ALK
Les inhibiteurs d'ALK sont des composés qui ciblent spécifiquement et inhibent la kinase du lymphome anaplasique (ALK), une tyrosine kinase réceptrice impliquée dans le développement et la progression de certains cancers, notamment le cancer du poumon non à petites cellules et le neuroblastome. En inhibant ALK, ces composés bloquent les voies de signalisation qui favorisent la croissance et la survie des cellules tumorales. Chez CymitQuimica, nous proposons des inhibiteurs d'ALK pour soutenir vos recherches en oncologie, thérapies ciblées contre le cancer et transduction du signal.
Produits appartenant à la catégorie "ALK"
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Alectinib hydrochloride
CAS :Alectinib hydrochloride (RO5424802 Hydrochloride) is a selective, and orally available inhibitor of ALK( IC50 : 1.9 nM)Formule :C30H35ClN4O2Degré de pureté :99.61% - 99.96%Couleur et forme :SolidMasse moléculaire :519.08LDN193189
CAS :LDN193189 blocks BMP signaling by inhibiting ALK2/3; IC50: ALK1/2/3/6 = 0.8/0.8/5.3/16.7 nM.Formule :C25H22N6Degré de pureté :98% - 99.86%Couleur et forme :SolidMasse moléculaire :406.48EW-7195
CAS :EW-7195 inhibits ALK5/TGFβR1 (>300x selective over p38α) with 4.83 nM IC50, blocking TGF-β1 signaling, EMT, and breast cancer lung metastasis.Formule :C23H18N8Degré de pureté :98.76%Couleur et forme :SolidMasse moléculaire :406.44Ref: TM-T38752
1mg131,00€2mg187,00€5mg311,00€10mg535,00€25mg1.064,00€50mg1.738,00€100mg2.745,00€1mL*10mM (DMSO)344,00€OD36
CAS :OD36: Potent RIPK2 inhibitor, IC50=5.3 nM; hinders ALK2 signaling and osteogenesis, KD=37 nM; targets ALK2 ATP pocket.Formule :C16H15ClN4O2Degré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :330.77DMH-1
CAS :DMH-1 is a BMP inhibitor that inhibits ALK1, ALK2, ALK3 and ALK6. DMH-1 promotes pluripotent stem cell differentiation. Cost-effective and quality-assured.Formule :C24H20N4ODegré de pureté :98% - 99.92%Couleur et forme :SolidMasse moléculaire :380.44CH5424802 analog
CAS :CH5424802 analog is a selective ALK inhibitor capable of blocking the resistant gatekeeper mutant.Formule :C28H30N4O2Degré de pureté :98.96%Couleur et forme :SolidMasse moléculaire :454.56Ref: TM-T9224
1mg131,00€5mg286,00€10mg430,00€25mg710,00€50mg998,00€100mg1.349,00€1mL*10mM (DMSO)343,00€(-)-Cevimeline hydrochloride hemihydrate
(-)-Cevimeline HCl hemihydrate, a muscarinic agonist, treats Sjogren's xerostomia. Quick absorption, species-dependent metabolism.Formule :C10H19ClNO1·5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :244.78ZX-29
CAS :ZX-29: Strong ALK inhibitor; IC50 - ALK 2.1 nM, L1196M 1.3 nM, G1202R 3.9 nM; triggers autophagy; anti-cancer.Formule :C23H28ClN7O3SDegré de pureté :98.32%Couleur et forme :SolidMasse moléculaire :518.03Ref: TM-T13416
1mg92,00€5mg230,00€10mg364,00€25mg620,00€50mg848,00€100mg1.121,00€1mL*10mM (DMSO)296,00€CEP-28122 mesylate salt (1022958-60-6 free base)
CEP-28122 mesylate salt (1022958-60-6 free base) is a highly selective orally active ALK inhibitor (IC50: 1.9 nM in an enzyme-based TRF assay).Formule :C29H39ClN6O6SDegré de pureté :99.79%Couleur et forme :SolidMasse moléculaire :635.17SB-505124 hydrochloride
CAS :SB-505124 hydrochloride (SB505124 hydrochloride) is a TGF-β type I receptor (ALK4, ALK5, ALK7) inhibitor for the study of colorectal cancer.Formule :C20H22ClN3O2Degré de pureté :98.71%Couleur et forme :SolidMasse moléculaire :371.86KER047
CAS :ALK2-IN-4, a highly effective ALK2 inhibitor.Formule :C26H30FN7ODegré de pureté :100% - 98.49%Couleur et forme :SolidMasse moléculaire :475.56Ref: TM-T39764
1mg96,00€5mg227,00€10mg369,00€25mg753,00€50mg1.074,00€100mg1.644,00€1mL*10mM (DMSO)250,00€AZD-3463
CAS :AZD-3463 (ALK/IGF1R inhibitor) , an orally bioavailable ALK inhibitor (Ki: 0.75 nM), can inhibit IGF1R with equivalent potency.Formule :C24H25ClN6ODegré de pureté :99.13%Couleur et forme :SolidMasse moléculaire :448.95ALKBH5-IN-5
CAS :ALKBH5-IN-5 is a highly selective, potent and covalently binding ALKBH5 inhibitor that alters m6A levels on mRNA, induces apoptosis, antitumo.Formule :C13H13NO3Degré de pureté :99.54%Couleur et forme :SoildMasse moléculaire :231.25Ref: TM-T203011
1mg185,00€5mg459,00€10mg657,00€25mg1.026,00€50mg1.415,00€100mg1.872,00€200mg2.555,00€RepSox
CAS :RepSox (ALK5 Inhibitor II) is a TGFβR-1/ALK5 inhibitor that selectively inhibits the binding of ATP to ALK5 and the autophosphorylation of ALK5 (IC50=23/4 nM).Formule :C17H13N5Degré de pureté :98.8% - 99.62%Couleur et forme :SolidMasse moléculaire :287.32Ref: TM-T6337
1mg35,00€2mg48,00€5mg66,00€10mg85,00€25mg123,00€50mg172,00€100mg255,00€500mg630,00€1mL*10mM (DMSO)72,00€BIBF0775
CAS :BIBF0775 is a selective TGFβ type I receptor (Alk5) inhibitor (IC50: 34 nM).Formule :C31H34N4O2Degré de pureté :99.02% - 99.45%Couleur et forme :SolidMasse moléculaire :494.63Ref: TM-T5197
1mg43,00€5mg96,00€10mg135,00€25mg215,00€50mg304,00€100mg437,00€200mg610,00€1mL*10mM (DMSO)96,00€HG-14-10-04
CAS :HG-14-10-04 is a potent and specific ALK inhibitor.Formule :C29H34ClN7ODegré de pureté :100% - 99.75%Couleur et forme :SolidMasse moléculaire :532.08A 77-01
CAS :A 77-01 is a potent inhibitor of TGF-(beta) type I receptor superfamily activin-like kinase ALK5 with IC50 of 25 nM.Formule :C18H14N4Degré de pureté :98.82% - ≥95%Couleur et forme :SolidMasse moléculaire :286.33INCB-000928
CAS :Zilurgisertib (INCB-000928) is a selective and potent ALK 2 inhibitor for the study of cancer and MF anemia.Formule :C30H38N4O3Degré de pureté :98.93%Couleur et forme :SolidMasse moléculaire :502.65SM 16
CAS :SM 16 is a ALK5/ALK4 kinase inhibitor (Ki: 10/1.5 nM).Formule :C25H26N4O3Degré de pureté :99.72%Couleur et forme :SolidMasse moléculaire :430.5AZ12601011
CAS :AZ12601011 is a TGFBR1 kinase inhibitor that inhibits the growth of breast tumors.Formule :C19H15N5Degré de pureté :98.81%Couleur et forme :SolidMasse moléculaire :313.36Ref: TM-T10426
1mg99,00€5mg235,00€10mg376,00€25mg728,00€50mg1.093,00€100mg1.510,00€1mL*10mM (DMSO)259,00€
