c-Met/HGFR
Les inhibiteurs de c-Met/HGFR ciblent le Récepteur du Facteur de Croissance des Hépatocytes (c-Met), une tyrosine kinase impliquée dans des processus cellulaires tels que la croissance, la motilité et la morphogenèse. La signalisation de c-Met est impliquée dans la progression du cancer, la métastase et la résistance aux thérapies. Inhiber c-Met peut perturber la croissance et la propagation des tumeurs, faisant de ces inhibiteurs des outils précieux dans la recherche sur le cancer. Chez CymitQuimica, nous proposons des inhibiteurs de c-Met/HGFR pour soutenir vos recherches en oncologie, métastase et thérapies ciblées contre le cancer.
Produits appartenant à la catégorie "c-Met/HGFR"
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Capmatinib
CAS :Capmatinib (INCB28060) is an orally bioavailable inhibitor of the proto-oncogene c-Met (HGFR)with potential antineoplastic activity.Formule :C23H17FN6ODegré de pureté :99.24%Couleur et forme :SolidMasse moléculaire :412.42Capmatinib 2HCl.H2O
CAS :Capmatinib 2HCl.H2O (NVP-INC280 2HCl.H2O) is an orally bioavailable inhibitor of the proto-oncogene c-Met (HGFR)with potential antineoplastic activity.Formule :C23H21Cl2FN6O2Degré de pureté :99.77%Couleur et forme :SolidMasse moléculaire :503.36Ref: TM-T8825
2mg35,00€5mg49,00€10mg69,00€25mg115,00€50mg177,00€100mg283,00€200mg378,00€1mL*10mM (DMSO)56,00€Foretinib
CAS :Foretinib (GSK1363089) is a broad-spectrum tyrosine kinase inhibitor with IC50s of 0.4 nM and 0.9 nM for Met and KDR.Formule :C34H34F2N4O6Degré de pureté :98.07% - 99.68%Couleur et forme :SolidMasse moléculaire :632.65Ref: TM-T3113
2mg39,00€5mg57,00€10mg79,00€25mg133,00€50mg207,00€100mg354,00€500mg848,00€1mL*10mM (DMSO)79,00€Antitumor agent-111
Antitumor Agent-111 (Compound 46), a c-Met kinase inhibitor (IC50 = 46 nM), exhibits both antitumor and antiproliferative effects.Formule :C34H29ClF2N6O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :675.08Pamufetinib
CAS :Pamufetinib (TAS-115) is a potent inhibitor of VEGFR and hepatocyte growth factor receptor (c-Met/HGFR)-targeted kinase.Formule :C27H23FN4O4SDegré de pureté :99.39%Couleur et forme :SolidMasse moléculaire :518.56Ref: TM-T13108
1mg50,00€5mg106,00€10mg158,00€25mg258,00€50mg379,00€100mg538,00€200mg733,00€1mL*10mM (DMSO)134,00€Herbacetin
CAS :1.Formule :C15H10O7Degré de pureté :96.89% - 99.51%Couleur et forme :SolidMasse moléculaire :302.24JNJ-38877618
CAS :JNJ-38877618 (OMO-1) is an effective and highly selective inhibitor of Met kinase (IC50s: 2 and 3 nM for wild type and mutant Met, respectively).Formule :C20H12F2N6Degré de pureté :98.84% - 99.52%Couleur et forme :SolidMasse moléculaire :374.35Ref: TM-T15617
1mg63,00€2mg89,00€5mg137,00€10mg210,00€25mg424,00€50mg627,00€100mg893,00€500mg1.786,00€1mL*10mM (DMSO)153,00€Rilotumumab
CAS :Rilotumumab (AMG 102) is an HGF-targeting antibody, inhibits HGF/MET signaling, and is used for CRPC and gastric cancer research.Degré de pureté :SDS-PAGE:95% SEC-HPLC:97.51%Couleur et forme :LiquidMasse moléculaire :145.2 kDaAltiratinib
CAS :Altiratinib (DCC-2701)(DCC-2701) is a novel c-MET/TIE-2/VEGFR inhibitor; effectively reduce tumor burden in vivo and block c-MET pTyr(1349)-mediated signaling,Formule :C26H21F3N4O4Degré de pureté :98.98% - 99.39%Couleur et forme :SolidMasse moléculaire :510.46BAY-474
CAS :BAY-474 is an inhibitor of tyrosine-protein kinase c-Met. It acts as an epigenetics probeFormule :C17H15N5Degré de pureté :98.98%Couleur et forme :SolidMasse moléculaire :289.33Ref: TM-T7900
1mg50,00€5mg97,00€10mg170,00€25mg306,00€50mg444,00€100mg620,00€200mg835,00€1mL*10mM (DMSO)114,00€Capmatinib xHCl
CAS :Capmatinib xHCl (INCB28060) is a potent, orally active, selective, and ATP competitive c-Met kinase inhibitor, potently blocking in vitro kinase activity (IC50Formule :C23H18ClFN6ODegré de pureté :98.62% - 99.12%Couleur et forme :SolidMasse moléculaire :448.89Telisotuzumab
CAS :Telisotuzumab(ABT-700) is a humanized recombinant antibody targeting the therapeutic hepatocyte growth factor receptor (MET) with high affinity for c-Met.Degré de pureté :SDS-PAGE:96.4%;SEC-HPLC:98.5%Couleur et forme :LiquidMasse moléculaire :145.50 kDaTerevalefim
CAS :Terevalefim (ANG-3777) is an hepatocyte growth factor (HGF) mimetic. Terevalefim selectively activates the c-Met receptor.Formule :C9H8N2SDegré de pureté :99.53%Couleur et forme :SolidMasse moléculaire :176.24Ref: TM-T37596
1mg56,00€5mg119,00€10mg210,00€25mg369,00€50mg537,00€100mg750,00€500mg1.539,00€1mL*10mM (DMSO)119,00€BMS 777607
CAS :BMS 777607 (BMS 817378) is a Met-related inhibitor for c-Met/Axl/Ron/Tyro3. BMS-777607 has been investigated for the basic science of Malignant Solid Tumour.Formule :C25H19ClF2N4O4Degré de pureté :100% - 99.89%Couleur et forme :SolidMasse moléculaire :512.89Ref: TM-T2699
1mg35,00€5mg79,00€10mg124,00€25mg217,00€50mg359,00€100mg533,00€500mg1.169,00€1mL*10mM (DMSO)92,00€Tyrosine kinase inhibitor
CAS :Tyrosine kinase inhibitor is a tyrosine kinase inhibitor used in combination with fragmenting aromatic nitrogen compounds as antiproliferative agents.Formule :C31H31FN6O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :586.61CSF1R-IN-2
CAS :CSF1R-IN-2 is an oral-active SRC, MET and c-FMS inhibitor (IC50s: 0.12 nM, 0.14 nM and 0.76 nM for SRC, MET and c-FMS respectively).Formule :C20H20FN7O2Degré de pureté :99.29%Couleur et forme :SolidMasse moléculaire :409.42C-Met inhibitor D9
CAS :C-Met inhibitor D9 is a c-Met kinase inhibitor.Formule :C17H15N3O2Degré de pureté :97%Couleur et forme :SolidMasse moléculaire :293.32BMS-794833
CAS :BMS-794833 is a potent ATP competitive inhibitor of Met/VEGFR2; a prodrug of BMS-817378.Formule :C23H15ClF2N4O3Degré de pureté :98% - 99.69%Couleur et forme :SolidMasse moléculaire :468.84Ref: TM-T2419
1mg42,00€2mg52,00€5mg88,00€10mg150,00€25mg296,00€50mg537,00€100mg772,00€1mL*10mM (DMSO)95,00€LMTK3-IN-1
CAS :Lmtk3-in-1 is a potent ATP-competitive lemur tyrosine kinase 3 (LMTK3) (Kd=2.5 μM) inhibitor that degrades LMTK3 through the ubiquitin proteasome pathway.Formule :C18H11F3N4ODegré de pureté :100%Couleur et forme :SoildMasse moléculaire :356.3SCR-1481B1
CAS :SCR-1481B1 (c-Met inhibitor 2) has activity against cancers dependent on Met activation and also has activity against cancers as a VEGFR inhibitorFormule :C32H40ClF2N6O13PDegré de pureté :98.07%Couleur et forme :SolidMasse moléculaire :821.12Ref: TM-T5349
1mg38,00€2mg49,00€5mg79,00€10mg119,00€25mg210,00€50mg350,00€100mg522,00€1mL*10mM (DMSO)107,00€XL092
CAS :XL092 (JUN04542) is an Axl Mer cMet KDR inhibitor for the treatment of Axl and Mer receptor tyrosine kinase- dependent disorders.Formule :C29H25FN4O5Degré de pureté :98.60%Couleur et forme :SolidMasse moléculaire :528.53Ensartinib hydrochloride
CAS :Ensartinib hydrochloride (X-396 dihydrochloride) is a potent new-generation ALK inhibitor with high activity against CNS metastases and a broad range of knownFormule :C26H29Cl4FN6O3Degré de pureté :98.73%Couleur et forme :SolidMasse moléculaire :634.36Ref: TM-T22324
1mg66,00€2mg93,00€5mg144,00€10mg227,00€25mg464,00€50mg677,00€100mg938,00€1mL*10mM (DMSO)188,00€JNJ-38877605
CAS :JNJ-38877605 is an ATP-competitive c-Met inhibitor (IC50: 4 nM), 600-fold selective for c-Met than 200 other tyrosine and serine-threonine kinases.Formule :C19H13F2N7Degré de pureté :97.04% - 98.27%Couleur et forme :SolidMasse moléculaire :377.35EGFR-IN-8
CAS :EGFR-IN-8, a dual inhibitor targeting both EGFR and c-Met, shows potential as a promising candidate for further development in treating EGFR TKI-resistant NSCLCFormule :C32H23ClF3N7O4Degré de pureté :97.45%Couleur et forme :SolidMasse moléculaire :662.02Glesatinib hydrochloride
CAS :Glesatinib hydrochloride is an orally active and potent dual inhibitor of MET/SMO.Formule :C31H28ClF2N5O3S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :656.16NPS-1034
CAS :NPS-1034 is a dual Met/Axl inhibitor with IC50 of 48 nM and 10.3 nM, respectively.Formule :C31H23F2N5O3Degré de pureté :98.48%Couleur et forme :SolidMasse moléculaire :551.54Ningetinib Tosylate
CAS :Ningetinib Tosylate is an orally bioavailable tyrosine kinase inhibitor with IC50s of <1.0, 1.9 and 6.7 nM for Axl, VEGFR2, and c-Met, respectively.Formule :C38H37FN4O8SDegré de pureté :99.93%Couleur et forme :SolidMasse moléculaire :728.79PF-04217903 phenolsulfonate
CAS :PF-04217903 phenolsulfonate is a potent ATP-competitive inhibitor of c-Met kinase (Ki of 4.8 nM for human c-Met).Formule :C25H22N8O5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :546.56Savolitinib
CAS :Savolitinib (Volitinib) (AZD-6094) is an effective, selective, and orally bioavailable c-Met inhibitor (IC50s: 5 nM/3 nM for c-Met/p-Met).Formule :C17H15N9Degré de pureté :98.12%Couleur et forme :SolidMasse moléculaire :345.36Ref: TM-TQ0210
1mg49,00€2mg64,00€5mg92,00€10mg131,00€25mg210,00€50mg373,00€100mg567,00€1mL*10mM (DMSO)97,00€SAR125844
CAS :SAR125844, a potent and highly selective inhibitor of the MET receptor tyrosine kinase (RTK), for intravenous administration. (IC50 value of 4.2 nmol/L)Formule :C25H23FN8O2S2Degré de pureté :98.39%Couleur et forme :SolidMasse moléculaire :550.63Ref: TM-T5467
1mg35,00€5mg79,00€10mg116,00€25mg227,00€50mg364,00€100mg588,00€200mg833,00€1mL*10mM (DMSO)96,00€Afatinib Dimaleate
CAS :Afatinib Dimaleate (BIBW 2992MA2) is an orally bioavailable anilino-quinazoline derivative and inhibitor of the EGFR family, with antineoplastic activity.Formule :C32H33ClFN5O11Degré de pureté :100% - 98.11%Couleur et forme :SolidMasse moléculaire :718.08Ref: TM-T1773
1g467,00€5mg40,00€10mg59,00€25mg87,00€50mg107,00€100mg140,00€200mg188,00€500mg313,00€1mL*10mM (DMSO)66,00€Fosgonimeton acetate
Fosgonimeton acetate is an agonist of hepatocyte growth factor (HGF).Formule :C29H49N4O10PDegré de pureté :97.05%Couleur et forme :SolidMasse moléculaire :644.69Ref: TM-T39507L
1mg116,00€2mg160,00€5mg238,00€10mg353,00€25mg563,00€50mg758,00€100mg1.017,00€200mg1.359,00€Bozitinib
CAS :Bozitinib (PLB-1001) (PLB-1001) is a highly selective inhibitor of the c-MET kinase with blood-brain barrier permeability.Formule :C20H15F3N8Degré de pureté :99.16%Couleur et forme :SolidMasse moléculaire :424.38Ref: TM-T10585
1mg97,00€5mg216,00€10mg354,00€25mg628,00€50mg905,00€100mg1.264,00€200mg1.700,00€1mL*10mM (DMSO)240,00€c-Met-IN-2
CAS :c-Met-IN-2 is a selective and orally available c-Met inhibitor (IC50: 0.6 nM) with antitumor activity.Formule :C24H21FN10ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :484.49PROTAC c-Met degrader-3
PROTACc-Met degrader-3 (Compound 22b) is a c-Met PROTAC degrader. It facilitates the ubiquitination and degradation of c-Met, with a DC50 of 0.59 nM in EBC-1 cells. PROTACc-Met degrader-3 is applicable in lung cancer research.Formule :C51H54N10O7Couleur et forme :SolidMasse moléculaire :919.037(Z)-Semaxinib
CAS :(Z)-Semaxinib (SU5416) is a potent and selective VEGFR(Flk-1/KDR) inhibitor (IC50: 1.23 μM), 20-fold more selective for VEGFR over PDGFRβ, no inhibition forFormule :C15H14N2ODegré de pureté :96.09% - ≥95%Couleur et forme :SolidMasse moléculaire :238.28Ref: TM-T2496
1mg57,00€5mg111,00€10mg188,00€25mg331,00€50mg568,00€100mg695,00€200mg948,00€1mL*10mM (DMSO)144,00€MK-2461
CAS :MK-2461 is a novel inhibitor that targets multiple proteins and competitively binds to ATP sites, specifically inhibiting the activated c-Met protein with anFormule :C24H25N5O5SDegré de pureté :95.41% - 99.53%Couleur et forme :SolidMasse moléculaire :495.55Ref: TM-T6094
1mg52,00€5mg120,00€10mg187,00€25mg363,00€50mg552,00€100mg842,00€200mg1.130,00€1mL*10mM (DMSO)134,00€NVP-BVU972
CAS :NVP-BVU972 is a selective and potent Met inhibitor with IC50 of 14 nM.Formule :C20H16N6Degré de pureté :100% - 98.61%Couleur et forme :SolidMasse moléculaire :340.38Ref: TM-T2680
2mg44,00€5mg74,00€10mg97,00€25mg178,00€50mg255,00€100mg359,00€200mg510,00€1mL*10mM (DMSO)84,00€AMG-337
CAS :AMG-337 is an effective and highly specific ATP-competitive MET kinase inhibitor. In enzymatic assays, AMG-337 inhibits MET kinase activity (IC50: < 5 nM).Formule :C23H22FN7O3Degré de pureté :99.26% - 99.9%Couleur et forme :SolidMasse moléculaire :463.46Ref: TM-T3209
1mg40,00€2mg52,00€5mg85,00€10mg124,00€25mg197,00€50mg350,00€100mg522,00€200mg748,00€1mL*10mM (DMSO)86,00€MET/PDGFRA-IN-2
MET/PDGFRA-IN-2 (compound 8h) serves as an inhibitor of MET and PDGFRA proteins, promoting apoptosis in cells and impeding the proliferation of MET-positiveFormule :C29H29N7ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :491.59c-Met-IN-17
c-Met-IN-17 is a potent inhibitor of c-Met kinase, demonstrating an IC50 of 0.031 μM, and is applicable in anticancer research. [1]Formule :C21H15FN4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :374.37
