Cellules souche et Dérivés
Les inhibiteurs de cellules souches sont des composés qui ciblent spécifiquement les voies de signalisation et les protéines impliquées dans le maintien, la différenciation et la prolifération des cellules souches. Ces inhibiteurs sont cruciaux pour comprendre la biologie des cellules souches et pour développer des stratégies visant à manipuler les cellules souches à des fins thérapeutiques, telles que la médecine régénérative et le traitement du cancer. En contrôlant le destin des cellules souches, ces inhibiteurs peuvent aider à orienter la différenciation des cellules souches en types cellulaires spécifiques ou à prévenir une croissance cellulaire indésirable. Chez CymitQuimica, nous offrons une sélection d'inhibiteurs de cellules souches de haute qualité pour soutenir vos recherches en biologie des cellules souches, biologie du développement et médecine régénérative.
Sous-catégories appartenant à la catégorie "Cellules souche et Dérivés"
- Gamma-sécrétase
- Hérisson/Smoothened
- Voie de signalisation Hippo
- JAK
- Porc-épic
- ROCK
- STAT
- Cellules souches
- TGF-beta/Smad
- Wnt/beta-caténine
Affichez 2 plus de sous-catégories
Produits appartenant à la catégorie "Cellules souche et Dérivés"
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Y-27632 dihydrochloride
CAS :View and buy Y-27632 dihydrochloride from TargetMol.Y-27632 is a selective inhibitor of ROCKs.Cited in 10 publications.Formule :C14H21N3O·2HClDegré de pureté :97.96% - 99.98%Couleur et forme :SolidMasse moléculaire :320.26Ref: TM-T1725
5mg47,00€10mg60,00€25mg99,00€50mg169,00€100mg273,00€200mg432,00€500mg715,00€1mL*10mM (DMSO)50,00€JI069
CAS :JI069 (WAY-354189) is a potent STAT3 inhibitor that inhibits gp130 signaling by inducing dissociation between gp130 and JAK1.Formule :C15H12Cl2N2O4SDegré de pureté :98.01%Couleur et forme :SolidMasse moléculaire :387.24Wnt/β-catenin agonist 4
CAS :Wnt/β-catenin agonist 4 is an agonist of Wnt that activates Wnt/β-catenin signaling and directs signaling.Formule :C16H15FN4O2Degré de pureté :99.61%Couleur et forme :SolidMasse moléculaire :314.31Ref: TM-T60803
1mg35,00€5mg70,00€10mg103,00€25mg182,00€50mg311,00€100mg512,00€200mg720,00€1mL*10mM (DMSO)81,00€GSK269962A hydrochloride
CAS :GSK269962A hydrochloride (GSK 269962 hydrochloride) is a ROCK inhibitor with anti-inflammatory and vasodilatory effects and inhibits ROCK1 and ROCK2.Formule :C29H31ClN8O5Couleur et forme :SolidMasse moléculaire :607.06STAT3-IN-34
STAT3-IN-34 (Compound 15E) acts as a STAT3 inhibitor, blocking both the nuclear translocation and the transcriptional regulator activity of STAT3. It effectively inhibits HaCaT cell proliferation with an IC50 value of 0.008 μM. Additionally, STAT3-IN-34 reduces IL-17A expression and mitigates Imiquimod-induced psoriasis in mouse models.Formule :C19H16N2O4SCouleur et forme :SolidMasse moléculaire :368.41Mouse TNC(Tenascin C) ELISA Kit
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse TNC. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse TNC. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Mouse TNC, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Mouse TNC in the samples is then determined by comparing the OD of the samples to the standard curve.(E)-SIS3
CAS :(E)-SIS3 (SIS3), a selective Smad3 inhibitor, can attenuate TGF-β1-dependent Smad3 phosphorylation and DNA bindingFormule :C28H27N3O3·HClDegré de pureté :95.64% - 98.83%Couleur et forme :SolidMasse moléculaire :489.99Ref: TM-T3636
1mg43,00€2mg57,00€5mg111,00€10mg167,00€25mg344,00€50mg512,00€100mg730,00€500mg1.473,00€1mL*10mM (DMSO)120,00€GNF4877
CAS :GNF4877 inhibits DYRK1A/GSK3β (IC50: 6/16 nM), blocks NFATc export, and boosts β-cell growth.Formule :C25H27FN6O4Degré de pureté :98.63% - 99.40%Couleur et forme :SolidMasse moléculaire :494.52Netarsudil mesylate
CAS :Netarsudil mesylate (AR-13324 mesylate) is a Rho-related protein kinase inhibitor used to study glaucoma and hypertension.Formule :C30H35N3O9S2Degré de pureté :99.7%Couleur et forme :SolidMasse moléculaire :645.74BP-1-102
CAS :BP-1-102 is an orally active, effective and specific STAT3 inhibitor.Formule :C29H27F5N2O6SDegré de pureté :99.25% - 99.81%Couleur et forme :SolidMasse moléculaire :626.59Ref: TM-T3708
1mg39,00€2mg51,00€5mg84,00€10mg119,00€25mg210,00€50mg354,00€100mg522,00€1mL*10mM (DMSO)104,00€IMR-1
CAS :IMR-1 is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 μMol/L.Formule :C15H15NO5S2Degré de pureté :97.96% - 98.38%Couleur et forme :SolidMasse moléculaire :353.41TNIK-IN-3
CAS :TNIK-IN-3 is a highly potent and orally active inhibitor of Traf2- and Nck-interacting protein kinase (TNIK).Formule :C23H18FN3O2Degré de pureté :99.56%Couleur et forme :SolidMasse moléculaire :387.41Ref: TM-T9556
1mg106,00€5mg259,00€10mg406,00€25mg652,00€50mg938,00€100mg1.454,00€1mL*10mM (DMSO)284,00€CHIR-99021 HCl
CAS :CHIR-99021 HCl is a selective GSK-3α/β inhibitor (IC50: 10/6.7 nM), 500x selective over other kinases, boosts Wnt pathway, and enhances stem cell renewal.Formule :C22H19Cl3N8Degré de pureté :98.07% - 98.44%Couleur et forme :SolidMasse moléculaire :501.8Ref: TM-T2310L
1mg35,00€2mg52,00€5mg77,00€10mg96,00€25mg163,00€50mg240,00€100mg465,00€200mg675,00€500mg1.026,00€1mL*10mM (DMSO)86,00€Sotatercept
CAS :Sotatercept (ACE-011) is an ActRIIA-Fc fusion protein and an inhibitor of activin signaling.Couleur et forme :Liquid(+)-ITD-1
CAS :(+)-ITD-1 is an inhibitor of TGF-β, effectively inhibiting TGF-β2 with an IC50 of 0.46 μM. It promotes the degradation of the TGF-β type II receptor (TGFBR2) and the differentiation of cardiomyocytes. Additionally, it suppresses the formation of the mesoderm during the early differentiation of mouse embryonic stem cells (mESCs).Formule :C27H29NO3Couleur et forme :SolidMasse moléculaire :415.52Baricitinib phosphate
CAS :Baricitinib phosphate (INCB028050) is a selective orally bioavailable JAK1/JAK2 inhibitor.Formule :C16H20N7O6PSDegré de pureté :98.87% - 99.68%Couleur et forme :SolidMasse moléculaire :469.41BIP-135
CAS :BIP-135 is a potent and selective ATP-competitive GSK-3 inhibitor.Formule :C21H13BrN2O3Degré de pureté :99.77%Couleur et forme :SolidMasse moléculaire :421.24Ref: TM-T14613
1mg34,00€5mg80,00€10mg116,00€25mg221,00€50mg329,00€100mg472,00€200mg652,00€1mL*10mM (DMSO)86,00€Cucurbitacin I
CAS :Cucurbitacin I (JSI-124), a natural compound, is a selective inhibitor of JAK2/STAT3 with anti-cancer activity.Formule :C30H42O7Degré de pureté :96.69% - 98.2%Couleur et forme :SolidMasse moléculaire :514.65ZM39923 hydrochloride
CAS :ZM39923 hydrochloride (JAK3 Inhibitor IV) is an JAK1/3 inhibitor, almost no activity to JAK2 and modestly potent to EGFR; also is sensitive to transglutaminase.Formule :C23H25NO·HClDegré de pureté :98.05%Couleur et forme :SolidMasse moléculaire :367.91ABBV-712
CAS :ABBV-712 is a selective Tyrosine Kinase 2 (TYK2) inhibitor, demonstrating an IC50 value of 0.195 μM, and is implicated in the regulation of autoimmune diseasesFormule :C24H28N4O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :452.5iCRT 14
CAS :iCRT 14 is a novel potent inhibitor of β-catenin-responsive transcription (CRT)(IC50= 40.3 nM in assays of Wnt pathway activity).Formule :C21H17N3O2SDegré de pureté :98.85% - 99.8%Couleur et forme :SolidMasse moléculaire :375.44IQ 1
CAS :IQ 1 has multiple roles, such as maintaining the multifunctionality of mouse ESCs, decreasing Wnt-stimulated phosphorylation, blocking PP2A/Nkd interactions.Formule :C21H22N4O2Degré de pureté :98.57% - ≥95%Couleur et forme :SolidMasse moléculaire :362.42Ref: TM-T3635
5mg51,00€10mg78,00€25mg140,00€50mg195,00€100mg350,00€200mg500,00€500mg810,00€1mL*10mM (DMSO)57,00€WHI-P97
CAS :WHI-P97 is a rationally designed potent inhibitor of JAK-3.Formule :C16H13Br2N3O3Degré de pureté :99.93%Couleur et forme :SolidMasse moléculaire :455.1CDK8-IN-11
CAS :CDK8-IN-11 is a CDK8 inhibitor that demonstrates anti-proliferative activity against colon cancer cell lines and inhibits the activation of WNT/β-catenin.Formule :C19H15F3N4O2Degré de pureté :99.74%Couleur et forme :SolidMasse moléculaire :388.34Ref: TM-T61742
1mg59,00€5mg127,00€10mg205,00€25mg454,00€50mg748,00€100mg1.054,00€200mg1.415,00€1mL*10mM (DMSO)139,00€ROCK2-IN-2
CAS :ROCK2-IN-2 is a selective inhibitor of ROCK2 (IC50 of <1 μM).Formule :C18H12N6OSDegré de pureté :98.45%Couleur et forme :SolidMasse moléculaire :360.39Ref: TM-T12747
1mg52,00€5mg117,00€10mg187,00€25mg320,00€50mg472,00€100mg730,00€200mg938,00€1mL*10mM (DMSO)143,00€(Rac)-SIS3 free base
CAS :SIS3 free base is a potent and selective Smad3 phosphorylation inhibitor. SIS3 free base inhibits the myofibroblast differentiation of fibroblasts by TGF-β1.Formule :C28H27N3O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :453.53YAP/TAZ inhibitor-2
CAS :Potent oral TEAD-YAP/TAZ inhibitor-2 with 3 nM EC50; exhibits anti-proliferative and antitumor effects.Formule :C19H14F4N4ODegré de pureté :98.84%Couleur et forme :SoildMasse moléculaire :390.33Ref: TM-T60218
1mg92,00€2mg119,00€5mg187,00€10mg298,00€25mg502,00€50mg725,00€100mg1.017,00€500mg2.023,00€1mL*10mM (DMSO)207,00€IWR-1
CAS :IWR-1 (IWR-1-endo), a Wnt pathway inhibitor, stabilizes the Axin destruction complex(EC50=0.2 uM).Formule :C25H19N3O3Degré de pureté :98.46% - 99.82%Couleur et forme :SolidMasse moléculaire :409.44IWP 12
CAS :IWP 12 is a potent inhibitor of porcupine (Porcn), blocking Wnt signaling and inhibiting fin regeneration in adult and juvenile fish.Formule :C18H18N4O2S3Degré de pureté :98.88%Couleur et forme :SolidMasse moléculaire :418.56JBJ-02-112-05
CAS :JBJ-02-112-05 is a potent, mutant-selective, allosteric and orally active inhibitor of EGFR with an IC 50 of 15 nM for EGFR L858R/T790M [1].Formule :C27H20N4O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :464.54Mouse TNC(Tenascin C) ELISA Kit
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse TNC. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse TNC. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Mouse TNC, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Mouse TNC in the samples is then determined by comparing the OD of the samples to the standard curve.Couleur et forme :Colourless TransparentliquidNetarsudil Dihydrochloride
CAS :Netarsudil Dihydrochloride (AR-13324 Dihydrochloride) is an inhibitor of Rho-related protein kinase (ROCK) and norepinephrine transporter (NET) and is effective in reducing intraocular pressure (IOP).Cost-effective and quality-assured.Formule :C28H29Cl2N3O3Degré de pureté :99.94% - 99.98%Couleur et forme :SolidMasse moléculaire :526.45LF3
CAS :LF3 is a specific inhibitor of canonical Wnt signaling by disrupting the interaction between β-catenin and TCF4 (IC50 < 2 μM)Formule :C20H24N4O2S2Degré de pureté :99.63%Couleur et forme :SolidMasse moléculaire :416.56MRT-10
CAS :MRT-10 is a Smoothened (Smo) receptor antagonist.Formule :C24H23N3O5SDegré de pureté :99.47%Couleur et forme :SolidMasse moléculaire :465.52Ref: TM-T23027
1mg47,00€2mg63,00€5mg96,00€10mg135,00€25mg265,00€50mg378,00€100mg530,00€200mg720,00€1mL*10mM (DMSO)87,00€GDC-9918
CAS :GDC-9918 (compound GDC-9918) is an inhibitor of Janus kinases.Formule :C20H18F2N6O5SCouleur et forme :SolidMasse moléculaire :492.46JAK3-IN-15
JAK3-IN-15 (compound 22) is a JAK3 inhibitor that reduces the secretion of p-JAK3 induced by LPS. It is utilized in research for rheumatoid arthritis.Couleur et forme :Odour SolidFM-381
CAS :FM381, a JAK3 inhibitor with 127 pM IC50, is 410-3600x more selective over JAK1/2/TYK2.Formule :C24H24N6O2Degré de pureté :98.44%Couleur et forme :SolidMasse moléculaire :428.49CJJ300
CAS :CJJ300 is a TGF-β inhibitor disrupting TGF-β-TβR complex formation, with an IC50 of 5.3 μM, and halts cell migration.Formule :C30H33N3Degré de pureté :99.41%Couleur et forme :SolidMasse moléculaire :435.6Ref: TM-T62483
2mg35,00€5mg51,00€10mg90,00€25mg164,00€50mg259,00€100mg393,00€200mg552,00€1mL*10mM (DMSO)57,00€BDP9066
CAS :BDP9066 is a potent and selective MRCK inhibitor, inhibits MRCKβ and MRCKα/β, and can be used for the prevention and treatment of skin cancer.Formule :C20H24N6Degré de pureté :98.18%Couleur et forme :SolidMasse moléculaire :348.44Ref: TM-T14521
1mg57,00€5mg120,00€10mg188,00€25mg432,00€50mg747,00€100mg1.293,00€500mg2.585,00€1mL*10mM (DMSO)133,00€WDR5-0103 hydrochloride[890190-22-4(free base)]
WDR5-0103 hydrochloride[890190-22-4(free base)] (WD-Repeat Protein 5-0103) is an effective and specific WD repeat-containing protein 5 (WDR5) antagonist (Kd:Formule :C21H26ClN3O4Degré de pureté :99.66%Couleur et forme :SolidMasse moléculaire :419.9LNK01004
CAS :LNK01004 is a JAK inhibitor that exhibits potent inhibitory effects on JAK1 (IC50: 10 nM), JAK2 (IC50: ＜0.51 nM), and TYK2 (IC50: 1.0 nM). It can concurrently inhibit multiple cytokine-induced p-STAT signaling pathways and is applicable for research on diseases such as atopic dermatitis.Formule :C26H31N7O2Couleur et forme :SolidMasse moléculaire :473.57NRX-103094
CAS :NRX-103094 boosts β-catenin binding to SCFβ-TrCP ligase with EC50 62 nM and Kd 0.6 nM.Formule :C20H11Cl2F3N2O4SDegré de pureté :99.50%Couleur et forme :SolidMasse moléculaire :503.28JI051
CAS :JI051 has anti-tumor effects and can interact with PHB2 to inhibit the proliferation of HEK293 cells and pancreatic cancer cells.Formule :C22H24N2O3Degré de pureté :≥98% - ≥98.0%Couleur et forme :SolidMasse moléculaire :364.44YAP/TAZ inhibitor-1
CAS :YAP/TAZ inhibitor-1 is a YAP/TAZ inhibitor (IC50 <0.100 μΜ) for the study of abnormal immune function and cancer.Formule :C33H39N3O5S2Degré de pureté :99.72%Couleur et forme :SolidMasse moléculaire :621.81JAK1-IN-16
JAK1-IN-16 (compound 4l) acts as an inhibitor of JAK1/STAT3 and effectively downregulates the expression of TLR4 protein.Formule :C20H15ClF3N3OSCouleur et forme :SolidMasse moléculaire :437.87Tyk2-IN-22
CAS :Tyk2-IN-22 (Compound A8) is a selective inhibitor of tyrosine kinase 2 (Tyk2), effectively inhibiting Tyk2, JAK1, and JAK3 with IC50 values of 9.7 nM, 148.6 nM, and 883.3 nM, respectively. Additionally, Tyk2-IN-22 suppresses downstream STAT5 phosphorylation.Formule :C16H16ClN5O2Couleur et forme :SolidMasse moléculaire :345.78JAK-STAT-IN-1
CAS :JAK-STAT-IN-1 is a specific JAK-STAT inhibitor indicated for the study of autoimmune diseases.Formule :C21H21N5O2Degré de pureté :99.21%Couleur et forme :SolidMasse moléculaire :375.42Rilogrotug
Rilogrotug is a humanized IgG1κ monoclonal antibody targeting GDF15, with its corresponding isotype control being HumanIgG1kappa, Isotype Control.Couleur et forme :Odour LiquidSB-747651A Dihydrochloride
CAS :SB-747651A dihydrochloride, an MSK1 inhibitor (IC50=11 nM), also targets PRK2, RSK1, p70S6K, ROCK-II; potential in inflammation study.Formule :C16H24Cl2N8ODegré de pureté :97.02%Couleur et forme :SolidMasse moléculaire :415.32Ref: TM-T9652
1mg73,00€5mg155,00€10mg220,00€25mg369,00€50mg525,00€100mg712,00€500mgÀ demander1mL*10mM (DMSO)169,00€MSC-1254
MSC-1254 is a reversible, selective, and covalent inhibitor of TEAD1, primarily utilized in cancer research.Formule :C25H22F2N4O4SCouleur et forme :SolidMasse moléculaire :512.53
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