Récepteur du facteur de croissance des fibroblastes (FGFR)
Les inhibiteurs des récepteurs du facteur de croissance des fibroblastes (FGFR) sont des thérapies ciblées qui bloquent l'activité des FGFR, impliqués dans la prolifération cellulaire, la différenciation et l'angiogenèse. La signalisation FGFR contribue à la formation de nouveaux vaisseaux sanguins dans les tumeurs, favorisant leur croissance et leur survie. Inhiber les FGFR peut donc réduire l'angiogenèse et la progression tumorale. Chez CymitQuimica, nous offrons une gamme d'inhibiteurs de FGFR de haute qualité pour soutenir vos recherches en cancérologie, biologie du développement et angiogenèse.
Produits appartenant à la catégorie "Récepteur du facteur de croissance des fibroblastes (FGFR)"
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FGFR1/DDR2 inhibitor 1
CAS :FGFR1/DDR2 inhibitor 1 is an inhibitor of discoindin domain receptor 2 (DDR2) and fibroblast growth factor receptor 1 (FGFR1), with IC50 values of 31.1 nM, 108Formule :C28H22F3N5ODegré de pureté :99.43%Couleur et forme :SolidMasse moléculaire :501.5Ref: TM-T11279
1mg92,00€5mg216,00€10mg354,00€25mg582,00€50mg802,00€100mg1.169,00€1mL*10mM (DMSO)240,00€CP-547632 hydrochloride
CAS :CP-547632 hydrochloride: oral VEGFR-2/FGF inhibitor (IC50: 11/9 nM), well-tolerated, antitumor.Formule :C20H25BrClF2N5O3SCouleur et forme :SolidMasse moléculaire :568.86KW-2449
CAS :KW-2449 is a multiple-targeted inhibitor, mostly for Flt3, modestly effective to Bcr-Abl, FGFR1, and Aurora A; little inhibitory on PDGFRβ, IGF-1R, EGFR.Formule :C20H20N4ODegré de pureté :98.43% - 99.89%Couleur et forme :SolidMasse moléculaire :332.4FGFR2/3-IN-2
CAS :FGFR2/3-IN-2 (compound 10) is an orally active inhibitor targeting FGFR2 and FGFR3. It exhibits IC50 values of 3.7 nM for FGFR2 and 31.2 nM for FGFR3, with a pre-incubation time of 1 hour. FGFR2/3-IN-2 demonstrates selectivity over FGFR1/4 and other kinases, and does not cause diarrhea or increased serum phosphate in vivo. In the SNU-16 gastric cancer model, FGFR2/3-IN-2 can induce tumor stasis or regression.Formule :C29H23FN6O3Couleur et forme :SolidMasse moléculaire :522.53DGY-06-116
DGY-06-116 is an selective and irreversible covalent inhibitor of Src and FGFR1 with IC50 value of 3nM and 8340 nM, respectively.Formule :C32H33ClN8O2Degré de pureté :97.65%Couleur et forme :SolidMasse moléculaire :597.11Ref: TM-T22306
2mg42,00€5mg64,00€10mg97,00€25mg183,00€50mg284,00€100mg425,00€200mg602,00€1mL*10mM (DMSO)70,00€SSR128129E
CAS :SSR128129E (SSR) is an allosteric and orally-active FGFR1 inhibitor (IC50: 1.9 μM), but not affecting other related RTKs.Formule :C18H15N2O4·NaDegré de pureté :98.79% - ≥95%Couleur et forme :SolidMasse moléculaire :346.31PD 173074
CAS :Formule :C28H41N7O3Degré de pureté :>95.0%(HPLC)Couleur et forme :White to Yellow to Orange powder to crystalMasse moléculaire :523.68FIIN-1
CAS :FIIN-1 (FGFR irreversible inhibitor-1) is an irreversible and selective FGFR inhibitor with Kd of 2.8, 6.9, 5.4, 120, 32 and 120 nM for FGFR1, FGFR2, FGFR3,Formule :C32H39Cl2N7O4Degré de pureté :97.30%Couleur et forme :SolidMasse moléculaire :656.6Ref: TM-T37426
1mg79,00€2mg103,00€5mg202,00€10mg329,00€25mg550,00€50mg783,00€100mg1.035,00€500mg2.118,00€PRN1371
CAS :PRN1371 is a specific and potent FGFR1-4 and CSF1R inhibitor (IC50s: 0.6/1.3/4.1/19.3/8.1 nM for FGFR1/2/3/4 and CSF1R).Formule :C26H30Cl2N6O4Degré de pureté :98.65%Couleur et forme :SolidMasse moléculaire :561.46Ref: TM-TQ0015
1mg81,00€2mg105,00€5mg170,00€10mg305,00€25mg520,00€50mg748,00€100mg1.026,00€1mL*10mM (DMSO)212,00€Aprutumab
CAS :Aprutumab, a human FGFR2 monoclonal antibody, targets FGFR2-IIIB/C and is used in antibody-drug conjugates.Degré de pureté :98.69% (SEC-HPLC) - 98.69% (SEC-HPLC)Couleur et forme :LiquidMasse moléculaire :150 kDaR1530
CAS :R1530 is a multikinase inhibitor with antineoplastic and antiangiogenesis activities.Formule :C18H14ClFN4ODegré de pureté :97.96%Couleur et forme :SolidMasse moléculaire :356.78TYRA-300
CAS :TYRA-300 is an oral and selective FGFR3 inhibito, in the Ba/F3 cell line for the treatment of metastatic uroepithelial carcinomas (mUCs) and chondrodysplasia.Formule :C25H24Cl2N6O3SDegré de pureté :99.66%Couleur et forme :SolidMasse moléculaire :559.47Ref: TM-T88841
1mg404,00€5mg735,00€10mg999,00€25mg1.588,00€50mg2.147,00€100mg2.902,00€1mL*10mM (DMSO)904,00€KHS101 hydrochloride
CAS :KHS101 is a TACC3 inhibitor and can selectively induce a neuronal differentiation phenotype.Formule :C18H22ClN5SDegré de pureté :99.6%Couleur et forme :SolidMasse moléculaire :375.92Ref: TM-T5170
2mg37,00€5mg55,00€10mg85,00€25mg156,00€50mg251,00€100mg369,00€200mg525,00€1mL*10mM (DMSO)62,00€PD-161570
CAS :PD-161570 is a potent and ATP-competitive human FGF-1 receptor inhibitor with an IC50 of 39.9 nM and a Ki of 42 nM.Formule :C26H35Cl2N7ODegré de pureté :99.23%Couleur et forme :SolidMasse moléculaire :532.51Ref: TM-T23127
1mg35,00€5mg92,00€10mg149,00€25mg305,00€50mg492,00€100mg700,00€200mg938,00€1mL*10mM (DMSO)125,00€Pazopanib
CAS :Pazopanib (GW786034) is an inhibitor of protein tyrosine kinases that inhibits VEGFR1/2/3. Pazopanib has antitumor activity. Cost-effective and quality-assured.Formule :C21H23N7O2SDegré de pureté :98.78% - 99.72%Couleur et forme :White PowderMasse moléculaire :437.52Ref: TM-T0097L
10mg49,00€25mg73,00€50mg96,00€100mg145,00€200mg236,00€500mg331,00€1mL*10mM (DMSO)59,00€BW710
BW710 is an orally active inhibitor specifically targeting fibroblast growth factor receptor 2 (FGFR2). It effectively inhibits the proliferation of BaF3-FGFR2 cells with an IC50 value of 2.8 nM. BW710 completely suppresses FGFR2 enzymatic activity and demonstrates selectivity among 75 tyrosine kinases, including FGFR1, FGFR3, and FGFR4, at a 1 μM concentration. Additionally, BW710 impedes FGFR2 signaling and selectively inhibits the proliferation of cancer cells driven by FGFR2. It exhibits promising pharmacokinetic properties, with an oral bioavailability of 29% in mice.Formule :C28H29FN6O2SCouleur et forme :SolidMasse moléculaire :532.63XL 999
CAS :Tyrosine kinase-IN-1 is a multi-targeted tyrosine kinase inhibitor(KDR, Flt-1, FGFR1 and PDGFRα with IC50s of 4nM, 20nM, 4nM, 2 nM ,respectively)Formule :C26H28FN5ODegré de pureté :98.24% - 99.55%Couleur et forme :SolidMasse moléculaire :445.53FGFR4-IN-16
CAS :FGFR4-IN-16 (CY-15-2) is a covalent inhibitor targeting FGFR-4, utilized in cancer research [1].Formule :C35H30Cl2N6O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :685.56Rogaratinib
CAS :Rogaratinib (BAY1163877) is an aberrant inhibitor of fibroblast growth factor receptor (FGFR).Formule :C23H26N6O3SDegré de pureté :99.54%Couleur et forme :SolidMasse moléculaire :466.56FGFR2-IN-3
CAS :FGFR2-IN-3 is an orally active selective FGFR2 inhibitor[1].Formule :C28H24FN7O2Degré de pureté :99.24%Couleur et forme :SoildMasse moléculaire :509.53Ref: TM-T60185
1mg95,00€5mg202,00€10mg298,00€25mg630,00€50mg938,00€100mg1.264,00€1mL*10mM (DMSO)224,00€Orantinib
CAS :Orantinib (NSC 702827) , a excellent effective against PDGFR autophosphorylation with Ki of 8 nM, also highly inhibits Flk-1 and FGFR1 trans-phosphorylation.Formule :C18H18N2O3Degré de pureté :100% - 98.01%Couleur et forme :SolidMasse moléculaire :310.35Pemigatinib
CAS :Pemigatinib (INCB054828) is an orally active, selective inhibitor of FGFR(IC50s of 0.4 nM, 0.5 nM, 1.2 nM, 30 nM for FGFR1, FGFR2, FGFR3, FGFR4, respectively).Formule :C24H27F2N5O4Degré de pureté :98.15% - 99.95%Couleur et forme :SolidMasse moléculaire :487.5LC-MB12
CAS :LC-MB12 is a PROTAC FGFR2 compound that degrades FGFR2 and can be used to study gastric cancer.Formule :C43H44Cl2N10O8Degré de pureté :99.16%Couleur et forme :SolidMasse moléculaire :899.78S49076 HCl
CAS :S49076 HCl (S-49076 Hydrochloride) is an effective inhibitor of MET, AXL/MER, and FGFR1/2/3.Formule :C22H18ClN3O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :439.85Infigratinib phosphate
CAS :Infigratinib phosphate (BGJ-398 phosphate) is an effective inhibitor of the FGFR family (IC50: 0.9 nM, 1.4 nM, 1 nM, and 60 nM for FGFR1, FGFR2, FGFR3, andFormule :C26H34Cl2N7O7PDegré de pureté :99.24% - 99.6%Couleur et forme :SolidMasse moléculaire :658.47Dovitinib
CAS :Dovitinib is an orally active, multi-targeted tyrosine kinase (RTK) inhibitor with anti-tumor effects.Cost-effective and quality-assured.Formule :C21H21FN6ODegré de pureté :99.66% - 99.78%Couleur et forme :SolidMasse moléculaire :392.43Ref: TM-T6289
5mg47,00€10mg70,00€25mg126,00€50mg202,00€100mg328,00€200mg490,00€500mg783,00€1mL*10mM (DMSO)50,00€Gunagratinib
CAS :Gunagratinib (ICP-192) is a pan-FGFR inhibitor, useful in research on FGFR-related diseases.Formule :C22H25N5O4Degré de pureté :99.68%Couleur et forme :SolidMasse moléculaire :423.47BO-264
CAS :BO-264 is a highly potent and orally active inhibitor of transforming acidic coiled-coil 3 (TACC3, IC50 of 188 nM and a Kd of 1.5 nM).Formule :C18H19N5O3Degré de pureté :98.03% - 99.81%Couleur et forme :SolidMasse moléculaire :353.38CHIR-98014
CAS :CHIR-98014 (CT98014) is a selective GSK3 inhibitor; potentiate insulin activation of glucose transport and utilization in vitro and in vivo.Formule :C20H17Cl2N9O2Degré de pureté :97.25% - 99.41%Couleur et forme :SolidMasse moléculaire :486.31Lucitanib
CAS :Lucitanib (E-3810) is a VEGFR/FGFR inhibitor targeting VEGFR1-3 and FGFR1-2 with IC50s 7-82.5 nM.Formule :C26H25N3O4Degré de pureté :96.13%Couleur et forme :SolidMasse moléculaire :443.49Ref: TM-T15185
1mg48,00€2mg63,00€5mg87,00€10mg144,00€25mg269,00€50mg487,00€100mg710,00€1mL*10mM (DMSO)96,00€FGFR3-IN-7
CAS :FGFR3-IN-7 is a potent, selective inhibitor of FGFR 3, demonstrating an IC50 value of less than 350 nM , and is utilized in cancer research [1].Formule :C25H24FN9ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :485.52SU 5402
CAS :SU 5402 is a potent multi-targeted receptor tyrosine kinase inhibitor with IC50 of 20 nM, 30 nM, and 510 nM for VEGFR2, FGFR1, and PDGF-Rβ, respectively.Formule :C17H16N2O3Degré de pureté :98.91% - 99.64%Couleur et forme :Yellow-Green SolidMasse moléculaire :296.32Fazpilodemab
CAS :Fazpilodemab (BFKB8488A) is a humanized agonistic bispecific antibody that targets fibroblast growth factor receptor 1c (FGFR1c) and Klothoβ.Degré de pureté :98%Couleur et forme :LiquidAZD4547
CAS :AZD4547 is an FGFR family inhibitor, and is able to act on FGFR1, FGFR2, FGFR3 and FGFR4. IC50:165 nM).Cost-effective and quality-assured.Formule :C26H33N5O3Degré de pureté :99.37% - 99.88%Couleur et forme :SolidMasse moléculaire :463.57Ref: TM-T1948
2mg39,00€5mg49,00€10mg63,00€25mg88,00€50mg113,00€100mg156,00€200mg219,00€500mg366,00€1mL*10mM (DMSO)55,00€PF 477736
CAS :PF 477736 (PF-736,PF-00477736) is a specifc, effective and ATP-competitive Chk1 inhibitor (Ki: 0.49 nM ) and also inhibits FGFR3, Aurora-A, VEGFR2, Flt3, Fms (Formule :C22H25N7O2Degré de pureté :98.34% - 99.62%Couleur et forme :SolidMasse moléculaire :419.48FGFR1 inhibitor-9
FGFR1 inhibitor-9 (Compound 7) is an FGFR1 inhibitor with potent binding affinity, exhibiting an IC50 of 0.85 nM.Formule :C27H20ClNO5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :473.9Infigratinib
CAS :Infigratinib (NVP-BGJ398) (BGJ398) is an orally bioavailable pan FGFR inhibitor (IC50: 0.9/1.4/1 nM for FGFR1/2/3), >40-fold selective for FGFR versus FGFR4 andFormule :C26H31Cl2N7O3Degré de pureté :98% - 98.97%Couleur et forme :SolidMasse moléculaire :560.48FGFR-IN-15
FGFR-IN-15 (compound 18i) acts as a pan-FGFR inhibitor, exhibiting potent inhibitory activity against FGFR1-4.Formule :C22H23N5O5SCouleur et forme :SolidMasse moléculaire :469.51Heparan Sulfate
CAS :Heparan sulfate is a natural product, a linear polysaccharide. Heparan sulfate occurs as a proteoglycan (HSPG). Cost effective and quality assured.Formule :C12H19NO20S3(monomer)Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :593.47(monomer)SU4984
CAS :SU4984 is a cell-permeable, ATP-competitive and reversible inhibitor of the fibroblast growth factor receptor 1 (FGFR1).Formule :C20H19N3O2Degré de pureté :100%Couleur et forme :SolidMasse moléculaire :333.38FGFR1 inhibitor-10
CAS :FGFR1 inhibitor-10 (Compound 4i), with an IC50 of 28 nM, effectively inhibits FGFR1 phosphorylation.Formule :C26H30F3N7O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :561.62PD168393
CAS :PD168393 is an irreversible EGFR inhibitor (IC50: 0.70 nM), irreversibly alkylate Cys-773; inactive against PKC, FGFR, PDGFR, and insulin.Formule :C17H13BrN4ODegré de pureté :99.13% - 99.7%Couleur et forme :SolidMasse moléculaire :369.22Ref: TM-T6932
1mg39,00€2mg49,00€5mg66,00€10mg89,00€25mg155,00€50mg222,00€100mg310,00€1mL*10mM (DMSO)56,00€PP58
CAS :PP58 is an inhibitor of PDGFR, FGFR and Src family.Formule :C22H19Cl2N5O2Degré de pureté :99.21%Couleur et forme :SolidMasse moléculaire :456.32FGFR1 inhibitor 7
FGFR1 Inhibitor 7 (compound 5), a potent FGFR1 tyrosine kinase inhibitor, exhibits an IC50 of 0.33 nM against its target and demonstrates broad-spectrumFormule :C25H16ClNO4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :429.85PD-161570
CAS :Formule :C26H35Cl2N7ODegré de pureté :>98.0%(HPLC)Couleur et forme :White to Light yellow powder to crystalMasse moléculaire :532.51FGFR3-IN-6
CAS :FGFR3-IN-6 is a potent, selective inhibitor of FGFR 3, exhibiting an IC50 value of less than 350 nM , and is utilized in cancer research [1].Formule :C25H23FN8O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :486.5FGFR1 inhibitor-16
CAS :FGFR1inhibitor-16 (Compound 89) functions as an FGFR1 inhibitor, demonstrating an inhibition rate of 53.00% at a concentration of 50 μM and 24.95% at 10 μM. It is utilized in tumor research.Formule :C16H9N5O3SCouleur et forme :SolidMasse moléculaire :351.339Dovitinib lactate hydrate
CAS :Dovitinib lactate hydrate (TKI258) is the Lactate of Dovitinib, which is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit).Formule :C24H27FN6O4Degré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :482.51Roblitinib
CAS :Roblitinib (FGF-401), an FGFR4 inhibitor, potentially blocks tumor growth by halting cell proliferation and survival.Formule :C25H30N8O4Degré de pureté :97.27% - 99%Couleur et forme :SolidMasse moléculaire :506.56Ref: TM-T4235
1mg58,00€2mg84,00€5mg103,00€10mg169,00€25mg306,00€50mg535,00€100mg752,00€500mg1.586,00€Nintedanib
CAS :Formule :C31H33N5O4Degré de pureté :>95.0%(T)(HPLC)Couleur et forme :White to Yellow to Yellow green powder to crystalMasse moléculaire :539.64
