Cellules souche et Dérivés
Les inhibiteurs de cellules souches sont des composés qui ciblent spécifiquement les voies de signalisation et les protéines impliquées dans le maintien, la différenciation et la prolifération des cellules souches. Ces inhibiteurs sont cruciaux pour comprendre la biologie des cellules souches et pour développer des stratégies visant à manipuler les cellules souches à des fins thérapeutiques, telles que la médecine régénérative et le traitement du cancer. En contrôlant le destin des cellules souches, ces inhibiteurs peuvent aider à orienter la différenciation des cellules souches en types cellulaires spécifiques ou à prévenir une croissance cellulaire indésirable. Chez CymitQuimica, nous offrons une sélection d'inhibiteurs de cellules souches de haute qualité pour soutenir vos recherches en biologie des cellules souches, biologie du développement et médecine régénérative.
Sous-catégories appartenant à la catégorie "Cellules souche et Dérivés"
- Gamma-sécrétase
- Hérisson/Smoothened
- Voie de signalisation Hippo
- JAK
- Porc-épic
- ROCK
- STAT
- Cellules souches
- TGF-beta/Smad
- Wnt/beta-caténine
Affichez 2 plus de sous-catégories
Produits appartenant à la catégorie "Cellules souche et Dérivés"
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IWP-O1
CAS :IWP-O1 is a highly potent Porcupine (Porcn) inhibitor (EC50: 80 pM), effectively suppresses the phosphorylation of Dvl2/3 and LRP6 in HeLa cells.Formule :C26H20N6ODegré de pureté :99.12%Couleur et forme :SolidMasse moléculaire :432.48Ref: TM-T5342
2mg39,00€5mg64,00€10mg101,00€25mg163,00€50mg226,00€100mg320,00€200mg459,00€1mL*10mM (DMSO)70,00€Ac-VDVAD-CHO
CAS :Ac-VDVAD-CHO is an inhibitor of caspase-2 and caspase-3 (IC50: 46 nM for caspase-2 and 15 nM for caspase-3) [1].Formule :C23H37N5O10Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :543.57Dynarrestin
CAS :Dynarrestin inhibits cytoplasmic dynein 1/2, preventing microtubule sliding without affecting ATP hydrolysis or ciliogenesis.Formule :C22H23F2N3O2SDegré de pureté :99.49%Couleur et forme :SolidMasse moléculaire :431.5Povorcitinib phosphate
CAS :Povorcitinib phosphate is a selective JAK1 inhibitor and can be used in studies about the treatment of cutaneous lupus erythematosus and Lichen planus.Formule :C23H25F5N7O5PDegré de pureté :97.71%Couleur et forme :SolidMasse moléculaire :605.45Ref: TM-T39113L
1mg65,00€2mg95,00€5mg145,00€10mg212,00€25mg359,00€50mg512,00€100mg695,00€200mg937,00€SANT 2
CAS :SANT 2 is a Hedgehog (Hh) signaling pathway antagonist with potential anti-inflammatory and anti-cancer activities.Formule :C26H26ClN3O4Degré de pureté :99.23%Couleur et forme :SolidMasse moléculaire :479.96Wnt pathway inhibitor 3
CAS :Wnt pathway inhibitor 3 is a potent AC1 inhibitor with an IC50 value of 45 nM.Wnt pathway inhibitor 3 has antiproliferative activity and can be used in studiesFormule :C21H17BrN2O5Degré de pureté :99.69%Couleur et forme :SoildMasse moléculaire :457.27E 2012
CAS :E2012 is a γ-secretase modulator (GSM).Formule :C25H26FN3O2Degré de pureté :99.18%Couleur et forme :SolidMasse moléculaire :419.49AT13148
CAS :AT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II.Formule :C17H16ClN3ODegré de pureté :98.04% - ≥95%Couleur et forme :SolidMasse moléculaire :313.78NRX-103095
CAS :NRX-103095 increases β-catenin binding to SCFβ-TrCP E3 ligase; EC50 is 163 nM for pSer33/Ser37 affinity boost.Formule :C22H16Cl2F3N3O3SDegré de pureté :99.16% - 99.60%Couleur et forme :SolidMasse moléculaire :530.35Ref: TM-T63730
1mg150,00€5mg364,00€10mg588,00€25mg1.169,00€50mg1.882,00€100mg2.822,00€1mL*10mM (DMSO)426,00€IMR-1A
CAS :IMR-1A is the metabolite of IMR-1 which is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 μMol/L.Formule :C13H11NO5S2Degré de pureté :97.1% - 99.06%Couleur et forme :SolidMasse moléculaire :325.36GSK-3β inhibitor 21
GSK-3β Inhibitor21 (compound 44) is an ATP-competitive inhibitor of GSK-3β with an IC50 value of 6.06 µM, characterized by its ability to inhibit tau phosphorylation and prevent amyloid protein aggregation. This compound is utilized in the research of Alzheimer's disease.Couleur et forme :Odour SolidSTAT3-IN-31
STAT3-IN-31 (compound K2071), derived from STATtic, acts as an inhibitor of both STAT3 and mitotic processes. This compound interrupts mitotic progression and impacts the formation of the mitotic spindle. Additionally, STAT3-IN-31 hampers migration in glioblastoma cells, suppresses cellular proliferation within tumor spheroids, induces senescence in glioblastoma, and inhibits the growth of Temozolomide-resistant cells while reducing the secretion of the pro-inflammatory cytokine monocyte chemoattractant protein (MCP-1).Formule :C16H15NO3SCouleur et forme :SolidMasse moléculaire :301.36JAK-IN-33
JAK-IN-33 (Compound 3 (R)) is a selective inhibitor of the Janus kinase (JAK) family [1].Degré de pureté :98%Couleur et forme :Odour SolidCDK8-IN-12
CAS :CDK8-IN-12: selective CDK8 inhibitor (Ki 14 nM), oral anticancer, blocks GSK-3α/β, PCK-θ, halts MV4-11 cell growth.Formule :C21H20ClN3O2Degré de pureté :98.97% - 99.83%Couleur et forme :SoildMasse moléculaire :381.86Ref: TM-T72048
1mg52,00€5mg101,00€10mg150,00€25mg250,00€50mg363,00€100mg509,00€200mg695,00€1mL*10mM (DMSO)116,00€KY-05009
CAS :KY-05009 blocks TGF-β1 EMT in lung cancer cells, inhibits TNIK, Wnt genes, induces apoptosis, and is an ATP-competitive TNIK inhibitor (Ki = 100 nM).Formule :C18H16N4O2SDegré de pureté :98.06%Couleur et forme :SolidMasse moléculaire :352.41Ref: TM-T11793
5mg50,00€10mg71,00€25mg117,00€50mg170,00€100mg245,00€200mg354,00€1mL*10mM (DMSO)51,00€Neocucurbitacin A
CAS :Neocucurbitacin A (compound 7), a STAT3 inhibitor extracted from the pericarp of Aquilaria crassna, serves as a potential agent for anticancer research [1].Formule :C31H42O8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :542.66RGB-286638 free base
CAS :RGB-286638 free base inhibits CDKs (1-5 nM), weaker on CDK7/6.Formule :C29H35N7O4Degré de pureté :97.29% - 99.91%Couleur et forme :SolidMasse moléculaire :545.63Peficitinib
CAS :Peficitinib (ASP015K) (ASP015K, JNJ-54781532) is an orally bioavailable JAK inhibitor. Phase 3.Formule :C18H22N4O2Degré de pureté :98.67% - 99.4%Couleur et forme :SolidMasse moléculaire :326.39Ref: TM-T6933
2mg40,00€5mg66,00€10mg104,00€25mg182,00€50mg283,00€100mg439,00€200mg645,00€1mL*10mM (DMSO)73,00€LGK974
CAS :LGK974 (NVP-LGK974) is a selective PORCN inhibitor that blocks Wnt signaling, used in metastatic colorectal and head/neck cancer trials. IC50: 0.4 nM.Formule :C23H20N6ODegré de pureté :100% - ≥98%Couleur et forme :SolidMasse moléculaire :396.44Ref: TM-T2618
1mg48,00€2mg65,00€5mg96,00€10mg164,00€25mg304,00€50mg545,00€100mg778,00€1mL*10mM (DMSO)96,00€FLLL32
CAS :FLLL32 is an effective JAK2/STAT3 inhibitor (IC50 of <5 μM).Formule :C28H32O6Degré de pureté :96.39% - 97.90%Couleur et forme :SolidMasse moléculaire :464.55Ref: TM-T6838
2mg46,00€5mg66,00€10mg93,00€25mg124,00€50mg197,00€100mg350,00€500mg840,00€1mL*10mM (DMSO)72,00€AZD2858
CAS :AZD2858 is a selective GSK-3 inhibitor, inhibiting tau phosphorylation at the S396 site and activating Wnt signaling pathway.Formule :C21H23N7O3SDegré de pureté :98% - 99.25%Couleur et forme :SolidMasse moléculaire :453.52Ref: TM-T1957
1mg38,00€2mg49,00€5mg79,00€10mg106,00€25mg198,00€50mg374,00€100mg555,00€500mg1.206,00€1mL*10mM (DMSO)108,00€RU-SKI 43
CAS :RU-SKI 43: Potent, selective Hhat inhibitor, IC50 850 nM. Anticancer; potential lung adenocarcinoma treatment. Inhibits Gli-1, Akt, mTOR pathways.Formule :C22H30N2O2SDegré de pureté :99.78%Couleur et forme :SolidMasse moléculaire :386.55Epiblastin A
CAS :Epiblastin A inhibits CK1, targets its isoenzymes, and converts EpiSCs to cESCs.Formule :C12H10ClN7Degré de pureté :99.45%Couleur et forme :SolidMasse moléculaire :287.71Cerdulatinib hydrochloride
CAS :Cerdulatinib hydrochloride is an oral tyrosine kinase inhibitor targeting JAK1/2/3, TYK2, Syk, and 19 others with IC50 < 200 nM.Formule :C20H28ClN7O3SDegré de pureté :99.23%Couleur et forme :SolidMasse moléculaire :482SMANT hydrochloride
CAS :SMANT hydrochloride (N-(4-bromophenyl)-3-(3,5-dimethylpiperidin-1-yl)propanamide hydrochloride) is an antagonist of Smoothened accumulation.Formule :C16H24BrClN2ODegré de pureté :100%Couleur et forme :SolidMasse moléculaire :375.73Disitertide acetate
Disitertide acetate: a TGF-β1 and PI3K blocker, promotes apoptosis; inhibits receptor interaction.Formule :C70H113N17O24S2Degré de pureté :95.11%Couleur et forme :SoildMasse moléculaire :1640.88IWP-3
CAS :IWP-3 is a potent inhibitor of Wnt production with an IC50 of 40 nM. It inhibits Porcupine (Porcn), blocking the palmitoylation of Wnt proteins, and moderately inhibits CK1γ3 and CK1ε, but does not inhibit CK1α [1] [2].Formule :C22H17FN4O2S3Degré de pureté :98.38%Couleur et forme :SolidMasse moléculaire :484.59GSK180736A
CAS :GSK180736A: GRK2 inhibitor (IC50 0.77µM), >100x selectivity vs GRKs, weak at PKA (IC50 30µM), strong vs ROCK1 (IC50 100nM).Formule :C19H16FN5O2Degré de pureté :98.16% - 98.44%Couleur et forme :SolidMasse moléculaire :365.36Ref: TM-T3513
1mg42,00€2mg52,00€5mg73,00€10mg88,00€25mg170,00€50mg306,00€100mg568,00€500mg1.225,00€1mL*10mM (DMSO)65,00€Tolnaftate
CAS :Tolnaftate (NP-27) is a synthetic antifungal agent.Formule :C19H17NOSDegré de pureté :98.85%Couleur et forme :White PowderMasse moléculaire :307.41MSC-4106
CAS :MSC-4106, an oral YAP/TAZ-TEAD inhibitor, blocks TEAD1/3 auto-palmitoylation and suppresses NCI-H226 tumors.Formule :C18H12F3N3O2Degré de pureté :100%Couleur et forme :SoildMasse moléculaire :359.3Ref: TM-T60148
1mg96,00€5mg235,00€10mg378,00€25mg630,00€50mg898,00€100mg1.216,00€200mg1.634,00€1mL*10mM (DMSO)271,00€Cerdulatinib
CAS :Cerdulatinib (PRT2070) is an novel oral dual Syk/JAK inhibitor.Formule :C20H27N7O3SDegré de pureté :98.74% - 99.49%Couleur et forme :SolidMasse moléculaire :445.54Ref: TM-T2487
1mg44,00€2mg55,00€5mg79,00€10mg106,00€25mg185,00€50mg283,00€100mg432,00€200mg605,00€500mg938,00€1mL*10mM (DMSO)86,00€Tofacitinib Citrate
CAS :Tofacitinib Citrate (CP-690550 citrate) is a a potent, cell-permeable inhibitor of JAK1/2/3 (IC50s: 1/20/112 nM).Formule :C22H28N6O8Degré de pureté :99.19% - 99.75%Couleur et forme :SolidMasse moléculaire :504.49TAK-901
CAS :TAK-901 has been used in trials studying the treatment of Lymphoma, Myelofibrosis, Multiple Myeloma, Myeloid Metaplasia, and Advanced Solid Tumors, among othersFormule :C28H32N4O3SDegré de pureté :97.38% - 99.1%Couleur et forme :SolidMasse moléculaire :504.64AR-A014418
CAS :AR-A014418 (GSK 3β inhibitor VIII) is an ATP-competitive, and selective GSK3β inhibitor.Formule :C12H12N4O4SDegré de pureté :99.94% - ≥95%Couleur et forme :SolidMasse moléculaire :308.31Aloisine B
CAS :Aloisine B (AloisineB) inhibited cyclin-dependent kinase and glycogen synthase kinase with IC50 values of 0.85 µM and 0.75 µM, respectively.Formule :C15H14ClN3Degré de pureté :95.15%Couleur et forme :SolidMasse moléculaire :271.74Tubastatin
CAS :Tubastatin inhibits TGF-β1-induced S6K phosphorylation, HIF-1α expression and VEG F expression.Formule :C21H22N2O2Degré de pureté :98.23%Couleur et forme :SolidMasse moléculaire :334.41Brevilin A
CAS :Brevilin A, a sesquiterpene from Centipeda minima, hinders JAK and blocks STAT3 (IC50=10.6μM), inducing apoptosis and autophagy in cancer cells.Formule :C20H26O5Degré de pureté :100% - 99.74%Couleur et forme :SolidMasse moléculaire :346.42Ref: TM-T4672
1mg96,00€5mg215,00€10mg369,00€25mg610,00€50mg840,00€100mg1.130,00€500mg2.308,00€1mL*10mM (DMSO)235,00€PIMPC
CAS :PIMPC, a compound endowed with antioxidant and metal-chelating properties, acts as a novel inhibitor of glycogen synthase kinase 3 (GSK-3), and exhibitsFormule :C21H19N5ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :357.41Rhodblock 6
CAS :Rhodblock 6 is a Rho kinase inhibitor, blocking phosphorylated MRLC localization by targeting ROCK activity.Formule :C12H13N3ODegré de pureté :98.27%Couleur et forme :SolidMasse moléculaire :215.25Wnt/β-catenin agonist 2
CAS :Wnt/β-catenin agonist 2 activates Wnt/β-catenin signaling and is an effective Wnt agonist.Formule :C13H12N4O3Degré de pureté :99.58%Couleur et forme :SolidMasse moléculaire :272.26Ref: TM-T41094
1mg54,00€5mg116,00€10mg187,00€25mg318,00€50mg449,00€100mg638,00€500mg1.264,00€1mL*10mM (DMSO)111,00€Ilginatinib hydrochloride
CAS :Ilginatinib hydrochloride (NS-018 hydrochloride) is a highly active and orally bioavailable inhibitor of JAK2.Formule :C21H21ClFN7Degré de pureté :99.55%Couleur et forme :SolidMasse moléculaire :425.89Ref: TM-T12266L2
1mg77,00€5mg165,00€10mg240,00€25mg408,00€50mg562,00€100mg800,00€200mg1.074,00€1mL*10mM (DMSO)177,00€CUR61414
CAS :CUR61414 is a cell-permeable inhibitor of Hedgehog signaling pathway (IC50 =100-200 nM) and selectively binds to smoothened (Ki = 44 nM).Formule :C31H42N4O5Degré de pureté :97.34% - 98.00%Couleur et forme :SolidMasse moléculaire :550.69Ref: TM-T15019
1mg52,00€5mg111,00€10mg180,00€25mg359,00€50mg550,00€100mg787,00€1mL*10mM (DMSO)123,00€LSKL TFA
CAS :LSKL TFA (H-Leu-Ser-Lys-Leu-NH2 TFA) is a TGF-尾1 antagonist that inhibits TSP-1 binding to LAP and reduces renal interstitial fibrosis and liver fibrosis.Formule :C23H43F3N6O7Degré de pureté :99.33%Couleur et forme :SolidMasse moléculaire :572.62CCG 203769
CAS :CCG 203769 (Thiadiazolidinone (TDZD) deriv. 6) is a selective inhibitor of RGS4 with an IC50 of 17 nM for the RGS4-Gαo protein-protein interaction.Formule :C8H14N2O2SDegré de pureté :99.46%Couleur et forme :SolidMasse moléculaire :202.27Ref: TM-T10705
1mg88,00€5mg187,00€10mg264,00€25mg469,00€50mg657,00€100mg944,00€500mg1.882,00€1mL*10mM (DMSO)207,00€DIF-3
CAS :DIF-3 activates GSK-3β, degrades cyclin D1/c-Myc, and inhibits Wnt/β-catenin in DLD-1 cells, curbing HeLa cell proliferation.Formule :C13H17ClO4Degré de pureté :99.57%Couleur et forme :SolidMasse moléculaire :272.72Ref: TM-T60485
1mg92,00€5mg235,00€10mg350,00€25mg588,00€50mg838,00€100mg1.130,00€500mg2.308,00€1mL*10mM (DMSO)215,00€2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide
CAS :2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide (GDC046), a potent lead analog, has good kinase selectivity and physicochemical properties.Formule :C16H13Cl2N3O2Degré de pureté :98.77%Couleur et forme :SolidMasse moléculaire :350.2SAG 21k
CAS :SAG 21k is an orally bioactive and potent Hedgehog signaling activator that crosses the blood-brain barrier for the study of cartilage regeneration.Formule :C29H28ClF2N3O2SDegré de pureté :99.51%Couleur et forme :SolidMasse moléculaire :556.07BMP signaling agonist sb4
CAS :BMP signaling agonist sb4 (SB 4) is an agonist of benzoxazole bone morphogenetic protein (BMP) signaling (EC50 :74 nM)Formule :C14H10BrNOSDegré de pureté :99.48% - 99.94%Couleur et forme :SolidMasse moléculaire :320.2Ref: TM-T7799
5mg47,00€10mg60,00€25mg88,00€50mg126,00€100mg187,00€200mg283,00€500mg490,00€1mL*10mM (DMSO)50,00€β-catenin modulator IIa-661
CAS :β-catenin modulator IIa-661 is a small molecule inhibitor of the Wnt pathway with antitumour activity.Formule :C19H23ClN2O3SDegré de pureté :99.53%Couleur et forme :SoildMasse moléculaire :394.92JAK3-IN-6
CAS :JAK3-IN-6 is irreversible Janus Associated Kinase 3 (JAK3) inhibitor, with an IC50 of 0.15 nMFormule :C19H18N4O3Degré de pureté :97.46% - 99.94%Couleur et forme :SolidMasse moléculaire :350.37
