :C28H32N4O3Degré de pureté :99.25% - 99.49%Couleur et forme :SolidMasse moléculaire :472.58CK2α-IN-1
CAS :CK2α-IN-1 is a selective non-ATP-competitive CK2α inhibitor with an IC50 of 7.0 µM and a Ki of 1.6 µM.CK2α-IN-1 exhibits potential anticancer activity and canFormule :C16H11N3O4SDegré de pureté :98.00%Couleur et forme :SolidMasse moléculaire :341.34Upadacitinib
CAS :Upadacitinib (ABT-494), a selective JAK1 inhibitor, is researched for autoimmune diseases; IC50: 43 nM.Formule :C17H19F3N6ODegré de pureté :98.96% - 99.93%Couleur et forme :SolidMasse moléculaire :380.37Ref: TM-T7503
1mg47,00€2mg62,00€5mg89,00€10mg130,00€25mg220,00€50mg306,00€100mg434,00€200mg662,00€500mg1.169,00€1mL*10mM (DMSO)48,00€Garetosmab
CAS :Garetosmab (REGN 2477), a human IgG4 monoclonal antibody, inhibits activin A for potential cancer treatment and FOP study.Degré de pureté :> 95% - SDS-PAGE:95% SEC-HPLC:95%Couleur et forme :LiquidMasse moléculaire :146 kDaMeBIO
CAS :MeBIO is an agonist of aryl hydrocarbon receptor, with IC50 of 44 and 55 μM for GSK-3 and CDK1/CyclinB, respectively. MeBIO does not affect GSK-3β.Formule :C17H12BrN3O2Degré de pureté :98.84%Couleur et forme :SolidMasse moléculaire :370.2Ref: TM-T21966
1mg39,00€5mg74,00€10mg117,00€25mg220,00€50mg354,00€100mg520,00€500mg1.130,00€1mL*10mM (DMSO)86,00€Tabituximab
CAS :BMS-986148 is a CHO-expressed humanized antibody-drug coupling targeting mesothelin-expressing cells for cytotoxic load delivery.Couleur et forme :LiquidMasse moléculaire :145.5 kDaGandotinib
CAS :LY2784544(Gandotinib (LY2784544)) is a potent JAK2 inhibitor (IC50: 3 nM), effective in JAK2V617F(Ki: 0.245 nM).Formule :C23H25ClFN7ODegré de pureté :99.33% - 99.86%Couleur et forme :SolidMasse moléculaire :469.94Ref: TM-T2638
5mg51,00€10mg88,00€25mg160,00€50mg296,00€100mg469,00€500mg1.035,00€1mL*10mM (DMSO)57,00€LH846
CAS :LH846 is a selective inhibitor of CK1δ (IC50 values are 290 nM, 1.3 uM and 2.5 uM for CK1δ, ε and α); exhibits no inhibitory activity at CK2.Formule :C16H13ClN2OSDegré de pureté :90% - 98.13%Couleur et forme :SolidMasse moléculaire :316.81JAK2-IN-7
CAS :JAK2-IN-7 selectively inhibits JAK2 (IC50: 3 nM), shows 14-fold selectivity over JAK1/3, FLT3, induces G0/G1 arrest, apoptosis, and has antitumor effects.Formule :C26H33N7ODegré de pureté :98.71%Couleur et forme :SolidMasse moléculaire :459.59Ref: TM-T35900
1mg145,00€5mg354,00€10mg630,00€25mg1.301,00€50mg1.738,00€100mg2.357,00€1mL*10mM (DMSO)358,00€AZ-3
CAS :AZ-3 is a potent and selective JAK1 inhibitor (IC50: 34 nM).Formule :C20H28FN7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :385.48JAK-IN-28
CAS :JAK-IN-28 (Compound 111) is a Janus kinase (JAK) inhibitor potentially applicable in the research of cancer and inflammatory diseases [1].Formule :C20H18ClN7ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :407.86Laduviglusib trihydrochloride
CAS :Laduviglusib trihydrochloride, a GSK-3α/β inhibitor (IC50: 10/6.7 nM), activates Wnt/β-catenin signaling and induces autophagy.Formule :C22H20Cl5N8Degré de pureté :99.03%Couleur et forme :SolidMasse moléculaire :573.71Ref: TM-T22657
1mg43,00€2mg57,00€5mg93,00€10mg136,00€25mg269,00€50mg510,00€100mg682,00€500mg1.415,00€1mL*10mM (DMSO)106,00€5-Bromoindole
CAS :5-bromoindole is a potential inhibitor of glycogen synthase kinase 3 (GSK-3)and an important pharmaceutical chemical intermediateFormule :C8H6BrNDegré de pureté :99.99%Couleur et forme :White To Beige Crystalline PowderMasse moléculaire :196.04WZ-2-033
CAS :WZ-2-033 is a potent STAT3 inhibitor. It inhibits proliferation, colony survival, migration, and invasion of MDA-MB-231, HCC70, and MDA-MB231-4175 cells, with IC50 values of 0.7, 1.3, and 1.3 μM respectively.Formule :C25H18F3N3O4SCouleur et forme :SolidMasse moléculaire :513.49GSK3-IN-1
CAS :GSK3-IN-1 is a GSK3B-glycogen synthase kinase-3 beta inhibitor.Formule :C14H10ClN3OSDegré de pureté :99.66%Couleur et forme :SolidMasse moléculaire :303.77Ref: TM-T9987
2mg44,00€5mg64,00€10mg105,00€25mg226,00€50mg335,00€100mg480,00€200mg652,00€1mL*10mM (DMSO)77,00€NT219
CAS :NT219 is a dual inhibitor of insulin receptor substrate 1/2 (IRS1/2) and STAT3 that enhances the aggregation of misfolded prion proteins NT219 Effects.Formule :C16H14BrNO5SDegré de pureté :98.06% - 99.72%Couleur et forme :SolidMasse moléculaire :412.26inS3-54-A26
CAS :inS3-54-A26 is an inhibitor of the DNA-binding domain of STAT3. inS3-54-A26 suppresses tumor growth, metastasis and the gene expression of STAT3.Formule :C25H19ClN2O2Degré de pureté :98.83%Couleur et forme :SolidMasse moléculaire :414.88Ref: TM-T27613
1mg115,00€2mg172,00€5mg255,00€10mg375,00€25mg562,00€50mg787,00€100mg1.074,00€500mgÀ demanderROCK-IN-7
CAS :ROCK-IN-7 (compound 9) serves as a ROCK kinase inhibitor and is utilized in the investigation of ocular conditions, including glaucoma and retinal diseases [1].Formule :C17H17N3O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :327.4HLY78
CAS :HLY78, a Wnt/β-catenin activator, enhances Axin-LRP6 binding by targeting Axin's DIX domain.Formule :C17H17NO2Degré de pureté :99.58%Couleur et forme :SolidMasse moléculaire :267.32DTP3
CAS :DTP3 is a selective MKK7/GADD45β inhibitor, which inhibits cancer-selective NF-κB survival pathway.Formule :C26H35N7O5Couleur et forme :SolidMasse moléculaire :525.6RO7185876
CAS :RO7185876 is a selective gamma secretase modulator, which can be used in the study of Alzheimer's disease.Formule :C25H28F3N7Degré de pureté :98.63%Couleur et forme :SolidMasse moléculaire :483.532Pumecitinib
CAS :Pumecitinib is a Janus kinase (JAK) inhibitor. Pumecitinib exhibits anti-inflammatory activity.Formule :C17H20N8O2SDegré de pureté :99.89%Couleur et forme :SoildMasse moléculaire :400.46Bikinin
CAS :Bikinin (Abrasin), a potent inhibitor of plant GSK-3/Shaggy-like kinase, activates BR signaling downstream of the BR receptor.Formule :C9H9BrN2O3Degré de pureté :100% - 99.86%Couleur et forme :SolidMasse moléculaire :273.08Ref: TM-T1965
10mg47,00€25mg77,00€50mg119,00€100mg187,00€200mg279,00€500mg472,00€1mL*10mM (DMSO)34,00€γ-Secretase modulator 13
CAS :γ-Secretase modulator 13 is a γ-secretase modulator (GSMs) that can be used to study Alzheimer's disease and tumors.Formule :C22H23FN6SDegré de pureté :99.68%Couleur et forme :SolidMasse moléculaire :422.52Kartogenin
CAS :Kartogenin (KGN) is an activator of the smad4/smad5 pathway, and promotes the selective differentiation of multipotent mesenchymal stem cells into chondrocytes.Formule :C20H15NO3Degré de pureté :96.25% - 97.79%Couleur et forme :SolidMasse moléculaire :317.34WIC1
CAS :2H-1-Benzopyran-3-carboxamide, N-[4-(4-ethyl-1-piperazinyl)phenyl]-2-oxo- is a compound that is potential for the treatment of tumours.Formule :C22H23N3O3Degré de pureté :99.57%Couleur et forme :SoildMasse moléculaire :377.44PF-670462
CAS :PF-670462 is a potent (IC50 = 7.7 ± 2.2 nM) and selective (>30-fold with respect to 42 additional kinases) inhibitor of CK1ε in isolated enzyme preparations.Formule :C19H22Cl2FN5Degré de pureté :99.42% - 99.56%Couleur et forme :SolidMasse moléculaire :410.32Fosifidancitinib
CAS :Fosifidancitinib is a potent inhibitor of JAK 1 and JAK 3.Formule :C21H21FN5O7PDegré de pureté :99.55%Couleur et forme :SolidMasse moléculaire :505.39Ref: TM-T38624
1mg87,00€2mg124,00€5mg187,00€10mg284,00€25mg452,00€50mg645,00€100mg867,00€200mg1.159,00€F7H
CAS :F7H is an FZD7 antagonist, a potent ligand for the FZD7 transmembrane domain (TMD), with potential antitumor and bacteriostatic activities.Formule :C24H18FN3O2S2Degré de pureté :99.85%Couleur et forme :SoildMasse moléculaire :463.55STAT3-IN-18
CAS :STAT3-IN-18 (compound SPP), a platinum (IV) complex featuring an axial ligand from sandalwood, suppresses the JAK2-STAT3 pathway in breast cancer (BC) cells andFormule :C18H24Cl2N2O6PtDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :630.38Naftifine hydrochloride
CAS :Naftifine HCl: synthetic antifungal; inhibits squalene epoxidase, disrupting fungal cell sterol synthesis.Formule :C21H22ClNDegré de pureté :98.75% - 99.84%Couleur et forme :SolidMasse moléculaire :323.86MNK8
CAS :MNK8 is a potent STAT3 inhibitor, impairs DNA binding, and inhibits liver cancer cell growth.Formule :C15H12N2O2Degré de pureté :99.74%Couleur et forme :SolidMasse moléculaire :252.27JW 67
CAS :JW 67 is an inhibitor of canonical Wnt pathway signaling.Formule :C21H18N2O6Degré de pureté :97.02%Couleur et forme :SolidMasse moléculaire :394.38Ref: TM-T22884
1mg46,00€2mg59,00€5mg87,00€10mg137,00€25mg273,00€50mg439,00€100mg647,00€1mL*10mM (DMSO)97,00€JAK1-IN-8
CAS :JAK1-IN-8, a specific inhibitor of Janus kinase 1 (JAK1, IC50<500 nM).Formule :C22H23FN4O3SDegré de pureté :98.36%Couleur et forme :SolidMasse moléculaire :442.51Ref: TM-T35899
5mg47,00€10mg79,00€25mg144,00€50mg250,00€100mg424,00€200mg568,00€1mL*10mM (DMSO)50,00€Jervine
CAS :Jervine inhibits Smoothened, blocking Hedgehog signaling and GLI1 transcription activation.Formule :C27H39NO3Degré de pureté :99.20% - 99.86%Couleur et forme :Needles From Methanol + Water SolidMasse moléculaire :425.6Ref: TM-T3363
5mg70,00€10mg119,00€25mg259,00€50mg499,00€100mg715,00€500mg1.444,00€1mL*10mM (DMSO)74,00€S-Ruxolitinib
CAS :S-Ruxolitinib can be used in related research in the field of life sciences. Its product number is T3066 and CAS number is 1160597-27-2.Formule :C17H18N6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :306.37TEAD-IN-6
CAS :TEAD-IN-6 (Example 11-1) is a TEAD modulator that inhibits the YAP1/TAZ-TEAD interaction, and has applications in cancer research [1].Formule :C19H17F3N4O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :438.42GNF-6231
CAS :GNF-6231 is a potent, selective, and orally bioavailable Porcupine inhibitor that blocks Wnt signaling.Formule :C24H25FN6O2Degré de pureté :100% - 99.54%Couleur et forme :SolidMasse moléculaire :448.49BRD0705
CAS :BRD0705: potent, selective GSK3α inhibitor, oral, IC50: 66 nM, 8x more selective than GSK3β.Formule :C20H23N3ODegré de pureté :99.01%Couleur et forme :SolidMasse moléculaire :321.42Ref: TM-T10606
1mg89,00€5mg183,00€10mg266,00€25mg395,00€50mg553,00€100mg742,00€1mL*10mM (DMSO)200,00€Teplinovivint
CAS :Teplinovivint is a potent inhibitor of the Wnt/β-catenin signaling pathway, demonstrating anti-inflammatory properties with potential utility in tendinopathyFormule :C25H26N6O2Degré de pureté :97.21%Couleur et forme :SolidMasse moléculaire :442.51Fosciclopirox
CAS :Fosciclopirox (CPX-POM), the phosphoryloxymethyl ester of CPX (Ciclopirox Prodrug, CPX-POM), selectively delivers the active metabolite, CPX, to the entireFormule :C13H20NO6PDegré de pureté :99.83%Couleur et forme :SolidMasse moléculaire :317.27Ref: TM-T9422
2mg35,00€5mg52,00€10mg90,00€25mg170,00€50mg259,00€100mg383,00€200mg545,00€1mL*10mM (DMSO)58,00€MF-Mouse TNNI3/cTn-I(Troponin I Type 3, Cardiac) ELISA Kit
This ELISA kit uses the Sandwich-ELISA principle. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to Mouse TNNI3/cTn-I. Samples (or Standards) are added to the micro ELISA plate wells and combined with the specific antibody and biotinylated detection antibody specific for Mouse TNNI3/cTn-I. Then Avidin-Horseradish Peroxidase (HRP) conjugate are added successively to each micro plate well and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain Mouse TNNI3/cTn-I, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of stop solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm. The OD value is proportional to the concentration of Mouse TNNI3/cTn-I. You can calculate the concentration of Mouse TNNI3/cTn-I in the samples by comparing the OD of the samples to the standard curve.CKI-7
CAS :CKI-7 is a potent and ATP-competitive inhibitor of casein kinase 1 (CK1; IC50: 6 μM; Ki: 8.5 μM) and a selective Cdc7 kinase inhibitor.Formule :C11H14Cl3N3O2SDegré de pureté :100.00% - 100.00%Couleur et forme :SolidMasse moléculaire :358.67Ref: TM-T19913
1mg114,00€5mg217,00€10mg325,00€25mg525,00€50mg712,00€100mg959,00€200mg1.293,00€1mL*10mM (DMSO)239,00€Londamocitinib
CAS :Londamocitinib (JAK1-IN-7) is a selective and potent JAK1 inhibitor with anti-inflammatory activity.Formule :C28H31F2N7O4SDegré de pureté :99.47%Couleur et forme :SolidMasse moléculaire :599.65Ref: TM-T11706
1mg180,00€5mg439,00€10mg597,00€25mg905,00€50mg1.169,00€100mg1.568,00€1mL*10mM (DMSO)567,00€MLN8054
CAS :MLN8054 is a potent and selective Aurora A kinase inhibitor with an IC50 of 4 nM.Formule :C25H15ClF2N4O2Degré de pureté :98.07% - 98.26%Couleur et forme :SolidMasse moléculaire :476.86Ref: TM-T6315
1mg52,00€2mg71,00€5mg88,00€10mg127,00€25mg233,00€50mg376,00€100mg567,00€1mL*10mM (DMSO)93,00€AZD8542
CAS :AZD8542 is an antagonist of Smoothened (SMO) with potential as an oncology therapeutic.Formule :C25H24N4O2Degré de pureté :99.96%Couleur et forme :SolidMasse moléculaire :412.48AS-252424
CAS :AS-252424 is a potent and selective inhibitor of PI3Kγ with IC50 of 33 nM; >10 fold selectivity for PI3Kγ versus PI3Kα.Formule :C14H8FNO4SDegré de pureté :99.06% - 99.26%Couleur et forme :SolidMasse moléculaire :305.28Ref: TM-T6208
1mg39,00€2mg50,00€5mg81,00€10mg135,00€25mg216,00€50mg325,00€100mg472,00€500mg1.026,00€1mL*10mM (DMSO)88,00€NIBR-LTSi
NIBR-LTSi is a selective LATS kinase inhibitor that also activates YAP signaling, promotes tissue stem cell expansion and tissue regeneration in vitro/vivo.Formule :C18H20N4ODegré de pureté :99.87%Couleur et forme :SolidMasse moléculaire :308.38(R)-9b
CAS :(R)-9b is an effective inhibitor of the ACK1 tyrosine kinase (IC50=56 nM) and exhibits anticancer activity. It selectively targets ACK1 but also inhibits kinases in the JAK family, specifically JAK2 and Tyk2. (R)-9b is used in research related to hormone-regulated cancers, such as prostate cancer and breast cancer.Formule :C20H27ClN6OCouleur et forme :SolidMasse moléculaire :402.92CK2-IN-4
CAS :CK2-IN-4 is a protein kinase (CK2) inhibitor with an IC50 value of 8.6 µM.Formule :C18H11N3O4SDegré de pureté :99.72%Couleur et forme :SolidMasse moléculaire :365.36CIA-1 hcl(452087-38-6 Free base)
CAS :CIA-1 inhibits the nuclear receptor COUP-TFII, with IC50s ranging from 1.2 μM to 7.6 μM in prostate cancer cell lines.CIA-1 inhibits the growth of a variety ofFormule :C17H20ClN3O2SDegré de pureté :99.02%Couleur et forme :SolidMasse moléculaire :365.88Myristoyl tetrapeptide-12
CAS :Myristoyl Tetrapeptide-12 activates SMAD2 and facilitates the association of SMAD3 with DNA, promoting eyelash hair growth [1] [2].Formule :C32H63N7O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :625.89SD-1029
CAS :SD-1029 is a JAK2 inhibitor and a novel Stat3 activation inhibitor that inhibits Stat3 phosphorylation and JAK-STAT signaling.Formule :C25H32Br2Cl2N2O3Couleur et forme :SolidMasse moléculaire :639.25SR-3029
CAS :SR-3029 is a potent and highly specific CK1δ/CK1ε inhibitor.Formule :C23H19F3N8ODegré de pureté :99.64%Couleur et forme :SolidMasse moléculaire :480.45TNIK-IN-5
CAS :TNIK-IN-5: strong TNIK inhibitor (IC50=0.05μM), halts Wnt signaling, effective against colorectal cancer in vitro.Formule :C22H17N3O3Degré de pureté :99.75%Couleur et forme :SolidMasse moléculaire :371.39MF-Rat TNNI3/cTn-I(Troponin I Type 3, Cardiac) ELISA Kit
This ELISA kit uses the Sandwich-ELISA principle. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to Rat TNNI3/cTn-I. Samples (or Standards) are added to the micro ELISA plate wells and combined with the specific antibody and biotinylated detection antibody specific for Rat TNNI3/cTn-I. Then Avidin-Horseradish Peroxidase (HRP) conjugate are added successively to each micro plate well and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain Rat TNNI3/cTn-I, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of stop solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm. The OD value is proportional to the concentration of Rat TNNI3/cTn-I. You can calculate the concentration of Rat TNNI3/cTn-I in the samples by comparing the OD of the samples to the standard curve.CIA-1 (Free base)
CAS :CIA-1, a COUP-TFII inhibitor, has IC50 of 1.2-7.6 μM in prostate cancer cells; inhibits tumor growth in mouse prostate cancer.Formule :C17H19N3O2SDegré de pureté :99%Couleur et forme :SolidMasse moléculaire :329.42JAK-IN-14
CAS :JAK-IN-14 (compound 16) is a specific JAK1 inhibitor. It prevents JAK1 phosphorylation by binding to the active site of JAK in immune, inflammation and cancer.Formule :C19H15FN4ODegré de pureté :98.27%Couleur et forme :SolidMasse moléculaire :334.35Ref: TM-T9764
1mg139,00€5mg330,00€10mg492,00€25mg797,00€50mg1.103,00€100mg1.491,00€200mg1.985,00€1mL*10mM (DMSO)340,00€Abrocitinib
CAS :Abrocitinib (PF-04965842) (PF-04965842) is a potent, specific and orally-active JAK1 inhibitor (IC50s: 29/803 nM for JAK1/2).Formule :C14H21N5O2SDegré de pureté :99.09% - 99.91%Couleur et forme :SolidMasse moléculaire :323.41Ref: TM-TQ0037
1mg85,00€2mg107,00€5mg167,00€10mg284,00€25mg467,00€50mg692,00€100mg938,00€1mL*10mM (DMSO)188,00€Bintrafusp alfa
CAS :Bintrafusp alfa (M7824) is a protein consisting of the extracellular structural domain of TGF-βRII with a monoclonal antibody to human immunoglobulin G1.Couleur et forme :LiquidMF-Mouse S100B(S100 Calcium Binding Protein B) ELISA Kit
This ELISA kit uses the Sandwich-ELISA principle. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to Human S100B. Samples (or Standards) are added to the micro ELISA plate wells and combined with the specific antibody and biotinylated detection antibody specific for Human S100B. Then Avidin-Horseradish Peroxidase (HRP) conjugate are added successively to each micro plate well and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain Human S100B, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of stop solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm. The OD value is proportional to the concentration of Human S100B. You can calculate the concentration of Human S100B in the samples by comparing the OD of the samples to the standard curve.SRI-011381 hydrochloride
CAS :SRI-011381 hydrochloride, a new-type agonist of the TGF-beta signaling pathway, is utilized in the treatment of Alzheimer's disease.Formule :C20H32ClN3ODegré de pureté :98.24% - 99.59%Couleur et forme :SolidMasse moléculaire :365.94Ref: TM-T5129
2mg47,00€5mg70,00€10mg111,00€25mg227,00€50mg378,00€100mg560,00€500mg1.216,00€1mL*10mM (DMSO)77,00€CEP-33779
CAS :CEP-33779 is a novel and selective inhibitor of JAK2 with an IC50 of 1.8±0.6 nM.Formule :C24H26N6O2SDegré de pureté :98.81% - ≥95%Couleur et forme :SolidMasse moléculaire :462.57Ref: TM-T6122
1mg46,00€2mg59,00€5mg87,00€10mg144,00€25mg245,00€50mg376,00€100mg560,00€500mg1.216,00€1mL*10mM (DMSO)97,00€LSKL, Inhibitor of Thrombospondin TSP-1 2TFA
LSKL, Inhibitor of Thrombospondin TSP-1 acetate is activation of TGF-β .Formule :C25H44F6N6O9Degré de pureté :≥98%Couleur et forme :SolidMasse moléculaire :686.64Ref: TM-T7676
2mg44,00€5mg57,00€10mg88,00€25mg145,00€50mg217,00€100mg334,00€200mg467,00€1mL*10mM (DMSO)87,00€YAP-TEAD-IN-1 acetate
YAP-TEAD-IN-1 acetate is an effective and competitive inhibitor of YAP-TEAD interaction with an IC50 of 25 nM.Formule :C95H148ClN23O23S2Degré de pureté :98.11% - 99.57%Couleur et forme :SoildMasse moléculaire :2079.92TLC1566-0618
CAS :TLC1566-0618 shows antitumor activity and targets stat.Formule :C20H15NO3S3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :413.53JAK1-IN-11
CAS :JAK1-IN-11 (compound 11) serves as a potent inhibitor of Janus kinases, exhibiting nanomolar inhibitory concentrations with IC50 values of 0.02 nM (JAK1) and 0.Formule :C26H36N6O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :528.67Neoprzewaquinone A
CAS :Neoprzewaquinone A (NEO), an active ingredient of S. miltiorrhiza, inhibits breast cancer cell migration and promotes smooth muscle relaxation by targeting PIM1 and blocking the ROCK2/STAT3 pathway.Formule :C36H28O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :556.6Lorpucitinib
CAS :Lorpucitinib (JNJ-64251330) is a JAK kinase inhibitor used in the study of inflammatory and gastrointestinal diseases.Formule :C22H28N6O2Degré de pureté :99.72%Couleur et forme :SolidMasse moléculaire :408.5Narciclasine
CAS :Narciclasine (Lycoricidinol), a natural product, modulates the Rho/Rho-kinase/LIM kinase/cofilin signaling pathway, greatly increasing GTPase RhoA activity.Formule :C14H13NO7Degré de pureté :98.79% - 99.58%Couleur et forme :SolidMasse moléculaire :307.26CK2-IN-14
CK2-IN-14 (Compound 10b) is an inhibitor of cyclin-dependent kinase 2α with an IC50 of 36.7 nM. It effectively hinders the growth of cancer cell lines 786-O and U937, with GI50 values of 7.3 μM and 7.5 μM, respectively.Formule :C19H20ClN5SCouleur et forme :SolidMasse moléculaire :385.91YO-01027
CAS :YO-01027 (DBZ) is a potent γ-secretase inhibitor.Formule :C26H23F2N3O3Degré de pureté :97.21% - 99.63%Couleur et forme :SolidMasse moléculaire :463.48LX-7101 hydrochloride
CAS :LX-7101 hydrochloride is a potent LIMK and ROCK2 inhibitor with antihypertensive activity, inhibits LIMK1/2, ROCK, PKA, and can be used to study glaucoma.Formule :C23H29N7O3xHClDegré de pureté :98.35%Couleur et forme :SolidMasse moléculaire :487.99Afuresertib hydrochloride
CAS :Afuresertib hydrochloride is an inhibitor of Akt kinase (Kis of 0.08/2/2.6 nM for Akt1/Akt2/Akt3 respectively)Formule :C18H18Cl3FN4OSDegré de pureté :99.96%Couleur et forme :SolidMasse moléculaire :463.8Ref: TM-T7885
2mg52,00€5mg74,00€10mg95,00€25mg163,00€50mg253,00€100mg437,00€200mg568,00€1mL*10mM (DMSO)86,00€TBCA
CAS :TBCA: selective CK2 inhibitor, IC50=110 nM, Ki=77 nM, favors CK2 over CK1, DYRK1A, and 27 other kinases.Formule :C9H4Br4O2Degré de pureté :99.31%Couleur et forme :SolidMasse moléculaire :463.74Rat Cys-C(Cystatin C) ELISA Kit
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Rat Cys-C. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Rat Cys-C. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Rat Cys-C, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Rat Cys-C in the samples is then determined by comparing the OD of the samples to the standard curve.TGFβ1-IN-1
CAS :TGFβ1-IN-1 is a TGF-β1 inhibitor that inhibits the production of TGF-β1-induced fibrosis markers (α-SMA and fibronectin) and can be used in cancer research.Formule :C22H24N2O3Degré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :364.438GSK-3β inhibitor 14
CAS :GSK-3β inhibitor 14 (1,5-Benzothiazepin-4(5H)-one, 2,3-dihydro-2-methyl-5-(phenylmethyl)-) is a weak GSK-3β inhibitor, IC50﹥ 100μM.Formule :C17H17NOSDegré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :283.39Mouse sCD14(SolubleCluster of Differentiation 14) ELISA Kit
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse sCD14. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse sCD14. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Mouse sCD14, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Mouse sCD14 in the samples is then determined by comparing the OD of the samples to the standard curve.Couleur et forme :Colourless TransparentliquidGS87
CAS :GS87 is a highly specific inhibitor of GSK3 (glycogen synthase kinase 3) that induces extensive differentiation of AML cells.Formule :C16H11N5O2SDegré de pureté :98.86%Couleur et forme :SolidMasse moléculaire :337.36Ref: TM-T8605
1mg131,00€2mg188,00€5mg283,00€10mg430,00€25mg710,00€50mg998,00€100mg1.349,00€1mL*10mM (DMSO)298,00€Miclxin
CAS :Miclxin (DS37262926) is a novel MIC60 inhibitor that induces apoptosis through mitochondrial stress in mutant tumor cells via β-catenin.Miclxin is a potentFormule :C26H27N5O2Degré de pureté :100% - 99.57%Couleur et forme :SolidMasse moléculaire :441.52Ref: TM-T73415
1mg64,00€5mg140,00€10mg192,00€25mg324,00€50mg452,00€100mg620,00€200mg835,00€1mL*10mM (DMSO)156,00€Vismodegib
CAS :Vismodegib (GDC-0449) is a hedgehog pathway inhibitor (IC50: 3 nM). It also inhibits P-gp (IC50: 3.0 μM), ABCG2 (IC50: 1.4 μM).Formule :C19H14Cl2N2O3SDegré de pureté :98% - 99.99%Couleur et forme :SolidMasse moléculaire :421.3KY19382
CAS :KY19382, a dual CXXC5-DVL and GSK3β inhibitor (IC50s: 19/10 nM), boosts Wnt/β-catenin signaling and may help in metabolic disease research.Formule :C17H11Cl2N3O2Degré de pureté :98.06%Couleur et forme :SolidMasse moléculaire :360.19Ref: TM-T9025
1mg99,00€5mg197,00€10mg350,00€25mg590,00€50mg840,00€100mg1.130,00€500mg2.308,00€1mL*10mM (DMSO)243,00€Tideglusib
CAS :Tideglusib (NP031112), a non-ATP competitive inhibitor of glycogen synthase kinase 3 (GSK-3), is with anti-inflammatory and neuroprotective activities.Formule :C19H14N2O2SDegré de pureté :98.40% - 99.35%Couleur et forme :SolidMasse moléculaire :334.39Ref: TM-T3067
10mg47,00€25mg77,00€50mg113,00€100mg187,00€200mg283,00€500mg490,00€1mL*10mM (DMSO)50,00€(E/Z)-GO289
CAS :(E/Z)-GO289, which strongly lengthened circadian period, is a potent and selective inhibitor of CK2.Formule :C17H15BrN4O2SDegré de pureté :98.10%Couleur et forme :SolidMasse moléculaire :419.3Ref: TM-T9356
1mg37,00€5mg80,00€10mg117,00€25mg255,00€50mg375,00€100mg535,00€200mg727,00€1mL*10mM (DMSO)81,00€Hydroxyfasudil
CAS :Hydroxyfasudil (Hydroxy-Fasudil) is a ROCK inhibitor(IC50s of 0.73 and 0.72 μM for ROCK1 and ROCK2, respectively).Formule :C14H17N3O3SDegré de pureté :98.13%Couleur et forme :SolidMasse moléculaire :307.37JDTic dihydrochloride
CAS :JDTic is a powerful antagonist of kappa-opioid receptors (KOR), effectively inhibiting the antinociceptive effects induced by the κ-agonist U50, 488.Formule :C28H41Cl2N3O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :538.55Aβ42-IN-2
CAS :Aβ42-IN-2 is a γ-secretase modulator. Aβ42-IN-2 has an IC 50 of 6.5 nM for Αβ 42. Aβ42-IN-2 can be used for the Alzheimer's disease research[1].Formule :C24H26N6O2Degré de pureté :100% - 99.49%Couleur et forme :SolidMasse moléculaire :430.5Ref: TM-T9641
1mg42,00€5mg94,00€10mg134,00€25mg215,00€50mg304,00€100mg420,00€200mg582,00€1mL*10mM (DMSO)93,00€SANT-1
CAS :SANT-1 directly binds to Smoothened (Smo) receptor (Kd: 1.2 nM) and inhibits Smo agonist effects (IC50: 20 nM).Formule :C23H27N5Degré de pureté :100% - 99.98%Couleur et forme :SolidMasse moléculaire :373.49GANT 61
CAS :GANT 61 (GANT61) is an inhibitor for Gli1 and Gli2.Formule :C27H35N5Degré de pureté :100% - ≥95%Couleur et forme :SolidMasse moléculaire :429.6HDAC6-IN-9
CAS :HDAC6-IN-9 is a γ-secretase modulator that can significantly reduce the level of Aβ42 in mouse brain and can be used to study neurological diseases.Formule :C19H16N2O3Degré de pureté :98.84%Couleur et forme :SolidMasse moléculaire :320.34JAK-IN-5
CAS :JAK-IN-5 is a JAK inhibitor.Formule :C27H31FN6ODegré de pureté :97.78% - 98.78%Couleur et forme :SolidMasse moléculaire :474.57Ref: TM-T11710
1mg187,00€5mg391,00€10mg582,00€25mg929,00€50mg1.254,00€100mg1.691,00€500mg3.382,00€1mL*10mM (DMSO)567,00€CRT0066854 hydrochloride
CAS :CRT0066854 HCl inhibits atypical PKCs; IC50: PKCι 132 nM, PKCζ 639 nM, ROCK-II 620 nM.Formule :C24H27Cl2N5SDegré de pureté :97.51%Couleur et forme :SolidMasse moléculaire :488.48STAT3-IN-37
CAS :STAT3-IN-37 (Compound 101) is an inhibitor of STAT3, with an IC50 of 15 nM as measured by DNA-HTRF assay and 2 nM as determined through human whole blood SOCS3 qPCR assay.Formule :C23H25Cl2N5O2Couleur et forme :SolidMasse moléculaire :474.38MBM-55
CAS :MBM-55 is an effective inhibitor of NIMA related kinase 2 (NEK2) with an IC50 of 1 nM.Formule :C28H27FN6O2Degré de pureté :99.98%Couleur et forme :SolidMasse moléculaire :498.55Ref: TM-T11960
1mg177,00€5mg298,00€10mg432,00€25mg662,00€50mg868,00€100mg1.169,00€500mg2.365,00€1mL*10mM (DMSO)325,00€BMS986260
CAS :BMS-986260 is a selective, and orally bioavailable TGFβR1 inhibitor(IC50 = 1.6 nM).Formule :C18H12ClFN6ODegré de pureté :97.67%Couleur et forme :SolidMasse moléculaire :382.78TGFβRI-IN-3
CAS :TGFβRI-IN-3 inhibits TGFβR1 with an IC 50 of 0.79 nM with 2000-fold selectivity against MAP4K4.Formule :C28H23N3O2SDegré de pureté :98.02%Couleur et forme :SoildMasse moléculaire :465.57Ref: TM-T9523
1mg88,00€5mg187,00€10mg298,00€25mg582,00€50mg908,00€100mg1.301,00€500mg2.593,00€1mL*10mM (DMSO)187,00€PRI-724
CAS :PRI-724 is a second-generation, selective small molecule inhibitor of the β-catenin/CBP interaction.Cost-effective and quality-assured.Formule :C33H35N6O7PDegré de pureté :98.25% - 99.11%Couleur et forme :SoildMasse moléculaire :658.64Indirubin-3'-monoxime
CAS :Indirubin-3'-monoxime (Indirubin-3'-oxime) is a potent inhibitor of GSK3β (IC50: 22 nM) and also inhibits CDKs ( (IC50s: 100/180/250 nM for Cdk5/p35, Cdk1/Formule :C16H11N3O2Degré de pureté :99.55%Couleur et forme :Dark Red SolidMasse moléculaire :277.28Ref: TM-T5200
2mg38,00€5mg55,00€10mg88,00€25mg165,00€50mg246,00€100mg366,00€200mg538,00€1mL*10mM (DMSO)60,00€Golidocitinib
CAS :Golidocitinib (AZD4205) is a selective JAK1 inhibitor (IC50: 73 nM) and weakly inhibits JAK2/JAK3 (IC50: >14.7, >30 μM).Formule :C25H31N9O2Degré de pureté :100% - 98.87%Couleur et forme :SolidMasse moléculaire :489.57Ref: TM-T10431
2mg96,00€5mg163,00€10mg268,00€25mg465,00€50mg618,00€100mg880,00€1mL*10mM (DMSO)170,00€1(R),2(S)-epoxy Cannabidiol
CAS :1(R),2(S)-epoxy Cannabidiol (Compound 2a) is a structural analog of phytocannabinoids, exhibiting significant inhibitory activity on the Wnt/β-catenin pathway. It holds potential for research as a neuroprotective agent.Formule :C21H30O3Couleur et forme :SolidMasse moléculaire :330.46
