Ubiquitination
Les inhibiteurs de l'ubiquitination sont des composés qui interfèrent avec le processus d'ubiquitination, par lequel les protéines sont marquées avec des molécules d'ubiquitine pour être dégradées par le protéasome. Ces inhibiteurs sont essentiels pour étudier le renouvellement des protéines, la transduction des signaux et la régulation de divers processus cellulaires. L'ubiquitination joue un rôle clé dans de nombreuses maladies, y compris le cancer, les troubles neurodégénératifs et les dysfonctionnements du système immunitaire. En modulant l'ubiquitination, ces inhibiteurs peuvent fournir des informations sur les mécanismes des maladies et ouvrir de nouvelles voies pour l'intervention thérapeutique. Chez CymitQuimica, nous offrons une large sélection d'inhibiteurs de l'ubiquitination de haute qualité pour soutenir vos recherches en biologie cellulaire, protéomique et découverte de médicaments.
Sous-catégories appartenant à la catégorie "Ubiquitination"
Produits appartenant à la catégorie "Ubiquitination"
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NSC232003
CAS :NSC232003 is a highly potent and cell-permeable inhibitor of UHRF1.Formule :C6H7N3O3Degré de pureté :97.72%Couleur et forme :SolidMasse moléculaire :169.14TAS4464 hydrochloride
CAS :TAS4464 hydrochloride is a highly potent and selective NEDD8 activating enzyme (NAE) inhibitor(IC50 of 0.955 nM).Formule :C21H24ClFN6O6SDegré de pureté :98.3% - 98.61%Couleur et forme :SolidMasse moléculaire :542.97Ref: TM-T13090
1mg66,00€5mg144,00€10mg227,00€25mg455,00€50mg753,00€100mg1.301,00€1mL*10mM (DMSO)167,00€USP28-IN-4
CAS :USP28-IN-4 is a USP28 inhibitor with anticancer activity that dose-dependently down-regulates cellular levels of c-Myc via the ubiquitin-proteasome system.Formule :C22H18Cl2N2O3SDegré de pureté :98.48%Couleur et forme :SolidMasse moléculaire :461.36NSC799462
NSC799462, a triazole inhibitor, specifically targets p97 ATPase, exerting its effect by binding to a designated site on the p97 enzyme. This interaction induces localized structural alterations in p97, effectively inhibiting its ATPase activity with an IC 50 value of 15 nM.Formule :C30H32F2N6O3SCouleur et forme :SolidMasse moléculaire :594.68COH000
CAS :COH000 is a covalent and irreversible inhibitor of small ubiquitin-like modifier (SUMO)-activating enzyme and inhibited SUMOylation (IC50: ~ 0.2 μM in vitro).Formule :C25H25NO5Degré de pureté :99.23%Couleur et forme :SolidMasse moléculaire :419.47Ref: TM-T5199
1mg188,00€5mg411,00€10mg593,00€25mg1.064,00€50mg1.501,00€100mg2.080,00€200mg2.832,00€1mL*10mM (DMSO)454,00€CYM5442
CAS :CYM5442 is an S1P agonist, targeting to Sphingosine.Formule :C23H27N3O4Degré de pureté :96.65% - 97.57%Couleur et forme :SolidMasse moléculaire :409.48WSB1 Degrader 1
CAS :WSB1 Degrader 1 is a potent, orally active degrader of WD repeat and SOCS box-containing 1, exhibiting anti-cancer metastatic effects.Formule :C21H22N2O2Degré de pureté :98.57%Couleur et forme :SolidMasse moléculaire :334.41Ref: TM-T9236
1mg52,00€5mg116,00€10mg182,00€25mg320,00€50mg449,00€100mg610,00€200mg822,00€1mL*10mM (DMSO)128,00€Cbl-b-IN-3
CAS :Cbl-b-IN-3 is a potent inhibitor of casitas b lineage lymphoma proto-oncogene-b (Cbl-b) (ic50 < 1 nM).Cost-effective and quality-assured.Formule :C30H34F3N5ODegré de pureté :98.99%Couleur et forme :SolidMasse moléculaire :537.62Cbl-b-IN-9
CAS :Cbl-b-IN-9 (Compound 300) is an inhibitor targeting casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting potent inhibitory activity with half-maximalFormule :C30H33F3N6O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :566.62USP7-IN-6
CAS :USP7-IN-6 is a potent inhibitor of ubiquitin-specific protease 7 (USP7, IC50: 6.8 nM).Formule :C41H43N7O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :729.89USP8-IN-3
CAS :USP8-IN-3 is a potent inhibitor of the deubiquitinating enzymes USP7 and USP8, with IC50 of 4.0 μM against USP8D.Formule :C18H18F3N5O2SDegré de pureté :99.18%Couleur et forme :SolidMasse moléculaire :425.43Ref: TM-T67873
1mg35,00€5mg64,00€10mg97,00€25mg207,00€50mg329,00€100mg475,00€500mg938,00€1mL*10mM (DMSO)84,00€P22074
CAS :P22074 is a USP7 inhibitor. It is not an active antagonist like its halogenated related compounds. p22074 has antitumour activity.Formule :C12H9NO3S2Degré de pureté :100%Couleur et forme :SolidMasse moléculaire :279.33UP158
CAS :UP158 enhances ATPase activity and stimulates valosin-containing protein (VCP), with an EC50 of 2.57 μM.Formule :C17H17ClN4O2Couleur et forme :SolidMasse moléculaire :344.8UC-764864
CAS :UC-764864, a UBE2N inhibitor, impedes the enzymatic activity of UBE2N and exhibits cytotoxic effects through the disruption of UBE2N-dependent signaling inFormule :C19H18N2OSDegré de pureté :99.3%Couleur et forme :SolidMasse moléculaire :322.42Subasumstat
CAS :Subasumstat (TAK-981) is a selective the SUMOylation enzymatic cascade inhibitor, has potential immune-activating and antineoplastic activities.Formule :C25H28ClN5O5S2Degré de pureté :97.02% - 98.22%Couleur et forme :SolidMasse moléculaire :578.1dCeMM3
CAS :dCeMM3 is a glue degrader that induces ubiquitination and degradation of cyclin K by promoting CDK12-cyclin K interaction with CRL4B ligase.Formule :C14H11ClN4OSDegré de pureté :98.48% - 99.19%Couleur et forme :SolidMasse moléculaire :318.78BI8626
CAS :BI8626 is a ubiquitin ligase inhibitor with protective effects against spontaneous dry syndrome in NOD/ShiLtj mice and inhibits the proliferation of CD4 T cellsFormule :C25H28N8Degré de pureté :98.66%Couleur et forme :SolidMasse moléculaire :440.54Ref: TM-T14569
1mg92,00€5mg188,00€10mg298,00€25mg502,00€50mg715,00€100mg938,00€1mL*10mM (DMSO)215,00€C527
CAS :C527 is a is a pan DUB enzyme inhibitor. Which has a high potency for the USP1/UAF1 complex (IC50=0.88 μM).Formule :C17H8FNO3Degré de pureté :97.22%Couleur et forme :SolidMasse moléculaire :293.25IU1-248
CAS :IU1-248 is a derivative of IU1. IU1-248 is a potent and selective USP14 inhibitor with an IC50 of 0.83 μM[1].Formule :C20H23N3O2Degré de pureté :99.30%Couleur et forme :SolidMasse moléculaire :337.42Ref: TM-T9375
1mg49,00€5mg104,00€10mg169,00€25mg334,00€50mg472,00€100mg658,00€200mg930,00€1mL*10mM (DMSO)115,00€UPCDC30766
CAS :UPCDC30766, a potent allosteric inhibitor of p97, exhibits an IC50 of 12 nM and is applicable for colon cancer research [1].Formule :C30H32F2N6O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :594.68ML-792
CAS :ML-792 is a specific small ubiquitin-like modifier activating enzyme (SUMO) inhibitor.Cost-effective and quality-assured.Formule :C21H23BrN6O5SDegré de pureté :99.32% - 99.82%Couleur et forme :SolidMasse moléculaire :551.41Ref: TM-T16102
1mg92,00€2mg119,00€5mg187,00€10mg274,00€25mg432,00€50mg590,00€100mg843,00€1mL*10mM (DMSO)236,00€Heclin
CAS :Heclin is an inhibitor of HECT E3 ubiquitin ligase that acts by inhibiting Smurf2, Nedd4, and WWP1 with IC50 values of 6.8, 6.3, and 6.9 μM, respectively.Formule :C17H17NO3Degré de pureté :94.99% - 99.25%Couleur et forme :SolidMasse moléculaire :283.32Ref: TM-T24136
1mg35,00€5mg70,00€10mg111,00€25mg205,00€50mg321,00€100mg512,00€200mg728,00€1mL*10mM (DMSO)77,00€GNE-6776
CAS :GNE-6776 is a selective USP7 inhibitor.Formule :C20H20N4O2Degré de pureté :96.59% - 98.2%Couleur et forme :SolidMasse moléculaire :348.4Ref: TM-T4634
1mg81,00€5mg170,00€10mg273,00€25mg525,00€50mg753,00€100mg1.026,00€1mL*10mM (DMSO)187,00€USP15-IN-1
CAS :USP15-IN-1 is a potent USP15 inhibitor (IC50 is 3.76 μM).Formule :C22H23N3O3Degré de pureté :99.35% - 99.81%Couleur et forme :SolidMasse moléculaire :377.44UP163
CAS :UP163 enhances ATPase activity and activates valosin-containing protein (VCP), with an EC50 of 9.0 μM. It also reduces MG-132-induced TDP-43 aggregation.Formule :C20H15ClN2O5SCouleur et forme :SolidMasse moléculaire :430.86SJB2-043
CAS :SJB2-043 is an inhibitor of USP1-UAF1 ( IC50 : 544 nM).Formule :C17H9NO3Degré de pureté :98.44%Couleur et forme :SolidMasse moléculaire :275.26TRAF6 peptide TFA
TRAF6 peptide TFA, a specific inhibitor of the TRAF6-p62 interaction, significantly inhibits NGF-dependent ubiquitination of TrkA.Formule :C145H238N34O44·xC2HF3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3161.64 (free acid)Nutlin-3
CAS :Nutlin-3 is an MDM2 antagonist that inhibits MDM2-p53 interaction and activates p53. Nutlin-3 has antitumor activity. Cost-effective and quality-assured.Formule :C30H30Cl2N4O4Degré de pureté :98.13% - 99.89%Couleur et forme :SolidMasse moléculaire :581.49Ref: TM-T2158
1mg37,00€5mg74,00€10mg97,00€25mg197,00€50mg301,00€100mg454,00€200mg650,00€1mL*10mM (DMSO)87,00€USP22-IN-1
CAS :USP22-IN-1 is a ubiquitin-specific peptidase 22 (USP22) inhibitor that can be used to treat proliferative diseases or cancer.Formule :C22H18N4Degré de pureté :98.2%Couleur et forme :SolidMasse moléculaire :338.41VLX1570
CAS :VLX1570 is a competitive inhibitor of proteasome DUB activity with IC50 ranging from 4.2 uM to 8.6 uM. It has potent inhibition for USP14.Formule :C23H17F2N3O6Degré de pureté :98.53% - 99.91%Couleur et forme :SolidMasse moléculaire :469.39Ref: TM-T4067
1mg96,00€2mg155,00€5mg259,00€10mg406,00€25mg680,00€50mg938,00€100mg1.301,00€1mL*10mM (DMSO)265,00€Skp2 inhibitor 3
Skp2 inhibitor 3 (E35), a potent antitumor agent, acts as a robust inhibitor of S-phase kinase-associated protein 2 (SKP2) with an IC50 of 4.86 μM for Skp2-Cks1 binding. It significantly suppresses colony formation and migration, while inducing cell cycle arrest in the S-phase.Couleur et forme :Odour SolidCbl-b-IN-12
CAS :Cbl-b-IN-12 (Example 10) is an inhibitor of casitas B-lineage lymphoma-b (CBL-B), demonstrating a half-maximal inhibitory concentration (IC50) of less than 100Formule :C28H29F3N6O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :538.56ICCB-19 hydrochloride
CAS :ICCB-19 hydrochloride (ICCB-19 HCl) is an inhibitor of TRADD (TNFRSF1A Associated Via Death Domain). It binds to a pocket on the TRADD-N.Formule :C12H22ClN3OSDegré de pureté :99.30%Couleur et forme :SolidMasse moléculaire :291.84Ref: TM-T8931L
5mg35,00€10mg52,00€25mg96,00€50mg145,00€100mg210,00€200mg313,00€500mg495,00€1mL*10mM (DMSO)35,00€NMS-873
CAS :NMS-873 is a potent, selective allosteric VCP/p97 inhibitor.Formule :C27H28N4O3S2Degré de pureté :99.05% - 99.5%Couleur et forme :SolidMasse moléculaire :520.67IU1-47
CAS :IU1-47 是一种特异性 USP14抑制剂,IC50为 0.6 μM。它诱导培养的神经元中 tau 蛋白降解。它抑制 IsoT/USP5, IC50为 20 μM。Formule :C19H23ClN2ODegré de pureté :98.94%Couleur et forme :SolidMasse moléculaire :330.85Ref: TM-T15604
1mg35,00€5mg74,00€10mg127,00€25mg263,00€50mg467,00€100mg785,00€200mg1.074,00€1mL*10mM (DMSO)81,00€Indole-3-carbinol
CAS :Indole-3-carbinol (I3C), a naturally occurring, orally available cleavage product of the glucosinolate glucobrassicanin, inhibits NF-κB and IκBα kinaseFormule :C9H9NODegré de pureté :100% - 97.06%Couleur et forme :SolidMasse moléculaire :147.17USP8-IN-1
CAS :USP8-IN-1 is an inhibitor of USP8 with an IC 50 of 1.9 μM. USP8-IN-1 inhibits H1975 cell growth with a GI 50 of 82.04 μM [1].Formule :C18H21N5O3SDegré de pureté :98.01%Couleur et forme :SoildMasse moléculaire :387.46Ref: TM-T60146
1mg88,00€5mg187,00€10mg264,00€25mg464,00€50mg655,00€100mg944,00€1mL*10mM (DMSO)207,00€USP7-IN-1
CAS :USP7-IN-1 is a selective and reversible ubiquitin-specific protease 7 (USP7) inhibitor (IC50 = 77 μM).Formule :C23H24ClN3O3Degré de pureté :98.70%Couleur et forme :SolidMasse moléculaire :425.91Ref: TM-T13268
1mg97,00€5mg188,00€10mg284,00€25mg452,00€50mg645,00€100mg867,00€200mg1.130,00€1mL*10mM (DMSO)217,00€Direct Black 38
CAS :Direct Black 38 (Chlorazol Black E) is a black azo dye that is genotoxic and induces unplanned DNA synthesis in rat liver and bone marrow micronuclei.Formule :C34H25N9Na2O7S2Degré de pureté :98%Couleur et forme :Grey-Black Powder Physical Description Gray-Black Microcrystals Or Black Powder (Ntp 1992)Masse moléculaire :781.73E3 ligase Ligand 36
CAS :E3 ligase Ligand 36 is an E3 ligase ligand that can be utilized for synthesizing PROTACs, such as PROTAC BRM/BRG1 degrader-1.Formule :C25H30N4O5SCouleur et forme :SolidMasse moléculaire :498.6IMP-1710
CAS :IMP-1710 is a selective UCH-L1 inhibitor with an IC50 value of 38 nM in a fluorescence polarization assay.[1]Cost-effective and quality-assured.Formule :C23H19N5ODegré de pureté :99.77%Couleur et forme :SolidMasse moléculaire :381.43Wu-5
CAS :Wu-5 is a potent USP10 inhibitor that inhibits FLT3 and AMPK pathways, promoting the breakdown of FLT3-ITD and inducing apoptosis.Formule :C15H13NO7SDegré de pureté :99.29%Couleur et forme :SoildMasse moléculaire :351.33M435-1279
CAS :M435-1279 is a UBE2T inhibitor. M435-1279 blocks UBE2T-mediated degradation of RACK1, leading to inhibit the hyperactivation of Wnt/β-catenin signaling pathway.Formule :C18H17N3O5S2Degré de pureté :97.16%Couleur et forme :SolidMasse moléculaire :419.47Ref: TM-T9500
1mg37,00€5mg80,00€10mg114,00€25mg212,00€50mg316,00€100mg447,00€200mg628,00€1mL*10mM (DMSO)95,00€BC-1382
CAS :BC-1382 is a potent ubiquitin E3 ligase HECTD2 inhibitor that specificly disrupts the HECTD2/PIAS1 interaction(IC50 of 5 nM).Formule :C23H29N3O5SDegré de pureté :99.15% - 99.72%Couleur et forme :SolidMasse moléculaire :459.56Ref: TM-T8564
1mg88,00€5mg188,00€10mg279,00€25mg535,00€50mg772,00€100mg1.074,00€200mg1.444,00€1mL*10mM (DMSO)254,00€OTUB2-IN-1
OTUB2-IN-1 is an OTUB2 inhibitor with antitumor activity and can be used to study skin cancer and non-small cell lung cancer (NSCLC).Formule :C19H18N2O6S2Degré de pureté :98.19%Couleur et forme :SolidMasse moléculaire :434.49USP1-IN-2
CAS :USP1-IN-2 is a potent USP1 inhibitor with potential anti-tumor activity for the study of cancer.Formule :C26H22F4N6ODegré de pureté :99.60% - 99.88%Couleur et forme :SolidMasse moléculaire :510.486XL177A
CAS :XL177A is a selective irreversible USP7 inhibitor(IC50 : 0.34 nM). XL177A elicits cancer cell killing through a p53-dependent mechanism.Formule :C48H57ClN8O5Degré de pureté :98.75%Couleur et forme :SolidMasse moléculaire :861.47Ref: TM-T9122
1mg96,00€5mg187,00€10mg298,00€25mg507,00€50mg730,00€100mg1.026,00€1mL*10mM (DMSO)283,00€HBX 19818
CAS :HBX 19818 is a specific ubiquitin-specific protease 7 (USP7) inhibitor (IC50: 28.1 μM).Formule :C25H28ClN3ODegré de pureté :98.76%Couleur et forme :SolidMasse moléculaire :421.96Ref: TM-T15464
1mg38,00€5mg85,00€10mg117,00€25mg187,00€50mg266,00€100mg373,00€200mg530,00€1mL*10mM (DMSO)94,00€E3 ligase Ligand 41
CAS :E3 Ligase Ligand 41 (Compound SI-13) serves as a ligand for the E3 ubiquitin ligase DCAF16. It is designed to connect with SLF through a linker, enabling the formation of KB03-SLF.Formule :C13H12ClF3N2O4Couleur et forme :SolidMasse moléculaire :352.69PR-619
CAS :PR-619 (2,6-Diamino-3,5-dithiocyanopyridine) is a DUB inhibitor. PR-619 induces endoplasmic reticulum stress and activates autophagy. Cost-effective and quality-assured.Formule :C7H5N5S2Degré de pureté :100% - 99.10%Couleur et forme :SolidMasse moléculaire :223.28
