Cellules souche et Dérivés
Les inhibiteurs de cellules souches sont des composés qui ciblent spécifiquement les voies de signalisation et les protéines impliquées dans le maintien, la différenciation et la prolifération des cellules souches. Ces inhibiteurs sont cruciaux pour comprendre la biologie des cellules souches et pour développer des stratégies visant à manipuler les cellules souches à des fins thérapeutiques, telles que la médecine régénérative et le traitement du cancer. En contrôlant le destin des cellules souches, ces inhibiteurs peuvent aider à orienter la différenciation des cellules souches en types cellulaires spécifiques ou à prévenir une croissance cellulaire indésirable. Chez CymitQuimica, nous offrons une sélection d'inhibiteurs de cellules souches de haute qualité pour soutenir vos recherches en biologie des cellules souches, biologie du développement et médecine régénérative.
Sous-catégories appartenant à la catégorie "Cellules souche et Dérivés"
- Gamma-sécrétase
- Hérisson/Smoothened
- Voie de signalisation Hippo
- JAK
- Porc-épic
- ROCK
- STAT
- Cellules souches
- TGF-beta/Smad
- Wnt/beta-caténine
Affichez 2 plus de sous-catégories
Produits appartenant à la catégorie "Cellules souche et Dérivés"
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DAPM
CAS :DAPM (gamma-Secretase Inhibitor XVI) is a Notch pathway inhibitor with anticancer activity and antiproliferative effects.Formule :C20H20F2N2O4Degré de pureté :99.76%Couleur et forme :SolidMasse moléculaire :390.38Anti-SOST Antibody (3R170)
Anti-SOST Antibody (3R170) is an antibody targeting SOST. Anti-SOST Antibody (3R170) can be used in ELISA, IHC.Couleur et forme :Odour LiquidXL019
CAS :XL019 is a potent and selective JAK2 inhibitor with IC50 of 2.2 nM, 100 fold selectivity over JAK1.Formule :C25H28N6O2Degré de pureté :99.19%Couleur et forme :SolidMasse moléculaire :444.53WP1066
CAS :WP1066 is a inhibitor of JAK2 (IC50: 2.30 μM) and STAT3 (IC50: 2.43 μM) in HEL cells; shows activity to JAK2, STAT3/5, and ERK1/2, not JAK1 and JAK3.Formule :C17H14BrN3ODegré de pureté :98.92% - 99.73%Couleur et forme :SolidMasse moléculaire :356.22SC99
CAS :SC99 inhibits JAK2-STAT3, reducing STAT3 genes, platelet activity, and has anti-myeloma, anti-thrombotic effects.Formule :C15H8Cl2FN3ODegré de pureté :99.56%Couleur et forme :SolidMasse moléculaire :336.15Ref: TM-T8719
1mg46,00€5mg93,00€10mg140,00€25mg240,00€50mg363,00€100mg452,00€200mg630,00€1mL*10mM (DMSO)99,00€JAK3 covalent inhibitor-1
CAS :JAK3 Covalent Inhibitor-1 is a compound characterized by its potent and selective inhibition of Janus kinase 3 (JAK3), possessing an IC50 of 11 nM andFormule :C22H17FN6O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :448.47Anti-NANOG Antibody (1M448)
Anti-NANOG Antibody (1M448) is a Mouse antibody targeting NANOG. Anti-NANOG Antibody (1M448) can be used in ELISA, WB, ICC, IF, FCM.Degré de pureté :>95%Couleur et forme :Odour LiquidMBM-55S
CAS :MBM-55S, a Nek2 inhibitor with 1 nM IC50, induces cell cycle arrest and apoptosis, suppressing tumor growth.Formule :C36H39FN6O10Degré de pureté :98.38% - 98.73%Couleur et forme :SolidMasse moléculaire :734.73Ref: TM-T11961
1mg185,00€2mg279,00€5mg426,00€10mg627,00€25mg938,00€50mg1.320,00€100mg1.786,00€500mg3.591,00€1mL*10mM (DMSO)630,00€AS1517499
CAS :AS1517499 is a potent STAT6 inhibitor with IC50 of 21 nMFormule :C20H20ClN5O2Degré de pureté :98.27% - 98.7%Couleur et forme :SolidMasse moléculaire :397.86Ref: TM-T4476
1mg40,00€2mg52,00€5mg88,00€10mg119,00€25mg235,00€50mg376,00€100mg469,00€500mg1.064,00€1mL*10mM (DMSO)87,00€Anti-GPC3 Antibody (4L576)
Anti-GPC3 Antibody (4L576) is an antibody targeting GPC3. Anti-GPC3 Antibody (4L576) can be used in ELISA, WB, IF.Couleur et forme :Odour LiquidWAY-262611
CAS :WAY262611 is a Wnt/β-catenin agonist and an inhibitor of Dkk1. It increases bone formation rate with EC50 of 0.63 μM in TCF-luciferase assay.Formule :C20H22N4Degré de pureté :98.09% - 99.09%Couleur et forme :SolidMasse moléculaire :318.42STAT3-IN-3
CAS :STAT3-IN-3 is a potent and selective signal transducer inhibitor and transcription 3 (STAT3) activator.Formule :C27H26BrN3O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :600.48Dual Cathepsin L/JAK-IN-1
CAS :DualCathepsinL/JAK-IN-1 (Compound A8) serves as a dual inhibitor of Cathepsin L (CTSL) and JAK, exhibiting IC50 values of 0.68 μM for CTSL and 337.1 nM, 5.251 nM, 27.29 nM, and 172.6 nM for JAK1/2/3 and TYK2, respectively. This compound effectively prevents the activation of MAPK, NF-κB, and JAK/STAT signaling pathways, leading to significant anti-inflammatory therapeutic effects. DualCathepsinL/JAK-IN-1 is applicable in research on acute lung injury (ALI).Formule :C19H18ClN5Couleur et forme :SolidMasse moléculaire :351.833Wnt-C59
CAS :Wnt-C59 (C59)(C59) is a highly effective and specific Wnt signaling antagonis with PORCN enzymatic activity.Formule :C25H21N3ODegré de pureté :99.56% - 99.95%Couleur et forme :SolidMasse moléculaire :379.45BMS-911543
CAS :BMS-911543 is a potent and selective inhibitor of JAK2 with IC50 of 1.1 nM, ~350-, 75- and 65-fold selective to JAK1, JAK3 and TYK2, respectively. Phase 1/2.Formule :C23H28N8ODegré de pureté :97.69% - 99.98%Couleur et forme :SolidMasse moléculaire :432.52Glasdegib
CAS :Glasdegib (PF-04449913) (PF-04449913) is a potent, and orally bioavailable Smoothened (Smo) inhibitor with IC50 of 5 nM. Phase 2.Formule :C21H22N6ODegré de pureté :98.72%Couleur et forme :SolidMasse moléculaire :374.44PF-04802367
CAS :PF-04802367 is a highly selective GSK-3 inhibitor with an IC50 of 2.1 nM based on a recombinant human GSK-3β enzyme assay and 1.1 nM based on ADP-Glo assay.Formule :C16H16ClN5O3Degré de pureté :98.76%Couleur et forme :SolidMasse moléculaire :361.78Ref: TM-T9611
1mg52,00€5mg105,00€10mg160,00€25mg279,00€50mg420,00€100mg562,00€200mg743,00€1mL*10mM (DMSO)117,00€CCT 031374 hydrobromide
CAS :CCT 031374 hydrobromide is a TCF/β-catenin inhibitor with antitumor activities.Formule :C23H20BrN3ODegré de pureté :98.61%Couleur et forme :SolidMasse moléculaire :434.33Ref: TM-T21685
1mg38,00€5mg71,00€10mg105,00€25mg207,00€50mg329,00€100mg472,00€200mg620,00€1mL*10mM (DMSO)87,00€Cotosudil
CAS :Cotosudil is a ROCK kinase inhibitor with antihypertensive activity used to treat or prevent neurodegenerative diseases.Formule :C16H21N3O2SDegré de pureté :98.41%Couleur et forme :SolidMasse moléculaire :319.42Hematein
CAS :Hematein blocks Akt/PKB, Wnt signaling, promotes apoptosis in lung cancer, is a dye from hematoxylin, and inhibits casein kinase II (IC50: 0.74 μM).Formule :C16H12O6Degré de pureté :98%Couleur et forme :Dark Brown Crystalline PowderMasse moléculaire :300.26I3MT-3
CAS :I3MT-3 (HMPSNE) is a selective inhibitor of 3MST, targeting active site cysteine residues and permeating cell membranes.Formule :C17H14N2O2SDegré de pureté :99.76%Couleur et forme :SolidMasse moléculaire :310.37Decernotinib
CAS :Decernotinib (VRT-831509)(VX-509; VRT-831509) is a potent and selective Janus kinase 3 (JAK3) inhibitor with Ki of 2.5 nM; IC50 is 50-170 nM in cellular assays.Formule :C18H19F3N6ODegré de pureté :100% - 99.45%Couleur et forme :SolidMasse moléculaire :392.38Ref: TM-T2636
1mg38,00€2mg52,00€5mg79,00€10mg110,00€25mg217,00€50mg329,00€100mg494,00€200mg705,00€1mL*10mM (DMSO)88,00€3,5-Bis(4-nitrophenoxy)benzoic acid
CAS :3,5-Bis(4-nitrophenoxy)benzoic acid (Compound W) is an inhibitor of γ-secretase. It decreases the released levels of Aβ42 and notch-1 Aβ-like peptide 25.Formule :C19H12N2O8Degré de pureté :99.14%Couleur et forme :SolidMasse moléculaire :396.31CBT-295
CBT-295, an orally active autotaxin (ATX) inhibitor, effectively decreases inflammatory cytokines including TGF-β, TNF-α, and IL-6, along with the bile duct proliferation marker CK-19, and ameliorates liver fibrosis. The compound's ability to reverse liver fibrosis contributes to lowered ammonia levels in the blood and brain, which in turn reduces ammonia-induced neuroinflammation. CBT-295 shows potential for the study of liver cirrhosis and related encephalopathy.Formule :C18H20ClN3OCouleur et forme :SolidMasse moléculaire :329.82MYF-01-37
CAS :MYF-01-37 (1-[3-Methyl-3-[3-(trifluoromethyl)anilino]pyrrolidin-1-yl]prop-2-en-1-one) is a novel covalent TEAD inhibitor.Formule :C15H17F3N2ODegré de pureté :98.72% - 99.46%Couleur et forme :SolidMasse moléculaire :298.3Ref: TM-T22372
2mg40,00€5mg60,00€10mg96,00€25mg170,00€50mg298,00€100mg444,00€500mg938,00€1mL*10mM (DMSO)66,00€SMO-IN-2
CAS :SMO-IN-2 is a SMO inhibitor with antiproliferative activity and anticancer activity and inhibits Hh signaling.SMO-IN-2 can be used in the study of cancer.Formule :C25H25F4N5O2Degré de pureté :98.64%Couleur et forme :SolidMasse moléculaire :503.49Crenigacestat
CAS :Crenigacestat (LY3039478) is an orally bioavailable Notch inhibitor with an IC50 of ~1 nM in most of the tumor cell lines tested.Formule :C22H23F3N4O4Degré de pureté :97.27% - 98.76%Couleur et forme :SolidMasse moléculaire :464.44VT103
CAS :VT103, an oral TEAD1 palmitoylation inhibitor, shows promise against various cancers by disrupting YAP/TAZ-TEAD interactions.Formule :C18H17F3N4O2SDegré de pureté :98.73%Couleur et forme :SolidMasse moléculaire :410.41Ref: TM-T62077
1mg124,00€5mg298,00€10mg472,00€25mg817,00€50mg1.198,00€100mg1.730,00€200mg2.337,00€1mL*10mM (DMSO)328,00€Silmitasertib
CAS :Silmitasertib (CX-4945) is a potent, orally bioavailable inhibitor of casein kinase 2 (CK2; Ki: 0.38 nM).Formule :C19H12ClN3O2Degré de pureté :98% - 99.90%Couleur et forme :SolidMasse moléculaire :349.77Ref: TM-T2259
1mg40,00€2mg51,00€5mg85,00€10mg125,00€25mg207,00€50mg329,00€100mg520,00€500mg1.111,00€1mL*10mM (DMSO)93,00€KenPaullone
CAS :KenPaullone (9-Bromopaullone), a potent CDK1, CDK2 and CDK5 inhibitor, as new enhancer for iTreg cell differentiation.Formule :C16H11BrN2ODegré de pureté :97.14% - 98.99%Couleur et forme :Tan SolidMasse moléculaire :327.18Ref: TM-T2247
1mg38,00€2mg49,00€5mg70,00€10mg95,00€25mg188,00€50mg319,00€100mg474,00€500mg1.074,00€1mL*10mM (DMSO)74,00€SWTX-143
CAS :SWTX-143, a novel covalent inhibitor, specifically and irreversibly binds to the palmitoylation pocket of all four TEAD isoforms, inhibiting the transcriptionalFormule :C19H18F3N3ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :361.3620(S)-Hydroxycholesterol
CAS :20(S)-Hydroxycholesterol (20α-Hydroxycholesterol) is an allosteric activator of the oncoprotein smoothened (Smo).Formule :C27H46O2Degré de pureté :99.25% - 99.25%Couleur et forme :SolidMasse moléculaire :402.65SAG
CAS :SAG (Smoothened Agonist) is a Smo receptor agonist (EC50=3 nM) that is cell-permeable and selective.Formule :C28H28ClN3OSDegré de pureté :98.16% - 98.88%Couleur et forme :SolidMasse moléculaire :490.06Ref: TM-T1779
1mg51,00€2mg71,00€5mg96,00€10mg153,00€25mg274,00€50mg376,00€100mg557,00€200mg797,00€500mg1.188,00€1mL*10mM (DMSO)97,00€Milpecitinib
CAS :Milpecitinib (Compound 21a) is a potent and selective Janus tyrosine kinase (JAK) inhibitor with anti-inflammatory properties. It shows promise for research in cancer and inflammatory diseases.Formule :C20H20N4O2SCouleur et forme :SolidMasse moléculaire :380.463Belumosudil mesylate
CAS :Belumosudil mesylate (KD025 mesylate) is a ROCK2 inhibitor with antifibrotic activity, and can be used in chronic graft-versus-host disease research.Formule :C27H28N6O5SCouleur et forme :SolidMasse moléculaire :548.61Ref: TM-T39555
1mg35,00€5mg74,00€10mg97,00€25mg172,00€50mg255,00€100mg376,00€200mg560,00€1mL*10mM (DMSO)94,00€γ-secretase modulator 1
CAS :gamma-secretase modulator 1 is a modulator of γ secretase and can be used in studies about the treatment of Alzheimer's disease.Formule :C24H24N4OSDegré de pureté :99.48% - 99.75%Couleur et forme :SolidMasse moléculaire :416.54IK-930
CAS :IK-930 is an orally active TEAD inhibitor (EC50 < 0.1 µM) with potent potency.Formule :C19H19F3N4O2SDegré de pureté :98.86%Couleur et forme :SoildMasse moléculaire :424.44Cardiogenol C hydrochloride
CAS :Cardiogenol C hydrochloride (Cardiogenol C) can induces the differentiation of ESCs into cardiomyocytes (EC50= 100 nM).Formule :C13H17ClN4O2Degré de pureté :99.89% - 99.94%Couleur et forme :SolidMasse moléculaire :296.75TNIK-IN-7
CAS :TNIK-IN-7 is a Traf2 and Nck interacting kinase (TNIK) inhibitor with antitumor activity for the study of signaling and proliferation in colorectal cancer cellsFormule :C23H22N4O2Degré de pureté :99.87%Couleur et forme :SoildMasse moléculaire :386.45STAT6-IN-2
CAS :STAT6-IN-2(R)-84 is a STAT6 inhibitor that inhibits the secretion of eotaxin-3 and the tyrosine phosphorylation of STAT6.Formule :C28H31N5O2Degré de pureté :99.67%Couleur et forme :SolidMasse moléculaire :469.58Tankyrase-IN-2
CAS :Tankyrase-IN-2 is a selective, potent and orally active inhibitor of tankyrase with IC50s of 10, 7, and 710 nM for TNKS1, TNKS2 as well as PARP1, respectivelyFormule :C17H14F2N2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :316.3Rat Cys-C(Cystatin C) ELISA Kit
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Rat Cys-C. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Rat Cys-C. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Rat Cys-C, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Rat Cys-C in the samples is then determined by comparing the OD of the samples to the standard curve.Couleur et forme :Colourless TransparentliquidIlginatinib
CAS :Ilginatinib (NS-018) is a highly active and orally bioavailable inhibitor of JAK2.Formule :C21H20FN7Degré de pureté :98.40% - 99.01%Couleur et forme :SolidMasse moléculaire :389.43Ref: TM-T12266
1mg64,00€5mg138,00€10mg187,00€25mg273,00€50mg393,00€100mg562,00€200mg743,00€1mL*10mM (DMSO)133,00€ALK5-IN-83
ALK5-IN-83 (compound 13b) is an ALK5 inhibitor with an IC50 of 0.13 μM. It suppresses TGF-β1-induced Smad2 phosphorylation and cell motility in A549 cells.Formule :C20H23N7O2SCouleur et forme :SolidMasse moléculaire :425.51JBJ-04-125-02
CAS :JBJ-04-125-02: Oral EGFR inhibitor, targets EGFRL858R/T790M with 0.26 nM IC50, halts cancer growth, anti-tumor.Formule :C29H26FN5O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :543.61JANEX-1
CAS :JANEX-1: cell-permeable, reversible Jak3 inhibitor (IC50: 78 μM), ATP-competitive, selective; weak on JAK1/2, Zap/Syk, SRC.Formule :C16H15N3O3Degré de pureté :98% - 99.73%Couleur et forme :SolidMasse moléculaire :297.31Ref: TM-T2045
1mg44,00€2mg55,00€5mg92,00€10mg150,00€25mg248,00€50mg444,00€100mg652,00€500mg1.378,00€1mL*10mM (DMSO)92,00€JAK3-IN-7
CAS :JAK3-IN-7 is a potent and selective JAK3 inhibitor (IC50<0.01 μM) for the treatment of rejection in organ transplantation, graft-versus-host reaction afterFormule :C17H20N6ODegré de pureté :98.81%Couleur et forme :SolidMasse moléculaire :324.38GSK-3β inhibitor 1
CAS :GSK-3β inhibitor 1 is an inhibitor of GSK-3β( IC50 of 4.9 nM) and demonstrates high antidiabetic efficacy.Formule :C14H10N2ODegré de pureté :99.08%Couleur et forme :SolidMasse moléculaire :222.24Carboxylesterase-IN-2
CAS :Carboxylesterase-IN-2 is a potent Carboxylesterase Notum inhibitor (IC50 <= 10 nM).Carboxylesterase-IN-2 has potential for the study of cancer diseases.Formule :C13H12N4OSDegré de pureté :100%Couleur et forme :SoildMasse moléculaire :272.33Ref: TM-T77524
1mg62,00€5mg140,00€10mg215,00€25mg369,00€50mg509,00€100mg702,00€200mg944,00€1mL*10mM (DMSO)156,00€MM-589
CAS :MM-589 is a potent WD repeat domain 5 (WDR5) inhibitor and mixed lineage leukemia (MLL) protein-protein interaction.Formule :C28H44N8O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :572.70
