c-Fms
Les inhibiteurs de c-Fms ciblent le récepteur du facteur de stimulation des colonies-1 (c-Fms), une tyrosine kinase impliquée dans la régulation des macrophages et d'autres cellules immunitaires. La signalisation de c-Fms joue un rôle dans la prolifération, la différenciation et la survie de ces cellules. La dérégulation de c-Fms est associée à des maladies telles que le cancer, les conditions inflammatoires et l'ostéoporose. Chez CymitQuimica, nous proposons des inhibiteurs de c-Fms pour soutenir vos recherches en immunologie, oncologie et maladies inflammatoires.
Produits appartenant à la catégorie "c-Fms"
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Plonmarlimab
CAS :Plonmarlimab(TJ003234) is an anti-GM-CSF monoclonal antibody with potential antiviral activity for the study of immune disorders and novel coronavirus infectionCouleur et forme :LiquidKi20227
CAS :Ki-20227 is a specific c-Fms tyrosine kinase(CSF1R) inhibitor (IC50: 2 nM).Formule :C24H24N4O5SDegré de pureté :97.16% - 99.37%Couleur et forme :SolidMasse moléculaire :480.54Ref: TM-T4315
1mg47,00€5mg96,00€10mg154,00€25mg283,00€50mg464,00€100mg740,00€200mg1.008,00€1mL*10mM (DMSO)96,00€Dovitinib
CAS :Dovitinib is an orally active, multi-targeted tyrosine kinase (RTK) inhibitor with anti-tumor effects.Cost-effective and quality-assured.Formule :C21H21FN6ODegré de pureté :99.66% - 99.78%Couleur et forme :SolidMasse moléculaire :392.43Ref: TM-T6289
5mg47,00€10mg70,00€25mg126,00€50mg202,00€100mg328,00€200mg490,00€500mg783,00€1mL*10mM (DMSO)50,00€CSF1R Protein, Human, Recombinant (His & Avi)
M-CSFR/CSF1R/CD115 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag.Couleur et forme :Lyophilized PowderMasse moléculaire :57.4 kDa (predicted). Due to glycosylation, the protein migrates to 75-105 kDa based on Tris-Bis PAGE result.Nampt-IN-1
CAS :Nampt-IN-1 (LSN3154567) (LSN3154567) is a potent and selective NAMPT inhibitor. Nampt-IN-1 inhibits purified NAMPT with an IC50 of 3.1 nM.Formule :C20H25N3O5SDegré de pureté :96.82% - 99.4%Couleur et forme :SolidMasse moléculaire :419.49Ref: TM-T4376
1mg39,00€2mg52,00€5mg84,00€10mg137,00€25mg259,00€50mg432,00€100mg638,00€1mL*10mM (DMSO)92,00€Anumigilimab
CAS :Anumigilimab (CSL-324) is a fully human therapeutic anti-G-CSFR antibody with potential anti-tumor activity for the study of inflammation.Degré de pureté :95.75% (SEC-HPLC) - 98.43% (SEC-HPLC)Couleur et forme :LiquidMasse moléculaire :143.86 kDaPexidartinib
CAS :Pexidartinib (PLX-3397) is a capsule formulation containing a small-molecule receptor tyrosine kinase (RTK) inhibitor of KIT, CSF1R and FLT3 with potentialFormule :C20H15ClF3N5Degré de pureté :98.34% - 99.51%Couleur et forme :SolidMasse moléculaire :417.81Ref: TM-T2115
5mg48,00€10mg62,00€25mg95,00€50mg120,00€100mg154,00€200mg202,00€500mg350,00€1mL*10mM (DMSO)52,00€Chiauranib
CAS :Chiauranib, a potent anticancer agent, inhibits angiogenesis kinases (VEGFR1-3, PDGFRα, c-Kit), Aurora B, and CSF1R with IC50 values of 1-9 nM.Formule :C27H21N3O3Degré de pureté :96.25%Couleur et forme :SolidMasse moléculaire :435.47Ref: TM-T35570
1mg90,00€5mg187,00€10mg305,00€25mg520,00€50mg748,00€100mg1.026,00€1mL*10mM (DMSO)215,00€PF 477736
CAS :PF 477736 (PF-736,PF-00477736) is a specifc, effective and ATP-competitive Chk1 inhibitor (Ki: 0.49 nM ) and also inhibits FGFR3, Aurora-A, VEGFR2, Flt3, Fms (Formule :C22H25N7O2Degré de pureté :98.34% - 99.62%Couleur et forme :SolidMasse moléculaire :419.48CSF1R Protein, Human, Recombinant (His & Avi), Biotinylated
M-CSFR/CSF1R/CD115 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag.Couleur et forme :Lyophilized PowderMasse moléculaire :57.4 kDa (predicted). Due to glycosylation, the protein migrates to 75-105 kDa based on Tris-Bis PAGE result.c-Fms-IN-14
CAS :c-Fms-IN-14 (Example 76) is a potent inhibitor of the c-Fms kinase with an IC50 of 4 nM, utilized in cancer and autoimmune disease research [1].Formule :C26H24N6ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :436.51PRN1371
CAS :PRN1371 is a specific and potent FGFR1-4 and CSF1R inhibitor (IC50s: 0.6/1.3/4.1/19.3/8.1 nM for FGFR1/2/3/4 and CSF1R).Formule :C26H30Cl2N6O4Degré de pureté :98.65%Couleur et forme :SolidMasse moléculaire :561.46Ref: TM-TQ0015
1mg81,00€2mg105,00€5mg170,00€10mg305,00€25mg520,00€50mg748,00€100mg1.026,00€1mL*10mM (DMSO)212,00€Sotuletinib
CAS :Sotuletinib (BLZ945) is an orally active, effective and specific CSF-1R inhibitor, >1000-fold selective against its closest receptor tyrosine kinase homologs.Formule :C20H22N4O3SDegré de pureté :97.43% - 99.82%Couleur et forme :SolidMasse moléculaire :398.48Ref: TM-T6119
1mg37,00€5mg79,00€10mg111,00€25mg172,00€50mg216,00€100mg378,00€500mg868,00€1mL*10mM (DMSO)87,00€CSF1R-IN-2
CAS :CSF1R-IN-2 is an oral-active SRC, MET and c-FMS inhibitor (IC50s: 0.12 nM, 0.14 nM and 0.76 nM for SRC, MET and c-FMS respectively).Formule :C20H20FN7O2Degré de pureté :99.29%Couleur et forme :SolidMasse moléculaire :409.42Pyrithyldione
CAS :Pyrithyldione is a sedative-hypnotic agent known to potentially induce agranulocytosis.Formule :C9H13NO2Couleur et forme :SolidMasse moléculaire :167.21Anti-CSF1R Antibody (2I506)
Anti-CSF1R Antibody (2I506) is a Mouse antibody targeting CSF1R. Anti-CSF1R Antibody (2I506) can be used in ELISA.Couleur et forme :Odour LiquidcFMS Receptor Inhibitor II
CAS :cFMS Receptor Inhibitor II is a CSF1R kinase inhibitorFormule :C23H20N4ODegré de pureté :99.80%Couleur et forme :SolidMasse moléculaire :368.43Ref: TM-T5586
1mg49,00€2mg65,00€5mg97,00€10mg154,00€25mg255,00€50mg376,00€100mg547,00€1mL*10mM (DMSO)106,00€Anti-CSF1R Antibody (4Y587)
Anti-CSF1R Antibody (4Y587) is a Mouse antibody targeting CSF1R. Anti-CSF1R Antibody (4Y587) can be used in FCM.Couleur et forme :Odour LiquidOSI-930
CAS :OSI-930 is an oral c-Kit/VEGFR-2 inhibitor targeting tumor growth and angiogenesis.Formule :C22H16F3N3O2SDegré de pureté :99.67%Couleur et forme :SolidMasse moléculaire :443.44Ref: TM-T2624
1mg51,00€5mg93,00€10mg144,00€25mg263,00€50mg424,00€100mg612,00€200mg873,00€1mL*10mM (DMSO)97,00€Enrupatinib
CAS :Enrupatinib is an inhibitor of the colony stimulating factor 1 receptor (CSF1R), exhibiting antitumor activity.Formule :C27H26N6O3Couleur et forme :SolidMasse moléculaire :482.53CSF1R Protein, Human, Recombinant (His & Avi), Biotinylated
CSF1R Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag.Couleur et forme :Lyophilized PowderMasse moléculaire :57.76 kDa (predicted); 82.52 kDa (reducing conditions)c-Fms-IN-2
CAS :c-Fms-IN-2 is an inhibitor of c-FMS kinase (IC50 = 24 nM).Formule :C19H21N3O3Degré de pureté :97.34%Couleur et forme :SolidMasse moléculaire :339.39Ref: TM-T10775
1mg96,00€5mg255,00€10mg375,00€25mg562,00€50mg792,00€100mg1.064,00€1mL*10mM (DMSO)190,00€Anti-CSF1R Antibody (5B661)
Anti-CSF1R Antibody (5B661) is a Mouse antibody targeting CSF1R. Anti-CSF1R Antibody (5B661) can be used in ELISA,ELISA(Cap).Couleur et forme :Odour Liquidc-Fms-IN-6
CAS :c-Fms-IN-6 is a potent inhibitor of c-FMS (IC50 ≤10 nM for unphosphorylated c-FMS) and also weakly inhibits unphosphorylated c-KIT and PDGFR (IC50: > 1 μM).Formule :C22H25N7O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :419.48CSF1R Protein, Human, Recombinant
CSF1R Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 55.1 kDa and the accession number is P07333-1.Couleur et forme :Lyophilized PowderMasse moléculaire :55.1 kDa (predicted); 80-90 kDa (reducing condition, due to glycosylation)CSF1R Protein, Human, Recombinant (mFc)
CSF1R Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag.Couleur et forme :Lyophilized PowderMasse moléculaire :81.5 kDa (predicted)c-Fms-IN-13
CAS :c-Fms-IN-13 (compound 14) is a potent FMS kinase inhibitor (IC50= 17 nM). c-Fms-IN-13 is an anti-inflammatory agent.Formule :C22H26N4O2Degré de pureté :100% - 99.83%Couleur et forme :SolidMasse moléculaire :378.47Lacnotuzumab
CAS :Lacnotuzumab (MCS110) is a humanized monoclonal antibody targeting CSF-1, which can be used in research on retinal diseases.Degré de pureté :>95%Couleur et forme :LiquidCSF1R Protein, Human, Recombinant (His & GST)
CSF1R Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag.Couleur et forme :Lyophilized PowderMasse moléculaire :76 kDa (predicted); 75 kDa (reducing conditions)Lenzilumab
CAS :Lenzilumab (KB 003) is a humanized GM-CSF neutralizing antibody for the study of COVID-19.Degré de pureté :95% - 95%Couleur et forme :LiquidCSF1R Protein, Cynomolgus, Recombinant (His)
M-CSFR/CSF1R/CD115 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag.Couleur et forme :Lyophilized PowderMasse moléculaire :56.3 kDa (predicted). Due to glycosylation, the protein migrates to 75-105 kDa based on Tris-Bis PAGE result.PLX5622
CAS :PLX5622 is a selective, orally active and blood-brain barrier permeable CSF1R inhibitor. PLX5622 induces elimination of microglia. Cost effective and quality assured.Formule :C21H19F2N5ODegré de pureté :98% - 99.89%Couleur et forme :SolidMasse moléculaire :395.41Ref: TM-T7100
5mg96,00€10mg158,00€25mg308,00€50mg510,00€100mg617,00€500mg1.311,00€1mL*10mM (DMSO)94,00€Gimsilumab
CAS :Gimsilumab (MORAb-022) is an anti-c-Fms humanized monoclonal antibody for the study of inflammation and hypoxemia caused by COVID-19.Degré de pureté :99.49% (SEC-HPLC) - 99.49% (SEC-HPLC)Couleur et forme :LiquidMasse moléculaire :145.8 kDaCSF1R-IN-17
CSF1R-IN-17 (compound 9) is a potent, selective antagonist of CSF1R, exhibiting an inhibition concentration half-maximum (IC50) of 0.2 nM.Formule :C20H25N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :367.44Pimicotinib
CAS :Pimicotinib (ABSK021) is a potent CSF1R inhibitor with antitumor activity and can be used to study advanced solid tumors.Formule :C22H24N6O3Degré de pureté :99.8%Couleur et forme :SolidMasse moléculaire :420.46CSF1R Protein (Ala299-Glu512), Human, Recombinant (His)
CSF1R Protein (Ala299-Glu512), Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.Couleur et forme :Lyophilized PowderMasse moléculaire :25.3 kDa (predicted)Edicotinib
CAS :Edicotinib (JNJ-527) is a blood-brain permeable, selective CSF-1R inhibitor, with lesser inhibitory effects on KIT and FLT3.Cost-effective and quality-assured.Formule :C27H35N5O2Degré de pureté :98.58% - 99.69%Couleur et forme :SolidMasse moléculaire :461.6Emactuzumab
CAS :Emactuzumab(RG 7155) is a monoclonal antibody against colony-stimulating factor-1 receptor targeting tumor-associated macrophages (TAMs) Emactuzumab hasDegré de pureté :SDS-PAGE:98.3%;SEC-HPLC:97.3%Couleur et forme :LiquidMasse moléculaire :144.4 kDaAnti-CSF1R Antibody (8O797)
Anti-CSF1R Antibody (8O797) is a Mouse antibody targeting CSF1R. Anti-CSF1R Antibody (8O797) can be used in ELISA.Couleur et forme :Odour LiquidAnti-CSF1R Antibody-FITC (4Y587)
Anti-CSF1R Antibody-FITC (4Y587) is a FITC-conjugated Mouse antibody targeting CSF1R. Anti-CSF1R Antibody-FITC (4Y587) can be used in FCM.Couleur et forme :Odour LiquidAnti-CSF1R Antibody (7V18)
Anti-CSF1R Antibody (7V18) is a Rabbit antibody targeting CSF1R. Anti-CSF1R Antibody (7V18) can be used in ELISA.Couleur et forme :Odour LiquidSotuletinib dihydrochloride
CAS :Sotuletinib (BLZ945) dihydrochloride is an orally administered, blood-brain barrier-permeable inhibitor specifically targeting CSF1-R with an IC50 of 1 nM.Formule :C20H24Cl2N4O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :471.4c-Fms-IN-9
CAS :c-Fms-IN-9 inhibits c-FMS/uFMS and uKIT with IC50 <0.01μM and 0.1-1μM, from patent WO2014145023A1.Formule :C21H23N7O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :405.45cFMS Receptor Inhibitor IV
CAS :cFMS Receptor Inhibitor IV is an inhibitor of c-Fms tyrosine kinase.Formule :C22H26N4O2Degré de pureté :99.73%Couleur et forme :SolidMasse moléculaire :378.47AZ304
CAS :AZ304 is an ATP-competitive dual BRAF kinase inhibitor, potently inhibits BRAF (WT), BRAF (V600E), and wild type CRAF (IC50s: 79/38/68 nM).Formule :C27H25N5O2Degré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :451.52CSF1R Protein (Met1-Glu512), Human, Recombinant (His)
CSF1R Protein (Met1-Glu512), Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.Degré de pureté :SDS-PAGE: 97.7%; SEC-HPLC: 99.7%Couleur et forme :Lyophilized PowderMasse moléculaire :56 kDa (predicted); 85-95 kDa (reducing condition, due to glycosylation)GW786034B
CAS :Pazopanib HCl (Votrient) inhibits VEGFR1-3, PDGFR, FGFR, c-Kit, c-Fms with IC50 range 10-146 nM in cell-free assays.Formule :C21H23N7O2S·HClDegré de pureté :99.87%Couleur et forme :SolidMasse moléculaire :473.98Ref: TM-T6930
10mg52,00€25mg90,00€50mg96,00€100mg140,00€200mg229,00€500mg359,00€1mL*10mM (DMSO)52,00€Vimseltinib
CAS :Vimseltinib (DCC-3014) is a c-FMS (CSF-IR) and c-Kit dual inhibitor (IC50s: <0.01 μM and 0.1-1 μM).Formule :C23H25N7O2Degré de pureté :99.05% - 99.57%Couleur et forme :SolidMasse moléculaire :431.49Ref: TM-T10652
1mg92,00€5mg188,00€10mg311,00€25mg533,00€50mg727,00€100mg938,00€1mL*10mM (DMSO)215,00€Linifanib
CAS :Linifanib (AL-39324) (ABT-869) is a novel, potent ATP-competitive VEGFR/PDGFR inhibitor for KDR (IC50: 4 nM), CSF-1R (IC50: 3 nM), Flt-1/3 (IC50: 3/4 nM) andFormule :C21H18FN5ODegré de pureté :98% - 98.24%Couleur et forme :SolidMasse moléculaire :375.4Ref: TM-T2514
5mg50,00€10mg85,00€25mg126,00€50mg188,00€100mg274,00€200mg505,00€500mg815,00€1mL*10mM (DMSO)52,00€c-Fms-IN-3
CAS :c-Fms-IN-3 is a novel inhibitor of the c-FMS and can be used in studies about antirheumatic and anti-inflammatory diseases.Formule :C23H30N6ODegré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :406.52Ref: TM-T10649
1mg50,00€5mg111,00€10mg170,00€25mg279,00€50mg378,00€100mg552,00€1mL*10mM (DMSO)116,00€
