Récepteur Sigma
Les récepteurs sigma sont des sites de liaison uniques qui, contrairement aux GPCR classiques, ne correspondent pas aux catégories traditionnelles des protéines réceptrices. Ils sont impliqués dans la modulation des systèmes de neurotransmetteurs et ont été associés à divers troubles neurologiques et psychiatriques. Les récepteurs sigma sont également associés à la survie cellulaire, et leurs ligands sont explorés pour des applications thérapeutiques dans la neuroprotection, le cancer et la gestion de la douleur. Chez CymitQuimica, nous offrons une sélection de modulateurs de récepteurs sigma de haute qualité pour soutenir vos recherches en neurosciences, oncologie et biologie des récepteurs.
Produits appartenant à la catégorie "Récepteur Sigma"
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53 produits dans cette catégorie.
Blarcamesine
CAS :Blarcamesine (AVex-73) is a muscarinic M1 agonist potentially for the treatment of Alzheimer's disease.Formule :C19H23NODegré de pureté :99.87%Couleur et forme :SolidMasse moléculaire :281.39BD-1047
CAS :BD-1047 is a selective functional antagonist of sigma receptors. It can alleviate climbing behavior induced by Apomorphine and head twitching caused by Phencyclidine.Formule :C13H20Cl2N2Couleur et forme :SolidMasse moléculaire :275.217Amitriptyline
CAS :Amitriptyline: a tricyclic antidepressant used for depression and neuropathic pain.Formule :C20H23NDegré de pureté :98.24% - 99.64%Couleur et forme :Crystals SolidMasse moléculaire :277.4Opipramol
CAS :Opipramol (Ensidon) is a compound with antidepressant activity, a sigma (σ) receptor agonist, and anxiolytic activity.Formule :C23H29N3ODegré de pureté :99.84% - 99.98%Couleur et forme :SolidMasse moléculaire :363.5Sigma-1 receptor antagonist 3
CAS :Sigma-1 receptor antagonist 3 is a more potent and selective antagonist of Sigma-1 (σ1) receptor (Ki = 1.14 nM) than σ2 receptor(Ki = 1239 nM).Formule :C19H23ClFN3ODegré de pureté :100%Couleur et forme :SolidMasse moléculaire :363.86Pre-084
CAS :Pre-084 is a high affinity, selective σ1 agonist.Formule :C19H28ClNO3Degré de pureté :99.91%Couleur et forme :SolidMasse moléculaire :353.88Sigma-LIGAND-1
CAS :Sigma-LIGAND-1 is a selective Sigma Receptor ligand with an IC50s of 16 nM, 19 nM at the DTG site and the PPP site, respectively.Formule :C27H33NO4Degré de pureté :100%Couleur et forme :SolidMasse moléculaire :435.56Ref: TM-T13510
1mg64,00€5mg149,00€10mg215,00€25mg335,00€50mg452,00€100mg620,00€200mg835,00€1mL*10mM (DMSO)172,00€KB-5492 free base
CAS :KB-5492 free base is an antiulcer agent that inhibits sigma receptors and can be used to study gastric lesions and gastric secretion.Formule :C23H30N2O6Degré de pureté :97.72% - 99.07%Couleur et forme :SolidMasse moléculaire :430.49Ref: TM-T62396
2mg42,00€5mg62,00€10mg87,00€25mg126,00€50mg177,00€100mg263,00€500mg647,00€1mL*10mM (DMSO)67,00€SARS-CoV-2-IN-57
CAS :SARS-CoV-2-IN-57 (compound (+)-R-26) is a potent inhibitor of SARS-CoV-2 with an IC50 of 80 nM and demonstrates high affinity for the Sigma Receptor, exhibitingFormule :C23H37N3ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :371.56UKH-1114
CAS :UKH-1114 is a potent σ2 receptor/Tmem97 agonist with a Ki value of 46 nM, demonstrating antinociceptive effects against mechanical hypersensitivity. This compound alleviates mechanical hypersensitivity in mice caused by nerve injury without inducing motor impairment and is a promising candidate for neuropathic pain research.Formule :C22H24F3NOCouleur et forme :SolidMasse moléculaire :375.43AB21 oxalate
AB21 oxalate, a potent and selective S1R antagonist, exhibits binding affinities (Kis) of 13 nM and 102 nM for S1R and S2R, respectively.Formule :C25H30N2O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :438.52BD1063 dhydrochloride
CAS :BD1063 dhydrochloride is a potent and selective sigma 1(σ1) receptor antagonist(Ki = 9 nM).Formule :C13H20Cl4N2Degré de pureté :99.52% - ≥95%Couleur et forme :SolidMasse moléculaire :346.12Ref: TM-T7488
2mg48,00€5mg72,00€10mg90,00€25mg187,00€50mg339,00€100mg499,00€200mg702,00€500mg1.074,00€Sigma-1 receptor antagonist 4
Sigma-1 receptor antagonist 4 (Compound 32) is a potent σ1R antagonist that significantly enhances morphine's analgesic effects and reverses morphine-inducedFormule :C22H26N2OCouleur et forme :SolidMasse moléculaire :334.45KB-5492 FA
KB-5492 FA is a selective sigma receptor inhibitor with antiulcerogenic effects.CAS 번호128-52-56-8Formule :C24H32N2O8Degré de pureté :98.54%Couleur et forme :SolidMasse moléculaire :476.52PD 144418
CAS :PD 144418 displays potential antipsychotic activity.Formule :C18H22N2ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :282.38Sigma-1 receptor antagonist 1
CAS :Sigma-1 receptor antagonist 1 is an effective and selective antagonist of sigma-1 receptor.Formule :C19H23Cl2N3ODegré de pureté :99.81%Couleur et forme :SolidMasse moléculaire :380.31S1RA
CAS :S1RA (E-52862)(E-52862) is a potent, selective antagonist of the sigma-1 receptor (σ1R, Ki=17 nM), demonstrating significant selectivity over the sigma-2Formule :C20H23N3O2Degré de pureté :99.45%Couleur et forme :SolidMasse moléculaire :337.42BMY-14802 hydrochloride
CAS :BMY-14802 hydrochloride (BMS 181100 hydrochloride) is a selective antagonist of σ receptor (IC50 = 112 nM) with antipsychotic effects.Formule :C18H23ClF2N4ODegré de pureté :98.64%Couleur et forme :SolidMasse moléculaire :384.85Sigma-1 receptor antagonist 2
CAS :Sigma-1 receptor antagonist 2 is a more potent and selective antagonist of sigma 1 receptor (σ1 R, Ki = 3.88 nM) than σ2 receptor (Ki = 1288 nM).Formule :C20H26ClN3O2Degré de pureté :99.52%Couleur et forme :SolidMasse moléculaire :375.89Ref: TM-T12911
1mg64,00€5mg145,00€10mg235,00€25mg394,00€50mg562,00€100mg758,00€200mg1.017,00€1mL*10mM (DMSO)160,00€Ditolylguanidine
CAS :Ditolylguanidine (Di-o-tolylguanidine) is an agonist of sigma receptor (σ1/σ2 receptor).Formule :C15H17N3Degré de pureté :98.42%Couleur et forme :White To Pinkish Solid PowderMasse moléculaire :239.32Glycerol phenylbutyrate
CAS :Glycerol phenylbutyrate (HPN-100) (GPB) is a new generation ammonia scavenger drug and it also is a sigma-2 (σ2) receptor ligand (pKi: 8.02).Formule :C33H38O6Degré de pureté :99.00% - 99.74%Couleur et forme :SolidMasse moléculaire :530.65AF-710B
CAS :AF710B is an enantiomer of AF710. AF-710B is also a sigma and M1 muscarinic receptors agonist.Formule :C20H27N3OSDegré de pureté :98.62% - 99.89%Couleur et forme :SolidMasse moléculaire :357.51KSK67
CAS :KSK67 is a selective dual antagonist of sigma-2 and histamine H3 receptors with inhibitory effects on H3 receptors, sigma-1, and sigma-2 receptors, with KiFormule :C22H27N3O2Degré de pureté :99.11%Couleur et forme :SoildMasse moléculaire :365.47PD 144418 oxalate
CAS :PD 144418 oxalate: σ1 receptor ligand, Ki=0.08 nM; 1377 nM for σ2, minimal affinity elsewhere; potential antipsychotic.Formule :C20H24N2O5Degré de pureté :99.08%Couleur et forme :SolidMasse moléculaire :372.42Siramesine
CAS :Siramesine (Lu 28-179)(Lu 28-179) is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of cancer cells and to exhibit a potentFormule :C30H31FN2ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :454.58σ1 Receptor ligand 1
σ1 Receptor ligand 1 (compound 5I) is a σ1 receptor ligand with a Ki value of 3.9 nM. It demonstrates a high plasma protein binding rate (89%) and exhibits good metabolic stability in the presence of mouse liver microsomes and NADPH. σ1 Receptor ligand 1 is applicable in neuroscience and cancer research.Formule :C22H28N2O2Couleur et forme :SolidMasse moléculaire :352.47S1R agonist 1 hydrochloride
CAS :S1R Agonist 1 (Compound 6b) hydrochloride is a selective S1R agonist, displaying K i values of 0.93 nM for S1R and 72 nM for S2R, and has demonstratedFormule :C20H26ClNODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :331.88S1R agonist 2 hydrochloride
Compound 8b hydrochloride, a selective S1R agonist, exhibits affinity with K i s of 1.1 nM for S1R and 88 nM for S2R.Formule :C21H28ClNODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :345.91BMY-14802
CAS :BMY-14802 (alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazine butanol) is a selective and orally active sigma-1 antagonist with an IC50 of 112 nM.Formule :C18H22F2N4ODegré de pureté :98.93%Couleur et forme :SoildMasse moléculaire :348.39Ref: TM-T67739
1mg40,00€5mg88,00€10mg137,00€25mg264,00€50mg432,00€100mg638,00€500mg1.359,00€1mL*10mM (DMSO)87,00€Sigma-1 receptor antagonist 6
CAS :Sigma-1 receptor antagonist 6 (Compound 12), a σ1R antagonist, demonstrates significant antiallodynic effects by targeting the Sigma-1 receptor (σ1R). This compound is effective in animal models for neuropathic pain, particularly for reducing mechanical allodynia caused by paclitaxel.Formule :C32H34N6Couleur et forme :SolidMasse moléculaire :502.65Sigma-1 receptor antagonist 5
Sigma-1 receptor antagonist 5 (compound 12), a 4-pyridylpiperidine derivative, exhibits analgesic properties through its antagonistic action on sigma receptorsFormule :C26H27N3ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :397.51Cutamesine dihydrochloride
CAS :Cutamesine dihydrochloride is a σ1 receptor agonist, selective over σ2, combating cardiomyocyte hypertrophy and improving stroke recovery.Formule :C23H32N2O2·2HClDegré de pureté :98.83% - 99%Couleur et forme :SolidMasse moléculaire :441.43Ref: TM-T3597
2mg38,00€5mg55,00€10mg96,00€25mg178,00€50mg281,00€100mg445,00€200mg640,00€1mL*10mM (DMSO)60,00€σ1 Receptor antagonist-1
CAS :σ1 Receptor antagonist-1 is a selective sigma 1 receptor antagonist.Formule :C21H23NOSDegré de pureté :99.80%Couleur et forme :SolidMasse moléculaire :337.48Ref: TM-T9244
2mg38,00€5mg55,00€10mg88,00€25mg170,00€50mg269,00€100mg391,00€200mg562,00€1mL*10mM (DMSO)59,00€OPC-14523 hydrochloride
CAS :OPC-14523 hydrochloride, an oral sigma/5-HT1A agonist, shows potent antidepressant activity with strong receptor affinity.Formule :C23H29Cl2N3O2Degré de pureté :99.70%Couleur et forme :SolidMasse moléculaire :450.4AD186
AD186, a potent and selective S1R agonist, exhibits dissociation constants (Kis) of 2.7 nM for S1R and 27 nM for S2R.Formule :C22H28N2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :320.47Siramesine hydrochloride
CAS :Siramesine hydrochloride (Lu 28-179 hydrochloride) is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of Y cells and to exhibitFormule :C30H32ClFN2ODegré de pureté :100% - 99.75%Couleur et forme :SolidMasse moléculaire :491.04Ref: TM-T1885
1mg60,00€2mg88,00€5mg111,00€10mg173,00€25mg354,00€50mg528,00€100mg743,00€1mL*10mM (DMSO)120,00€Roluperidone
CAS :Roluperidone (CYR-101) is a novel cyclic amide derivative.Formule :C22H23FN2O2Degré de pureté :96.46% - 97.77%Couleur et forme :SolidMasse moléculaire :366.43NE-100 hydrochloride
CAS :NE-100 hydrochloride (NE-100 HCl) is a potent and selective antagonist of σ1 (IC50 = 4.16 nM) with antipsychotic activity.Formule :C23H34ClNO2Degré de pureté :98.85%Couleur et forme :SolidMasse moléculaire :391.98Ref: TM-T20797
1mg46,00€2mg57,00€5mg92,00€10mg137,00€25mg221,00€50mg329,00€100mg490,00€200mg700,00€500mg1.035,00€4-PPBP maleate
CAS :4-PPBP maleate: potent σ1 agonist, selective NR1a/2B NMDA antagonist, neuroprotective.Formule :C25H31NO4Degré de pureté :99.54%Couleur et forme :SolidMasse moléculaire :409.52Ref: TM-T22513
5mg48,00€10mg74,00€25mg135,00€50mg210,00€100mg313,00€200mg442,00€1mL*10mM (DMSO)56,00€Blarcamesine hydrochloride
CAS :Blarcamesine hydrochloride (AVex-73 hydrochloride) is a Sigma-1 Receptor agonist (IC50: 860 nM).Formule :C19H24ClNODegré de pureté :98.62% - 99.57%Couleur et forme :SolidMasse moléculaire :317.85Ref: TM-T4111
1mg46,00€2mg59,00€5mg93,00€10mg139,00€25mg255,00€50mg457,00€100mg655,00€500mg1.406,00€1mL*10mM (DMSO)97,00€4-IBP
CAS :4-IBP is a selective σ1 agonist with a high level of affinity for the σ1 receptor (Ki = 1.7 nM) and a moderate affinity for the σ2 receptor (Ki = 25.2 nM) .Formule :C19H21IN2ODegré de pureté :98.99%Couleur et forme :SolidMasse moléculaire :420.29AD353
AD353 is a selective sigma-1 receptor ligand. It demonstrates high efficacy in models of capsaicin-induced allodynia and PGE2-induced mechanical hyperalgesia. Additionally, AD353 exhibits favorable pharmacokinetic properties.Formule :C23H30N2O2Couleur et forme :SolidMasse moléculaire :366.5Blonanserin
CAS :Blonanserin (AD-5423), approved in Japan (2008), is an atypical antipsychotic with fewer side effects like EPS, sedation, or hypotension.Formule :C23H30FN3Degré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :367.5BD 1008 dihydrobromide
CAS :BD 1008 dihydrobromide: selective σ1 receptor antagonist (Ki=2 nM), high σ1 and moderate σ2 affinity.Formule :C15H24Br2Cl2N2Degré de pureté :97.81%Couleur et forme :SolidMasse moléculaire :463.08Ref: TM-T21788
1mg65,00€5mg133,00€10mg202,00€25mg341,00€50mg507,00€100mg722,00€1mL*10mM (DMSO)157,00€BD-1047 dihydrobromide
CAS :BD-1047 dihydrobromide (BD1047.2HBr) , a selective functional antagonist of sigma receptors, has antipsychotic activity in animal models predictive of efficacyFormule :C13H22Br2Cl2N2Degré de pureté :98.13% - 99.39%Couleur et forme :SolidMasse moléculaire :437.04Ref: TM-T1740
1mg37,00€2mg48,00€5mg73,00€10mg95,00€25mg168,00€50mg290,00€100mg490,00€1mL*10mM (DMSO)74,00€UMB24
CAS :UMB24 is an effective antagonist of the σ2 receptor, exhibiting dissociation constants (Ki values) of 170 nM for the σ2 receptor and 322 nM for the σ1 receptor. This compound mitigates cocaine-induced convulsions and hyperactivity without causing mortality.Formule :C17H21N3Couleur et forme :SolidMasse moléculaire :267.37EST64454 hydrochloride
CAS :EST64454 hydrochloride (EST64454) is a highly soluble σ1 receptor antagonist (Ki : 22 nM),has the potential for Pain Management.Formule :C18H23ClF2N4O2Degré de pureté :99.15%Couleur et forme :SolidMasse moléculaire :400.85Ref: TM-T8834
2mg44,00€5mg65,00€10mg97,00€25mg197,00€50mg320,00€100mg509,00€200mg698,00€1mL*10mM (DMSO)81,00€S1R agonist 2
CAS :S1R agonist 2 is a selective S1R agonist with a Ki of 88 nM for S2R and 1.1 nM for S1R and is protective against ROS and NMDA-induced neurotoxicity.Formule :C21H27NODegré de pureté :99.04%Couleur et forme :SolidMasse moléculaire :309.45PRE-084 hydrochloride
CAS :PRE-084 hydrochloride is a selective agonist of σ1(IC50:44 nM, in the sigma receptor assay).Formule :C19H28ClNO3Degré de pureté :99.54%Couleur et forme :SolidMasse moléculaire :353.88Ref: TM-T3198L
5mg44,00€10mg65,00€25mg120,00€50mg207,00€100mg369,00€200mg565,00€1mL*10mM (DMSO)72,00€WLB-89462
CAS :WLB-89462 (Compound 20c) is a selective σ2 receptor ligand with a K i of 13 nM, exhibiting neuroprotective properties and the ability to ameliorate Aβ peptide-Formule :C21H29N5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :399.49AB21 HCl
AB21 HCl: σ1 receptor antagonist, Ki 13 nM; less potent at σ2 (102 nM). Reduces mechanical hypersensitivity.Formule :C23H29ClN2ODegré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :384.2Dimemorfan phosphate
CAS :Dimemorfan phosphate (3,17-dimethylmorphinan) is a sigma 1 receptor agonist. Dimemorfan phosphate is used as a potent antitussive.Formule :C18H25N·H3O4PDegré de pureté :99.65%Couleur et forme :SolidMasse moléculaire :353.4Sigma-2 Radioligand 2
CAS :Sigma-2 Radioligand 2 (compound 4) exhibits low nanomolar affinity for the σ2 receptor (Ki=2.30 nM) and high subtype selectivity (Ki(σ1)/Ki(σ2) > 1500).Formule :C23H28FN3O3Couleur et forme :SolidMasse moléculaire :413.49
