Cellules souche et Dérivés
Les inhibiteurs de cellules souches sont des composés qui ciblent spécifiquement les voies de signalisation et les protéines impliquées dans le maintien, la différenciation et la prolifération des cellules souches. Ces inhibiteurs sont cruciaux pour comprendre la biologie des cellules souches et pour développer des stratégies visant à manipuler les cellules souches à des fins thérapeutiques, telles que la médecine régénérative et le traitement du cancer. En contrôlant le destin des cellules souches, ces inhibiteurs peuvent aider à orienter la différenciation des cellules souches en types cellulaires spécifiques ou à prévenir une croissance cellulaire indésirable. Chez CymitQuimica, nous offrons une sélection d'inhibiteurs de cellules souches de haute qualité pour soutenir vos recherches en biologie des cellules souches, biologie du développement et médecine régénérative.
Sous-catégories appartenant à la catégorie "Cellules souche et Dérivés"
- Gamma-sécrétase
- Hérisson/Smoothened
- Voie de signalisation Hippo
- JAK
- Porc-épic
- ROCK
- STAT
- Cellules souches
- TGF-beta/Smad
- Wnt/beta-caténine
Affichez 2 plus de sous-catégories
Produits appartenant à la catégorie "Cellules souche et Dérivés"
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IHMT-MST1-58
CAS :IHMT-MST1-58 is a STE20-like protein 1 kinase (MST1) inhibitor (IC50:23 nM) with high efficiency, selectivity and oral activity.Formule :C21H22N6O3SDegré de pureté :98% - 98.48%Couleur et forme :SolidMasse moléculaire :438.5STAT3-IN-20
CAS :STAT3-IN-20 (Compound 40), with an IC50 of 0.65 μM, is a selective inhibitor targeting the SH2 domain of STAT3, thereby impeding its phosphorylation, nuclearFormule :C30H27F4N7SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :593.64BIO-013077-01
CAS :BIO-013077-01 is a potent TGFbeta family type I receptors antagonist.Formule :C17H13N5Degré de pureté :99.87%Couleur et forme :SolidMasse moléculaire :287.32Ref: TM-T8330
1mg50,00€5mg92,00€10mg140,00€25mg273,00€50mg393,00€100mg557,00€200mg753,00€1mL*10mM (DMSO)138,00€Ponsegromab
CAS :Ponsegromab (PF 06946860), a humanized anti-GDF15 antibody, may treat cancer cachexia by blocking GDF15/GFRAL signaling.Degré de pureté :100% (SEC-HPLC) - > 95%Couleur et forme :LiquidMasse moléculaire :146.08 kDaFz7-21
CAS :Fz7-21, a peptide antagonist of FZD7, inhibits Wnt/β-catenin signaling (IC50=50-100nM) in cells with WNT3A.Formule :C83H114N18O23S2Degré de pureté :99.8%Couleur et forme :SolidMasse moléculaire :1796.03STAT3 degrader-2
CAS :STAT3 Degrader-2 is a PROTAC-based compound that effectively reduces the total STAT3 protein levels, and is utilized in the research of cancer and variousFormule :C59H62N9O13PDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1136.15JAK/HDAC-IN-4
JAK/HDAC-IN-4 (compound 11 i) is a dual inhibitor targeting both JAK2 and HDAC6, with IC50 values of 0.49 nM and 12 nM respectively. It inhibits cell proliferation and the production of nitric oxide. In a mouse model induced by Imiquimod, JAK/HDAC-IN-4 ameliorates psoriasiform skin lesions with low toxicity.Formule :C30H32N8O5SCouleur et forme :SolidMasse moléculaire :616.69Carboxylesterase-IN-3
CAS :Carboxylesterase-IN-3 is a potent inhibitor of Carboxylesterase Notum (IC50 ≤ 10 nM).Carboxylesterase-IN-3 has the potential to study cancer diseases.Formule :C11H6Cl2N4OSDegré de pureté :97.49% - 97.89%Couleur et forme :SolidMasse moléculaire :313.16Gossypolone
CAS :Gossypolone is is a proposed major metabolite of gossypol. Gossypolone reduces Notch/Wnt signaling and induces apoptosis.Formule :C30H26O10Degré de pureté :96.66%Couleur et forme :SolidMasse moléculaire :546.52M3686
CAS :M3686 (Compound 29) is a potent and selective TEAD1 inhibitor with an IC50 value of 51 nM. It exhibits weaker binding activity toward TEAD3. M3686 significantly inhibits the cellular activity of YAP-dependent NCI-H226 cell lines, with an IC50 value of 0.06 μM, and demonstrates strong antitumor effects in the NCI-H226 xenograft model.Formule :C21H18F3N5O2Couleur et forme :SolidMasse moléculaire :429.395WHI-P97 HCl
WHI-P97 HCl is a potent and selective JAK-3 inhibitor.Formule :C16H14Br2ClN3O3Degré de pureté :99.49%Couleur et forme :SolidMasse moléculaire :491.56Verosudil
CAS :Verosudil (AR-12286), a ROCK1/2 inhibitor (Ki: 2 nM), lowers intraocular pressure in mice by enhancing aqueous outflow.Formule :C17H17N3O2SDegré de pureté :99.72%Couleur et forme :SolidMasse moléculaire :327.4Ref: TM-T60924
1mg87,00€5mg250,00€10mg406,00€25mg652,00€50mg919,00€100mg1.216,00€1mL*10mM (DMSO)274,00€WHI-P154
CAS :WHI-P154 (Jak3 inhibitor ii) is a potent JAK3 inhibitor.Formule :C16H14BrN3O3Degré de pureté :98% - 99.6%Couleur et forme :SolidMasse moléculaire :376.2Purmorphamine
CAS :Purmorphamine (Shh Signaling Antagonist VI), which directly binds and activates Smoothened, blocks BODIPY-cyclopamine binding to Smo.Formule :C31H32N6O2Degré de pureté :97.19% - 99.48%Couleur et forme :Light Tan SolidMasse moléculaire :520.62Brontictuzumab
CAS :Brontictuzumab (OMP 52M5) is an anti-Notch1 monoclonal antibody with antitumor activity that inhibits tumor cell proliferation.Couleur et forme :LiquidCCG-222740
CAS :CCG-222740 is an inhibitor of Rho/MRTF pathwayFormule :C23H19ClF2N2O3Degré de pureté :98.76%Couleur et forme :SolidMasse moléculaire :444.86Ref: TM-T7764
2mg42,00€5mg65,00€10mg99,00€25mg182,00€50mg279,00€100mg414,00€200mg587,00€1mL*10mM (DMSO)70,00€Rovalpituzumab
CAS :Rovalpituzumab: humanized antibody against DLL3, forms ADCs, treats small cell lung cancer.Degré de pureté :> 95%Couleur et forme :LiquidMasse moléculaire :145.02 kDa3,7-DMF
CAS :3,7-Dimethylfumarate (3,7-DMF) serves as an oral inhibitor of transforming growth factor-beta 1 (TGF-β1)-mediated hepatic stellate cell (HSC) activation.Formule :C17H14O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :282.29SAR407899 hydrochloride
CAS :SAR407899 hydrochloride is a selective, potent and ATP-competitive ROCK inhibitor, with an IC50 of 135 nM for ROCK-2, and Kis of 36 nM and 41 nM for human andFormule :C14H17ClN2O2Degré de pureté :98.01%Couleur et forme :SolidMasse moléculaire :280.75CX-5011
CAS :CX-5011, a CK2 inhibitor, induces Rac1 activation and promotes apoptosis, effectively causing cancer cell death [1] [2].Formule :C20H12N4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :340.33Casein kinase 1δ-IN-5
CAS :Casein kinase 1δ-IN-5 is a potent and selective CK-1δ inhibitor, exhibiting an IC50 of 47 nM, and demonstrates neuroprotective and anti-inflammatory effects inFormule :C16H11F3N2OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :336.33Taladegib
CAS :Taladegib (LY2940680), an oral Smo receptor antagonist, targets Hedgehog signaling for cancer treatment.Formule :C26H24F4N6ODegré de pureté :100% - 99.39%Couleur et forme :SolidMasse moléculaire :512.5JAK3/BTK-IN-1
CAS :JAK3/ BTk-in-1 is a dual JAK3/BTK inhibitor that specifically targets and inhibits Janus kinase 3 (JAK3) and Bruton's tyrosine kinase (BTK), two importantFormule :C25H28N8ODegré de pureté :97.89%Couleur et forme :SolidMasse moléculaire :456.54Ruxolitinib phosphate
CAS :Ruxolitinib phosphate (INCB18424 phosphate) is a JAK1/2 inhibitor with IC50 of 3.3 nM/2.8 nM. Cost-effective and quality-assured.Formule :C17H21N6O4PDegré de pureté :100% - 99.91%Couleur et forme :SolidMasse moléculaire :404.36Ref: TM-T3043
1g615,00€5mg52,00€10mg65,00€25mg82,00€50mg97,00€100mg145,00€200mg227,00€500mg418,00€1mL*10mM (DMSO)59,00€URMC-099
CAS :URMC-099: oral, brain-accessible MLK/LRRK2 inhibitor; IC50 - MLK1/2/3/DLK: 19/42/14/150 nM, LRRK2: 11 nM.Formule :C27H27N5Degré de pureté :98.43% - 99.32%Couleur et forme :SolidMasse moléculaire :421.54Pyrvinium pamoate
CAS :Pyrvinium pamoate (Pyrvinium embonate) is an old anthelminthic medicine for the treatment of enterobiasis , which re-attracts attention as an anti-cancer drugFormule :C26H28N3C23H14O6Degré de pureté :100% - 98.43%Couleur et forme :SolidMasse moléculaire :575.71MRT-81
CAS :MRT-81 blocks Smo receptors in Shh-light2 cells at 41 nM IC50, showing strong hedgehog pathway inhibition, useful in cancer research.Formule :C31H29N3O5SDegré de pureté :98.31%Couleur et forme :SolidMasse moléculaire :555.64Ref: TM-T9532
1mg48,00€5mg97,00€10mg145,00€25mg255,00€50mg368,00€100mg505,00€200mg692,00€1mL*10mM (DMSO)116,00€Casein kinase 1δ-IN-6
CAS :CK1δ-IN-6: potent, selective CK-1δ inhibitor, IC50 23 nM, neuroprotective, anti-inflammatory, for neurodegenerative research.Formule :C16H10ClF3N2OSDegré de pureté :99%Couleur et forme :SoildMasse moléculaire :370.78Ref: TM-T77500
1mg127,00€2mg177,00€5mg283,00€10mg424,00€25mg740,00€50mg1.035,00€100mg1.454,00€500mg2.822,00€Nisevokitug
CAS :Nisevokitug (NIS-793) is an IgG2λ human monoclonal antibody that targets TGF-β (TGFB1/TGFB2). It is produced in CHO-K1 cells [1].Degré de pureté :98%Couleur et forme :Liquid2-(1,8-naphthyridin-2-yl)phenol
CAS :2-NP is a STAT1 enhancer.Formule :C14H10N2ODegré de pureté :99.33% - 99.82%Couleur et forme :SolidMasse moléculaire :222.24Ref: TM-T2168
5mg60,00€10mg96,00€25mg187,00€50mg298,00€100mg469,00€200mg682,00€500mg1.035,00€1mL*10mM (DMSO)66,00€(R)-Lisofylline
CAS :(R)-Lisofylline ((R)-Lisophylline) is an inhibitor of lysophosphatidic acid acyltransferase (IC50 = 0.6 µM).Formule :C13H20N4O3Degré de pureté :99.50%Couleur et forme :SolidMasse moléculaire :280.32BMS-906024
CAS :BMS-906024 (Osugacestat) is a gamma secretase inhibitor, a Notch inhibitor.BMS-906024 has broad-spectrum antitumour activity.Formule :C26H26F6N4O3Degré de pureté :100% - 99.87%Couleur et forme :SolidMasse moléculaire :556.5GSK3β inhibitor II
CAS :GSK3β inhibitor II is a GSK3β inhibitor. GSK3β inhibitor II exhibits the research potential of Alzheimer's disease (AD).Formule :C14H10IN3OSDegré de pureté :99.32%Couleur et forme :SolidMasse moléculaire :395.22TNKS-2-IN-2
CAS :TNKS-2-IN-2 is a TNKS2 selective inhibitor (IC50: 22 nM) with potential anti-tumour activity for the study of colon cancer lung cancer and breast cancer.Formule :C26H23N3O6Degré de pureté :99.45%Couleur et forme :SoildMasse moléculaire :473.48GSK-3 inhibitor 1
CAS :GSK-3 inhibitor 1 is a GSK-3 inhibitor.Formule :C22H17ClFN5O2Degré de pureté :98.11%Couleur et forme :SolidMasse moléculaire :437.85Ref: TM-T11468
1mg104,00€5mg216,00€10mg354,00€25mg677,00€50mg1.008,00€100mg1.491,00€1mL*10mM (DMSO)240,00€ROCK inhibitor-2
CAS :ROCK inhibitor-2 is a selective dual inhibitor of ROCK1 and ROCK2 (IC50s of 17 nM and 2 nM, respectively).Formule :C21H20N2O2Degré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :332.4Ref: TM-T12746
1mg66,00€5mg144,00€10mg216,00€25mg432,00€50mg645,00€100mg905,00€1mL*10mM (DMSO)106,00€Oclacitinib maleate
CAS :Oclacitinib maleate is a selective JAK inhibitor (IC50: 10-99 nM; JAK1 cytokines: 36-249 nM), with no effect on 38 non-JAK kinases.Formule :C15H23N5O2S·C4H4O4Degré de pureté :99.17%Couleur et forme :SolidMasse moléculaire :453.51Ref: TM-T6914
1mg39,00€2mg50,00€5mg79,00€10mg99,00€25mg170,00€50mg271,00€100mg457,00€1mL*10mM (DMSO)86,00€STAT3-IN-B9
CAS :STAT3-IN-B9 (B9) is an inhibitor of abnormal STAT3 activation and inhibits the proliferation of tumor cells including MDA-MB-468, MDA-MB-231, and DU145.Formule :C20H13NO5SDegré de pureté :98.16%Couleur et forme :SolidMasse moléculaire :379.39Ref: TM-T28865
1mg115,00€2mg162,00€5mg249,00€10mg369,00€25mg562,00€50mg787,00€100mg1.054,00€200mg1.406,00€1mL*10mM (DMSO)269,00€GANT 58
CAS :GANT 58 (NSC-75503) is a potent antagonist of Gli. Which inhibits GLI1-induced transcription (IC50: 5 μM).Formule :C24H16N4SDegré de pureté :99.53%Couleur et forme :SolidMasse moléculaire :392.48KYA1797K
CAS :KYA1797K is a highly potent and selective inhibitor. Wnt/β-catenin IC50 is 0.75 μM through TOPflash assay.Formule :C17H11N2O6S2·KDegré de pureté :97.57% - 99.33%Couleur et forme :SolidMasse moléculaire :442.51EHT 1610
CAS :EHT 1610 (EHT 5372) is a potent inhibitor of DYRK, with an IC50 of 0.36 nM and 0.59 nM for DYRK1A and DYRK1B, respectively.Formule :C18H14FN5O2SDegré de pureté :98.27%Couleur et forme :SolidMasse moléculaire :383.4Casein kinase 1δ-IN-1
CAS :Casein kinase 1δ-IN-1 (WAY-643895) is an inhibitor of casein kinase 1δ (CK1δ), which inhibits CK1δ.Formule :C11H7N3OSDegré de pureté :99.46%Couleur et forme :SolidMasse moléculaire :229.26N-(3-Methoxybenzyl)-(9Z,12Z,15Z)-octadecatrienamide
CAS :Macamide Impurity 14 promotes bone growth by activating Wnt/β-catenin, aiding osteoporosis study.Formule :C26H39NO2Degré de pureté :98.66%Couleur et forme :SolidMasse moléculaire :397.59MRT-92
CAS :MRT-92 is an antagonist of Smoothened (Smo) with anti-cancer activity, featuring a binding affinity (Ki) of 0.7 nM. It inhibits the Hedgehog signaling pathway by obstructing the overlapping binding sites within the transmembrane domain of the Smoothened receptor and suppresses the proliferation of cerebellar granule cells in rodents (IC50=0.4 nM). MRT-92 is utilized for research into cerebellar gliomas.Formule :C33H34N4O5Couleur et forme :SolidMasse moléculaire :566.65XL413 xHCl
CAS :BMS-863233 HCl is an ATP-competitive Cdc7 inhibitor (IC50: 3.4 nM) that is potent and selective.BMS-863233 HCl inhibited CK2 and PIM1 with IC50 values of 215Formule :C14H12ClN3O2·xHClDegré de pureté :99.42% - 99.67%Couleur et forme :SolidMasse moléculaire :326.18TT-10
CAS :TT-10 (TAZ-K) activates YAP-TEAD; useful in heart disease with cardiomyocyte loss research.Formule :C11H10FN3OS2Degré de pureté :99.29%Couleur et forme :SolidMasse moléculaire :283.35γ-secretase modulator 3
CAS :Gamma-secretase modulator 3 (γ-secretase modulator 3) is a γ-secretase modulator that reduces Aβ production.Formule :C24H23FN4OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :434.53Tegatrabetan
CAS :Tegatrabetan (BC2059) is a small molecule inhibitor of the Wnt/beta-catenin pathway with potential antineoplastic activity.Formule :C28H36N4O6S2Degré de pureté :98.01% - 99.18%Couleur et forme :SolidMasse moléculaire :588.74Ref: TM-T5642
1mg40,00€2mg52,00€5mg85,00€10mg124,00€25mg210,00€50mg334,00€100mg565,00€1mL*10mM (DMSO)96,00€JAK2-IN-4
CAS :JAK2-IN-4 is a selective JAK2/JAK3 inhibitor, with IC50 values of 0.7 nM and 23.2 nM for JAK2 and JAK3, respectively.Formule :C23H27N5O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :469.56C-Peptide 1 (rat)
CAS :C-Peptide 1 (rat), a β-catenin/GSK-3β activator and regulator of the Wnt/β-catenin signaling pathway, is utilized in cancer research [1].Formule :C140H228N38O51Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3259.58
