Ubiquitination
Les inhibiteurs de l'ubiquitination sont des composés qui interfèrent avec le processus d'ubiquitination, par lequel les protéines sont marquées avec des molécules d'ubiquitine pour être dégradées par le protéasome. Ces inhibiteurs sont essentiels pour étudier le renouvellement des protéines, la transduction des signaux et la régulation de divers processus cellulaires. L'ubiquitination joue un rôle clé dans de nombreuses maladies, y compris le cancer, les troubles neurodégénératifs et les dysfonctionnements du système immunitaire. En modulant l'ubiquitination, ces inhibiteurs peuvent fournir des informations sur les mécanismes des maladies et ouvrir de nouvelles voies pour l'intervention thérapeutique. Chez CymitQuimica, nous offrons une large sélection d'inhibiteurs de l'ubiquitination de haute qualité pour soutenir vos recherches en biologie cellulaire, protéomique et découverte de médicaments.
Sous-catégories appartenant à la catégorie "Ubiquitination"
Produits appartenant à la catégorie "Ubiquitination"
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BIO-2007817
BIO-2007817 is a positive allosteric modulator (PAM) of Parkin, an E3 ubiquitin ligase. This compound enhances the activity of wild-type Parkin, stimulates Parkin's autoubiquitination, and induces the appearance of mono-ubiquitinated forms of Miro1 (a Parkin substrate) with an EC50 of 0.17 μM.Formule :C32H36N6O3Couleur et forme :SolidMasse moléculaire :552.67Vialinin A
CAS :Vialinin A, a p-terphenyl with antioxidant properties, inhibits TNF-α/USP4/5/SENP1, used in autoimmune/cancer research.Formule :C34H26O8Degré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :562.57ZM223
CAS :ZM223 is an inhibitor of NEDD8 activating enzyme (NAE).Formule :C23H17F3N4O2S2Degré de pureté :99.67%Couleur et forme :SolidMasse moléculaire :502.53Ref: TM-T13412
1mg115,00€2mg172,00€5mg255,00€10mg374,00€25mg562,00€50mg787,00€100mg1.074,00€500mg2.147,00€USP7-797
CAS :USP7-797 is a selective non-covalent active site USP7 inhibitor, inhibiting USP7 and ubiquitin binding, with anti-tumor, oral and high efficiency properties.Formule :C27H28ClN3O3SDegré de pureté :96.18%Couleur et forme :SolidMasse moléculaire :510.05Cbl-b-IN-7
CAS :Cbl-b-IN-7 (Compound 248) is an inhibitor of casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting inhibitory half-maximal inhibitory concentrations (IC50sFormule :C29H31F4N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :557.58TAS4464
CAS :TAS4464 is a highly potent and selective inhibitor of the NEDD8 activating enzyme (IC50: 0.955 nM).Formule :C21H23FN6O6SDegré de pureté :98.27%Couleur et forme :SolidMasse moléculaire :506.51USP30 inhibitor 11
CAS :USP30 inhibitor 11 (USP30-IN-11) is a USP30 inhibitor that inhibits SVA and can be used in studies of cancer, mitochondrial dysfunction and Parkinson's.Formule :C17H16N6O2SDegré de pureté :100% - 96.31%Couleur et forme :SolidMasse moléculaire :368.41MID-1
CAS :MID-1 is an inhibitor of MG53-IRS-1 (Mitsugumin 53-Insulin Receptor Substrate-1) interaction.Formule :C12H11N3O4SDegré de pureté :99.39%Couleur et forme :SolidMasse moléculaire :293.3Ref: TM-T8773
1mg50,00€5mg97,00€10mg145,00€25mg259,00€50mg383,00€100mg545,00€200mg740,00€1mL*10mM (DMSO)109,00€Cbl-b-IN-13
CAS :Cbl-b-IN-13 (Example 520) is a potent Cbl-b inhibitor exhibiting an IC50 of less than 100 nM and is capable of activating T-cells [1].Formule :C29H30F3N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :537.58Pevonedistat
CAS :Pevonedistat (MLN4924) is a potent and selective NEDD8 activating enzyme (NAE) inhibitor (IC50=4.7 nM).Formule :C21H25N5O4SDegré de pureté :95% - 99.92%Couleur et forme :SolidMasse moléculaire :443.52Ref: TM-T6332
1mg52,00€2mg70,00€5mg96,00€10mg144,00€25mg259,00€50mg424,00€100mg717,00€1mL*10mM (DMSO)94,00€USP8-IN-2
CAS :USP8-IN-2 is a potent inhibitor of the deubiquitinating enzymes USP7 and USP8, with an IC50 of 4.0 μM against USP8D.Formule :C19H20ClF3N4OSDegré de pureté :98.83%Couleur et forme :SolidMasse moléculaire :444.9Ref: TM-T67876
1mg88,00€5mg210,00€10mg329,00€25mg548,00€50mg782,00€100mg1.035,00€1mL*10mM (DMSO)245,00€Skp2 Inhibitor C1
CAS :Skp2 Inhibitor C1 (SKPin C1)(SKPin C1) is a specific small molecule inhibitor of Skp2-mediated p27 degradation.Formule :C18H13BrN2O4S2Degré de pureté :100%Couleur et forme :SolidMasse moléculaire :465.34Ref: TM-T4253
2mg37,00€5mg55,00€10mg89,00€25mg167,00€50mg279,00€100mg408,00€200mg567,00€1mL*10mM (DMSO)57,00€DT204
CAS :DT204 is an SCFSkp2 inhibitor that reduces the binding of Skp2 to Cullin-1 and Commd1. It can be used to study multiple myeloma.Formule :C19H13BrClNO5SDegré de pureté :99.71%Couleur et forme :SolidMasse moléculaire :482.73LANOSTEROL
CAS :Lanosterol (3β-Hydroxy-8,24-lanostadiene) is a tetracyclic triterpenoid which is the compound from which all steroids are derived.Formule :C30H50ODegré de pureté :97.99% - 99.67%Couleur et forme :SolidMasse moléculaire :426.72NSC632839
CAS :NSC-632839 (Ubiquitin Isopeptidase Inhibitor II) is a nonselective isopeptidase inhibitor, which inhibits USP2 (EC50: 45±4 μM), USP7 (EC50: 37±1 μM), and SENP2Formule :C21H22ClNODegré de pureté :99.74% - 99.87%Couleur et forme :SolidMasse moléculaire :339.86USP7-IN-8
CAS :Benzamide, 4-[6-amino-4-ethyl-5-(4-hydroxyphenyl)-3-pyridinyl]-N-methyl- is a selective ubiquitin-specific protease 7 (USP7) inhibitor with an IC50 of 1.4 μM.Formule :C21H21N3O2Degré de pureté :99.31%Couleur et forme :SolidMasse moléculaire :347.41Ref: TM-T9217
1mg48,00€5mg97,00€10mg156,00€25mg284,00€50mg411,00€100mg562,00€200mg743,00€1mL*10mM (DMSO)105,00€TCID
CAS :TCID (UCH-L3 Inhibitor)(IC50=0.6 μM) is a DUB inhibitor of ubiquitin C-terminal hydrolase L3. It has the 125-fold selectivity to L1.Formule :C9H2Cl4O2Degré de pureté :99.34%Couleur et forme :SolidMasse moléculaire :283.92OTUB1/USP8-IN-1 HCl
OTUB1/USP8-IN-1 HCL is a potent dual inhibitor of OTUB1 and USP8 with potential antitumour activity, inhibiting both OTUB1 and USP8 for leukaemiaFormule :C22H17Cl2FN2O4Degré de pureté :99.90%Couleur et forme :SolidMasse moléculaire :463.29NSC697923
CAS :NSC-697923 inhibits UBE2N, triggers p53-dependent and JNK-mediated apoptosis, blocks DNA damage and NF-κB signaling in neuroblastoma cells.Formule :C11H9NO5SDegré de pureté :97% - 99.69%Couleur et forme :SolidMasse moléculaire :267.26Cbl-b-IN-26
CAS :Cbl-b-IN-26 (Example A1) is an inhibitor of Cbl-b with a dissociation constant (Kd) of 34.6 nM. It is used in the research of chronic viral infections and cancer.Formule :C21H19F3N6Couleur et forme :SolidMasse moléculaire :412.41DUB-IN-3
CAS :DUB-IN-3 is a potent deubiquitinase (USP) enzyme inhibitor and the IC50 for USP8 is 0.56 μM.Formule :C16H9N5ODegré de pureté :99.34%Couleur et forme :SolidMasse moléculaire :287.28Ref: TM-T11112
1mg137,00€2mg188,00€5mg325,00€10mg465,00€25mg743,00€50mg1.035,00€100mg1.406,00€500mg2.802,00€1mL*10mM (DMSO)341,00€USP30 inhibitor 18
CAS :USP30 inhibitor 18 is a selective inhibitor of USP30 (IC50 = 0.02 μM). USP30 inhibitor 18 is able to accelerate mitophagy and increase protein ubiquitination.Formule :C26H28FN3O4SDegré de pureté :99.03%Couleur et forme :SolidMasse moléculaire :497.58Ref: TM-T36682
1mg144,00€5mg298,00€10mg472,00€25mg753,00€50mg1.074,00€100mg1.444,00€500mg2.822,00€1mL*10mM (DMSO)325,00€WS-383
CAS :WS-383 is a selective, potent and reversible DCN1-UBC12 interaction inhibitor(IC50 of 11 nM).Formule :C18H21Cl2N9S2Degré de pureté :98.46%Couleur et forme :SolidMasse moléculaire :498.46Ref: TM-T13349
1mg46,00€2mg58,00€5mg87,00€10mg144,00€25mg283,00€50mg558,00€100mg797,00€500mg1.634,00€1mL*10mM (DMSO)97,00€Ginkgolic Acid
CAS :Ginkgolic Acid (Romanicardic acid) C15:1 represses curli genes and prophage genes in EHEC.Formule :C22H34O3Degré de pureté :98.69% - 99.9%Couleur et forme :White PowderMasse moléculaire :346.5P005091
CAS :P005091 (P5091) is a selective and potent inhibitor of ubiquitin-specific protease 7 (USP7) with EC50 of 4.2 μM.Formule :C12H7Cl2NO3S2Degré de pureté :99.53% - 99.87%Couleur et forme :SolidMasse moléculaire :348.22MSC1094308
CAS :MSC1094308 is a reversible, non-ATP-competitive inhibitor targeting type II AAA ATPase (VCP/p97) and type I AAA ATPase (VPS4B) and affects protein degradation.Formule :C29H29F3N2Couleur et forme :SolidMasse moléculaire :462.55CB-5339
CAS :p97-IN-1 is a potent inhibitor of p97 with an IC 50 <30 nM [1].Formule :C24H24N6ODegré de pureté :98.5%Couleur et forme :SoildMasse moléculaire :412.49Smurf1-IN-1
CAS :Smurf1-IN-1, a selective E3 ubiquitin protein ligase 1 (SMURF1) inhibitor, exhibits oral activity with an IC50 of 92 nM and demonstrates considerable efficacyFormule :C24H29ClN6O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :468.98DUB-IN-1
CAS :DUB-IN-1, with an IC50 value of 0.24 for USP8, is an active inhibitor of ubiquitin-specific protease (USPs).Formule :C20H11N5ODegré de pureté :98.33% - 98.96%Couleur et forme :SolidMasse moléculaire :337.33Ref: TM-T11110
1mg65,00€5mg116,00€10mg183,00€25mg353,00€50mg495,00€100mg652,00€200mg895,00€1mL*10mM (DMSO)128,00€MF-094
CAS :MF-094 is a selective USP30 inhibitor with IC50 of 0.12 μM. MF-094 can increase protein ubiquitination and accelerate mitophagy.Cost-effective and quality-assured.Formule :C30H37N3O4SDegré de pureté :98.46%Couleur et forme :SolidMasse moléculaire :535.7Ref: TM-T12024
1mg43,00€5mg87,00€10mg144,00€25mg283,00€50mg454,00€100mg655,00€500mg1.454,00€1mL*10mM (DMSO)120,00€I-138
CAS :I-138 is an orally active and reversible inhibitor of USP1-UAF1.I-138 induces mono-ubiquitination of FANCD2 and PCNA and inhibits USP1 auto-cleavage in cells.Formule :C26H23F3N6ODegré de pureté :99.41%Couleur et forme :SolidMasse moléculaire :492.5Ref: TM-T73560
1mg188,00€2mg255,00€5mg369,00€10mg597,00€25mg1.121,00€50mg1.700,00€100mg2.205,00€1mL*10mM (DMSO)425,00€Cbl-b-IN-11
CAS :Cbl-b-IN-11 (Compound 466) is an inhibitor of both casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting half-maximal inhibitory concentrations (IC50s) ofFormule :C31H35F5N6ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :602.64EOAI3402143
CAS :EOAI3402143 inhibits Usp9x and Usp24 activity, increases tumor cell apoptosis.Formule :C25H28Cl2N4O3Degré de pureté :98.09%Couleur et forme :SolidMasse moléculaire :503.42Ref: TM-T11209
1mg66,00€5mg144,00€10mg227,00€25mg445,00€50mg717,00€100mg1.064,00€1mL*10mM (DMSO)160,00€ML240
CAS :ML240 is a selective, ATP-competitive p97 inhibitor.Formule :C23H20N6ODegré de pureté :100% - 99.66%Couleur et forme :SolidMasse moléculaire :396.44Ref: TM-T3535
1mg38,00€5mg81,00€10mg116,00€25mg205,00€50mg329,00€100mg528,00€200mg752,00€1mL*10mM (DMSO)88,00€STD1T
CAS :STD1T is a USP2a inhibitor with anticancer activity that reduces levels of the cell cycle protein D1 protein in HCT116 colon cancer cells.Formule :C19H19N3O4S2Degré de pureté :98.77%Couleur et forme :SolidMasse moléculaire :417.5OTUB1/USP8-IN-1
CAS :OTUB1/USP8-IN-1 is an OTUB1/USP8 inhibitor with anticancer activity for the study of non-small cell lung cancer.Formule :C22H16ClFN2O4Degré de pureté :98.59%Couleur et forme :SoildMasse moléculaire :426.83USP7/USP47 inhibitor
CAS :USP7/USP47 inhibitor (USP7/47 inhibitor-1) is a selective ubiquitin-specific protease 7/47 (USP7/USP47) inhibitor, with EC50s of 0.42 μM and 1.0 μM,Formule :C18H11Cl2N3O3S3Degré de pureté :97.98% - 98.5%Couleur et forme :SolidMasse moléculaire :484.4Ref: TM-T4338
1mg43,00€5mg92,00€10mg160,00€25mg329,00€50mg547,00€100mg905,00€500mg1.786,00€1mL*10mM (DMSO)99,00€ML241 hydrochloride
CAS :ML241 is a potent and selective inhibitors of p97 ATPase.ML241 inhibits degradation of a p97-dependent but not a p97-independent proteasome substrate in a dual-Formule :C23H25ClN4ODegré de pureté :99.91% - 99.96%Couleur et forme :SolidMasse moléculaire :408.92FT671
CAS :FT671 is a non-covalent and selective inhibitor of USP7 (IC50: 52 nM) It also binds to the USP7 catalytic domain (Kd: 65 nM).Formule :C24H23F4N7O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :533.48ML364
CAS :ML364 is an inhibitor of ubiquitin specific peptidase 2 (USP2) and can be used for the research of breast cancer.Formule :C24H18F3N3O3S2Degré de pureté :100% - 99.92%Couleur et forme :SolidMasse moléculaire :517.54DKM 2-93
CAS :DKM 2-93 is a relatively selective inhibitor of UBA5(IC50 : 430 μM).Formule :C11H14ClNO3Degré de pureté :98.37%Couleur et forme :SolidMasse moléculaire :243.69USP25/28 inhibitor AZ1
CAS :USP25/28 inhibitor AZ1 is a selective, orally active and non-competitive dual ubiquitin-specific protease USP25/28 inhibitor.Cost-effective and quality-assured.Formule :C17H16BrF4NO2Degré de pureté :99.79% - 99.79%Couleur et forme :SolidMasse moléculaire :422.21Ref: TM-T7685
1mg35,00€5mg70,00€10mg97,00€25mg210,00€50mg321,00€100mg472,00€500mg1.035,00€1mL*10mM (DMSO)78,00€SJB3-019A
CAS :SJB3-019A is a potent, potent and novel ubiquitin-specific protease 1 (USP1) inhibitor, which promotes ID1 degradation and cytotoxicity in K562 cells 5 timesFormule :C16H8N2O3Degré de pureté :99.75%Couleur et forme :SolidMasse moléculaire :276.25Ref: TM-T12926
1mg94,00€2mg137,00€5mg224,00€10mg339,00€25mg560,00€50mg810,00€100mg1.121,00€500mg2.232,00€IU1
CAS :IU1 是一种可逆的特异性人类 USP14 蛋白酶体抑制剂,可以穿透细胞,IC50为 4.7 μM。Formule :C18H21FN2ODegré de pureté :98% - 99.30%Couleur et forme :SolidMasse moléculaire :300.37CB-5083
CAS :CB-5083 is a potent, selective, and orally bioavailable p97 AAA ATPase inhibitor ( IC50=11 nM).Formule :C24H23N5O2Degré de pureté :100% - 99.92%Couleur et forme :SolidMasse moléculaire :413.47Ref: TM-T6796
1mg46,00€2mg59,00€5mg87,00€10mg137,00€25mg298,00€50mg469,00€100mg687,00€500mg1.444,00€1mL*10mM (DMSO)97,00€LDN-91946
CAS :LDN-91946 is an effective and selective inhibitor of ubiquitin C-terminal hydrolase-L1 (UCH-L1) (Ki = 2.8 μM).Formule :C15H10N2O4SDegré de pureté :92.78%Couleur et forme :SolidMasse moléculaire :314.32Ubiquitination-IN-1
CAS :Ubiquitination-IN-1 is an inhibitor of ubiquitination and Cksl-Skp2 protein-protein interaction (IC50: 0.17 μM).Formule :C21H14F3N3O2SDegré de pureté :98.36% - 99.71%Couleur et forme :SolidMasse moléculaire :429.42Ref: TM-T13244
5mg70,00€10mg96,00€25mg168,00€50mg279,00€100mg418,00€500mg938,00€1mL*10mM (DMSO)77,00€Cbl-b-IN-6
CAS :Cbl-b-IN-6 (Compound 246) is an inhibitor of both casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting inhibitory half-maximal inhibitory concentrations (Formule :C30H32F5N5ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :573.6GNE-6640
CAS :GNE-6640: non-covalent USP7 inhibitor; IC50s: 0.75 µM (full), 0.43 µM (catalytic), 20.3 µM (USP43), 0.23 µM (Ub-MDM2).Formule :C20H18N4ODegré de pureté :98.64%Couleur et forme :SolidMasse moléculaire :330.38Ref: TM-T5461
1mg70,00€2mg92,00€5mg153,00€10mg250,00€25mg535,00€50mg772,00€100mg1.074,00€1mL*10mM (DMSO)166,00€GSK2643943A
CAS :GSK2643943A is a deubiquitylating enzyme (DUB) inhibitor, with an IC 50 of 160 nM for USP20/Ub-Rho. GSK2643943A has anti-tumor efficacy.Formule :C17H12FN3Degré de pureté :97.09%Couleur et forme :SolidMasse moléculaire :277.3
