PKA
La protéine kinase A (PKA) est une enzyme clé dans la cascade de signalisation des GPCR, activée par l'AMP cyclique (cAMP) en réponse à divers signaux extracellulaires. La PKA régule un large éventail de processus cellulaires, y compris le métabolisme, l'expression des gènes et la croissance cellulaire. La dérégulation de l'activité de la PKA est associée à diverses maladies, notamment le cancer, les troubles métaboliques et les affections cardiovasculaires. Les modulateurs de la PKA sont des outils précieux dans la recherche visant à comprendre les voies de signalisation des GPCR et à développer de nouvelles stratégies thérapeutiques. Chez CymitQuimica, nous offrons une sélection de modulateurs de PKA de haute qualité pour soutenir vos recherches en transduction de signal, régulation cellulaire et mécanismes des maladies.
Produits appartenant à la catégorie "PKA"
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29 produits dans cette catégorie.
8-Bromo-cAMP sodium salt
CAS :8-Bromo-cAMP sodium salt (8-Br-Camp sodium salt) is a long-acting derivative of cyclic AMP. 8-Bromo-cAMP is an activator of cyclic AMP-dependent protein kinase.Formule :C10H10BrN5NaO6PDegré de pureté :98% - 99.94%Couleur et forme :Off-White PowderMasse moléculaire :430.08KT5720
CAS :KT5720 is a cell-permeable, reversible, and ATP-competitive inhibitor of protein kinase A (PKA) (Ki: 60 nM).Formule :C32H31N3O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :537.61H-89 dihydrochloride
CAS :H-89 dihydrochloride (5-Isoquinolinesulfonamide) is a potent inhibitor of protein kinase A (PKA; IC50: 0.14 μM, Ki: 48 nM).Formule :C20H20BrN3O2S·2HClDegré de pureté :100% - 99.40%Couleur et forme :SolidMasse moléculaire :519.28Ref: TM-T6250
5mg39,00€10mg58,00€25mg106,00€50mg202,00€100mg344,00€200mg512,00€500mg815,00€1mL*10mM (DMSO)52,00€Protein kinase G inhibitor-1
CAS :Protein kinase G inhibitor-1 is a potent Protein kinase G inhibitor, IC50= 0.9 uM.Formule :C14H18N2O2SDegré de pureté :98.11%Couleur et forme :SoildMasse moléculaire :278.37Ref: TM-T67755
1mg115,00€5mg255,00€10mg375,00€25mg562,00€50mg792,00€100mg1.064,00€200mg1.444,00€1mL*10mM (DMSO)235,00€H-89
CAS :H-89 is a PKA inhibitor, a candidate cardioprotectant, induces spatial learning impairment in rats, and can be used to study myocardial infarction.Formule :C20H20BrN3O2SDegré de pureté :98.06%Couleur et forme :Off-White PowderMasse moléculaire :446.36Ref: TM-T11524
5mg40,00€10mg59,00€25mg114,00€50mg170,00€100mg254,00€500mg627,00€1mL*10mM (DMSO)44,00€Fasudil hydrochloride
CAS :Fasudil hydrochloride (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK with Ki of 0.33 μM, 1.0 μM, 9.3 μM and 55 μM, respectively.Formule :C14H18ClN3O2SDegré de pureté :100% - ≥95%Couleur et forme :White SolidMasse moléculaire :327.83Aplithianines A
Aplithianines A effectively inhibits J-PKAcα with an IC50 value of 1 μM and displays higher potency against wild-type PKA, achieving an IC50 of 84 nM byDegré de pureté :98%Couleur et forme :Odour SolidAT13148
CAS :AT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II.Formule :C17H16ClN3ODegré de pureté :98.04% - ≥95%Couleur et forme :SolidMasse moléculaire :313.78CCG215022
CAS :CCG215022 is a G protein-coupled receptor kinases (GRKs) inhibitor with IC50s of 0.15±0.07 μM, 0.38±0.06 μM and 3.9±1 μM for GRK2, 5 and 1, respectively.Formule :C26H22FN7O3Degré de pureté :97.63% - 99.69%Couleur et forme :SolidMasse moléculaire :499.5Ref: TM-T3498
1mg96,00€2mg140,00€5mg235,00€10mg378,00€25mg630,00€50mg898,00€100mg1.216,00€500mg2.442,00€1mL*10mM (DMSO)259,00€HA-100
CAS :HA-100 is an inhibitor of protein kinaseFormule :C13H15N3O2SDegré de pureté :99.44%Couleur et forme :Pale Yellow Crystalline SolidMasse moléculaire :277.34Rp-cAMPS triethylammonium salt
CAS :Rp-cAMPS triethylammonium salt is a competitive inhibitor of cAMP-dependent protein kinase I and II.Formule :C16H27N6O5PSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :446.46Bucladesine sodium
CAS :Bucladesine sodium (DC2797) is a cAMP analog with cell-permeable properties.Formule :C18H23N5NaO8PDegré de pureté :96.56% - 99.76%Couleur et forme :White PowderMasse moléculaire :491.37AP-C2
CAS :AP-C2 is a potent small molecule guanosine 3',5'-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) inhibitor with a pIC50 of 5.2 for cGKII.Formule :C18H16N4SDegré de pureté :100%Couleur et forme :SoildMasse moléculaire :320.41A-3 hydrochloride
CAS :A-3 hydrochloride: potent, reversible kinase antagonist; permeable; inhibits PKC, CKI, PKA, CKII, MLCK; Ki: 4.3-80 μM.Formule :C12H14Cl2N2O2SDegré de pureté :99.32%Couleur et forme :SolidMasse moléculaire :321.22Ref: TM-T14069
1mg35,00€5mg66,00€10mg96,00€25mg170,00€50mg274,00€100mg439,00€500mg938,00€1mL*10mM (DMSO)90,00€Bilobetin
CAS :Bilobetin ameliorates insulin resistance by PKA-mediated phosphorylation of PPARα in rats fed a high-fat diet.Formule :C31H20O10Degré de pureté :97.74% - 99.73%Couleur et forme :SolidMasse moléculaire :552.48Ref: TM-T4S2128
1mg47,00€2mg70,00€5mg144,00€10mg250,00€25mg424,00€50mg613,00€100mg843,00€1mL*10mM (DMSO)187,00€AT7867
CAS :AT7867 inhibits Akt1/2/3 & p70S6K/PKA (IC50: 32/17/47 nM & 85/20 nM), minimal effect beyond AGC kinases.Formule :C20H20ClN3Degré de pureté :99.63%Couleur et forme :SolidMasse moléculaire :337.85Ref: TM-T6304
2mg44,00€5mg65,00€10mg86,00€25mg135,00€50mg210,00€100mg313,00€200mg452,00€1mL*10mM (DMSO)65,00€Gliotoxin
CAS :Gliotoxin, a mycotoxin, inhibits Wnt pathway, causing apoptosis in mutated colorectal cancer cells and blocks NF-κB by preserving IκB.Formule :C13H14N2O4S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :326.39PKG drug G1
CAS :PKG drug G1 targets PKG Iα C42. PKG drug G1 can couple to vasodilation and blood pressure lowering by a C42 PKG Iα-independent mechanism.Formule :C13H11N3OSDegré de pureté :97.57% - 97.67%Couleur et forme :SolidMasse moléculaire :257.31Ref: TM-T4661
2mg39,00€5mg56,00€10mg87,00€25mg156,00€50mg227,00€100mg344,00€500mg812,00€1mL*10mM (DMSO)62,00€Staurosporine
CAS :Staurosporine (AM-2282) is a protein kinase inhibitor with ATP-competitive and non-selective inhibitory activity (IC50=6/15/2/3/3000 nM) against PKC, PKA, c-FgrFormule :C28H26N4O3Degré de pureté :99.24% - 99.98%Couleur et forme :Off-White PowderMasse moléculaire :466.53Ref: TM-T6680
1mg62,00€2mg87,00€5mg97,00€10mg145,00€25mg246,00€50mg401,00€100mg597,00€500mg1.283,00€1mL*10mM (DMSO)109,00€Metadoxine
CAS :Metadoxine (Metadoxil) is a neurotransmitter stimulant.Formule :C8H11NO3·C5H7NO3Degré de pureté :99.19%Couleur et forme :Off-White PowderMasse moléculaire :298.29PKA/AKAP-IN-2
CAS :PKA/AKAP-IN-2 (WAY-298350) is a PKA and AKAP interaction inhibitor, used in metabolic disease research.Formule :C17H17NO3Degré de pureté :99.82%Couleur et forme :SoildMasse moléculaire :283.32Ref: TM-T201919
1mg185,00€5mg459,00€10mg657,00€25mg1.026,00€50mg1.415,00€100mg1.872,00€200mg2.555,00€Daphnetin
CAS :Daphnetin (7,8-Dihydroxycoumarin), a natural coumarin derivative, is a protein kinase inhibitor with inhibitory for EGFR (IC50: 7.67 μM), PKA (IC50: 9.33 μM),Formule :C9H6O4Degré de pureté :97.47% - 99.8%Couleur et forme :SolidMasse moléculaire :178.14PKA-IN-1
CAS :PKA-IN-1 is a selective and potent cyclic AMP-dependent protein kinase (PKA) catalytic subunit (cAK) inhibitor (IC50: 0.03 μM).PKA-IN-1 can be used to studyFormule :C13H11N3ODegré de pureté :97.52%Couleur et forme :SolidMasse moléculaire :225.25Kiss2 peptide acetate
Kiss2 peptide acetate is the acetate form of Kiss2 peptide, serving as a positive regulator of reproduction. It binds to its homologous receptor Kiss2R (GPR54) in COS-7 cells, activating the PKA and PKC signaling pathways through Gas and Gaq proteins. This activation enhances the activity of both cAMP response element-dependent luciferase (CRE-luc) and serum response element-dependent luciferase (SRE-luc).Formule :C63H84N16O12·xC2H4O2Couleur et forme :SolidMasse moléculaire :1257.44 (free base)Fasudil
CAS :Fasudil (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK.Formule :C14H17N3O2SDegré de pureté :99.79% - 99.84%Couleur et forme :SolidMasse moléculaire :291.37JAK1/2/3 Inhibitor 1
CAS :JAK1/2/3 Inhibitor 1 is a potent protein kinase inhibitor.JAK1/2/3 Inhibitor 1 has antitumor activity that inhibits the growth of a variety of cancer cell linesFormule :C6H2Cl2N2SDegré de pureté :99.32%Couleur et forme :SolidMasse moléculaire :205.06Kemptide
CAS :Kemptide is a synthetic heptapeptide, acting as a substrate for cAMP-dependent protein kinase (PK).Formule :C32H61N13O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :771.91H-8 hydrochloride
CAS :H-8 hydrochloride is a reversible and ATP-competitive PKA inhibitor. It can be used to study metabolic diseases.Formule :C12H17Cl2N3O2SDegré de pureté :99.93%Couleur et forme :White To Off-White Crystalline SolidMasse moléculaire :338.25MR-L2
CAS :MR-L2 is a reversible and noncompetitive allosteric activator of long-isoform phosphodiesterase-4 (PDE4).Formule :C19H16Cl3FN4ODegré de pureté :98.09% - 98.94%Couleur et forme :SolidMasse moléculaire :441.71Ref: TM-T12103
1mg145,00€2mg207,00€5mg354,00€10mg528,00€25mg852,00€50mg1.159,00€100mg1.568,00€500mg3.125,00€1mL*10mM (DMSO)378,00€
