
DUB
Les inhibiteurs de déubiquitinases (DUB) ciblent les enzymes qui retirent les molécules d'ubiquitine des protéines, régulant ainsi la stabilité, la localisation et l'activité des protéines dans la cellule. Les déubiquitinases jouent un rôle essentiel dans divers processus cellulaires, notamment la régulation du cycle cellulaire, la réparation de l'ADN et les réponses immunitaires. La dérégulation de l'activité des DUB est liée au cancer, aux troubles neurodégénératifs et aux infections virales. Les inhibiteurs de DUB peuvent moduler ces processus, offrant des approches thérapeutiques potentielles pour ces conditions. Chez CymitQuimica, nous proposons des inhibiteurs de DUB pour soutenir vos recherches en homéostasie des protéines, en oncologie et en neurobiologie.
Produits appartenant à la catégorie "DUB"
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54 produits dans cette catégorie.
C527
CAS :C527 is a is a pan DUB enzyme inhibitor. Which has a high potency for the USP1/UAF1 complex (IC50=0.88 μM).Formule :C17H8FNO3Degré de pureté :97.22%Couleur et forme :SolidMasse moléculaire :293.25IU1-248
CAS :IU1-248 is a derivative of IU1. IU1-248 is a potent and selective USP14 inhibitor with an IC50 of 0.83 μM[1].Formule :C20H23N3O2Degré de pureté :99.30%Couleur et forme :SolidMasse moléculaire :337.42Ref: TM-T9375
1mg49,00€5mg104,00€10mg169,00€25mg334,00€50mg472,00€100mg658,00€200mg930,00€1mL*10mM (DMSO)115,00€GNE-6776
CAS :GNE-6776 is a selective USP7 inhibitor.Formule :C20H20N4O2Degré de pureté :96.59% - 98.2%Couleur et forme :SolidMasse moléculaire :348.4Ref: TM-T4634
1mg81,00€5mg170,00€10mg273,00€25mg525,00€50mg753,00€100mg1.026,00€1mL*10mM (DMSO)187,00€USP15-IN-1
CAS :USP15-IN-1 is a potent USP15 inhibitor (IC50 is 3.76 μM).Formule :C22H23N3O3Degré de pureté :99.35% - 99.81%Couleur et forme :SolidMasse moléculaire :377.44SJB2-043
CAS :SJB2-043 is an inhibitor of USP1-UAF1 ( IC50 : 544 nM).Formule :C17H9NO3Degré de pureté :98.44%Couleur et forme :SolidMasse moléculaire :275.26USP22-IN-1
CAS :USP22-IN-1 is a ubiquitin-specific peptidase 22 (USP22) inhibitor that can be used to treat proliferative diseases or cancer.Formule :C22H18N4Degré de pureté :98.2%Couleur et forme :SolidMasse moléculaire :338.41VLX1570
CAS :VLX1570 is a competitive inhibitor of proteasome DUB activity with IC50 ranging from 4.2 uM to 8.6 uM. It has potent inhibition for USP14.Formule :C23H17F2N3O6Degré de pureté :98.53% - 99.91%Couleur et forme :SolidMasse moléculaire :469.39Ref: TM-T4067
1mg96,00€2mg155,00€5mg259,00€10mg406,00€25mg680,00€50mg938,00€100mg1.301,00€1mL*10mM (DMSO)265,00€IU1-47
CAS :IU1-47 是一种特异性 USP14抑制剂,IC50为 0.6 μM。它诱导培养的神经元中 tau 蛋白降解。它抑制 IsoT/USP5, IC50为 20 μM。Formule :C19H23ClN2ODegré de pureté :98.94%Couleur et forme :SolidMasse moléculaire :330.85Ref: TM-T15604
1mg35,00€5mg74,00€10mg127,00€25mg263,00€50mg467,00€100mg785,00€200mg1.074,00€1mL*10mM (DMSO)81,00€USP8-IN-1
CAS :USP8-IN-1 is an inhibitor of USP8 with an IC 50 of 1.9 μM. USP8-IN-1 inhibits H1975 cell growth with a GI 50 of 82.04 μM [1].Formule :C18H21N5O3SDegré de pureté :98.01%Couleur et forme :SoildMasse moléculaire :387.46Ref: TM-T60146
1mg88,00€5mg187,00€10mg264,00€25mg464,00€50mg655,00€100mg944,00€1mL*10mM (DMSO)207,00€USP7-IN-1
CAS :USP7-IN-1 is a selective and reversible ubiquitin-specific protease 7 (USP7) inhibitor (IC50 = 77 μM).Formule :C23H24ClN3O3Degré de pureté :98.70%Couleur et forme :SolidMasse moléculaire :425.91Ref: TM-T13268
1mg97,00€5mg188,00€10mg284,00€25mg452,00€50mg645,00€100mg867,00€200mg1.130,00€1mL*10mM (DMSO)217,00€IMP-1710
CAS :IMP-1710 is a selective UCH-L1 inhibitor with an IC50 value of 38 nM in a fluorescence polarization assay.[1]Cost-effective and quality-assured.Formule :C23H19N5ODegré de pureté :99.77%Couleur et forme :SolidMasse moléculaire :381.43Wu-5
CAS :Wu-5 is a potent USP10 inhibitor that inhibits FLT3 and AMPK pathways, promoting the breakdown of FLT3-ITD and inducing apoptosis.Formule :C15H13NO7SDegré de pureté :99.29%Couleur et forme :SoildMasse moléculaire :351.33OTUB2-IN-1
OTUB2-IN-1 is an OTUB2 inhibitor with antitumor activity and can be used to study skin cancer and non-small cell lung cancer (NSCLC).Formule :C19H18N2O6S2Degré de pureté :98.19%Couleur et forme :SolidMasse moléculaire :434.49USP1-IN-2
CAS :USP1-IN-2 is a potent USP1 inhibitor with potential anti-tumor activity for the study of cancer.Formule :C26H22F4N6ODegré de pureté :99.60% - 99.88%Couleur et forme :SolidMasse moléculaire :510.486XL177A
CAS :XL177A is a selective irreversible USP7 inhibitor(IC50 : 0.34 nM). XL177A elicits cancer cell killing through a p53-dependent mechanism.Formule :C48H57ClN8O5Degré de pureté :98.75%Couleur et forme :SolidMasse moléculaire :861.47Ref: TM-T9122
1mg96,00€5mg187,00€10mg298,00€25mg507,00€50mg730,00€100mg1.026,00€1mL*10mM (DMSO)283,00€HBX 19818
CAS :HBX 19818 is a specific ubiquitin-specific protease 7 (USP7) inhibitor (IC50: 28.1 μM).Formule :C25H28ClN3ODegré de pureté :98.76%Couleur et forme :SolidMasse moléculaire :421.96Ref: TM-T15464
1mg38,00€5mg85,00€10mg117,00€25mg187,00€50mg266,00€100mg373,00€200mg530,00€1mL*10mM (DMSO)94,00€DUB-IN-2
CAS :Dub-in-2, with an IC50 value of 0.28 for USP8, is an effective deubiquitinase inhibitor.Formule :C15H9N5ODegré de pureté :98.96%Couleur et forme :SolidMasse moléculaire :275.26Ref: TM-T11111
1mg79,00€5mg172,00€10mg259,00€25mg518,00€50mg758,00€100mg1.103,00€200mg1.483,00€1mL*10mM (DMSO)182,00€P 22077
CAS :P 22077 (P22077) is an inhibitor of ubiquitin-specific protease USP7 with EC50 of 8.6 μM. It also inhibits the closely related USP47.Formule :C12H7F2NO3S2Degré de pureté :97.9% - 99.58%Couleur et forme :SolidMasse moléculaire :315.32USP28-IN-3
CAS :USP28-IN-3 is a USP28 inhibitor with anticancer activity that dose-dependently down-regulates cellular levels of c-Myc via the ubiquitin-proteasome system.Formule :C23H20Cl2N2O3SDegré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :475.39USP5-IN-1
USP5-IN-1, a powerful USP5 deubiquitinase inhibitor, selectively binds with 2.8 μM affinity, blocking USP5's di-ubiquitin cleavage.Formule :C19H20ClN3O5SDegré de pureté :99.53%Couleur et forme :SoildMasse moléculaire :437.9FT827
CAS :FT827 is a covalent inhibitor of USP7 that targets the catalytic center of the autoinhibitory apolipoprotein form of USP7 for cancer research.Formule :C27H28N6O5SDegré de pureté :98.76%Couleur et forme :SolidMasse moléculaire :548.61HBX 41108
CAS :HBX 41108: non-competitive, reversible USP7 inhibitor; IC50: 424nM; blocks USP7-p53 deubiquitination; IC50: 0.8μM.Formule :C13H3ClN4ODegré de pureté :95.63%Couleur et forme :SolidMasse moléculaire :266.64ML-323
CAS :ML323 is a reversible and effective USP1-UAF1 inhibitor in a Ub-Rho assay and in orthogonal gel-based assays using K63-linked di-Ub and Ub-PCNA as substrates.Formule :C23H24N6Degré de pureté :99.87% - 99.96%Couleur et forme :SolidMasse moléculaire :384.48Ref: TM-T1757
1mg89,00€5mg207,00€10mg331,00€25mg512,00€50mg775,00€100mg1.140,00€1mL*10mM (DMSO)245,00€USP7-IN-3
CAS :USP7-IN-3 is a potent and selective allosteric inhibitor of ubiquitin-specific protease 7 (USP7).Formule :C29H31F3N6O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :568.59Vialinin A
CAS :Vialinin A, a p-terphenyl with antioxidant properties, inhibits TNF-α/USP4/5/SENP1, used in autoimmune/cancer research.Formule :C34H26O8Degré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :562.57USP7-797
CAS :USP7-797 is a selective non-covalent active site USP7 inhibitor, inhibiting USP7 and ubiquitin binding, with anti-tumor, oral and high efficiency properties.Formule :C27H28ClN3O3SDegré de pureté :96.18%Couleur et forme :SolidMasse moléculaire :510.05USP30 inhibitor 11
CAS :USP30 inhibitor 11 (USP30-IN-11) is a USP30 inhibitor that inhibits SVA and can be used in studies of cancer, mitochondrial dysfunction and Parkinson's.Formule :C17H16N6O2SDegré de pureté :100% - 96.31%Couleur et forme :SolidMasse moléculaire :368.41USP8-IN-2
CAS :USP8-IN-2 is a potent inhibitor of the deubiquitinating enzymes USP7 and USP8, with an IC50 of 4.0 μM against USP8D.Formule :C19H20ClF3N4OSDegré de pureté :98.83%Couleur et forme :SolidMasse moléculaire :444.9Ref: TM-T67876
1mg88,00€5mg210,00€10mg329,00€25mg548,00€50mg782,00€100mg1.035,00€1mL*10mM (DMSO)245,00€NSC632839
CAS :NSC-632839 (Ubiquitin Isopeptidase Inhibitor II) is a nonselective isopeptidase inhibitor, which inhibits USP2 (EC50: 45±4 μM), USP7 (EC50: 37±1 μM), and SENP2Formule :C21H22ClNODegré de pureté :99.74% - 99.87%Couleur et forme :SolidMasse moléculaire :339.86USP7-IN-8
CAS :Benzamide, 4-[6-amino-4-ethyl-5-(4-hydroxyphenyl)-3-pyridinyl]-N-methyl- is a selective ubiquitin-specific protease 7 (USP7) inhibitor with an IC50 of 1.4 μM.Formule :C21H21N3O2Degré de pureté :99.31%Couleur et forme :SolidMasse moléculaire :347.41Ref: TM-T9217
1mg48,00€5mg97,00€10mg156,00€25mg284,00€50mg411,00€100mg562,00€200mg743,00€1mL*10mM (DMSO)105,00€TCID
CAS :TCID (UCH-L3 Inhibitor)(IC50=0.6 μM) is a DUB inhibitor of ubiquitin C-terminal hydrolase L3. It has the 125-fold selectivity to L1.Formule :C9H2Cl4O2Degré de pureté :99.34%Couleur et forme :SolidMasse moléculaire :283.92OTUB1/USP8-IN-1 HCl
OTUB1/USP8-IN-1 HCL is a potent dual inhibitor of OTUB1 and USP8 with potential antitumour activity, inhibiting both OTUB1 and USP8 for leukaemiaFormule :C22H17Cl2FN2O4Degré de pureté :99.90%Couleur et forme :SolidMasse moléculaire :463.29DUB-IN-3
CAS :DUB-IN-3 is a potent deubiquitinase (USP) enzyme inhibitor and the IC50 for USP8 is 0.56 μM.Formule :C16H9N5ODegré de pureté :99.34%Couleur et forme :SolidMasse moléculaire :287.28Ref: TM-T11112
1mg137,00€2mg188,00€5mg325,00€10mg465,00€25mg743,00€50mg1.035,00€100mg1.406,00€500mg2.802,00€1mL*10mM (DMSO)341,00€USP30 inhibitor 18
CAS :USP30 inhibitor 18 is a selective inhibitor of USP30 (IC50 = 0.02 μM). USP30 inhibitor 18 is able to accelerate mitophagy and increase protein ubiquitination.Formule :C26H28FN3O4SDegré de pureté :99.03%Couleur et forme :SolidMasse moléculaire :497.58Ref: TM-T36682
1mg144,00€5mg298,00€10mg472,00€25mg753,00€50mg1.074,00€100mg1.444,00€500mg2.822,00€1mL*10mM (DMSO)325,00€P005091
CAS :P005091 (P5091) is a selective and potent inhibitor of ubiquitin-specific protease 7 (USP7) with EC50 of 4.2 μM.Formule :C12H7Cl2NO3S2Degré de pureté :99.53% - 99.87%Couleur et forme :SolidMasse moléculaire :348.22DUB-IN-1
CAS :DUB-IN-1, with an IC50 value of 0.24 for USP8, is an active inhibitor of ubiquitin-specific protease (USPs).Formule :C20H11N5ODegré de pureté :98.33% - 98.96%Couleur et forme :SolidMasse moléculaire :337.33Ref: TM-T11110
1mg65,00€5mg116,00€10mg183,00€25mg353,00€50mg495,00€100mg652,00€200mg895,00€1mL*10mM (DMSO)128,00€MF-094
CAS :MF-094 is a selective USP30 inhibitor with IC50 of 0.12 μM. MF-094 can increase protein ubiquitination and accelerate mitophagy.Cost-effective and quality-assured.Formule :C30H37N3O4SDegré de pureté :98.46%Couleur et forme :SolidMasse moléculaire :535.7Ref: TM-T12024
1mg43,00€5mg87,00€10mg144,00€25mg283,00€50mg454,00€100mg655,00€500mg1.454,00€1mL*10mM (DMSO)120,00€I-138
CAS :I-138 is an orally active and reversible inhibitor of USP1-UAF1.I-138 induces mono-ubiquitination of FANCD2 and PCNA and inhibits USP1 auto-cleavage in cells.Formule :C26H23F3N6ODegré de pureté :99.41%Couleur et forme :SolidMasse moléculaire :492.5Ref: TM-T73560
1mg188,00€2mg255,00€5mg369,00€10mg597,00€25mg1.121,00€50mg1.700,00€100mg2.205,00€1mL*10mM (DMSO)425,00€EOAI3402143
CAS :EOAI3402143 inhibits Usp9x and Usp24 activity, increases tumor cell apoptosis.Formule :C25H28Cl2N4O3Degré de pureté :98.09%Couleur et forme :SolidMasse moléculaire :503.42Ref: TM-T11209
1mg66,00€5mg144,00€10mg227,00€25mg445,00€50mg717,00€100mg1.064,00€1mL*10mM (DMSO)160,00€STD1T
CAS :STD1T is a USP2a inhibitor with anticancer activity that reduces levels of the cell cycle protein D1 protein in HCT116 colon cancer cells.Formule :C19H19N3O4S2Degré de pureté :98.77%Couleur et forme :SolidMasse moléculaire :417.5OTUB1/USP8-IN-1
CAS :OTUB1/USP8-IN-1 is an OTUB1/USP8 inhibitor with anticancer activity for the study of non-small cell lung cancer.Formule :C22H16ClFN2O4Degré de pureté :98.59%Couleur et forme :SoildMasse moléculaire :426.83USP7/USP47 inhibitor
CAS :USP7/USP47 inhibitor (USP7/47 inhibitor-1) is a selective ubiquitin-specific protease 7/47 (USP7/USP47) inhibitor, with EC50s of 0.42 μM and 1.0 μM,Formule :C18H11Cl2N3O3S3Degré de pureté :97.98% - 98.5%Couleur et forme :SolidMasse moléculaire :484.4Ref: TM-T4338
1mg43,00€5mg92,00€10mg160,00€25mg329,00€50mg547,00€100mg905,00€500mg1.786,00€1mL*10mM (DMSO)99,00€FT671
CAS :FT671 is a non-covalent and selective inhibitor of USP7 (IC50: 52 nM) It also binds to the USP7 catalytic domain (Kd: 65 nM).Formule :C24H23F4N7O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :533.48USP25/28 inhibitor AZ1
CAS :USP25/28 inhibitor AZ1 is a selective, orally active and non-competitive dual ubiquitin-specific protease USP25/28 inhibitor.Cost-effective and quality-assured.Formule :C17H16BrF4NO2Degré de pureté :99.79% - 99.79%Couleur et forme :SolidMasse moléculaire :422.21Ref: TM-T7685
1mg35,00€5mg70,00€10mg97,00€25mg210,00€50mg321,00€100mg472,00€500mg1.035,00€1mL*10mM (DMSO)78,00€SJB3-019A
CAS :SJB3-019A is a potent, potent and novel ubiquitin-specific protease 1 (USP1) inhibitor, which promotes ID1 degradation and cytotoxicity in K562 cells 5 timesFormule :C16H8N2O3Degré de pureté :99.75%Couleur et forme :SolidMasse moléculaire :276.25Ref: TM-T12926
1mg94,00€2mg137,00€5mg224,00€10mg339,00€25mg560,00€50mg810,00€100mg1.121,00€500mg2.232,00€IU1
CAS :IU1 是一种可逆的特异性人类 USP14 蛋白酶体抑制剂,可以穿透细胞,IC50为 4.7 μM。Formule :C18H21FN2ODegré de pureté :98% - 99.30%Couleur et forme :SolidMasse moléculaire :300.37LDN-91946
CAS :LDN-91946 is an effective and selective inhibitor of ubiquitin C-terminal hydrolase-L1 (UCH-L1) (Ki = 2.8 μM).Formule :C15H10N2O4SDegré de pureté :92.78%Couleur et forme :SolidMasse moléculaire :314.32GNE-6640
CAS :GNE-6640: non-covalent USP7 inhibitor; IC50s: 0.75 µM (full), 0.43 µM (catalytic), 20.3 µM (USP43), 0.23 µM (Ub-MDM2).Formule :C20H18N4ODegré de pureté :98.64%Couleur et forme :SolidMasse moléculaire :330.38Ref: TM-T5461
1mg70,00€2mg92,00€5mg153,00€10mg250,00€25mg535,00€50mg772,00€100mg1.074,00€1mL*10mM (DMSO)166,00€GSK2643943A
CAS :GSK2643943A is a deubiquitylating enzyme (DUB) inhibitor, with an IC 50 of 160 nM for USP20/Ub-Rho. GSK2643943A has anti-tumor efficacy.Formule :C17H12FN3Degré de pureté :97.09%Couleur et forme :SolidMasse moléculaire :277.3USP28-IN-4
CAS :USP28-IN-4 is a USP28 inhibitor with anticancer activity that dose-dependently down-regulates cellular levels of c-Myc via the ubiquitin-proteasome system.Formule :C22H18Cl2N2O3SDegré de pureté :98.48%Couleur et forme :SolidMasse moléculaire :461.36USP7-IN-6
CAS :USP7-IN-6 is a potent inhibitor of ubiquitin-specific protease 7 (USP7, IC50: 6.8 nM).Formule :C41H43N7O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :729.89USP8-IN-3
CAS :USP8-IN-3 is a potent inhibitor of the deubiquitinating enzymes USP7 and USP8, with IC50 of 4.0 μM against USP8D.Formule :C18H18F3N5O2SDegré de pureté :99.18%Couleur et forme :SolidMasse moléculaire :425.43Ref: TM-T67873
1mg35,00€5mg64,00€10mg97,00€25mg207,00€50mg329,00€100mg475,00€500mg938,00€1mL*10mM (DMSO)84,00€P22074
CAS :P22074 is a USP7 inhibitor. It is not an active antagonist like its halogenated related compounds. p22074 has antitumour activity.Formule :C12H9NO3S2Degré de pureté :100%Couleur et forme :SolidMasse moléculaire :279.33ML364
CAS :ML364 is an inhibitor of ubiquitin specific peptidase 2 (USP2) and can be used for the research of breast cancer.Formule :C24H18F3N3O3S2Degré de pureté :100% - 99.92%Couleur et forme :SolidMasse moléculaire :517.54