c-Met/HGFR
Les inhibiteurs de c-Met/HGFR ciblent le Récepteur du Facteur de Croissance des Hépatocytes (c-Met), une tyrosine kinase impliquée dans des processus cellulaires tels que la croissance, la motilité et la morphogenèse. La signalisation de c-Met est impliquée dans la progression du cancer, la métastase et la résistance aux thérapies. Inhiber c-Met peut perturber la croissance et la propagation des tumeurs, faisant de ces inhibiteurs des outils précieux dans la recherche sur le cancer. Chez CymitQuimica, nous proposons des inhibiteurs de c-Met/HGFR pour soutenir vos recherches en oncologie, métastase et thérapies ciblées contre le cancer.
Produits appartenant à la catégorie "c-Met/HGFR"
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Golvatinib
CAS :Golvatinib (E-7050) is an orally bioavailable dual kinase inhibitor of c-Met (hepatocyte growth factor receptor) and VEGFR-2 (vascular endothelial growth factorFormule :C33H37F2N7O4Degré de pureté :98.24% - ≥95%Couleur et forme :SolidMasse moléculaire :633.69MK-8033
CAS :MK-8033 is a new and selective dual ATP competitive c-Met/Ron inhibitor (IC50: 1 nM Wt c-Met).Formule :C25H21N5O3SDegré de pureté :97.16%Couleur et forme :SolidMasse moléculaire :471.53MET/PDGFRA-IN-1
MET/PDGFRA-IN-1 (compound 8c) serves as an inhibitor of MET and PDGFRA proteins, displaying an IC50 of 36 μM against MET.Formule :C26H23N7ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :449.51Ningetinib
CAS :Ningetinib (CT-053) (CT053PTSA) is an orally bioavailable tyrosine kinase inhibitor with IC50s of <1.0, 1.9 and 6.7 nM for Axl, VEGFR2, and c-Met, respectively.Formule :C31H29FN4O5Degré de pureté :99.77% - 99.95%Couleur et forme :SolidMasse moléculaire :556.58PHA-665752
CAS :PHA-665752 is an effective, specific and ATP-competitive c-Met inhibitor (IC50: 9 nM), >50-fold selectivity for c-Met than STKs or RTKs.Formule :C32H34Cl2N4O4SDegré de pureté :97.01% - 99.35%Couleur et forme :SolidMasse moléculaire :641.61MGCD-265 analog
CAS :Glesatinib, an oral tyrosine kinase inhibitor, targets c-Met and VEGFR2 with IC50s of 29 nM and 10 nM, may treat cancer.Formule :C26H20FN5O2S2Degré de pureté :98.06% - 98.68%Couleur et forme :SolidMasse moléculaire :517.6AMG-208
CAS :AMG-208 is a highly selective c-Met inhibitor with IC50 of 9 nM. Phase 1.Formule :C22H17N5O2Degré de pureté :98.56%Couleur et forme :SolidMasse moléculaire :383.4Tepotinib hydrochloride(1 : x)
CAS :Tepotinib hydrochloride(1 : x) is an orally bioavailable, mesenchymal-epithelial transition (MET) TKI developed mainly for selected NSCLC patients with METex14Formule :C29H29ClN6O2Degré de pureté :99.81%Couleur et forme :SolidMasse moléculaire :529.04Capmatinib 2HCl
CAS :Capmatinib 2HCl (INC-280 2HCl), a c-MET inhibitor, is potent (IC50 = 0.13 nM), highly specific, and induces apoptosis in tumor cells.Formule :C23H19Cl2FN6ODegré de pureté :98.80%Couleur et forme :SolidMasse moléculaire :485.34Ref: TM-T4260
1mg44,00€2mg55,00€5mg70,00€10mg87,00€25mg145,00€50mg258,00€100mg430,00€500mg998,00€1mL*10mM (DMSO)97,00€c-Met inhibitor 1
CAS :c-Met inhibitor 1 is a c-Met receptor signaling pathway inhibitor, used for the treatment of cancer including glioblastoma, gastric, and pancreatic cancer.Formule :C17H14N8SDegré de pureté :98.77%Couleur et forme :SolidMasse moléculaire :362.41Ref: TM-T10655
1mg85,00€5mg172,00€10mg236,00€25mg398,00€50mg588,00€100mg838,00€1mL*10mM (DMSO)188,00€Capmatinib
CAS :Capmatinib (INCB28060) is an orally bioavailable inhibitor of the proto-oncogene c-Met (HGFR)with potential antineoplastic activity.Formule :C23H17FN6ODegré de pureté :99.24%Couleur et forme :SolidMasse moléculaire :412.42Capmatinib 2HCl.H2O
CAS :Capmatinib 2HCl.H2O (NVP-INC280 2HCl.H2O) is an orally bioavailable inhibitor of the proto-oncogene c-Met (HGFR)with potential antineoplastic activity.Formule :C23H21Cl2FN6O2Degré de pureté :99.77%Couleur et forme :SolidMasse moléculaire :503.36Ref: TM-T8825
2mg35,00€5mg49,00€10mg69,00€25mg115,00€50mg177,00€100mg283,00€200mg378,00€1mL*10mM (DMSO)56,00€Foretinib
CAS :Foretinib (GSK1363089) is a broad-spectrum tyrosine kinase inhibitor with IC50s of 0.4 nM and 0.9 nM for Met and KDR.Formule :C34H34F2N4O6Degré de pureté :98.07% - 99.68%Couleur et forme :SolidMasse moléculaire :632.65Ref: TM-T3113
2mg39,00€5mg57,00€10mg79,00€25mg133,00€50mg207,00€100mg354,00€500mg848,00€1mL*10mM (DMSO)79,00€Antitumor agent-111
Antitumor Agent-111 (Compound 46), a c-Met kinase inhibitor (IC50 = 46 nM), exhibits both antitumor and antiproliferative effects.Formule :C34H29ClF2N6O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :675.08Pamufetinib
CAS :Pamufetinib (TAS-115) is a potent inhibitor of VEGFR and hepatocyte growth factor receptor (c-Met/HGFR)-targeted kinase.Formule :C27H23FN4O4SDegré de pureté :99.39%Couleur et forme :SolidMasse moléculaire :518.56Ref: TM-T13108
1mg50,00€5mg106,00€10mg158,00€25mg258,00€50mg379,00€100mg538,00€200mg733,00€1mL*10mM (DMSO)134,00€Herbacetin
CAS :1.Formule :C15H10O7Degré de pureté :96.89% - 99.51%Couleur et forme :SolidMasse moléculaire :302.24JNJ-38877618
CAS :JNJ-38877618 (OMO-1) is an effective and highly selective inhibitor of Met kinase (IC50s: 2 and 3 nM for wild type and mutant Met, respectively).Formule :C20H12F2N6Degré de pureté :98.84% - 99.52%Couleur et forme :SolidMasse moléculaire :374.35Ref: TM-T15617
1mg63,00€2mg89,00€5mg137,00€10mg210,00€25mg424,00€50mg627,00€100mg893,00€500mg1.786,00€1mL*10mM (DMSO)153,00€Rilotumumab
CAS :Rilotumumab (AMG 102) is an HGF-targeting antibody, inhibits HGF/MET signaling, and is used for CRPC and gastric cancer research.Degré de pureté :SDS-PAGE:95% SEC-HPLC:97.51%Couleur et forme :LiquidMasse moléculaire :145.2 kDaAltiratinib
CAS :Altiratinib (DCC-2701)(DCC-2701) is a novel c-MET/TIE-2/VEGFR inhibitor; effectively reduce tumor burden in vivo and block c-MET pTyr(1349)-mediated signaling,Formule :C26H21F3N4O4Degré de pureté :98.98% - 99.39%Couleur et forme :SolidMasse moléculaire :510.46BAY-474
CAS :BAY-474 is an inhibitor of tyrosine-protein kinase c-Met. It acts as an epigenetics probeFormule :C17H15N5Degré de pureté :98.98%Couleur et forme :SolidMasse moléculaire :289.33Ref: TM-T7900
1mg50,00€5mg97,00€10mg170,00€25mg306,00€50mg444,00€100mg620,00€200mg835,00€1mL*10mM (DMSO)114,00€
