Récepteur Trk
Les inhibiteurs des récepteurs Trk ciblent les kinases des récepteurs de la tropomyosine (Trk), une famille de récepteurs à activité tyrosine kinase qui jouent un rôle important dans le développement et la fonction du système nerveux. Les récepteurs Trk sont impliqués dans la signalisation des neurotrophines, essentielle à la survie, à la différenciation et à la croissance des neurones. La dérégulation de la signalisation Trk est associée à des troubles neurologiques et à certains cancers. Chez CymitQuimica, nous proposons des inhibiteurs de récepteurs Trk pour soutenir vos recherches en neurobiologie, oncologie et maladies neurodégénératives.
Produits appartenant à la catégorie "Récepteur Trk"
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TRK II-IN-1
CAS :TRK II-IN-1: potent type II TRK inhibitor; IC50s: TRKA (3.3 nM), TRKB (6.4 nM), TRKC (4.3 nM), TRKA G667C (9.4 nM); also targets FLT3, RET, VEGFR2.Formule :C29H31F3N8ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :564.6BNN-20
CAS :BNN-20 is a synthetic micro-neurotrophic factor that mimics Brain-Derived Neurotrophic Factor (BDNF) and exhibits region-specific neuroprotective and neurogenesis-promoting effects. It is applicable in research related to Parkinson's disease.Formule :C20H30O2Couleur et forme :SolidMasse moléculaire :302.45Entrectinib
CAS :Entrectinib (RXDX-101) is an orally Trk, ROS1, and ALK inhibitor. Entrectinib exhibits antitumor activity. Cost-effective and quality-assured.Formule :C31H34F2N6O2Degré de pureté :98.03% - 99.61%Couleur et forme :SolidMasse moléculaire :560.64Ref: TM-T3678
2mg42,00€5mg59,00€10mg88,00€25mg111,00€50mg168,00€100mg283,00€500mg692,00€1mL*10mM (DMSO)69,00€Protein kinase inhibitor 5 sulfate hydrate
Protein kinase inhibitor 5 sulfate hydrate, a potent TRK-A inhibitor, exhibits an IC50 of 1.8 nM and impairs cell viability [1].Formule :C29H35F2N7O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :647.69Sitravatinib
CAS :Sitravatinib (MGCD516) (MGCD516) is an inhibitor targeting multiple RTKs involved in driving sarcoma cell growth, including c-Met, c-Kit, PDGFRα/β, PDGFR, andFormule :C33H29F2N5O4SDegré de pureté :98.9% - 99.74%Couleur et forme :SolidMasse moléculaire :629.68Ref: TM-T4349
5mg51,00€10mg79,00€25mg137,00€50mg210,00€100mg338,00€200mg535,00€500mg845,00€1mL*10mM (DMSO)72,00€GNF-5837
CAS :GNF-5837 is a specific, and orally bioavailable pan-TRK inhibitor for TrkA/TrkB (IC50: 8/12 nM).Formule :C28H21F4N5O2Degré de pureté :96.17% - 99.29%Couleur et forme :SolidMasse moléculaire :535.49Ref: TM-T6097
5mg50,00€10mg85,00€25mg124,00€50mg188,00€100mg311,00€200mg404,00€500mg657,00€1mL*10mM (DMSO)56,00€ALE-0540
CAS :ALE-0540: nonpeptidic heterocycle, blocks NGF binding to p75/TrkA and TrkA-mediated signaling.Formule :C14H11N3O5Degré de pureté :97.25%Couleur et forme :SolidMasse moléculaire :301.25Ref: TM-T9292
2mg35,00€5mg55,00€10mg88,00€25mg133,00€50mg188,00€100mg269,00€200mg369,00€1mL*10mM (DMSO)60,00€TrkB-IN-1
CAS :TrkB-IN-1 is a potent, orally active agonist of the TrkB receptor, with favorable pharmacokinetic (PK) properties.Formule :C19H16N2O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :368.34Type II TRK inhibitor 1
CAS :Type II TRK Inhibitor 1 is a potent inhibitor targeting multiple tropomyosin receptor kinase (TRK) fusion protein variants as well as the wild type.Formule :C35H33F3N8O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :670.68TrkA-IN-1
CAS :TrkA-IN-1 is a potent and selective inhibitor of Tropomyosin-related kinase A (TrkA) (IC50: 99 nM in a cell-based assay) with analgesic activity.Formule :C25H20N4ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :392.45Protein kinase inhibitor 5
CAS :Protein kinase inhibitor 5 is a potent inhibitor of TRK-A, demonstrating an IC50 of 1.8 nM, and effectively suppresses cell viability [1].Formule :C29H31F2N7ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :531.6CH7057288
CAS :CH7057288 is an effective and selective TRK inhibitor with an IC50 value of 1.1 nM, 7.8 nM and 5.1 nM for TRKA, TRKB and TRKC, respectively.Formule :C32H31N3O5SDegré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :569.67Selitrectinib
CAS :Selitrectinib (LOXO-195) is a potent and selective inhibitor of the receptor tyrosine kinases(TRK).Cost-effective and quality-assured.Formule :C20H21FN6ODegré de pureté :99.55% - ≥95%Couleur et forme :SolidMasse moléculaire :380.42PF-06273340
CAS :PF-06273340 是一种口服具有活力的、具有选择性的外周限制性Trk 泛抑制剂。Formule :C23H22ClN7O3Degré de pureté :98% - 98.00%Couleur et forme :SolidMasse moléculaire :479.92ENT-C225
CAS :ENT-C225 is a potent TrkB neurotrophin receptor (TrkBR) activator with neuroprotective activity for the study of Alzheimer's disease and Parkinson's disease.Formule :C26H40N4O5Degré de pureté :99.16% - 99.16%Couleur et forme :SolidMasse moléculaire :488.62ONO-7475
CAS :ONO-7475 is an inhibitor with high specificity for anexelekto and MER tyrosine kinaseFormule :C32H26N4O6Degré de pureté :98.74%Couleur et forme :SolidMasse moléculaire :562.57ANA-12
CAS :ANA-12 is a potent and selective TrkB antagonist with anxiolytic and antidepressant activity in mice.Formule :C22H21N3O3SDegré de pureté :99.28% - 99.87%Couleur et forme :SolidMasse moléculaire :407.49NMS-P626
CAS :NMS-P626 functions as an inhibitor targeting TRKA, TRKB, and TRKC, exhibiting IC 50 values of 8 nM, 7 nM, and 3 nM respectively. It effectively suppresses KM12 cell growth by inhibiting the phosphorylation of TPM3-TRKA and the subsequent downstream signaling, demonstrating an IC 50 of 19 nM specifically for KM12 cells. This compound is applicable in the study of colorectal cancer.Formule :C28H35F2N7O4SCouleur et forme :SolidMasse moléculaire :603.68Larotrectinib
CAS :Larotrectinib (LOXO-101) is an orally administered inhibitor of the TRK kinase and is highly selective only for the TRK family of receptors(IC50s = 2-20 nM).Formule :C21H22F2N6O2Degré de pureté :100% - 99.15%Couleur et forme :SolidMasse moléculaire :428.44Ref: TM-T5995
1mg39,00€5mg79,00€10mg96,00€25mg165,00€50mg250,00€100mg376,00€500mg867,00€1mL*10mM (DMSO)86,00€LM22B-10
CAS :LM22B-10 is an activator of TrkB/TrkC neurotrophin receptor and can induce TrkB, TrkC, ERK and AKT activation in vitro and in vivo.Formule :C27H33ClN2O4Degré de pureté :98.18%Couleur et forme :SolidMasse moléculaire :485.01LM22A-4
CAS :LM22A-4: BDNF mimetic, TrkB agonist, IC50=47 nM (fluorescence anisotropy).Formule :C15H21N3O6Degré de pureté :99.56%Couleur et forme :SolidMasse moléculaire :339.34Tyrphostin AG 879
CAS :Tyrphostin AG 879 (AG 879) effectively inhibits HER2/ErbB2 (IC50: 1 μM), 100- and 500-fold higher selective to ErbB2 than EGFR and PDGFR.Formule :C18H24N2OSDegré de pureté :99.05%Couleur et forme :SolidMasse moléculaire :316.46PF-06733804
CAS :PF-06733804 is a potent inhibitor of pan-Trk in cell-based assays (IC50s: 8.4 nM, 6.2 nM, and 2.2 nM for TrkA, TrkB, and TrkC) with anti-hyperalgesic effect.Formule :C20H19F5N4O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :474.38CG 428
CAS :CG 428 is a potent tropomyosin receptor Kinase (TRK) Degrader (uSMITETM) with a DC50 of 0.36 nM.Formule :C43H43FN10O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :814.86Ref: TM-T41224
1mg170,00€5mg423,00€10mg623,00€25mg938,00€50mg1.311,00€100mg1.786,00€500mg3.591,00€1mL*10mM (DMSO)437,00€Paltimatrectinib
CAS :Paltimatrectinib (PBI-200) is a tyrosine kinase inhibitor with anticancer activity, and is used in the study of bladder, breast, and colorectal cancers.Formule :C20H15F5N6Degré de pureté :99.96%Couleur et forme :SolidMasse moléculaire :434.37Multi-kinase-IN-6
Multi-kinase-IN-6 (compound 10e) is a multikinase inhibitor that effectively impedes the activity of TrkA, ALK2, c-KIT, EGFR, PIM1, CK2α, CHK1, and CDK2.Degré de pureté :98%Couleur et forme :Odour SolidLarotrectinib sulfate
CAS :Larotrectinib sulfate (LOXO-101 sulfate) is an oral active and specific ATP-competitive inhibitor of tropomyosin receptor kinases (TRK).Formule :C21H22F2N6O2·H2O4SDegré de pureté :98.62% - 99.69%Couleur et forme :SolidMasse moléculaire :526.51Ref: TM-T6880
2mg39,00€5mg57,00€10mg93,00€25mg131,00€50mg163,00€100mg274,00€500mg658,00€1mL*10mM (DMSO)66,00€GW 441756
CAS :GW 441756 is a specific Tropomyosin-related kinase A (TrkA) inhibitor with an IC50 value of 2 nM.Formule :C17H13N3ODegré de pureté :97.73% - 99.8%Couleur et forme :SolidMasse moléculaire :275.3TrkA-IN-8
CAS :TrkA-IN-8 (Compound 2) is a TrkA inhibitor with a Kd value of 3.3 µM. RTKs-IN-1 demonstrates a concentration-dependent inhibitory effect on the proliferation of lung cancer cell lines and holds potential for research in non-small cell lung cancer.Formule :C20H16N4Couleur et forme :SolidMasse moléculaire :312.368Amitriptyline hydrochloride
CAS :Amitriptyline hydrochloride (Annoyltin) is the hydrochloride salt of the tricyclic dibenzocycloheptadiene amitriptyline with antidepressant and antinociceptiveFormule :C20H24ClNDegré de pureté :97% - 99.94%Couleur et forme :Crystals White To Off-White PowderMasse moléculaire :313.86Repotrectinib
CAS :Repotrectinib (TPX-0005) is a potent ALK/ROS1/TRK inhibitor, with IC50 of 1.01/5.3/1.08/1.26 nM for WT ALK, SRC, ALK L1196M and ALK G1202R, respectively.Formule :C18H18FN5O2Degré de pureté :100% - 99.92%Couleur et forme :SolidMasse moléculaire :355.37Ref: TM-T4071
1mg49,00€2mg70,00€5mg96,00€10mg169,00€25mg296,00€50mg474,00€100mg688,00€1mL*10mM (DMSO)100,00€DS-1205
CAS :DS-1205: AXL kinase inhibitor (IC50=1.3 nM), also targets MER, MET, TRKA (IC50s: 63, 104, 407 nM), hinders cell migration and tumor growth.Formule :C41H42FN5O7Degré de pureté :99.28%Couleur et forme :SolidMasse moléculaire :735.8TRK-IN-23
CAS :TRK-IN-23 (compound 24b) is a potent, orally active inhibitor of TRK with IC50s of 0.5 nM for TRKA, 9 nM for TRKC, 14 nM for TRKA G595R, 4.4 nM for TRKA F589L,Formule :C20H17FN4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :364.37CE-245677
CAS :CE-245677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases. With a cellular IC50s of 4.7 and 1 nM.Formule :C24H22Cl2N6O3Degré de pureté :98.99% - 99.23%Couleur et forme :SolidMasse moléculaire :513.38Ref: TM-T14921
1mg62,00€2mg87,00€5mg119,00€10mg187,00€25mg313,00€50mg432,00€100mg638,00€1mL*10mM (DMSO)136,00€Anti-TrkB/NTRK2 Antibody
Anti-TrkB/NTRK2 Antibody is a human-derived antibody produced in CHO cells, targeting TrkB. For the isotype control of Anti-TrkB/NTRK2 Antibody, refer to HumanIgG2kappa, Isotype Control.Couleur et forme :Odour LiquidHS-345
CAS :HS-345, a TrkA/Akt inhibitor, exhibits potent anti-pancreatic cancer properties. This compound inhibits the growth and proliferation of pancreatic cancer cells by blocking the TrkA/Akt signaling pathway and induces cell apoptosis (Apoptosis). Additionally, HS-345 inhibits angiogenesis by reducing the expression of HIF-1α and VEGF. It holds promise for use in pancreatic cancer research.Formule :C19H18N6O2SCouleur et forme :SolidMasse moléculaire :394.45BMS-754807
CAS :BMS-754807 is an oral IGF-1R/InsR inhibitor with potential anti-cancer properties.Formule :C23H24FN9ODegré de pureté :98.86%Couleur et forme :SolidMasse moléculaire :461.49Ref: TM-T2349
1mg49,00€2mg70,00€5mg96,00€10mg166,00€25mg328,00€50mg537,00€100mg772,00€1mL*10mM (DMSO)116,00€LOXO-195
CAS :(6RS)-LOXO-195 (BAY 2731954) is a potent and selective Trk tyrosine kinase inhibitor.Formule :C20H21FN6ODegré de pureté :97.92%Couleur et forme :SolidMasse moléculaire :380.42PF-06737007
CAS :PF-06737007 is an effective inhibitor of pan-Trk in cell-based assays (IC50s: 7.7 nM, 15 nM, and 3.9 nM for TrkA, TrkB, and TrkC, respectively).Formule :C25H28F4N2O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :528.49Altiratinib
CAS :Altiratinib (DCC-2701)(DCC-2701) is a novel c-MET/TIE-2/VEGFR inhibitor; effectively reduce tumor burden in vivo and block c-MET pTyr(1349)-mediated signaling,Formule :C26H21F3N4O4Degré de pureté :98.98% - 99.39%Couleur et forme :SolidMasse moléculaire :510.46Tepotinib
CAS :Tepotinib (EMD-1214063) is a selective, orally, and ATP-competitive c-MET tyrosine kinase inhibitor. Tepotinib has antitumor effect. Cost-effective and quality-assured.Formule :C29H28N6O2Degré de pureté :98% - 99.91%Couleur et forme :SolidMasse moléculaire :492.57Ref: TM-T6121
1mg42,00€2mg55,00€5mg88,00€10mg127,00€25mg235,00€50mg395,00€100mg558,00€200mg810,00€1mL*10mM (DMSO)96,00€Belizatinib
CAS :Belizatinib (TSR-011) is an effective, oral and dual inhibitor of ALK (IC50: 0.7 nM, wild-type recombinant ALK) and TRKA, TRKB, and TRKC.Formule :C33H44FN5O3Degré de pureté :99.33% - 99.44%Couleur et forme :SolidMasse moléculaire :577.73Ref: TM-T4257
1mg43,00€2mg57,00€5mg87,00€10mg140,00€25mg274,00€50mg378,00€100mg528,00€1mL*10mM (DMSO)111,00€7,8-Dihydroxyflavone
CAS :7,8-Dihydroxyflavone (7,8-DHF) is a naturally-occurring flavone and exist in Tridax procumbens, Godmania aesculifolia, and primula tree leaves.Formule :C15H10O4Degré de pureté :98.37% - 99.81%Couleur et forme :SolidMasse moléculaire :254.24Trk-IN-4
CAS :Trk-IN-4 is an effective pan-Trk inhibitor in cell-based assays (IC50s: 1.9 nM, 2.6 nM, and 1.1 nM for TrkA, TrkB, and TrkC, respectively).Formule :C24H23F4N5O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :521.46ONO-7579
CAS :ONO-7579, an orally active TRKA inhibitor, effectively suppresses tumor growth by inhibiting TRKA phosphorylation. In KM12 colorectal cancer cells, it exhibits an EC 50 of 17.6 ng/g, indicating that a concentration of 17.6 ng per gram of tumor tissue reduces the activity of phosphorylated TRKA by 50%. This compound is utilized in cancer research.Formule :C24H18ClF3N6O4SCouleur et forme :SolidMasse moléculaire :578.95Milciclib
CAS :Milciclib (PHA-848125) is a potent CDK2 inhibitor with a 45 nM IC50, selective over CDK1/2/4/5/7. In Phase 2 trials.Formule :C25H32N8ODegré de pureté :99.28%Couleur et forme :SolidMasse moléculaire :460.57Ref: TM-T6081
1mg51,00€5mg106,00€10mg177,00€25mg376,00€50mg603,00€100mg905,00€200mg1.216,00€1mL*10mM (DMSO)110,00€Tavilermide
CAS :Tavilermide (MIM-D3) is a selective TrkA agonist, a cyclic mimetic, which can be used to study dry keratoconjunctivitis and dry eye syndrome.Formule :C24H32N6O11Degré de pureté :98.98%Couleur et forme :SolidMasse moléculaire :580.54Ensartinib hydrochloride
CAS :Ensartinib hydrochloride (X-396 dihydrochloride) is a potent new-generation ALK inhibitor with high activity against CNS metastases and a broad range of knownFormule :C26H29Cl4FN6O3Degré de pureté :98.73%Couleur et forme :SolidMasse moléculaire :634.36Ref: TM-T22324
1mg66,00€2mg93,00€5mg144,00€10mg227,00€25mg464,00€50mg677,00€100mg938,00€1mL*10mM (DMSO)188,00€N-Acetyl-5-hydroxytryptamine
CAS :N-Acetyl-5-hydroxytryptamine, or Normelatonin, is melatonin's precursor, made from serotonin, and activates TrkB receptor.Formule :C12H14N2O2Degré de pureté :98.03% - 99.91%Couleur et forme :SolidMasse moléculaire :218.25TRK-IN-24
CAS :TRK-IN-24 (compound 10g) is a selective inhibitor of Trk receptors, effectively targeting TRKA, TRKC, and mutant forms TRKA G595R, TRKA G667C, and TRKA F589L,Formule :C39H45N7O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :659.82
