Cellules souches
Les inhibiteurs de cellules souches sont des composés qui ciblent spécifiquement les cellules souches et leurs voies de signalisation, affectant leur capacité à s'auto-renouveler et à se différencier. Ces inhibiteurs sont essentiels dans la recherche axée sur le contrôle du comportement des cellules souches, la compréhension des processus de développement et le développement de thérapies pour des maladies comme le cancer, où les cellules souches sont censées jouer un rôle clé. Chez CymitQuimica, nous proposons une variété d'inhibiteurs de cellules souches pour soutenir vos recherches en médecine régénérative, biologie du développement et oncologie.
Produits appartenant à la catégorie "Cellules souches"
Trier par
BP-1-102
CAS :BP-1-102 is an orally active, effective and specific STAT3 inhibitor.Formule :C29H27F5N2O6SDegré de pureté :99.25% - 99.81%Couleur et forme :SolidMasse moléculaire :626.59Ref: TM-T3708
1mg39,00€2mg51,00€5mg84,00€10mg119,00€25mg210,00€50mg354,00€100mg522,00€1mL*10mM (DMSO)104,00€IMR-1
CAS :IMR-1 is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 μMol/L.Formule :C15H15NO5S2Degré de pureté :97.96% - 98.38%Couleur et forme :SolidMasse moléculaire :353.41CHIR-99021 HCl
CAS :CHIR-99021 HCl is a selective GSK-3α/β inhibitor (IC50: 10/6.7 nM), 500x selective over other kinases, boosts Wnt pathway, and enhances stem cell renewal.Formule :C22H19Cl3N8Degré de pureté :98.07% - 98.44%Couleur et forme :SolidMasse moléculaire :501.8Ref: TM-T2310L
1mg35,00€2mg52,00€5mg77,00€10mg96,00€25mg163,00€50mg240,00€100mg465,00€200mg675,00€500mg1.026,00€1mL*10mM (DMSO)86,00€BIP-135
CAS :BIP-135 is a potent and selective ATP-competitive GSK-3 inhibitor.Formule :C21H13BrN2O3Degré de pureté :99.77%Couleur et forme :SolidMasse moléculaire :421.24Ref: TM-T14613
1mg34,00€5mg80,00€10mg116,00€25mg221,00€50mg329,00€100mg472,00€200mg652,00€1mL*10mM (DMSO)86,00€JAK-IN-28
CAS :JAK-IN-28 (Compound 111) is a Janus kinase (JAK) inhibitor potentially applicable in the research of cancer and inflammatory diseases [1].Formule :C20H18ClN7ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :407.86ABBV-712
CAS :ABBV-712 is a selective Tyrosine Kinase 2 (TYK2) inhibitor, demonstrating an IC50 value of 0.195 μM, and is implicated in the regulation of autoimmune diseasesFormule :C24H28N4O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :452.5NT219
CAS :NT219 is a dual inhibitor of insulin receptor substrate 1/2 (IRS1/2) and STAT3 that enhances the aggregation of misfolded prion proteins NT219 Effects.Formule :C16H14BrNO5SDegré de pureté :98.06% - 99.72%Couleur et forme :SolidMasse moléculaire :412.26ROCK2-IN-2
CAS :ROCK2-IN-2 is a selective inhibitor of ROCK2 (IC50 of <1 μM).Formule :C18H12N6OSDegré de pureté :98.45%Couleur et forme :SolidMasse moléculaire :360.39Ref: TM-T12747
1mg52,00€5mg117,00€10mg187,00€25mg320,00€50mg472,00€100mg730,00€200mg938,00€1mL*10mM (DMSO)143,00€ROCK-IN-7
CAS :ROCK-IN-7 (compound 9) serves as a ROCK kinase inhibitor and is utilized in the investigation of ocular conditions, including glaucoma and retinal diseases [1].Formule :C17H17N3O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :327.4(Rac)-SIS3 free base
CAS :SIS3 free base is a potent and selective Smad3 phosphorylation inhibitor. SIS3 free base inhibits the myofibroblast differentiation of fibroblasts by TGF-β1.Formule :C28H27N3O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :453.53YAP/TAZ inhibitor-2
CAS :Potent oral TEAD-YAP/TAZ inhibitor-2 with 3 nM EC50; exhibits anti-proliferative and antitumor effects.Formule :C19H14F4N4ODegré de pureté :98.84%Couleur et forme :SoildMasse moléculaire :390.33Ref: TM-T60218
1mg92,00€2mg119,00€5mg187,00€10mg298,00€25mg502,00€50mg725,00€100mg1.017,00€500mg2.023,00€1mL*10mM (DMSO)207,00€IWR-1
CAS :IWR-1 (IWR-1-endo), a Wnt pathway inhibitor, stabilizes the Axin destruction complex(EC50=0.2 uM).Formule :C25H19N3O3Degré de pureté :98.46% - 99.82%Couleur et forme :SolidMasse moléculaire :409.44IWP 12
CAS :IWP 12 is a potent inhibitor of porcupine (Porcn), blocking Wnt signaling and inhibiting fin regeneration in adult and juvenile fish.Formule :C18H18N4O2S3Degré de pureté :98.88%Couleur et forme :SolidMasse moléculaire :418.56JBJ-02-112-05
CAS :JBJ-02-112-05 is a potent, mutant-selective, allosteric and orally active inhibitor of EGFR with an IC 50 of 15 nM for EGFR L858R/T790M [1].Formule :C27H20N4O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :464.54Netarsudil Dihydrochloride
CAS :Netarsudil Dihydrochloride (AR-13324 Dihydrochloride) is an inhibitor of Rho-related protein kinase (ROCK) and norepinephrine transporter (NET) and is effective in reducing intraocular pressure (IOP).Cost-effective and quality-assured.Formule :C28H29Cl2N3O3Degré de pureté :99.94% - 99.98%Couleur et forme :SolidMasse moléculaire :526.45Bikinin
CAS :Bikinin (Abrasin), a potent inhibitor of plant GSK-3/Shaggy-like kinase, activates BR signaling downstream of the BR receptor.Formule :C9H9BrN2O3Degré de pureté :100% - 99.86%Couleur et forme :SolidMasse moléculaire :273.08Ref: TM-T1965
10mg47,00€25mg77,00€50mg119,00€100mg187,00€200mg279,00€500mg472,00€1mL*10mM (DMSO)34,00€Kartogenin
CAS :Kartogenin (KGN) is an activator of the smad4/smad5 pathway, and promotes the selective differentiation of multipotent mesenchymal stem cells into chondrocytes.Formule :C20H15NO3Degré de pureté :96.25% - 97.79%Couleur et forme :SolidMasse moléculaire :317.34MRT-10
CAS :MRT-10 is a Smoothened (Smo) receptor antagonist.Formule :C24H23N3O5SDegré de pureté :99.47%Couleur et forme :SolidMasse moléculaire :465.52Ref: TM-T23027
1mg47,00€2mg63,00€5mg96,00€10mg135,00€25mg265,00€50mg378,00€100mg530,00€200mg720,00€1mL*10mM (DMSO)87,00€GDC-9918
CAS :GDC-9918 (compound GDC-9918) is an inhibitor of Janus kinases.Formule :C20H18F2N6O5SCouleur et forme :SolidMasse moléculaire :492.46JAK3-IN-15
JAK3-IN-15 (compound 22) is a JAK3 inhibitor that reduces the secretion of p-JAK3 induced by LPS. It is utilized in research for rheumatoid arthritis.Couleur et forme :Odour SolidFM-381
CAS :FM381, a JAK3 inhibitor with 127 pM IC50, is 410-3600x more selective over JAK1/2/TYK2.Formule :C24H24N6O2Degré de pureté :98.44%Couleur et forme :SolidMasse moléculaire :428.49MNK8
CAS :MNK8 is a potent STAT3 inhibitor, impairs DNA binding, and inhibits liver cancer cell growth.Formule :C15H12N2O2Degré de pureté :99.74%Couleur et forme :SolidMasse moléculaire :252.27JAK1-IN-8
CAS :JAK1-IN-8, a specific inhibitor of Janus kinase 1 (JAK1, IC50<500 nM).Formule :C22H23FN4O3SDegré de pureté :98.36%Couleur et forme :SolidMasse moléculaire :442.51Ref: TM-T35899
5mg47,00€10mg79,00€25mg144,00€50mg250,00€100mg424,00€200mg568,00€1mL*10mM (DMSO)50,00€Jervine
CAS :Jervine inhibits Smoothened, blocking Hedgehog signaling and GLI1 transcription activation.Formule :C27H39NO3Degré de pureté :99.20% - 99.86%Couleur et forme :Needles From Methanol + Water SolidMasse moléculaire :425.6Ref: TM-T3363
5mg70,00€10mg119,00€25mg259,00€50mg499,00€100mg715,00€500mg1.444,00€1mL*10mM (DMSO)74,00€CJJ300
CAS :CJJ300 is a TGF-β inhibitor disrupting TGF-β-TβR complex formation, with an IC50 of 5.3 μM, and halts cell migration.Formule :C30H33N3Degré de pureté :99.41%Couleur et forme :SolidMasse moléculaire :435.6Ref: TM-T62483
2mg35,00€5mg51,00€10mg90,00€25mg164,00€50mg259,00€100mg393,00€200mg552,00€1mL*10mM (DMSO)57,00€S-Ruxolitinib
CAS :S-Ruxolitinib can be used in related research in the field of life sciences. Its product number is T3066 and CAS number is 1160597-27-2.Formule :C17H18N6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :306.37BDP9066
CAS :BDP9066 is a potent and selective MRCK inhibitor, inhibits MRCKβ and MRCKα/β, and can be used for the prevention and treatment of skin cancer.Formule :C20H24N6Degré de pureté :98.18%Couleur et forme :SolidMasse moléculaire :348.44Ref: TM-T14521
1mg57,00€5mg120,00€10mg188,00€25mg432,00€50mg747,00€100mg1.293,00€500mg2.585,00€1mL*10mM (DMSO)133,00€GNF-6231
CAS :GNF-6231 is a potent, selective, and orally bioavailable Porcupine inhibitor that blocks Wnt signaling.Formule :C24H25FN6O2Degré de pureté :100% - 99.54%Couleur et forme :SolidMasse moléculaire :448.49WDR5-0103 hydrochloride[890190-22-4(free base)]
WDR5-0103 hydrochloride[890190-22-4(free base)] (WD-Repeat Protein 5-0103) is an effective and specific WD repeat-containing protein 5 (WDR5) antagonist (Kd:Formule :C21H26ClN3O4Degré de pureté :99.66%Couleur et forme :SolidMasse moléculaire :419.9Londamocitinib
CAS :Londamocitinib (JAK1-IN-7) is a selective and potent JAK1 inhibitor with anti-inflammatory activity.Formule :C28H31F2N7O4SDegré de pureté :99.47%Couleur et forme :SolidMasse moléculaire :599.65Ref: TM-T11706
1mg180,00€5mg439,00€10mg597,00€25mg905,00€50mg1.169,00€100mg1.568,00€1mL*10mM (DMSO)567,00€NRX-103094
CAS :NRX-103094 boosts β-catenin binding to SCFβ-TrCP ligase with EC50 62 nM and Kd 0.6 nM.Formule :C20H11Cl2F3N2O4SDegré de pureté :99.50%Couleur et forme :SolidMasse moléculaire :503.28JI051
CAS :JI051 has anti-tumor effects and can interact with PHB2 to inhibit the proliferation of HEK293 cells and pancreatic cancer cells.Formule :C22H24N2O3Degré de pureté :≥98% - ≥98.0%Couleur et forme :SolidMasse moléculaire :364.44AZD8542
CAS :AZD8542 is an antagonist of Smoothened (SMO) with potential as an oncology therapeutic.Formule :C25H24N4O2Degré de pureté :99.96%Couleur et forme :SolidMasse moléculaire :412.48Tyk2-IN-22
CAS :Tyk2-IN-22 (Compound A8) is a selective inhibitor of tyrosine kinase 2 (Tyk2), effectively inhibiting Tyk2, JAK1, and JAK3 with IC50 values of 9.7 nM, 148.6 nM, and 883.3 nM, respectively. Additionally, Tyk2-IN-22 suppresses downstream STAT5 phosphorylation.Formule :C16H16ClN5O2Couleur et forme :SolidMasse moléculaire :345.78NIBR-LTSi
NIBR-LTSi is a selective LATS kinase inhibitor that also activates YAP signaling, promotes tissue stem cell expansion and tissue regeneration in vitro/vivo.Formule :C18H20N4ODegré de pureté :99.87%Couleur et forme :SolidMasse moléculaire :308.38JAK-STAT-IN-1
CAS :JAK-STAT-IN-1 is a specific JAK-STAT inhibitor indicated for the study of autoimmune diseases.Formule :C21H21N5O2Degré de pureté :99.21%Couleur et forme :SolidMasse moléculaire :375.42SB-747651A Dihydrochloride
CAS :SB-747651A dihydrochloride, an MSK1 inhibitor (IC50=11 nM), also targets PRK2, RSK1, p70S6K, ROCK-II; potential in inflammation study.Formule :C16H24Cl2N8ODegré de pureté :97.02%Couleur et forme :SolidMasse moléculaire :415.32Ref: TM-T9652
1mg73,00€5mg155,00€10mg220,00€25mg369,00€50mg525,00€100mg712,00€500mgÀ demander1mL*10mM (DMSO)169,00€MSC-1254
MSC-1254 is a reversible, selective, and covalent inhibitor of TEAD1, primarily utilized in cancer research.Formule :C25H22F2N4O4SCouleur et forme :SolidMasse moléculaire :512.53IHMT-MST1-58
CAS :IHMT-MST1-58 is a STE20-like protein 1 kinase (MST1) inhibitor (IC50:23 nM) with high efficiency, selectivity and oral activity.Formule :C21H22N6O3SDegré de pureté :98% - 98.48%Couleur et forme :SolidMasse moléculaire :438.5STAT3-IN-20
CAS :STAT3-IN-20 (Compound 40), with an IC50 of 0.65 μM, is a selective inhibitor targeting the SH2 domain of STAT3, thereby impeding its phosphorylation, nuclearFormule :C30H27F4N7SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :593.64BIO-013077-01
CAS :BIO-013077-01 is a potent TGFbeta family type I receptors antagonist.Formule :C17H13N5Degré de pureté :99.87%Couleur et forme :SolidMasse moléculaire :287.32Ref: TM-T8330
1mg50,00€5mg92,00€10mg140,00€25mg273,00€50mg393,00€100mg557,00€200mg753,00€1mL*10mM (DMSO)138,00€CK2-IN-4
CAS :CK2-IN-4 is a protein kinase (CK2) inhibitor with an IC50 value of 8.6 µM.Formule :C18H11N3O4SDegré de pureté :99.72%Couleur et forme :SolidMasse moléculaire :365.36Ponsegromab
CAS :Ponsegromab (PF 06946860), a humanized anti-GDF15 antibody, may treat cancer cachexia by blocking GDF15/GFRAL signaling.Degré de pureté :100% (SEC-HPLC) - > 95%Couleur et forme :LiquidMasse moléculaire :146.08 kDaFz7-21
CAS :Fz7-21, a peptide antagonist of FZD7, inhibits Wnt/β-catenin signaling (IC50=50-100nM) in cells with WNT3A.Formule :C83H114N18O23S2Degré de pureté :99.8%Couleur et forme :SolidMasse moléculaire :1796.03STAT3 degrader-2
CAS :STAT3 Degrader-2 is a PROTAC-based compound that effectively reduces the total STAT3 protein levels, and is utilized in the research of cancer and variousFormule :C59H62N9O13PDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1136.15CIA-1 (Free base)
CAS :CIA-1, a COUP-TFII inhibitor, has IC50 of 1.2-7.6 μM in prostate cancer cells; inhibits tumor growth in mouse prostate cancer.Formule :C17H19N3O2SDegré de pureté :99%Couleur et forme :SolidMasse moléculaire :329.42Abrocitinib
CAS :Abrocitinib (PF-04965842) (PF-04965842) is a potent, specific and orally-active JAK1 inhibitor (IC50s: 29/803 nM for JAK1/2).Formule :C14H21N5O2SDegré de pureté :99.09% - 99.91%Couleur et forme :SolidMasse moléculaire :323.41Ref: TM-TQ0037
1mg85,00€2mg107,00€5mg167,00€10mg284,00€25mg467,00€50mg692,00€100mg938,00€1mL*10mM (DMSO)188,00€JAK/HDAC-IN-4
JAK/HDAC-IN-4 (compound 11 i) is a dual inhibitor targeting both JAK2 and HDAC6, with IC50 values of 0.49 nM and 12 nM respectively. It inhibits cell proliferation and the production of nitric oxide. In a mouse model induced by Imiquimod, JAK/HDAC-IN-4 ameliorates psoriasiform skin lesions with low toxicity.Formule :C30H32N8O5SCouleur et forme :SolidMasse moléculaire :616.69Gossypolone
CAS :Gossypolone is is a proposed major metabolite of gossypol. Gossypolone reduces Notch/Wnt signaling and induces apoptosis.Formule :C30H26O10Degré de pureté :96.66%Couleur et forme :SolidMasse moléculaire :546.52M3686
CAS :M3686 (Compound 29) is a potent and selective TEAD1 inhibitor with an IC50 value of 51 nM. It exhibits weaker binding activity toward TEAD3. M3686 significantly inhibits the cellular activity of YAP-dependent NCI-H226 cell lines, with an IC50 value of 0.06 μM, and demonstrates strong antitumor effects in the NCI-H226 xenograft model.Formule :C21H18F3N5O2Couleur et forme :SolidMasse moléculaire :429.395WHI-P97 HCl
WHI-P97 HCl is a potent and selective JAK-3 inhibitor.Formule :C16H14Br2ClN3O3Degré de pureté :99.49%Couleur et forme :SolidMasse moléculaire :491.56Verosudil
CAS :Verosudil (AR-12286), a ROCK1/2 inhibitor (Ki: 2 nM), lowers intraocular pressure in mice by enhancing aqueous outflow.Formule :C17H17N3O2SDegré de pureté :99.72%Couleur et forme :SolidMasse moléculaire :327.4Ref: TM-T60924
1mg87,00€5mg250,00€10mg406,00€25mg652,00€50mg919,00€100mg1.216,00€1mL*10mM (DMSO)274,00€SRI-011381 hydrochloride
CAS :SRI-011381 hydrochloride, a new-type agonist of the TGF-beta signaling pathway, is utilized in the treatment of Alzheimer's disease.Formule :C20H32ClN3ODegré de pureté :98.24% - 99.59%Couleur et forme :SolidMasse moléculaire :365.94Ref: TM-T5129
2mg47,00€5mg70,00€10mg111,00€25mg227,00€50mg378,00€100mg560,00€500mg1.216,00€1mL*10mM (DMSO)77,00€YAP-TEAD-IN-1 acetate
YAP-TEAD-IN-1 acetate is an effective and competitive inhibitor of YAP-TEAD interaction with an IC50 of 25 nM.Formule :C95H148ClN23O23S2Degré de pureté :98.11% - 99.57%Couleur et forme :SoildMasse moléculaire :2079.92CCG-222740
CAS :CCG-222740 is an inhibitor of Rho/MRTF pathwayFormule :C23H19ClF2N2O3Degré de pureté :98.76%Couleur et forme :SolidMasse moléculaire :444.86Ref: TM-T7764
2mg42,00€5mg65,00€10mg99,00€25mg182,00€50mg279,00€100mg414,00€200mg587,00€1mL*10mM (DMSO)70,00€Rovalpituzumab
CAS :Rovalpituzumab: humanized antibody against DLL3, forms ADCs, treats small cell lung cancer.Degré de pureté :> 95%Couleur et forme :LiquidMasse moléculaire :145.02 kDa3,7-DMF
CAS :3,7-Dimethylfumarate (3,7-DMF) serves as an oral inhibitor of transforming growth factor-beta 1 (TGF-β1)-mediated hepatic stellate cell (HSC) activation.Formule :C17H14O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :282.29Narciclasine
CAS :Narciclasine (Lycoricidinol), a natural product, modulates the Rho/Rho-kinase/LIM kinase/cofilin signaling pathway, greatly increasing GTPase RhoA activity.Formule :C14H13NO7Degré de pureté :98.79% - 99.58%Couleur et forme :SolidMasse moléculaire :307.26CX-5011
CAS :CX-5011, a CK2 inhibitor, induces Rac1 activation and promotes apoptosis, effectively causing cancer cell death [1] [2].Formule :C20H12N4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :340.33Afuresertib hydrochloride
CAS :Afuresertib hydrochloride is an inhibitor of Akt kinase (Kis of 0.08/2/2.6 nM for Akt1/Akt2/Akt3 respectively)Formule :C18H18Cl3FN4OSDegré de pureté :99.96%Couleur et forme :SolidMasse moléculaire :463.8Ref: TM-T7885
2mg52,00€5mg74,00€10mg95,00€25mg163,00€50mg253,00€100mg437,00€200mg568,00€1mL*10mM (DMSO)86,00€TGFβ1-IN-1
CAS :TGFβ1-IN-1 is a TGF-β1 inhibitor that inhibits the production of TGF-β1-induced fibrosis markers (α-SMA and fibronectin) and can be used in cancer research.Formule :C22H24N2O3Degré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :364.438Taladegib
CAS :Taladegib (LY2940680), an oral Smo receptor antagonist, targets Hedgehog signaling for cancer treatment.Formule :C26H24F4N6ODegré de pureté :100% - 99.39%Couleur et forme :SolidMasse moléculaire :512.5GS87
CAS :GS87 is a highly specific inhibitor of GSK3 (glycogen synthase kinase 3) that induces extensive differentiation of AML cells.Formule :C16H11N5O2SDegré de pureté :98.86%Couleur et forme :SolidMasse moléculaire :337.36Ref: TM-T8605
1mg131,00€2mg188,00€5mg283,00€10mg430,00€25mg710,00€50mg998,00€100mg1.349,00€1mL*10mM (DMSO)298,00€Vismodegib
CAS :Vismodegib (GDC-0449) is a hedgehog pathway inhibitor (IC50: 3 nM). It also inhibits P-gp (IC50: 3.0 μM), ABCG2 (IC50: 1.4 μM).Formule :C19H14Cl2N2O3SDegré de pureté :98% - 99.99%Couleur et forme :SolidMasse moléculaire :421.3URMC-099
CAS :URMC-099: oral, brain-accessible MLK/LRRK2 inhibitor; IC50 - MLK1/2/3/DLK: 19/42/14/150 nM, LRRK2: 11 nM.Formule :C27H27N5Degré de pureté :98.43% - 99.32%Couleur et forme :SolidMasse moléculaire :421.54KY19382
CAS :KY19382, a dual CXXC5-DVL and GSK3β inhibitor (IC50s: 19/10 nM), boosts Wnt/β-catenin signaling and may help in metabolic disease research.Formule :C17H11Cl2N3O2Degré de pureté :98.06%Couleur et forme :SolidMasse moléculaire :360.19Ref: TM-T9025
1mg99,00€5mg197,00€10mg350,00€25mg590,00€50mg840,00€100mg1.130,00€500mg2.308,00€1mL*10mM (DMSO)243,00€Nisevokitug
CAS :Nisevokitug (NIS-793) is an IgG2λ human monoclonal antibody that targets TGF-β (TGFB1/TGFB2). It is produced in CHO-K1 cells [1].Degré de pureté :98%Couleur et forme :LiquidAβ42-IN-2
CAS :Aβ42-IN-2 is a γ-secretase modulator. Aβ42-IN-2 has an IC 50 of 6.5 nM for Αβ 42. Aβ42-IN-2 can be used for the Alzheimer's disease research[1].Formule :C24H26N6O2Degré de pureté :100% - 99.49%Couleur et forme :SolidMasse moléculaire :430.5Ref: TM-T9641
1mg42,00€5mg94,00€10mg134,00€25mg215,00€50mg304,00€100mg420,00€200mg582,00€1mL*10mM (DMSO)93,00€(R)-Lisofylline
CAS :(R)-Lisofylline ((R)-Lisophylline) is an inhibitor of lysophosphatidic acid acyltransferase (IC50 = 0.6 µM).Formule :C13H20N4O3Degré de pureté :99.50%Couleur et forme :SolidMasse moléculaire :280.32BMS-906024
CAS :BMS-906024 (Osugacestat) is a gamma secretase inhibitor, a Notch inhibitor.BMS-906024 has broad-spectrum antitumour activity.Formule :C26H26F6N4O3Degré de pureté :100% - 99.87%Couleur et forme :SolidMasse moléculaire :556.5GSK3β inhibitor II
CAS :GSK3β inhibitor II is a GSK3β inhibitor. GSK3β inhibitor II exhibits the research potential of Alzheimer's disease (AD).Formule :C14H10IN3OSDegré de pureté :99.32%Couleur et forme :SolidMasse moléculaire :395.22TNKS-2-IN-2
CAS :TNKS-2-IN-2 is a TNKS2 selective inhibitor (IC50: 22 nM) with potential anti-tumour activity for the study of colon cancer lung cancer and breast cancer.Formule :C26H23N3O6Degré de pureté :99.45%Couleur et forme :SoildMasse moléculaire :473.48CRT0066854 hydrochloride
CAS :CRT0066854 HCl inhibits atypical PKCs; IC50: PKCι 132 nM, PKCζ 639 nM, ROCK-II 620 nM.Formule :C24H27Cl2N5SDegré de pureté :97.51%Couleur et forme :SolidMasse moléculaire :488.48STAT3-IN-B9
CAS :STAT3-IN-B9 (B9) is an inhibitor of abnormal STAT3 activation and inhibits the proliferation of tumor cells including MDA-MB-468, MDA-MB-231, and DU145.Formule :C20H13NO5SDegré de pureté :98.16%Couleur et forme :SolidMasse moléculaire :379.39Ref: TM-T28865
1mg115,00€2mg162,00€5mg249,00€10mg369,00€25mg562,00€50mg787,00€100mg1.054,00€200mg1.406,00€1mL*10mM (DMSO)269,00€GANT 58
CAS :GANT 58 (NSC-75503) is a potent antagonist of Gli. Which inhibits GLI1-induced transcription (IC50: 5 μM).Formule :C24H16N4SDegré de pureté :99.53%Couleur et forme :SolidMasse moléculaire :392.48KYA1797K
CAS :KYA1797K is a highly potent and selective inhibitor. Wnt/β-catenin IC50 is 0.75 μM through TOPflash assay.Formule :C17H11N2O6S2·KDegré de pureté :97.57% - 99.33%Couleur et forme :SolidMasse moléculaire :442.51Casein kinase 1δ-IN-1
CAS :Casein kinase 1δ-IN-1 (WAY-643895) is an inhibitor of casein kinase 1δ (CK1δ), which inhibits CK1δ.Formule :C11H7N3OSDegré de pureté :99.46%Couleur et forme :SolidMasse moléculaire :229.26STAT3-IN-37
CAS :STAT3-IN-37 (Compound 101) is an inhibitor of STAT3, with an IC50 of 15 nM as measured by DNA-HTRF assay and 2 nM as determined through human whole blood SOCS3 qPCR assay.Formule :C23H25Cl2N5O2Couleur et forme :SolidMasse moléculaire :474.38N-(3-Methoxybenzyl)-(9Z,12Z,15Z)-octadecatrienamide
CAS :Macamide Impurity 14 promotes bone growth by activating Wnt/β-catenin, aiding osteoporosis study.Formule :C26H39NO2Degré de pureté :98.66%Couleur et forme :SolidMasse moléculaire :397.59Golidocitinib
CAS :Golidocitinib (AZD4205) is a selective JAK1 inhibitor (IC50: 73 nM) and weakly inhibits JAK2/JAK3 (IC50: >14.7, >30 μM).Formule :C25H31N9O2Degré de pureté :100% - 98.87%Couleur et forme :SolidMasse moléculaire :489.57Ref: TM-T10431
2mg96,00€5mg163,00€10mg268,00€25mg465,00€50mg618,00€100mg880,00€1mL*10mM (DMSO)170,00€TT-10
CAS :TT-10 (TAZ-K) activates YAP-TEAD; useful in heart disease with cardiomyocyte loss research.Formule :C11H10FN3OS2Degré de pureté :99.29%Couleur et forme :SolidMasse moléculaire :283.35γ-secretase modulator 3
CAS :Gamma-secretase modulator 3 (γ-secretase modulator 3) is a γ-secretase modulator that reduces Aβ production.Formule :C24H23FN4OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :434.53Tegatrabetan
CAS :Tegatrabetan (BC2059) is a small molecule inhibitor of the Wnt/beta-catenin pathway with potential antineoplastic activity.Formule :C28H36N4O6S2Degré de pureté :98.01% - 99.18%Couleur et forme :SolidMasse moléculaire :588.74Ref: TM-T5642
1mg40,00€2mg52,00€5mg85,00€10mg124,00€25mg210,00€50mg334,00€100mg565,00€1mL*10mM (DMSO)96,00€GSK269962A hydrochloride
CAS :GSK269962A hydrochloride (GSK 269962 hydrochloride) is a ROCK inhibitor with anti-inflammatory and vasodilatory effects and inhibits ROCK1 and ROCK2.Formule :C29H31ClN8O5Couleur et forme :SolidMasse moléculaire :607.06JAK2-IN-4
CAS :JAK2-IN-4 is a selective JAK2/JAK3 inhibitor, with IC50 values of 0.7 nM and 23.2 nM for JAK2 and JAK3, respectively.Formule :C23H27N5O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :469.56C-Peptide 1 (rat)
CAS :C-Peptide 1 (rat), a β-catenin/GSK-3β activator and regulator of the Wnt/β-catenin signaling pathway, is utilized in cancer research [1].Formule :C140H228N38O51Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3259.58HC-258
CAS :HC-258 is a direct TEAD inhibitor covalent Cys380, and reduces the transcriptional levels and inhibits the migration of CTGF, CYR61, AXL and NF2 MDA-MB-231.Formule :C20H24N2O2Couleur et forme :SolidMasse moléculaire :324.42STAT3-IN-8
CAS :"STAT3-IN-8 (compound H172) is a potent inhibitor of STAT3 with potential applications in cancer research [1]."Formule :C19H7F7N2O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :444.26ROCK2-IN-7
CAS :ROCK2 inhibitor is a chemical compound associated with the therapeutic management of psoriasis.Formule :C26H28FN5ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :445.53Silmitasertib sodium salt
CAS :Silmitasertib sodium salt (CX-4945 sodium salt) is a potent and orally bioavailable, highly selective inhibitor of CK2(IC50 of 1 nM, CK2α).Formule :C19H11ClN3NaO2Degré de pureté :99.49% - 99.62%Couleur et forme :SolidMasse moléculaire :371.75JAK3-IN-1
CAS :JAK3-IN-1 is an orally active, selective and potent JAK3 inhibitor for the study of immune system disorders.Formule :C26H30ClN7O2Couleur et forme :SolidMasse moléculaire :508.02Ac-GpYLPQTV-NH2 acetate
Ac-GpYLPQTV-NH2 acetate is a STAT3 inhibitor with an IC50 value of 0.33 μM. It also exhibits antitumor properties.Formule :C38H60N9O14P·xC2H4O2Couleur et forme :SolidMasse moléculaire :897.91 (free base)WHN-88
CAS :WHN-88, a Porcupine (PORCN) inhibitor, disrupts the palmitoylation of Wnt ligands, which inhibits their secretion and subsequent Wnt/β-catenin signaling. This compound has shown efficacy in reducing cancer cell stemness and suppressing the progression and development of breast tumors in MMTV-Wnt1 transgenic mice.Formule :C18H13I2N3O2Couleur et forme :SolidMasse moléculaire :557.12TNIK-IN-3
CAS :TNIK-IN-3 is a highly potent and orally active inhibitor of Traf2- and Nck-interacting protein kinase (TNIK).Formule :C23H18FN3O2Degré de pureté :99.56%Couleur et forme :SolidMasse moléculaire :387.41Ref: TM-T9556
1mg106,00€5mg259,00€10mg406,00€25mg652,00€50mg938,00€100mg1.454,00€1mL*10mM (DMSO)284,00€Sotatercept
CAS :Sotatercept (ACE-011) is an ActRIIA-Fc fusion protein and an inhibitor of activin signaling.Couleur et forme :Liquid(+)-ITD-1
CAS :(+)-ITD-1 is an inhibitor of TGF-β, effectively inhibiting TGF-β2 with an IC50 of 0.46 μM. It promotes the degradation of the TGF-β type II receptor (TGFBR2) and the differentiation of cardiomyocytes. Additionally, it suppresses the formation of the mesoderm during the early differentiation of mouse embryonic stem cells (mESCs).Formule :C27H29NO3Couleur et forme :SolidMasse moléculaire :415.52Golotimod (TFA) (229305-39-9 free base)
Golotimod (TFA), an immunomodulating peptide, boosts antituberculosis treatments and enhances immune cell growth and macrophage function.Formule :C18H20F3N3O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :447.36Ritlecitinib
CAS :Ritlecitinib (PF-06651600) is an orally available, selective JAK3 inhibitor and does not affect the activity of JAK1/2.Cost-effective and quality-assured.Formule :C15H19N5ODegré de pureté :98.82% - 99.92%Couleur et forme :SolidMasse moléculaire :285.34Ref: TM-T5382
2mg47,00€5mg70,00€10mg111,00€25mg216,00€50mg329,00€100mg495,00€200mg705,00€500mg1.064,00€1mL*10mM (DMSO)77,00€TDZD-8
CAS :TDZD-8 (NP 01139) is an inhibitor of GSK-3β, with an IC50 of 2 μM; minimal inhibitory effect observed on CDK1, casein kinase II, PKA and PKC.Formule :C10H10N2O2SDegré de pureté :97.13% - 99.48%Couleur et forme :White SolidMasse moléculaire :222.26MRT-14
CAS :MRT-14 is a potent Smo antagonist and can be used in several types of cancers linked to abnormal Hh signaling studies.Formule :C24H24N4O5Degré de pureté :98.55%Couleur et forme :SolidMasse moléculaire :448.47Ref: TM-T9531
2mg35,00€5mg52,00€10mg85,00€25mg138,00€50mg220,00€100mg329,00€200mg469,00€1mL*10mM (DMSO)65,00€BDP5290
CAS :BDP5290 is a potent inhibitor of both ROCK and MRCK(IC50s of 5 nM, 50 nM, 10 nM and 100 nM for ROCK1, ROCK2, MRCKα and MRCKβ, respectively.)Formule :C17H18ClN7ODegré de pureté :97.22%Couleur et forme :SolidMasse moléculaire :371.82Ref: TM-T7301
1mg56,00€2mg81,00€5mg119,00€10mg188,00€25mg389,00€50mg565,00€100mg822,00€1mL*10mM (DMSO)131,00€Casein kinase 1δ-IN-7
CAS :Casein kinase 1δ-IN-7 is a Casein kinase 1δ inhibitor for neurodegenerative diseases such as Alzheimer's disease.Formule :C17H14N4O2SDegré de pureté :98.6%Couleur et forme :SolidMasse moléculaire :338.38ROCK/HDAC-IN-1
ROCK/HDAC-IN-1 (Compound 10h) serves as an orally effective inhibitor of ROCK/HDAC. This compound suppresses ROCK1/2 (IC50: 254.9 nM, 58.18 nM) and HDAC1/2/3/6/8 (IC50: 9.09, 8.03, 6.26, 0.41, 7.69 nM). It stimulates the activation of DAMPs, notably calreticulin (CRT) exposure and HMGB1 release, suggesting its potential as an inducer of immunogenic cell death (ICD). ROCK/HDAC-IN-1 exhibits antiproliferative effects against breast cancer cells (IC50: 0.37 μM for MDA-MB-231 cells), inhibits tumor growth, activates T cells, and shows no significant toxicity.Formule :C19H22N4O3SCouleur et forme :SolidMasse moléculaire :386.47YLIU-4-105-1
CAS :YLIU-4-105-1 is a type II JAK2 inhibitor. Demonstrating in vivo pharmacological activity, YLIU-4-105-1 reduces splenic weight, decreases blood reticulocyte counts in a dose-dependent manner, and inhibits pSTAT5.Formule :C32H34F3N7O2Couleur et forme :SolidMasse moléculaire :605.65ZW4864 free base
CAS :ZW4864 (free base) is an orally active and selective β catenin/B-Cell lymphoma 9 protein protein interaction ( β catenin/BCL9 PPI ) inhibitor.Formule :C33H42N6O3Degré de pureté :99.54%Couleur et forme :SolidMasse moléculaire :570.72Ref: TM-T9642
1mg160,00€5mg393,00€10mg587,00€25mg935,00€50mg1.264,00€100mg1.700,00€500mg3.410,00€1mL*10mM (DMSO)432,00€MGD-28
CAS :MGD-28 is a Cullin-CRBN-dependent IKZF family protein degrader for IKZF1 (Ikaros), IKZF2 (Helios), IKZF3 (Aiolos) ,and CK1α, antiproliferative.Formule :C33H34FN7O3Degré de pureté :99.39%Couleur et forme :SolidMasse moléculaire :595.67iCRT 14
CAS :iCRT 14 is a novel potent inhibitor of β-catenin-responsive transcription (CRT)(IC50= 40.3 nM in assays of Wnt pathway activity).Formule :C21H17N3O2SDegré de pureté :98.85% - 99.8%Couleur et forme :SolidMasse moléculaire :375.44H-1152
CAS :H-1152 is a potent, specific, ATP-competitive, and cell permeable ROCK inhibitor (Ki = 1.6 nM).Formule :C16H21N3O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :319.42IQ 1
CAS :IQ 1 has multiple roles, such as maintaining the multifunctionality of mouse ESCs, decreasing Wnt-stimulated phosphorylation, blocking PP2A/Nkd interactions.Formule :C21H22N4O2Degré de pureté :98.57% - ≥95%Couleur et forme :SolidMasse moléculaire :362.42Ref: TM-T3635
5mg51,00€10mg78,00€25mg140,00€50mg195,00€100mg350,00€200mg500,00€500mg810,00€1mL*10mM (DMSO)57,00€Itacitinib
CAS :Itacitinib (INCB039110) is an orally bioavailable inhibitor of Janus-associated kinase 1 (JAK1) with potential antineoplastic activity.Formule :C26H23F4N9ODegré de pureté :96.4% - 99.01%Couleur et forme :SolidMasse moléculaire :553.51Ref: TM-T3998
1mg49,00€2mg71,00€5mg111,00€10mg180,00€25mg325,00€50mg543,00€100mg780,00€500mg1.549,00€1mL*10mM (DMSO)137,00€WHI-P97
CAS :WHI-P97 is a rationally designed potent inhibitor of JAK-3.Formule :C16H13Br2N3O3Degré de pureté :99.93%Couleur et forme :SolidMasse moléculaire :455.1STAT5-IN-1
CAS :STAT5-IN-1 (STAT5 Inhibitor) is a cell-permeable inhibitor which suppresses Stat5 via binding to the SH2 domain.Formule :C16H11N3O3Degré de pureté :99.44% - ≥95%Couleur et forme :SolidMasse moléculaire :293.28CDK8-IN-11
CAS :CDK8-IN-11 is a CDK8 inhibitor that demonstrates anti-proliferative activity against colon cancer cell lines and inhibits the activation of WNT/β-catenin.Formule :C19H15F3N4O2Degré de pureté :99.74%Couleur et forme :SolidMasse moléculaire :388.34Ref: TM-T61742
1mg59,00€5mg127,00€10mg205,00€25mg454,00€50mg748,00€100mg1.054,00€200mg1.415,00€1mL*10mM (DMSO)139,00€Foxy-5 Ammonium Salt
Foxy-5 Ammonium Salt, a WNT5A mimetic, blocks epithelial cancer cell migration without β-catenin impact and curbs prostate cancer spread.Formule :C26H46N7O12S2Degré de pureté :97.70%Couleur et forme :SolidMasse moléculaire :712.26Ref: TM-TP1565L1
1mg96,00€5mg304,00€10mg454,00€25mg743,00€50mg1.035,00€100mg1.396,00€1mL*10mM (DMSO)325,00€Mouse TNC(Tenascin C) ELISA Kit
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse TNC. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse TNC. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Mouse TNC, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Mouse TNC in the samples is then determined by comparing the OD of the samples to the standard curve.Couleur et forme :Colourless TransparentliquidSonidegib
CAS :Sonidegib (Erismodegib), a Smoothened (Smo) antagonist, inhibits Hedgehog (Hh) signaling with IC50 of 1.3 nM (mouse) and 2.5 nM (human), respectively.Formule :C26H26F3N3O3Degré de pureté :98% - 99.97%Couleur et forme :SolidMasse moléculaire :485.5(E/Z)-GSK-3β inhibitor 1
CAS :(E/Z)-GSK-3β inhibitor 1 is a glycogen synthase kinase 3β (GSK-3β) inhibitor and demonstrates high antidiabetic efficacy.Formule :C14H10N2ODegré de pureté :98.60%Couleur et forme :SolidMasse moléculaire :222.24Ref: TM-T9178
1mg38,00€5mg85,00€10mg126,00€25mg225,00€50mg335,00€100mg480,00€200mg652,00€1mL*10mM (DMSO)94,00€YW2036
CAS :YW2036 is an inhibitor of Wnt signaling pathway.Formule :C20H16N4ODegré de pureté :100%Couleur et forme :SoildMasse moléculaire :328.37LF3
CAS :LF3 is a specific inhibitor of canonical Wnt signaling by disrupting the interaction between β-catenin and TCF4 (IC50 < 2 μM)Formule :C20H24N4O2S2Degré de pureté :99.63%Couleur et forme :SolidMasse moléculaire :416.56SR-1277
CAS :SR-1277 is a potent, highly selective and ATP-competitive CK1δ/ε inhibitor, regulating Wee1 activity at the G2/M cell-cycle interface, and antiproliferative.Formule :C21H19N9O3SCouleur et forme :SolidMasse moléculaire :477.5AF-2112
AF-2112, a TEAD inhibitor derived from Flufenamic acid, significantly diminishes the expression of CTGF, Cyr61, Axl, and NF2.Formule :C21H18FNO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :351.37ROCK-IN-9
CAS :ROCK-IN-9 (Compound T345), a ROCK inhibitor, exhibits cytotoxicity in HepG2 cells with an IC50 of 40.8 μM.Formule :C20H20FN5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :381.4Lepzacitinib
CAS :Lepzacitinib is a selective, inflammatory, small molecule JAK1/3(Janus kinase) inhibitor primarily used for the treatment of atopic dermatitis.Formule :C18H21N5O3Degré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :355.39Ref: TM-T78207
1mg52,00€5mg116,00€10mg178,00€25mg359,00€50mg533,00€100mg750,00€200mg1.064,00€1mL*10mM (DMSO)127,00€Jagged-1 (188-204)
CAS :Jagged-1 (188-204)is a fragment of the JAG-1 protein. JAG-1 is Notch ligand, a peptide that is the most conspicuously expressed ligand in skin.Formule :C93H127N25O26S3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2107.4CAY10746
CAS :CAY10746 selectively inhibits ROCK I/II with IC50s: 0.014/0.003 μM, useful for diabetic retinopathy research.Formule :C26H23N3O5Degré de pureté :99.04%Couleur et forme :SolidMasse moléculaire :457.48Ref: TM-T36196
1mg35,00€5mg81,00€10mg117,00€25mg259,00€50mg393,00€100mg620,00€200mg832,00€1mL*10mM (DMSO)81,00€Casein kinase 1δ-IN-13
CAS :Casein kinase1δ-IN-13 (compound 401) is an inhibitor of Casein kinase1δ. It is utilized in the research of neurodegenerative diseases.Formule :C15H13N3O2SCouleur et forme :SolidMasse moléculaire :299.35DC-TEADin02
CAS :DC-TEADin02 is an inhibitor of TEAD auto palmitoylation (IC50 = 197 nM). DC-TEADin02 can be in studies about development, regeneration, and tissue homeostasis.Formule :C19H17NO2SDegré de pureté :98.82%Couleur et forme :SoildMasse moléculaire :323.41SRI 37892
CAS :SRI 37892 is a Fzd7 inhibitor with potent activities against Wnt/β-catenin signaling and cancer cell viability.Formule :C26H19N5O2SDegré de pureté :98.92%Couleur et forme :SolidMasse moléculaire :465.53Ref: TM-T9662
1mg378,00€5mg922,00€10mg1.225,00€25mg1.853,00€50mg2.490,00€100mg3.353,00€1mL*10mM (DMSO)1.074,00€GI-560192
CAS :GI-560192 (RL-0070933), a potent smo modulator, EC50: 0.02µM; affects smoothened in cilia via hedgehog signaling.Formule :C20H16N2O2Degré de pureté :99.44%Couleur et forme :SoildMasse moléculaire :316.35Ref: TM-T64351
1mg115,00€5mg255,00€10mg375,00€25mg562,00€50mg787,00€100mg1.074,00€200mg1.444,00€1mL*10mM (DMSO)249,00€YAP/TAZ inhibitor-1
CAS :YAP/TAZ inhibitor-1 is a YAP/TAZ inhibitor (IC50 <0.100 μΜ) for the study of abnormal immune function and cancer.Formule :C33H39N3O5S2Degré de pureté :99.72%Couleur et forme :SolidMasse moléculaire :621.81JAK1-IN-16
JAK1-IN-16 (compound 4l) acts as an inhibitor of JAK1/STAT3 and effectively downregulates the expression of TLR4 protein.Formule :C20H15ClF3N3OSCouleur et forme :SolidMasse moléculaire :437.87GSA-10
CAS :GSA-10 is a potent Smoothened (Smo) receptor agonist with an EC50 of 1.2 μM.Formule :C26H30N2O5Degré de pureté :≥98%Couleur et forme :SolidMasse moléculaire :450.53Gusacitinib
CAS :Gusacitinib (ASN-002) (ASN-002) is spleen tyrosine kinase (SYK) and janus kinase (JAK) inhibitor (IC50: 5-46 nM).Formule :C24H28N8O2Degré de pureté :98.06% - 99.94%Couleur et forme :SolidMasse moléculaire :460.53Ref: TM-T14331
1mg42,00€5mg88,00€10mg123,00€25mg188,00€50mg350,00€100mg522,00€200mg750,00€1mL*10mM (DMSO)116,00€Rilogrotug
Rilogrotug is a humanized IgG1κ monoclonal antibody targeting GDF15, with its corresponding isotype control being HumanIgG1kappa, Isotype Control.Couleur et forme :Odour LiquidROCK2-IN-9
ROCK2-IN-9 (compound 7u), a selective ROCK2 inhibitor with an IC50 value of 36.8 nM, demonstrates anticancer properties by impeding cancer cell migration and invasion. This action is achieved through the regulation of various actin cytoskeleton cellular activities. It holds potential for use in breast cancer research.Formule :C28H30N8O2Couleur et forme :SolidMasse moléculaire :510.59HJC0152 free base
CAS :HJC0152 (free base) is an orally active, potent STAT3 inhibitor that impedes cell cycle progression, induces apoptosis, and notably reduces MDA-MB-231 xenograftFormule :C15H13Cl2N3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :370.19Sonidegib diphosphate
CAS :Sonidegib diphosphate (LDE225 diphosphate) is a selective antagonist of Smo that inhibits murine Smo and human Smo.Cost-effective and quality-assured.Formule :C26H32F3N3O11P2Degré de pureté :99.48%Couleur et forme :SolidMasse moléculaire :681.49Ref: TM-T15727
1g852,00€5g2.133,00€10g3.201,00€5mg50,00€10mg57,00€25mg90,00€50mg114,00€100mg188,00€1mL*10mM (DMSO)72,00€Momelotinib sulfate
CAS :Momelotinib sulfate is an ATP-competitive JAK1/JAK2 inhibitor (IC50: 11 nM/18 nM). It has 10-fold selectivity versus JAK3.Formule :C23H26N6O10S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :610.62FzM1.8
CAS :FzM1.8: allosteric FZD4 agonist, pEC50=6.4; boosts TCF/LEF, activates WNT/β-catenin with no WNT needed.Formule :C18H14N2O4Degré de pureté :100%Couleur et forme :SolidMasse moléculaire :322.31Ref: TM-T15363
2mg42,00€5mg60,00€10mg96,00€25mg177,00€50mg283,00€100mg454,00€200mg653,00€1mL*10mM (DMSO)95,00€JAK-IN-26
CAS :JAK-IN-26 (compound 2) is an orally active inhibitor of the Janus kinase (JAK) enzyme with favorable pharmacokinetic properties, exhibiting potency inFormule :C22H24N6O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :420.46Neurodazine
CAS :Neurodazine is a neural inducer that promotes the differentiation of pluripotent cells into neuronal cells.Formule :C27H21ClN2O3Degré de pureté :98.01%Couleur et forme :SolidMasse moléculaire :456.92QL-1200186
CAS :QL-1200186 is an orally active, selective TYK2 inhibitor that, upon dose-dependent oral administration, suppresses interferon-γ (IFNγ) production followingFormule :C26H27N7O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :485.54PI-828
CAS :PI-828 (LY 294002), a PI3K inhibitor, researches PI3K function and aids stem cell differentiation into mesoderm.Formule :C19H18N2O3Degré de pureté :99.39%Couleur et forme :SolidMasse moléculaire :322.36Ref: TM-T16528
1mg35,00€5mg78,00€10mg117,00€25mg197,00€50mg283,00€100mg386,00€200mg550,00€1mL*10mM (DMSO)55,00€Carboxylesterase-IN-3
CAS :Carboxylesterase-IN-3 is a potent inhibitor of Carboxylesterase Notum (IC50 ≤ 10 nM).Carboxylesterase-IN-3 has the potential to study cancer diseases.Formule :C11H6Cl2N4OSDegré de pureté :97.49% - 97.89%Couleur et forme :SolidMasse moléculaire :313.16Stafib-1
CAS :Stafib-1 is a selective inhibitor of STAT5β targeting SH2 domain with an IC50 of 154 nM and a Ki of 44 nM.Formule :C26H24N2O11P2Degré de pureté :97.18%Couleur et forme :SolidMasse moléculaire :602.42YAP/TAZ-TEAD-IN-2
YAP/TAZ-TEAD-IN-2 (Compound 51) is a YAP/TAZ-TEAD inhibitor that disrupts the interaction between YAP/TAZ and TEAD. It inhibits the transcriptional activity of TEAD with an IC50 of 1.2 nM. Additionally, YAP/TAZ-TEAD-IN-2 suppresses the expression of target genes (Cyr61, CTGF, AXL, and Survivin) and the proliferation of breast cancer cells.Formule :C19H20N2O3SCouleur et forme :SolidMasse moléculaire :356.44JAK3i
CAS :JAK3i selectively inhibits JAK3 kinase, targeting the second, vital wave of STAT5 phosphorylation for T cell growth.Formule :C18H15FN4O3Degré de pureté :98.61% - 99.81%Couleur et forme :SolidMasse moléculaire :354.34PF-06952229
CAS :PF-06952229 is a selective inhibitor of TGFβRI. PF-06952229 can be used in studies about the treatment of solid tumors, specifically metastatic breast cancer.Formule :C23H24ClFN4O3Degré de pureté :99.45%Couleur et forme :SolidMasse moléculaire :458.91MRT-83
CAS :MRT-83 is a potent Smo antagonist.Formule :C31H30N4O5Degré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :538.59Ref: TM-T12109
2mg46,00€5mg64,00€10mg92,00€25mg183,00€50mg316,00€100mg447,00€200mg628,00€1mL*10mM (DMSO)74,00€Purmorphamine
CAS :Purmorphamine (Shh Signaling Antagonist VI), which directly binds and activates Smoothened, blocks BODIPY-cyclopamine binding to Smo.Formule :C31H32N6O2Degré de pureté :97.19% - 99.48%Couleur et forme :Light Tan SolidMasse moléculaire :520.62Brontictuzumab
CAS :Brontictuzumab (OMP 52M5) is an anti-Notch1 monoclonal antibody with antitumor activity that inhibits tumor cell proliferation.Couleur et forme :LiquidSolcitinib
CAS :Solcitinib (GLPG-0778), a JAK1 inhibitor, may treat psoriasis, ulcerative colitis, and lupus.Formule :C22H23N5O2Degré de pureté :99.61% - 99.82%Couleur et forme :SolidMasse moléculaire :389.45SAR407899 hydrochloride
CAS :SAR407899 hydrochloride is a selective, potent and ATP-competitive ROCK inhibitor, with an IC50 of 135 nM for ROCK-2, and Kis of 36 nM and 41 nM for human andFormule :C14H17ClN2O2Degré de pureté :98.01%Couleur et forme :SolidMasse moléculaire :280.75Galunisertib
CAS :Galunisertib (LY2157299) is a selective TGF-β receptor type I (TGF-βRI) inhibitor. Galunisertib has antitumor activity. Cost-effective and quality-assured.Formule :C22H19N5ODegré de pureté :97.09% - 99.98%Couleur et forme :SolidMasse moléculaire :369.42Ref: TM-T2510
1g692,00€5mg48,00€10mg55,00€25mg88,00€50mg120,00€100mg188,00€200mg284,00€500mg467,00€1mL*10mM (DMSO)50,00€JAK-IN-29
JAK-IN-29 (Compound 3) is a potent inhibitor of Janus kinases (JAK) [1].Formule :C17H14ClN5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :355.78Nefopam hydrochloride
CAS :Nefopam hydrochloride (Nefopam HCl) is the hydrochloride salt form of nefopam, a centrally-acting, non-opioid benzoxazocine with analgesic activity.Formule :C17H20ClNODegré de pureté :99.32% - 99.85%Couleur et forme :SolidMasse moléculaire :289.8STAT3 HiBiT degrader 1
CAS :STAT3HiBiT degrader 1 is a potent degrader of STAT3HiBiT, exhibiting a DC50 of less than 0.05 μM in A549 cells.Formule :C58H63F4N10O14PSCouleur et forme :SolidMasse moléculaire :1263.21Casein kinase 1δ-IN-5
CAS :Casein kinase 1δ-IN-5 is a potent and selective CK-1δ inhibitor, exhibiting an IC50 of 47 nM, and demonstrates neuroprotective and anti-inflammatory effects inFormule :C16H11F3N2OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :336.33JK184
CAS :JK184 is a potent Hedgehog (Hh) pathway inhibitor.Formule :C19H18N4OSDegré de pureté :99.09% - 99.89%Couleur et forme :SolidMasse moléculaire :350.44TINK-IN-1
CAS :TINK-IN-1 is a selective and potent TNIK inhibitor (IC50: 8 nM).TINK-IN-1 inhibits colorectal cancer cell viability and can be used to study mental retardation.Formule :C24H24N4O3Degré de pureté :99.4%Couleur et forme :SoildMasse moléculaire :416.47Ref: TM-T77660
1mg42,00€2mg52,00€5mg87,00€10mg127,00€25mg250,00€50mg373,00€100mg547,00€500mg1.159,00€Fresolimumab
CAS :Fresolimumab (GC1008) is a human monoclonal antibody targeting active TGFβ1, TGFβ2, TGFβ3, studied for cancer and focal segmental glomerulosclerosis.Degré de pureté :> 95% - > 95%Couleur et forme :LiquidMasse moléculaire :144.4 kDaTAK-441
CAS :TAK-441: oral Hedgehog signal blocker, potent anticancer, IC50=4.4 nM, reduces Gli1 mRNA & tumor growth.Formule :C28H31F3N4O6Degré de pureté :98.79%Couleur et forme :SolidMasse moléculaire :576.56JAK3/BTK-IN-1
CAS :JAK3/ BTk-in-1 is a dual JAK3/BTK inhibitor that specifically targets and inhibits Janus kinase 3 (JAK3) and Bruton's tyrosine kinase (BTK), two importantFormule :C25H28N8ODegré de pureté :97.89%Couleur et forme :SolidMasse moléculaire :456.54β-catenin/CBP-IN-1
CAS :β-catenin/CBP-IN-1 is a potent and selective inhibitor of CBP/β-cateninFormule :C33H35N6O7PDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :658.64Chroman 1
CAS :Chroman 1 is a potent inhibitor of ROCK1 (IC50 = 52 pM) and ROCK2 (IC50 = 1 pM).Formule :C24H28N4O4Degré de pureté :99.28% - 99.91%Couleur et forme :SolidMasse moléculaire :436.5Ref: TM-T14960
1mg77,00€5mg169,00€10mg264,00€25mg485,00€50mg705,00€100mg938,00€1mL*10mM (DMSO)183,00€Pyrvinium pamoate
CAS :Pyrvinium pamoate (Pyrvinium embonate) is an old anthelminthic medicine for the treatment of enterobiasis , which re-attracts attention as an anti-cancer drugFormule :C26H28N3C23H14O6Degré de pureté :100% - 98.43%Couleur et forme :SolidMasse moléculaire :575.71β-catenin-IN-2
CAS :β-catenin-IN-2 is a potent inhibitor of β-catenin that can be used in colorectal cancer research.Formule :C15H14FN3Degré de pureté :98.78%Couleur et forme :SolidMasse moléculaire :255.29Ref: TM-T9696
1mg96,00€5mg227,00€10mg359,00€25mg607,00€50mg868,00€100mg1.169,00€500mg2.365,00€1mL*10mM (DMSO)264,00€KY02111
CAS :KY02111 facilitates differentiation of hPSCs to cardiomyocytes by inhibiting Wnt signaling, maybe affect downstream of GSK3β and APC.Formule :C18H17ClN2O3SDegré de pureté :97.71%（96.56%） - 98.68%Couleur et forme :SolidMasse moléculaire :376.86MRT-81
CAS :MRT-81 blocks Smo receptors in Shh-light2 cells at 41 nM IC50, showing strong hedgehog pathway inhibition, useful in cancer research.Formule :C31H29N3O5SDegré de pureté :98.31%Couleur et forme :SolidMasse moléculaire :555.64Ref: TM-T9532
1mg48,00€5mg97,00€10mg145,00€25mg255,00€50mg368,00€100mg505,00€200mg692,00€1mL*10mM (DMSO)116,00€Casein kinase 1δ-IN-6
CAS :CK1δ-IN-6: potent, selective CK-1δ inhibitor, IC50 23 nM, neuroprotective, anti-inflammatory, for neurodegenerative research.Formule :C16H10ClF3N2OSDegré de pureté :99%Couleur et forme :SoildMasse moléculaire :370.78Ref: TM-T77500
1mg127,00€2mg177,00€5mg283,00€10mg424,00€25mg740,00€50mg1.035,00€100mg1.454,00€500mg2.822,00€2-(1,8-naphthyridin-2-yl)phenol
CAS :2-NP is a STAT1 enhancer.Formule :C14H10N2ODegré de pureté :99.33% - 99.82%Couleur et forme :SolidMasse moléculaire :222.24Ref: TM-T2168
5mg60,00€10mg96,00€25mg187,00€50mg298,00€100mg469,00€200mg682,00€500mg1.035,00€1mL*10mM (DMSO)66,00€Avagacestat
CAS :Avagacestat (BMS-708163) (BMS-708163) is a potent, selective, orally bioavailable γ-secretase inhibitor of Aβ40 and Aβ42 with IC50 of 0.3 nM and 0.27 nM,Formule :C20H17ClF4N4O4SDegré de pureté :98.87% - 99.77%Couleur et forme :SolidMasse moléculaire :520.89Ref: TM-T6249
1mg63,00€5mg120,00€10mg197,00€25mg376,00€50mg547,00€100mg793,00€200mg1.064,00€1mL*10mM (DMSO)139,00€Simian OC/BGP(Osteocalcin) ELISA Kit
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Simian OC/BGP. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Simian OC/BGP. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Simian OC/BGP, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Simian OC/BGP in the samples is then determined by comparing the OD of the samples to the standard curve.Couleur et forme :Colourless TransparentliquidAZD1080
CAS :AZD1080 is a selective, orally active, brain permeable GSK3 inhibitor.Formule :C19H18N4O2Degré de pureté :97.72% - 99.75%Couleur et forme :SolidMasse moléculaire :334.37Ref: TM-T1741
1mg43,00€2mg56,00€5mg85,00€10mg124,00€25mg219,00€50mg350,00€100mg429,00€1mL*10mM (DMSO)63,00€GSK-3 inhibitor 1
CAS :GSK-3 inhibitor 1 is a GSK-3 inhibitor.Formule :C22H17ClFN5O2Degré de pureté :98.11%Couleur et forme :SolidMasse moléculaire :437.85Ref: TM-T11468
1mg104,00€5mg216,00€10mg354,00€25mg677,00€50mg1.008,00€100mg1.491,00€1mL*10mM (DMSO)240,00€ROCK inhibitor-2
CAS :ROCK inhibitor-2 is a selective dual inhibitor of ROCK1 and ROCK2 (IC50s of 17 nM and 2 nM, respectively).Formule :C21H20N2O2Degré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :332.4Ref: TM-T12746
1mg66,00€5mg144,00€10mg216,00€25mg432,00€50mg645,00€100mg905,00€1mL*10mM (DMSO)106,00€EHT 1610
CAS :EHT 1610 (EHT 5372) is a potent inhibitor of DYRK, with an IC50 of 0.36 nM and 0.59 nM for DYRK1A and DYRK1B, respectively.Formule :C18H14FN5O2SDegré de pureté :98.27%Couleur et forme :SolidMasse moléculaire :383.4GSK-3 inhibitor 3
CAS :GSK-3 inhibitor 3 is a selective, orally active, brain-permeable GSK-3 inhibitor that inhibits GSK-3α and GSK-3β with IC50s of 0.35 nM and 0.25 nM, respectivelyFormule :C23H15FN6ODegré de pureté :98.36%Couleur et forme :SoildMasse moléculaire :410.4MRT-92
CAS :MRT-92 is an antagonist of Smoothened (Smo) with anti-cancer activity, featuring a binding affinity (Ki) of 0.7 nM. It inhibits the Hedgehog signaling pathway by obstructing the overlapping binding sites within the transmembrane domain of the Smoothened receptor and suppresses the proliferation of cerebellar granule cells in rodents (IC50=0.4 nM). MRT-92 is utilized for research into cerebellar gliomas.Formule :C33H34N4O5Couleur et forme :SolidMasse moléculaire :566.65YAP-TEAD-IN-3
CAS :YAP-TEAD-IN-3 inhibitor YAP/TAZ-TEAD interactions Avi-human TEAD (4217-434) YAP-TEAD-IN-3 inhibits YAP reporter gene expression and NCI-H2052 cell proliferationFormule :C27H26ClF2N3O4Degré de pureté :97.81% - 98.71%Couleur et forme :SoildMasse moléculaire :529.96GDC-0214
CAS :GDC-0214 is an inhaled small-molecule JAK1 inhibitor and reduces fractional exhaled nitric oxide (Feno).Formule :C28H28ClF2N9O3Degré de pureté :98.54%Couleur et forme :SolidMasse moléculaire :612.03Ref: TM-T9826
1mg87,00€5mg192,00€10mg284,00€25mg452,00€50mg645,00€100mg867,00€200mg1.159,00€1mL*10mM (DMSO)259,00€XL413 xHCl
CAS :BMS-863233 HCl is an ATP-competitive Cdc7 inhibitor (IC50: 3.4 nM) that is potent and selective.BMS-863233 HCl inhibited CK2 and PIM1 with IC50 values of 215Formule :C14H12ClN3O2·xHClDegré de pureté :99.42% - 99.67%Couleur et forme :SolidMasse moléculaire :326.18VT104
CAS :VT104 is a potent and orally active YAP/TAZ inhibitor for cancer research.Cost-effective and quality-assured.Formule :C25H19F3N2ODegré de pureté :99.43% - 99.5%Couleur et forme :SolidMasse moléculaire :420.43Ref: TM-T67872
1mg79,00€5mg243,00€10mg394,00€25mg640,00€50mg898,00€100mg1.206,00€1mL*10mM (DMSO)225,00€RKI1313
CAS :RKI1313 (RKI-1313) was a selective inhibitor for ROCK-dependent signaling, cytoskeletal changes, anchorage-independent colony formation, migration, and invasionFormule :C17H16N4O2SDegré de pureté :99.06% - ≥95%Couleur et forme :SolidMasse moléculaire :340.4VT107
CAS :VT107 is a potent pan-TEAD autopalmitoylation inhibitor. VT-107 can be used in cancer therapy research.Cost-effective and quality-assured.Formule :C25H20F3N3ODegré de pureté :98.43% - 99.73%Couleur et forme :SolidMasse moléculaire :435.44Ref: TM-T35545
1mg137,00€5mg329,00€10mg502,00€25mg810,00€50mg1.103,00€100mg1.483,00€200mg1.985,00€1mL*10mM (DMSO)360,00€Pentabromophenol
CAS :Pentabromophenol (NSC-5717) suppressed TGF-β response by accelerating the turnover rate of TGF-β receptors.Formule :C6HBr5ODegré de pureté :98.89%Couleur et forme :Monoclinic Prisms From Acetic Acid; Needles From Alcohol Physical Description Light Brown Powder Insoluble In Water (Ntp 1992)Masse moléculaire :488.59dCK1α-2
dCK1α-2 is an orally effective CK1α molecular glue (Molecular Glue) degrader that targets p53 pathway-related targets. It demonstrates antitumor efficacy in mouse models by enhancing the expression of p53-related genes.Formule :C24H24ClN5O4Couleur et forme :SolidMasse moléculaire :481.93GSK-3β inhibitor 11
CAS :GSK-3β inhibitor 11 (compound 21) is a potent inhibitor of glycogen synthase kinase-3β (GSK-3β) with an inhibitory concentration (IC50) of 10.02 μM.Formule :C20H15N3O4SDegré de pureté :97.33%Couleur et forme :SolidMasse moléculaire :393.42BRD5648
CAS :BRD5648 ((R)-BRD0705) is an inactive (R)-enantiomer of BRD0705.Formule :C20H23N3ODegré de pureté :99.37%Couleur et forme :SolidMasse moléculaire :321.42JLK6
CAS :JLK6 was a gamma-secretase inhibitor that does not interfere with Notch signallingFormule :C10H8ClNO3Degré de pureté :96.50%Couleur et forme :SolidMasse moléculaire :225.63Ref: TM-T21890
1mg131,00€5mg259,00€10mg371,00€25mg622,00€50mg885,00€100mg1.206,00€500mg2.403,00€1mL*10mM (DMSO)271,00€Linavonkibart
CAS :Linavonkibart (SRK181) is a humanized antibody targeting TGFβ1 that blocks the release of TGF-β1 protein by specifically binding latent TGF-β1.Degré de pureté :95% - 95%Couleur et forme :LiquidXMU-MP-1
CAS :XMU-MP-1 is an inhibitor of the pro-apoptotic, sterile 20-like kinases MST1 and 2.Formule :C17H16N6O3S2Degré de pureté :99.68% - 99.68%Couleur et forme :SolidMasse moléculaire :416.48Ref: TM-T4212
1mg52,00€2mg79,00€5mg97,00€10mg153,00€25mg305,00€50mg512,00€100mg740,00€1mL*10mM (DMSO)95,00€STAT3-IN-36
CAS :STAT3-IN-36 (compound 11g) is a tritarget inhibitor that selectively targets LRPPRC, STAT3, and CDK1, exhibiting potent anticancer activity. This compound binds to LRPPRC, STAT3, and CDK1, demonstrating more effective anticancer effects than those of TMF or Capecitabine. Additionally, STAT3-IN-36 exhibits an IC50 value of 1.8 μM in HGC27 cells.Formule :C30H24F2N2O9S2Couleur et forme :SolidMasse moléculaire :658.65SSTC3
CAS :SSTC3 is a casein kinase 1α (CK1α) activator with potential antitumor activity that inhibits WNT signaling.Formule :C23H17F3N4O3S2Degré de pureté :98.65%Couleur et forme :SolidMasse moléculaire :518.53GSK269962A
CAS :GSK269962A (GSK269962A HCl) is a selective ROCK(Rho-associated protein kinase) inhibitor with IC50 values of 1.6 and 4 nM for ROCK1 and ROCK2, respectively.Formule :C29H30N8O5Degré de pureté :99.14% - 99.71%Couleur et forme :SolidMasse moléculaire :570.6Akt/ROCK-IN-1
Akt/ROCK-IN-1 (B12) is a dual inhibitor targeting Akt and ROCK, exhibiting IC50 values of 0.023 nM and 1.47 nM, respectively.Formule :C21H19BrF2N4O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :509.37JAK-IN-11
CAS :JAK-IN-11 (R-348) is a potent and selective inhibitor of JAK, has the potential for the skin disorders treatment.Formule :C23H22FN5O4SDegré de pureté :99.57%Couleur et forme :SolidMasse moléculaire :483.52CWP232228
CAS :CWP232228 is a selective Wnt/β-catenin pathway inhibitor targeting β-catenin/TCF binding, halting breast/liver CSC growth and metastasis safely.Formule :C33H34N7Na2O7PDegré de pureté :96.13%Couleur et forme :SolidMasse moléculaire :717.63GSK-3 Inhibitor XIII
CAS :GSK-3 InhibitorXIII, an ATP-competitive GSK-3 inhibitor (Ki: 24 nM), can be used to study diabetes and obesity.Formule :C18H15N5Degré de pureté :100% - 98.57%Couleur et forme :SolidMasse moléculaire :301.35SJ000291942
CAS :SJ000291942 is an activator of the canonical bone morphogenetic proteins (BMP) signaling pathway.Formule :C16H15FN2O4Degré de pureté :99.66%Couleur et forme :SolidMasse moléculaire :318.3
![WDR5-0103 hydrochloride[890190-22-4(free base)]](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FTM%2Fthumb-webp%2FT5140.webp&w=3840&q=75)
