c-Kit
Les inhibiteurs de c-Kit sont des composés qui bloquent l'activité du Récepteur du Facteur de Cellules Souches (c-Kit), une tyrosine kinase jouant un rôle crucial dans la survie, la prolifération et la différenciation cellulaires, en particulier dans les cellules hématopoïétiques. Les mutations de c-Kit sont liées à divers cancers, notamment les tumeurs stromales gastro-intestinales (GIST) et la leucémie. Chez CymitQuimica, nous proposons des inhibiteurs de c-Kit pour soutenir vos recherches en oncologie, hématologie et biologie des cellules souches.
Produits appartenant à la catégorie "c-Kit"
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AC710
CAS :AC710 is a potent PDGFR inhibitor (Kds: 0.6, 1, 1.57, 1.3, 1 nM for FLT3, KIT, CSF1R, PDGFRα and PDGFRβ).Formule :C31H42N6O4Degré de pureté :99.48%Couleur et forme :SolidMasse moléculaire :562.7Sitravatinib
CAS :Sitravatinib (MGCD516) (MGCD516) is an inhibitor targeting multiple RTKs involved in driving sarcoma cell growth, including c-Met, c-Kit, PDGFRα/β, PDGFR, andFormule :C33H29F2N5O4SDegré de pureté :98.9% - 99.74%Couleur et forme :SolidMasse moléculaire :629.68Ref: TM-T4349
5mg51,00€10mg79,00€25mg137,00€50mg210,00€100mg338,00€200mg535,00€500mg845,00€1mL*10mM (DMSO)72,00€N-Desmethyl imatinib
CAS :N-Desmethyl imatinib (Imatinib metabolite N-Desmethyl imatinib) is a metabolite of Imatinib, which is a multi-target inhibitor of c-Kit, v-Abl, and PDGFR.Formule :C28H29N7ODegré de pureté :98.60%Couleur et forme :Off-White To Pale-Yellow SolidMasse moléculaire :479.58Ref: TM-T11641
1mg92,00€5mg170,00€10mg319,00€25mg540,00€50mg777,00€100mg1.074,00€1mL*10mM (DMSO)178,00€Anti-CD117 Antibody (9H202)
Anti-CD117 Antibody (9H202) is an antibody targeting CD117. Anti-CD117 Antibody (9H202) can be used in ELISA, IHC, FCM.Couleur et forme :Odour LiquidLenvatinib mesylate
CAS :Lenvatinib mesylate (E7080 (mesylate)) is an oral and multi-targeted inhibitor of VEGFR1-3, FGFR1-4, PDGFR, KIT, and RET, with potent antitumor activities.Formule :C22H23ClN4O7SDegré de pureté :99.03% - 99.79%Couleur et forme :SolidMasse moléculaire :522.96Midostaurin
CAS :PKC412(Midostaurin (PKC412); CGP41231; CGP41251) is a broad spectrum protein kinase inhibitor.Formule :C35H30N4O4Degré de pureté :100% - 99.47%Couleur et forme :SolidMasse moléculaire :570.64Ref: TM-T3211
1mg51,00€5mg88,00€10mg126,00€25mg216,00€50mg328,00€100mg487,00€500mg1.093,00€1mL*10mM (DMSO)96,00€Anti-C-Kit Antibody-APC (1R766)
Anti-C-Kit Antibody-APC (1R766) is a APC-conjugated Rabbit antibody targeting C-Kit. Anti-C-Kit Antibody-APC (1R766) can be used in FCM.Couleur et forme :Odour LiquidAnti-C-Kit Antibody-FITC (8E724)
Anti-C-Kit Antibody-FITC (8E724) is a FITC-conjugated Mouse antibody targeting C-Kit. Anti-C-Kit Antibody-FITC (8E724) can be used in FCM.Couleur et forme :Odour Liquidc-Kit-IN-3
CAS :c-Kit-IN-3 is a selective inhibitor of c-KIT kinase with IC50s of 4 nM and 8 nM for c-Kit (wt) and c-Kit (T670I).Formule :C26H20ClF3N2O4Degré de pureté :99.43%Couleur et forme :SolidMasse moléculaire :516.9Ref: TM-T10651
1mg87,00€5mg162,00€10mg254,00€25mg419,00€50mg562,00€100mg787,00€500mg1.578,00€1mL*10mM (DMSO)334,00€Dovitinib lactate
CAS :Dovitinib lactate (TKI-258 lactate)(TKI258) lactate is a potent inhibitor of fibroblast growth factor receptor 3 (FGFR3) (IC50 :5 nM).Formule :C24H27FN6O4Degré de pureté :98.44% - 99.54%Couleur et forme :SolidMasse moléculaire :482.51Ref: TM-T7104
5mg51,00€10mg79,00€25mg129,00€50mg213,00€100mg358,00€200mg535,00€500mg843,00€1mL*10mM (DMSO)57,00€CD117 Protein, Mouse, Recombinant (His)
The c-kit proto-oncogen (CD 117) has been shown to be present in several cell types including normal and neoplastic hemopoietic cells.Couleur et forme :Lyophilized PowderMasse moléculaire :56.63 kDa (predicted). Due to glycosylation, the protein migrates to 75-100 kDa based on Tris-Bis PAGE result.Avapritinib
CAS :Avapritinib (BLU-285) is a selective, highly potent, and orally active inhibitor of KIT and PDGFRA activation loop mutant kinases.Cost-effective and quality-assured.Formule :C26H27FN10Degré de pureté :96.59% - 99.7%Couleur et forme :SolidMasse moléculaire :498.56Ref: TM-T5109
1mg88,00€5mg187,00€10mg305,00€25mg520,00€50mg748,00€100mg1.026,00€500mg2.072,00€1mL*10mM (DMSO)205,00€AMG-25
CAS :AMG-25 (c-Kit-IN-5-1) is a c-Kit inhibitor that inhibits c-Kit, KDR, p38, Lck, and Src, and can be used for the study of mast cell-associated fibrotic diseases.Formule :C23H17N5O2Degré de pureté :98.16%Couleur et forme :SolidMasse moléculaire :395.41c-Kit Protein, Human, Recombinant (aa 50-190, His)
c-Kit Protein, Human, Recombinant (aa 50-190, His) is expressed in E.Couleur et forme :Lyophilized PowderMasse moléculaire :17.9 kDa (predicted); 18 kDa (reducing conditions)c-Kit Protein, Mouse, Recombinant (hFc)
c-Kit Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag.Couleur et forme :Lyophilized PowderMasse moléculaire :82.5 kDa (predicted); 100-110 kDa (reducing condition, due to glycosylation)Anti-C-Kit Antibody-PE (7P530)
Anti-C-Kit Antibody-PE (7P530) is a PE-conjugated Mouse antibody targeting C-Kit. Anti-C-Kit Antibody-PE (7P530) can be used in FCM.Couleur et forme :Odour LiquidCabozantinib
CAS :Cabozantinib (XL184) is a multi-targeted tyrosine kinase receptor inhibitor that inhibits VEGFR2, c-Met, Kit, Axl, and Flt3 (IC50=0.035/1.3/4.6/7/11.3 nM).Formule :C28H24FN3O5Degré de pureté :99.59% - 99.88%Couleur et forme :SolidMasse moléculaire :501.51Anti-C-Kit Antibody-FITC (7P530)
Anti-C-Kit Antibody-FITC (7P530) is a FITC-conjugated Mouse antibody targeting C-Kit. Anti-C-Kit Antibody-FITC (7P530) can be used in FCM.Couleur et forme :Odour LiquidSU14813
CAS :SU14813: inhibits multiple kinases (VEGFR2, VEGFR1, PDGFRβ, KIT) with IC50s of 50, 2, 4, 15 nM; antiangiogenic and antitumor.Formule :C23H27FN4O4Degré de pureté :99.72%Couleur et forme :SolidMasse moléculaire :442.48Tyrphostin AG1296
CAS :Tyrphostin AG1296 (Tyrphostin AG 1296) is an inhibitor of PDGFR with IC50 of 0.3-0.5 μM, no activity to EGFR.Formule :C16H14N2O2Degré de pureté :99.66% - 99.68%Couleur et forme :SolidMasse moléculaire :266.29Ref: TM-T6711
2mg40,00€5mg58,00€10mg90,00€25mg180,00€50mg279,00€100mg411,00€200mg585,00€1mL*10mM (DMSO)81,00€Flumatinib
CAS :Flumatinib (HHGV678) is an orally bioavailable tyrosine kinase inhibitor flumatinib, with potential antineoplastic activity.Formule :C29H29F3N8ODegré de pureté :99.52% - 99.95%Couleur et forme :SolidMasse moléculaire :562.59Ref: TM-T4320
1mg35,00€5mg66,00€10mg87,00€25mg127,00€50mg163,00€100mg273,00€200mg409,00€500mg677,00€1mL*10mM (DMSO)87,00€CD117 Protein, Human, Recombinant (His & Avi), Biotinylated
The c-kit proto-oncogen (CD 117) has been shown to be present in several cell types including normal and neoplastic hemopoietic cells.Couleur et forme :Lyophilized PowderMasse moléculaire :58.60 kDa (predicted). Due to glycosylation, the protein migrates to 75-105 kDa based on Tris-Bis PAGE result.c-Kit Protein, Human, Recombinant (aa 540-972, His & GST)
c-Kit Protein, Human, Recombinant (aa 540-972, His & GST) is expressed in Baculovirus insect cells with His and GST tag.Couleur et forme :Lyophilized PowderMasse moléculaire :76.8 kDa (predicted); 68 kDa (reducing conditions)Toceranib
CAS :Toceranib phosphate, orally active, inhibits RTK, PDGFR, VEGFR, Kit; Kis 5 nM PDGFRβ, 6 nM KDR; has antitumor effects.Formule :C22H25FN4O2Degré de pureté :97.14%Couleur et forme :SolidMasse moléculaire :396.46Anti-C-Kit Antibody-PE (8E724)
Anti-C-Kit Antibody-PE (8E724) is a PE-conjugated Mouse antibody targeting C-Kit. Anti-C-Kit Antibody-PE (8E724) can be used in FCM.Couleur et forme :Odour LiquidMotesanib
CAS :Motesanib (AMG 706) orally blocks VEGFR, PDGFR, Kit, Ret; curbing angiogenesis and cancer cell growth.Formule :C22H23N5ODegré de pureté :98% - 98.87%Couleur et forme :SolidMasse moléculaire :373.45Imatinib Mesylate
CAS :Imatinib Mesylate (STI-571) is a tyrosine kinase receptor inhibitor with antineoplastic activity (IC50s: 0.6 μM, 0.1 μM and 0.1 μM for v-Abl, c-Kit and PDGFR,Formule :C29H31N7O·CH4SO3Degré de pureté :100% - 99.97%Couleur et forme :White Crystalline PowderMasse moléculaire :589.71Anti-C-Kit Antibody (8E724)
Anti-C-Kit Antibody (8E724) is a Mouse antibody targeting C-Kit. Anti-C-Kit Antibody (8E724) can be used in FCM.Couleur et forme :Odour LiquidMasitinib
CAS :Masitinib (AB1010) is a tyrosine-kinase inhibitor used in the treatment of mast cell tumors in animals, specifically dogs.Formule :C28H30N6OSDegré de pureté :100% - 99.55%Couleur et forme :SolidMasse moléculaire :498.64SKLB4771
CAS :SKLB4771 (FLT3-IN-1) is a novel potent and selective Flt3 inhibitor.Formule :C25H27N7O3S2Degré de pureté :100% - 98.27%Couleur et forme :SolidMasse moléculaire :537.66Ref: TM-T2051
1mg66,00€2mg87,00€5mg131,00€10mg187,00€25mg393,00€50mg587,00€100mg835,00€500mg1.700,00€1mL*10mM (DMSO)157,00€Flumatinib mesylate
CAS :Flumatinib mesylate (HHGV678 mesylate) is a selective inhibitor of c-Abl, PDGFRβ and c-Kit, effectively overcomes drug resistance of certain KIT mutants.Formule :C30H33F3N8O4SDegré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :658.69Ref: TM-T7861
1mg37,00€5mg88,00€10mg133,00€25mg250,00€50mg393,00€100mg628,00€500mg1.301,00€1mL*10mM (DMSO)139,00€Anti-C-Kit Antibody (9Y519)
Anti-C-Kit Antibody (9Y519) is a Mouse antibody targeting C-Kit. Anti-C-Kit Antibody (9Y519) can be used in ELISA.Couleur et forme :Odour LiquidLenvatinib
CAS :Lenvatinib (E7080) is a multi-target receptor tyrosine kinase inhibitor that inhibits VEGFR1-3, FGFR1-4, KIT, PDGFR, and RET, and has oral activity.Formule :C21H19ClN4O4Degré de pureté :98.46% - 99.8000%Couleur et forme :SolidMasse moléculaire :426.85AZD3229
CAS :AZD3229 is a potent pan-KIT mutant inhibitor for the treatment of gastrointestinal stromal tumors.Formule :C24H26FN7O3Degré de pureté :98.83%Couleur et forme :SolidMasse moléculaire :479.51Ref: TM-T5409
1mg44,00€5mg87,00€10mg140,00€25mg248,00€50mg364,00€100mg509,00€200mg698,00€1mL*10mM (DMSO)99,00€Tandutinib
CAS :Tandutinib (CT53518) (MLN518, CT53518), an effective FLT3 antagonist (IC50: 0.22 μM), can also inhibit c-Kit and PDGFR, 15-20 fold higher potency for FLT3Formule :C31H42N6O4Degré de pureté :99.45% - ≥98%Couleur et forme :White SolidMasse moléculaire :562.7Amuvatinib
CAS :Amuvatinib (MP470) is an orally bioavailable synthetic carbothioamide with potential antineoplastic activity.Formule :C23H21N5O3SDegré de pureté :98.48% - 99.54%Couleur et forme :SolidMasse moléculaire :447.51Anti-C-Kit Antibody (6X205)
Anti-C-Kit Antibody (6X205) is a Mouse antibody targeting C-Kit. Anti-C-Kit Antibody (6X205) can be used in ELISA.Couleur et forme :Odour LiquidGW786034B
CAS :Pazopanib HCl (Votrient) inhibits VEGFR1-3, PDGFR, FGFR, c-Kit, c-Fms with IC50 range 10-146 nM in cell-free assays.Formule :C21H23N7O2S·HClDegré de pureté :99.87%Couleur et forme :SolidMasse moléculaire :473.98Ref: TM-T6930
10mg52,00€25mg90,00€50mg96,00€100mg140,00€200mg229,00€500mg359,00€1mL*10mM (DMSO)52,00€Regorafenib
CAS :Regorafenib (BAY 73-4506) is a multi-targeted receptor tyrosine kinase inhibitor that inhibits RET, C-RAF, VEGFR2, c-Kit, VEGFR1, and PDGFRβ and is orallyFormule :C21H15ClF4N4O3Degré de pureté :98% - 99.95%Couleur et forme :SolidMasse moléculaire :482.82Ref: TM-T1792
5mg35,00€10mg51,00€25mg80,00€50mg96,00€100mg144,00€200mg185,00€500mg309,00€1mL*10mM (DMSO)57,00€Vimseltinib
CAS :Vimseltinib (DCC-3014) is a c-FMS (CSF-IR) and c-Kit dual inhibitor (IC50s: <0.01 μM and 0.1-1 μM).Formule :C23H25N7O2Degré de pureté :99.05% - 99.57%Couleur et forme :SolidMasse moléculaire :431.49Ref: TM-T10652
1mg92,00€5mg188,00€10mg311,00€25mg533,00€50mg727,00€100mg938,00€1mL*10mM (DMSO)215,00€Linifanib
CAS :Linifanib (AL-39324) (ABT-869) is a novel, potent ATP-competitive VEGFR/PDGFR inhibitor for KDR (IC50: 4 nM), CSF-1R (IC50: 3 nM), Flt-1/3 (IC50: 3/4 nM) andFormule :C21H18FN5ODegré de pureté :98% - 98.24%Couleur et forme :SolidMasse moléculaire :375.4Ref: TM-T2514
5mg50,00€10mg85,00€25mg126,00€50mg188,00€100mg274,00€200mg505,00€500mg815,00€1mL*10mM (DMSO)52,00€Anti-C-Kit Antibody (7P530)
Anti-C-Kit Antibody (7P530) is a Mouse antibody targeting C-Kit. Anti-C-Kit Antibody (7P530) can be used in FCM.Couleur et forme :Odour Liquidc-Kit-IN-1
CAS :c-Kit-IN-1 (DCC-2618) is an effective inhibitor of c-Met and c-Kit (IC50s<200 nM).Formule :C26H21F2N5O3Degré de pureté :98.16% - 98.72%Couleur et forme :SolidMasse moléculaire :489.47Ref: TM-T4332
1mg46,00€2mg59,00€5mg87,00€10mg144,00€25mg304,00€50mg542,00€100mg778,00€500mg1.605,00€1mL*10mM (DMSO)94,00€Protein kinase inhibitor 10
CAS :Protein kinase inhibitor 10 is a protein kinase inhibitor with IC50 values of 28.9 μM, 13.6 μM, and 2.41 μM for TAM receptors, FAK, and KIT, respectively. It can inhibit abnormal and excessive cell proliferation, showing potential for research in the field of cancer treatment.Formule :C14H9FN6S2Couleur et forme :SolidMasse moléculaire :344.39Toceranib Phosphate
CAS :Toceranib Phosphate (SU11654 phosphate), is a selective inhibitor of the tyrosine kinase activity of several members of the split kinase RTK family.Formule :C22H28FN4O6PDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :494.45c-Kit-IN-8
CAS :C-Kit-IN-8 (Compound 53) acts as an inhibitor of c-Kit kinase, hampering uKIT kinase activity with an IC50 greater than 1 μM. Additionally, it inhibits the proliferation of both wild-type and mutant GIST430 and BaF3 cancer cells, exhibiting an IC50 greater than 0.1 μM.Formule :C24H26FN5O4Couleur et forme :SolidMasse moléculaire :467.49Masitinib mesylate
CAS :Masitinib mesylate (AB-1010 mesylate) is a selective and orally bioavailable c-Kit inhibitor (IC50 of 200 nM,540/800 nM,510 nM for human recombinant c-Kit;Formule :C29H34N6O4S2Degré de pureté :100% - 97.67%Couleur et forme :SolidMasse moléculaire :594.75Ref: TM-T8544
5mg35,00€10mg51,00€25mg77,00€50mg95,00€100mg144,00€200mg225,00€500mg373,00€1mL*10mM (DMSO)49,00€Ripretinib
CAS :Ripretinib (DCC-2618) is an orally bioavailable inhibitor of KIT and PDGFRA.Formule :C24H21BrFN5O2Degré de pureté :99.07%Couleur et forme :SolidMasse moléculaire :510.36Ref: TM-T8482
1mg80,00€5mg167,00€10mg281,00€25mg500,00€50mg727,00€100mg1.198,00€200mg1.596,00€1mL*10mM (DMSO)213,00€Cabozantinib hydrochloride
CAS :Cabozantinib hydrochloride (XL184) is a potent pan-tyrosine kinases inhibitor that inhibits VEGFR2, c-Met, Kit, Axl, and Flt4 (IC50s: 0.035, 1.3, 4.6, 7 and 6Formule :C28H25ClFN3O5Degré de pureté :99.97%Couleur et forme :SolidMasse moléculaire :537.96Ref: TM-T5164
1mg44,00€2mg55,00€5mg69,00€10mg97,00€25mg169,00€50mg248,00€100mg349,00€200mg568,00€500mg908,00€c-Kit-IN-2
CAS :c-Kit-IN-2 is a c-KIT inhibitor (IC50: 82 nM), shows superior antiproliferative activities against all the three GIST cell lines, GIST430, GIST882, and GIST48 (Formule :C25H29N9O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :519.62
