c-Met/HGFR
Les inhibiteurs de c-Met/HGFR ciblent le Récepteur du Facteur de Croissance des Hépatocytes (c-Met), une tyrosine kinase impliquée dans des processus cellulaires tels que la croissance, la motilité et la morphogenèse. La signalisation de c-Met est impliquée dans la progression du cancer, la métastase et la résistance aux thérapies. Inhiber c-Met peut perturber la croissance et la propagation des tumeurs, faisant de ces inhibiteurs des outils précieux dans la recherche sur le cancer. Chez CymitQuimica, nous proposons des inhibiteurs de c-Met/HGFR pour soutenir vos recherches en oncologie, métastase et thérapies ciblées contre le cancer.
Produits appartenant à la catégorie "c-Met/HGFR"
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Canlitinib
CAS :Canlitinib, a tyrosine kinase inhibitor, holds potential for cancer research.Formule :C33H31F2N3O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :619.61SRI 31215 TFA
CAS :SRI 31215 TFA acts as a triplex inhibitor of matriptase, hepsin and HGFA and mimics the activity of HAI-1/2, endogenous inhibitors of HGF activation.Formule :C27H34F3N5O3Degré de pureté :98.25% - 99.97%Couleur et forme :SolidMasse moléculaire :533.6Ref: TM-T5478
1mg43,00€5mg96,00€10mg135,00€25mg261,00€50mg391,00€100mg557,00€200mg753,00€1mL*10mM (DMSO)101,00€1D228
1D228, a c-Met/TRK inhibitor with antitumor properties, suppresses cyclin D1 to precipitate G0/G1 arrest, thereby inhibiting proliferation and migration ofDegré de pureté :98%Couleur et forme :Odour SolidCEP-40783
CAS :CEP-40783 (RXDX-106) is an effective, specific and orally active AXL/c-Met inhibitor (IC50: 7/12 nM). It also inhibits MER and TYRO3 (IC50: 29/19 nM).Formule :C31H26F2N4O6Degré de pureté :99.45% - 99.64%Couleur et forme :SolidMasse moléculaire :588.56Merestinib
CAS :Merestinib (LY2801653) is an orally available, small molecule inhibitor of the proto-oncogene c-Met (Ki: 2 nM) with potential antineoplastic activity.Formule :C30H22F2N6O3Degré de pureté :95% - 99.56%Couleur et forme :SolidMasse moléculaire :552.53Ref: TM-T3455
1mg49,00€2mg70,00€5mg105,00€10mg144,00€25mg254,00€50mg424,00€100mg605,00€500mg1.264,00€1mL*10mM (DMSO)126,00€PF-04217903
CAS :MET Tyrosine Kinase Inhibitor PF-04217903 is an orally bioavailabe, small-molecule tyrosine kinase inhibitor with potential antineoplastic activity.Formule :C19H16N8ODegré de pureté :98.41% - 98.55%Couleur et forme :SolidMasse moléculaire :372.38Ref: TM-T2676
1mg38,00€2mg49,00€5mg73,00€10mg97,00€25mg172,00€50mg288,00€100mg520,00€1mL*10mM (DMSO)79,00€Afatinib
CAS :Afatinib (BIBW 2992) is an irreversible and orally EGFR family inhibitor that inhibits EGFR and HER2. Afatinib has antitumor activity. Cost effective and quality assured.Formule :C24H25ClFN5O3Degré de pureté :97.56% - 99.9%Couleur et forme :Off-White SolidMasse moléculaire :485.94Ref: TM-T21312
5mg35,00€10mg51,00€25mg86,00€50mg115,00€100mg144,00€200mg177,00€500mg300,00€1mL*10mM (DMSO)52,00€PROTAC c-Met degrader-1
CAS :PROTACc-Met degrader-1 (Compound Met-DD4) is an orally effective PROTAC degrader targeting c-Met with a DC50 of 6.21 nM. It inhibits the proliferation of c-Met-addicted MKN-45 cells with an IC50 of 4.37 nM and causes cell cycle arrest in the G0/G1 phase. In a xenograft mouse model using MKN-45 cells, PROTACc-Met degrader-1 demonstrates antitumor activity.Formule :C45H41FN10O5Couleur et forme :SolidMasse moléculaire :820.87Onartuzumab
CAS :Onartuzumab (MetMAb) is a humanized monoclonal antibody targeting c-MET, with antitumor effects by blocking HGF and signal transduction.Degré de pureté :97.3%Couleur et forme :LiquidMasse moléculaire :146.99 kDaEmibetuzumab
CAS :Emibetuzumab: potent humanized MET antibody, antitumor, inhibits HGF/MET pathways, for advanced prostate cancer research.Degré de pureté :SDS-PAGE:96.2%;SEC-HPLC:98.8%Couleur et forme :LiquidMasse moléculaire :143.74 kDaCabozantinib
CAS :Cabozantinib (XL184) is a multi-targeted tyrosine kinase receptor inhibitor that inhibits VEGFR2, c-Met, Kit, Axl, and Flt3 (IC50=0.035/1.3/4.6/7/11.3 nM).Formule :C28H24FN3O5Degré de pureté :99.59% - 99.88%Couleur et forme :SolidMasse moléculaire :501.51Crizotinib hydrochloride
CAS :Crizotinib hydrochloride (PF-02341066 hydrochloride) is a novel inhibitor of anaplastic lymphoma kinase and c-Met(IC50s of 20 and 8 nM)Formule :C21H23Cl3FN5ODegré de pureté :98.73% - 98.87%Couleur et forme :SolidMasse moléculaire :486.8Ref: TM-T8399
5mg37,00€10mg52,00€25mg82,00€50mg99,00€100mg138,00€200mg171,00€500mg227,00€1mL*10mM (DMSO)59,00€c-met-IN-1
CAS :c-met-IN-1 is a potent and selective c-Met inhibitor (IC50: 1.1 nM) with antitumor activity.Formule :C35H37FN6O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :640.7Hepln-13
CAS :Hepln-13 is a hepsin inhibitor that acts by hindering prostate cancer bone metastasis.Formule :C17H13BrN2Degré de pureté :97.67%Couleur et forme :SolidMasse moléculaire :325.2Ref: TM-T25492
1mg38,00€2mg50,00€5mg85,00€10mg126,00€25mg245,00€50mg364,00€100mg507,00€200mg700,00€1mL*10mM (DMSO)96,00€Crizotinib
CAS :Crizotinib (PF-02341066) is an ATP-competitive small-molecule tyrosine kinases inhibitor of c-MET (IC50: 8 nM) and ALK (IC50: 20 nM) receptor.Formule :C21H22Cl2FN5ODegré de pureté :99% - 99.87%Couleur et forme :SolidMasse moléculaire :450.34Narnatumab
CAS :Narnatumab (IMC-RON8) is a humanized antibody targeting the macrophage-stimulating receptor (RON) with antitumor activity, used in advanced malignant solid tumors research.Couleur et forme :LiquidSYN1143
CAS :SYN1143 (AMG-1) strongly inhibits RON & c-Met with IC50s: 9 & 4 nmol/L.Formule :C31H29FN4O5Degré de pureté :98.86%Couleur et forme :SolidMasse moléculaire :556.58SU11274
CAS :SU11274 (Met Kinase Inhibitor)(IC50=10 nM) is a specific Met inhibitor. It shows no significant effects on PGDFRβ, EGFR or Tie2.Formule :C28H30ClN5O4SDegré de pureté :98.62% - 99.44%Couleur et forme :Orange PowderMasse moléculaire :568.09Ref: TM-T6154
1mg47,00€2mg59,00€5mg97,00€10mg150,00€25mg283,00€50mg465,00€100mg688,00€1mL*10mM (DMSO)150,00€SAR125884 hydrochlorid (1116743-46-4(free base))
CAS :SAR125844 is a potent and selective MET kinase inhibitor with a favorable preclinical toxicity profile,(IC50=4.2 nM).Formule :C25H23FN8O2S2·HClDegré de pureté :97.95%Couleur et forme :SolidMasse moléculaire :587Ref: TM-T5677
1mg38,00€5mg60,00€10mg90,00€25mg188,00€50mg279,00€100mg395,00€200mg567,00€1mL*10mM (DMSO)101,00€Glumetinib
CAS :Glumetinib (SCC244) (SCC 244) is a novel potent and selective inhibitor of c-Met kinase (IC50: 0.42 nM).Formule :C21H17N9O2SDegré de pureté :99.79%Couleur et forme :SolidMasse moléculaire :459.48
