c-Met/HGFR
Les inhibiteurs de c-Met/HGFR ciblent le Récepteur du Facteur de Croissance des Hépatocytes (c-Met), une tyrosine kinase impliquée dans des processus cellulaires tels que la croissance, la motilité et la morphogenèse. La signalisation de c-Met est impliquée dans la progression du cancer, la métastase et la résistance aux thérapies. Inhiber c-Met peut perturber la croissance et la propagation des tumeurs, faisant de ces inhibiteurs des outils précieux dans la recherche sur le cancer. Chez CymitQuimica, nous proposons des inhibiteurs de c-Met/HGFR pour soutenir vos recherches en oncologie, métastase et thérapies ciblées contre le cancer.
Produits appartenant à la catégorie "c-Met/HGFR"
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Capmatinib xHCl
CAS :Capmatinib xHCl (INCB28060) is a potent, orally active, selective, and ATP competitive c-Met kinase inhibitor, potently blocking in vitro kinase activity (IC50Formule :C23H18ClFN6ODegré de pureté :98.62% - 99.12%Couleur et forme :SolidMasse moléculaire :448.89Telisotuzumab
CAS :Telisotuzumab(ABT-700) is a humanized recombinant antibody targeting the therapeutic hepatocyte growth factor receptor (MET) with high affinity for c-Met.Degré de pureté :SDS-PAGE:96.4%;SEC-HPLC:98.5%Couleur et forme :LiquidMasse moléculaire :145.50 kDaTerevalefim
CAS :Terevalefim (ANG-3777) is an hepatocyte growth factor (HGF) mimetic. Terevalefim selectively activates the c-Met receptor.Formule :C9H8N2SDegré de pureté :99.53%Couleur et forme :SolidMasse moléculaire :176.24Ref: TM-T37596
1mg56,00€5mg119,00€10mg210,00€25mg369,00€50mg537,00€100mg750,00€500mg1.539,00€1mL*10mM (DMSO)119,00€BMS 777607
CAS :BMS 777607 (BMS 817378) is a Met-related inhibitor for c-Met/Axl/Ron/Tyro3. BMS-777607 has been investigated for the basic science of Malignant Solid Tumour.Formule :C25H19ClF2N4O4Degré de pureté :100% - 99.89%Couleur et forme :SolidMasse moléculaire :512.89Ref: TM-T2699
1mg35,00€5mg79,00€10mg124,00€25mg217,00€50mg359,00€100mg533,00€500mg1.169,00€1mL*10mM (DMSO)92,00€Tyrosine kinase inhibitor
CAS :Tyrosine kinase inhibitor is a tyrosine kinase inhibitor used in combination with fragmenting aromatic nitrogen compounds as antiproliferative agents.Formule :C31H31FN6O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :586.61CSF1R-IN-2
CAS :CSF1R-IN-2 is an oral-active SRC, MET and c-FMS inhibitor (IC50s: 0.12 nM, 0.14 nM and 0.76 nM for SRC, MET and c-FMS respectively).Formule :C20H20FN7O2Degré de pureté :99.29%Couleur et forme :SolidMasse moléculaire :409.42C-Met inhibitor D9
CAS :C-Met inhibitor D9 is a c-Met kinase inhibitor.Formule :C17H15N3O2Degré de pureté :97%Couleur et forme :SolidMasse moléculaire :293.32BMS-794833
CAS :BMS-794833 is a potent ATP competitive inhibitor of Met/VEGFR2; a prodrug of BMS-817378.Formule :C23H15ClF2N4O3Degré de pureté :98% - 99.69%Couleur et forme :SolidMasse moléculaire :468.84Ref: TM-T2419
1mg42,00€2mg52,00€5mg88,00€10mg150,00€25mg296,00€50mg537,00€100mg772,00€1mL*10mM (DMSO)95,00€LMTK3-IN-1
CAS :Lmtk3-in-1 is a potent ATP-competitive lemur tyrosine kinase 3 (LMTK3) (Kd=2.5 μM) inhibitor that degrades LMTK3 through the ubiquitin proteasome pathway.Formule :C18H11F3N4ODegré de pureté :100%Couleur et forme :SoildMasse moléculaire :356.3SCR-1481B1
CAS :SCR-1481B1 (c-Met inhibitor 2) has activity against cancers dependent on Met activation and also has activity against cancers as a VEGFR inhibitorFormule :C32H40ClF2N6O13PDegré de pureté :98.07%Couleur et forme :SolidMasse moléculaire :821.12Ref: TM-T5349
1mg38,00€2mg49,00€5mg79,00€10mg119,00€25mg210,00€50mg350,00€100mg522,00€1mL*10mM (DMSO)107,00€XL092
CAS :XL092 (JUN04542) is an Axl Mer cMet KDR inhibitor for the treatment of Axl and Mer receptor tyrosine kinase- dependent disorders.Formule :C29H25FN4O5Degré de pureté :98.60%Couleur et forme :SolidMasse moléculaire :528.53Ensartinib hydrochloride
CAS :Ensartinib hydrochloride (X-396 dihydrochloride) is a potent new-generation ALK inhibitor with high activity against CNS metastases and a broad range of knownFormule :C26H29Cl4FN6O3Degré de pureté :98.73%Couleur et forme :SolidMasse moléculaire :634.36Ref: TM-T22324
1mg66,00€2mg93,00€5mg144,00€10mg227,00€25mg464,00€50mg677,00€100mg938,00€1mL*10mM (DMSO)188,00€JNJ-38877605
CAS :JNJ-38877605 is an ATP-competitive c-Met inhibitor (IC50: 4 nM), 600-fold selective for c-Met than 200 other tyrosine and serine-threonine kinases.Formule :C19H13F2N7Degré de pureté :97.04% - 98.27%Couleur et forme :SolidMasse moléculaire :377.35EGFR-IN-8
CAS :EGFR-IN-8, a dual inhibitor targeting both EGFR and c-Met, shows potential as a promising candidate for further development in treating EGFR TKI-resistant NSCLCFormule :C32H23ClF3N7O4Degré de pureté :97.45%Couleur et forme :SolidMasse moléculaire :662.02Glesatinib hydrochloride
CAS :Glesatinib hydrochloride is an orally active and potent dual inhibitor of MET/SMO.Formule :C31H28ClF2N5O3S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :656.16NPS-1034
CAS :NPS-1034 is a dual Met/Axl inhibitor with IC50 of 48 nM and 10.3 nM, respectively.Formule :C31H23F2N5O3Degré de pureté :98.48%Couleur et forme :SolidMasse moléculaire :551.54Ningetinib Tosylate
CAS :Ningetinib Tosylate is an orally bioavailable tyrosine kinase inhibitor with IC50s of <1.0, 1.9 and 6.7 nM for Axl, VEGFR2, and c-Met, respectively.Formule :C38H37FN4O8SDegré de pureté :99.93%Couleur et forme :SolidMasse moléculaire :728.79PF-04217903 phenolsulfonate
CAS :PF-04217903 phenolsulfonate is a potent ATP-competitive inhibitor of c-Met kinase (Ki of 4.8 nM for human c-Met).Formule :C25H22N8O5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :546.56Savolitinib
CAS :Savolitinib (Volitinib) (AZD-6094) is an effective, selective, and orally bioavailable c-Met inhibitor (IC50s: 5 nM/3 nM for c-Met/p-Met).Formule :C17H15N9Degré de pureté :98.12%Couleur et forme :SolidMasse moléculaire :345.36Ref: TM-TQ0210
1mg49,00€2mg64,00€5mg92,00€10mg131,00€25mg210,00€50mg373,00€100mg567,00€1mL*10mM (DMSO)97,00€SAR125844
CAS :SAR125844, a potent and highly selective inhibitor of the MET receptor tyrosine kinase (RTK), for intravenous administration. (IC50 value of 4.2 nmol/L)Formule :C25H23FN8O2S2Degré de pureté :98.39%Couleur et forme :SolidMasse moléculaire :550.63Ref: TM-T5467
1mg35,00€5mg79,00€10mg116,00€25mg227,00€50mg364,00€100mg588,00€200mg833,00€1mL*10mM (DMSO)96,00€
