Récepteur cannabinoïde
Les récepteurs cannabinoïdes sont des GPCR qui médiatisent les effets des cannabinoïdes endogènes (endocannabinoïdes) et des phytocannabinoïdes, tels que ceux trouvés dans le cannabis. Les deux principaux types de récepteurs cannabinoïdes, CB1 et CB2, sont impliqués dans la régulation d'une large gamme de processus physiologiques, y compris la perception de la douleur, l'appétit, l'humeur et la fonction immunitaire. Les modulateurs des récepteurs cannabinoïdes ont un potentiel thérapeutique dans le traitement de conditions telles que la douleur chronique, l'épilepsie et la sclérose en plaques. Chez CymitQuimica, nous offrons une large gamme de modulateurs de récepteurs cannabinoïdes de haute qualité pour soutenir vos recherches en neuropharmacologie, gestion de la douleur et immunologie.
Produits appartenant à la catégorie "Récepteur cannabinoïde"
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OMDM-5
CAS :OMDM-5 is a potent vanilloid receptor type 1 (TRPV1, EC50 = 75 nM) agonist, showing weak ligand activity at cannabinoid type 1 receptor (CB1, Ki=4.9 μM).Formule :C26H44N2O3Degré de pureté :99.72%Couleur et forme :SolidMasse moléculaire :432.64Ref: TM-T12306
1mg87,00€5mg187,00€10mg284,00€25mg452,00€50mg645,00€100mg867,00€200mg1.130,00€1mL*10mM (DMSO)221,00€A-836339
CAS :A-836339: Potent cannabinoid, CB2-focused (Ki=0.64nM), lesser CB1 affinity (Ki=270nM); analgesic, anti-inflammatory in mice.Formule :C16H26N2O2SDegré de pureté :99.94%Couleur et forme :SolidMasse moléculaire :310.45Ref: TM-T7375
2mg48,00€5mg92,00€10mg164,00€25mg266,00€50mg393,00€100mg557,00€200mg753,00€1mL*10mM (DMSO)94,00€CB2R agonist 3
CB2R agonist 3, a potent activator of cannabinoid receptor 2 (CB2R), exhibits an EC50 value of 0.37μM, indicative of its significant role in the immune system [Degré de pureté :98%Couleur et forme :Odour SolidN-Arachidonyldopamine
CAS :N-Arachidonyldopamine (NADA) is a selective and potent endogenous CB1 receptor agonist (Ki: 250 nM).N-Arachidonyldopamine is also a potent and selective TRPV1Formule :C28H41NO3Degré de pureté :97.65%Couleur et forme :SolidMasse moléculaire :439.63BML-190
CAS :BML-190 (Indomethacin morpholinylamide) 是一种 CB2 受体的配体,其对 CB2 受体 (Ki:435 nM) 和 CB1受体 (Ki> 2 μM)。Formule :C23H23ClN2O4Degré de pureté :97.70%Couleur et forme :SolidMasse moléculaire :426.89CB1 antagonist 2
CAS :CB1 antagonist 2 (AM4113) is caimabinoid 1 (CB1) antagonist which inhibits CB1 in vivo with an IC50 of 25.5 nM.Formule :C17H12Cl3N3ODegré de pureté :99.75%Couleur et forme :SolidMasse moléculaire :380.66Δ8-THC-C8
CAS :Δ8-THC-C8 is a semi-synthetic cannabinoid. It acts as an agonist for the cannabinoid receptor 1 (CB1) with an EC50 value of 13.8 nM.Formule :C24H36O2Couleur et forme :SolidMasse moléculaire :356.54AM841
CAS :AM841, a high-affinity electrophilic ligand, covalently interacts with a cysteine residue in helix six, thus activating the CB1 cannabinoid receptor.Formule :C26H39NO3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :445.66CB2 receptor agonist 9
CAS :CB2 receptor agonist 9 (Compound 33) is an orally active agonist of cannabinoid receptor 2 (CB2 receptor) with an EC50 of 16.2 nM. It inhibits the expression of TNF-α, IL-1β, and IL-6, demonstrating anti-inflammatory activity in a DSS-induced acute colitis model in mice.Formule :C16H23N3O2SCouleur et forme :SolidMasse moléculaire :321.44CB2R/FAAH modulator-1
CAS :CB2R/FAAH modulator-1: agonizes CB2R, inhibits FAAH (IC50=4 μM), alters cytokine production; used in inflammation research. Ki: CB2R=14.8 nM, CB1R=241.3 nM.Formule :C24H27NO2Degré de pureté :100%Couleur et forme :SoildMasse moléculaire :361.48Ref: TM-T67896
1mg77,00€5mg158,00€10mg225,00€25mg338,00€50mg472,00€100mg645,00€200mg868,00€1mL*10mM (DMSO)163,00€CB2 modulator 1
CAS :CB2 modulator 1 is a potent CB2 modulator. It can be used for the research for immune disorders, osteoporosis, inflammation, renal ischemia.Formule :C18H19F3N4O2Degré de pureté :99.02%Couleur et forme :SolidMasse moléculaire :380.36Ref: TM-T10696
1mg35,00€5mg56,00€10mg79,00€25mg114,00€50mg167,00€100mgÀ demander1mL*10mM (DMSO)64,00€Evofolin B
CAS :Evofolin B is a natural compound isolated from the stem bark of Zanthoxylum ailanthoides.Formule :C17H18O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :318.32JHU 75528
CAS :JHU 75528 (JHU-75528) is a novel PET tracer with inhibitory effects on CB that can be used to study the cannabinoid system in schizophrenic patients.Formule :C23H21Cl2N5O2Degré de pureté :99.97%Couleur et forme :SolidMasse moléculaire :470.35CB2R/FAAH modulator-3
CAS :CB2R/FAAH modulator-3 (compound 27) is a modulator targeting at CB2R and FAAH.Formule :C22H31NO2Degré de pureté :99.02%Couleur et forme :SoildMasse moléculaire :341.49Ref: TM-T67747
2mg38,00€5mg58,00€10mg90,00€25mg164,00€50mg259,00€100mg383,00€200mg545,00€1mL*10mM (DMSO)64,00€AM251
CAS :AM251: potent CB1 blocker (IC50: 8 nM), 306x CB2 selective; GPR55 activator (EC50: 39 nM).Formule :C22H21Cl2IN4ODegré de pureté :97.38% - 97.88%Couleur et forme :A Crystalline SolidMasse moléculaire :555.24Pregnenolone acetate
CAS :Pregnenolone acetate inhibits CB1 receptors, blocking THC effects and shielding the brain from cannabis intoxication.Formule :C23H34O3Degré de pureté :99.66%Couleur et forme :White To Light Yellow Crystalline PowderMasse moléculaire :358.51Rimonabant
CAS :Rimonabant (SR141716) is an inverse agonist for the cannabinoid receptor CB1.Formule :C22H21Cl3N4ODegré de pureté :98% - 99.91%Couleur et forme :White Or Almost White Crystalline PowderMasse moléculaire :463.79GW 833972A
CAS :GW 833972A: selective CB2 agonist; reduces neural depolarization and citric acid cough in animals.Formule :C18H14Cl2F3N5ODegré de pureté :99.93%Couleur et forme :SoildMasse moléculaire :444.24ML-193
CAS :ML-193: GPR55 antagonist, IC50 221nM, 27x selective over GPR35/CB1/CB2, may aid Parkinson's symptoms.Formule :C28H25N5O4SDegré de pureté :97.74%Couleur et forme :SolidMasse moléculaire :527.59AM-2232
CAS :AM-2232 (UNII-40KCH8YIKP) is a potent and unselective agonist of the cannabinoid receptors.Formule :C24H20N2ODegré de pureté :99.37%Couleur et forme :SolidMasse moléculaire :352.43(R)-Monlunabant
CAS :(R)-Monlunabant ((R)-MRI-1891) serves as a CB1 receptor antagonist utilized in obesity and metabolic disease research [1].Formule :C26H22ClF3N6O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :591Monlunabant
CAS :Monlunabant ((S)-MRI-1891), a solid dispersion compound, functions as an inhibitor of the cannabinoid CB1 receptor [1].Formule :C26H22ClF3N6O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :591.00δ8-THC acetate
CAS :Delta8-THC acetate (Delta8-tetrahydrocannabinol) is a psychoactive cannabinoid that binds to the cannabinoid receptor 1 (CB1 receptor) and exhibits anti-nausea, appetite-stimulating, and anti-inflammatory effects. It may also offer neuroprotective benefits and has potential applications in research on anxiety and depression.Formule :C23H32O3Couleur et forme :SolidMasse moléculaire :356.52'-Hydroxydaidzein
CAS :2'-Hydroxydaidzein is an isoflavonoid phytonutrient found in plant species, when a natural compound. 2'-Hydroxydaidzein has antioxidant activity, driven mainly by o-hydrogen bond dissociation enthalpy (BDE) and hydrogen atom transfer (HAT) mechanisms. 2'-Hydroxydaidzein inhibits chemical mediators in inflammatory cells and may be of value in the treatment and prevention of inflammatory diseases associated with excessive chemical mediator production. It may have a role in the treatment and prevention of central and peripheral inflammatory diseases associated with excessive chemical mediator production. 2'-Hydroxydaidzein inhibited the release of neutrophils and formyl-Met-Leu-Phe/cytochalasin B (fMLP/CB) in rats, with IC(50) values of 2.8+/-0.1 and 5.9+/-1.4 microM, respectively.Formule :C15H10O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :270.24WIN 55,212-2 Mesylate
CAS :WIN 55,212-2 Mesylate ((R)-(+)-WIN 55212) is a potent aminoalkylindole cannabinoid (CB) receptor agonist with Kis of 62.3 and 3.3 nM for human recombinant CB1 and CB2 receptors, respectively. Cannabinoid analogue WIN 55,212-2 Mesylate exhibited a novel anticancer effect against human tumors.Formule :C28H30N2O6SDegré de pureté :98% - 99.71%Couleur et forme :White To Off-White SolidMasse moléculaire :522.61RTICBM-189
CAS :RTICBM-189 is a potent, brain-penetrant allosteric modulator of the cannabinoid type-1 (CB1) receptor with a pIC50 of 7.54 in Ca2+ mobilization assay.Formule :C15H14Cl2N2ODegré de pureté :98.32%Couleur et forme :SolidMasse moléculaire :309.19Ref: TM-T9466
2mg37,00€5mg50,00€10mg88,00€25mg170,00€50mg264,00€100mg389,00€200mg550,00€1mL*10mM (DMSO)71,00€Bay 59-3074
CAS :Bay 59-3074 is a CB1/CB2 receptor partial agonist (Ki: 48.3/45.5 nM).Formule :C18H13F6NO4SDegré de pureté :97.68% - 99.69%Couleur et forme :SolidMasse moléculaire :453.36CB2R PAM
CAS :CB2R PAM, an oral drug, boosts CB2 receptor response to specific agonists, showing potential in neuropathic pain relief.Formule :C21H24BrFN2O2Degré de pureté :98.17%Couleur et forme :SolidMasse moléculaire :435.33CB1R/AMPK modulator 1
Compound 38-S is an orally active CB1R/AMPK modulator with a K i of 0.81 nM and an IC50 of 3.9 nM for CB1R.Formule :C25H22Cl2N6O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :557.45CB2 receptor agonist 2
CAS :CB2 receptor agonist 2 (ZINC72105556): potent, Ki=8.5 nM, high selectivity for CB2.Formule :C30H36N2O4Degré de pureté :98.07%Couleur et forme :SolidMasse moléculaire :488.62CB2R/FAAH modulator-2
CAS :CB2R/FAAH modulator-2 (compound 26) is a dual modulator targeting at CB2R and FAAH.Formule :C24H33NO2Degré de pureté :99.52%Couleur et forme :SoildMasse moléculaire :367.52Olivetol
CAS :Olivetol, found in lichens, is an organic antioxidant and THC synthesis precursor.Formule :C11H16O2Degré de pureté :99.98%Couleur et forme :(Melting Point 102-106°F) (Ntp 1992)Masse moléculaire :180.24ML192
CAS :ML192 (CID1434953) is a selective GPR55 ligand antagonist.Formule :C20H22N4O2SDegré de pureté :99.79%Couleur et forme :SolidMasse moléculaire :382.48Ref: TM-T33452
1mg35,00€5mg74,00€10mg110,00€25mg182,00€50mg263,00€100mg369,00€200mg507,00€1mL*10mM (DMSO)96,00€(±)-Cannabichromene
CAS :(±)-Cannabichromene is a major non-psychotropic phytocannabinoid that inhibits endocannabinoid inactivation and activates the TRPA1.Formule :C21H30O2Degré de pureté :96.89% - 99.1%Couleur et forme :SolidMasse moléculaire :314.46Ref: TM-TN3575
1mg170,00€5mg410,00€10mg597,00€25mg937,00€50mg1.254,00€100mg1.700,00€500mg3.410,00€1mL*10mM (DMSO)522,00€ML-184
CAS :ML-184 (CID2440433) is a potent synthetic agonist of GPR55 with EC50 of 0.26 μM.Formule :C25H34N4O3SDegré de pureté :99.45%Couleur et forme :SolidMasse moléculaire :470.63Ref: TM-T8571
2mg48,00€5mg88,00€10mg137,00€25mg274,00€50mg432,00€100mg747,00€200mg1.017,00€1mL*10mM (DMSO)92,00€SCH-336
CAS :SCH-336: potent, selective CB2 agonist (Ki=1.8 nM, EC50=2 nM), orally active, 100x CB2 vs. CB1 preference, reduces leukocyte migration and eosinophilia.Formule :C23H25NO8S3Degré de pureté :95.01%Couleur et forme :SolidMasse moléculaire :539.64Ref: TM-T24771
5mg52,00€10mg78,00€25mg160,00€50mg225,00€100mg325,00€200mg469,00€1mL*10mM (DMSO)64,00€EHP-101
CAS :EHP-101 is a PPARγ/CB2 dual agonist with anti-inflammatory properties, inhibits fat formation, and combats diet-related obesity.Formule :C28H35NO3Degré de pureté :99.22%Couleur et forme :SolidMasse moléculaire :433.58Ref: TM-T13289
1mg107,00€5mg227,00€10mg378,00€25mg620,00€50mg868,00€100mg1.169,00€1mL*10mM (DMSO)250,00€Pregnenolone
CAS :Pregnenolone (Arthenolone) is an endogenous steroid hormone synthesized from cholesterol, used in the treatment of Alzheimer's disease.Formule :C21H32O2Degré de pureté :100% - 99.5%Couleur et forme :SolidMasse moléculaire :316.48Taranabant
CAS :Taranabant: potent CB1 receptor inverse agonist; inhibits agonists with 0.13 nM Ki in vitro.Formule :C27H25ClF3N3O2Degré de pureté :99.06% - 99.06%Couleur et forme :SolidMasse moléculaire :515.96CB1-IN-1
CAS :CB1-IN-1 (DBPR211) is a peripherally restricted CB1R antagonist, for CB1R and CB2R with Ki of 0.3 nM and 21 nM,respectively.Formule :C33H31Cl2F3N6O3S2Degré de pureté :99.08% - 99.55%Couleur et forme :SolidMasse moléculaire :751.67Ref: TM-T5996
1mg87,00€2mg116,00€5mg190,00€10mg271,00€25mg445,00€50mg622,00€100mg837,00€500mg1.681,00€1mL*10mM (DMSO)226,00€CB1/2 agonist 3
CAS :CB1/2 agonist 3 is a competitive and potent CB1/CB2 agonist with high affinity for hCB1 and hCB2 and can be used to study neurological disorders.Formule :C25H41NO2Degré de pureté :98.78%Couleur et forme :SolidMasse moléculaire :387.6β-Caryophyllene
CAS :β-Caryophyllene ((-)-(E)-Caryophyllene) acts as an CB2 receptor agonist.Formule :C15H24Degré de pureté :95.43% - 99.11%Couleur et forme :Turpentine (Ntp 1992)Masse moléculaire :204.35Pregnenolone monosulfate sodium
CAS :Pregnenolone monosulfate sodium salt is an neurosteroid, enhances NMDA receptor,CREB phosphorylation, TRPM3 channels, and may inhibit GABA A receptors.Formule :C21H31NaO5SDegré de pureté :99.763%Couleur et forme :SolidMasse moléculaire :418.52Noladin ether
CAS :Noladin ether (2-AG ether) is a cannabinoid CB1 receptor agonist.Formule :C23H40O3Couleur et forme :SolidMasse moléculaire :364.56Otenabant
CAS :Otenabant (CP-945598) has been investigated for the treatment of Obesity.Formule :C25H25Cl2N7ODegré de pureté :100%Couleur et forme :SolidMasse moléculaire :510.42OMDM-6
CAS :OMDM-6 is a dual agonist of TRPV1(EC50 = 75 nM) and CB1 (Ki = 3.2 μM). OMDM-6 inhibits anandamide cellular uptake with a Ki of 7.0 μM.Formule :C28H42N2O3Degré de pureté :99.49%Couleur et forme :SolidMasse moléculaire :454.64Ref: TM-T12307
1mg115,00€5mg255,00€10mg375,00€25mg562,00€50mg787,00€100mg1.074,00€200mg1.444,00€1mL*10mM (DMSO)283,00€CB1R antagonist 1
CAS :CB1R antagonist 1 is a potent CB1R antagonist that can be used to study diseases related to the nervous system.Formule :C18H23F3N2O3SDegré de pureté :99.65%Couleur et forme :SolidMasse moléculaire :404.45(±)-Ibipinabant
CAS :(±)-Ibipinabant ((±)-SLV319) has been used in trials studying the treatment of Obesity and Obesity and Type 2 Diabetes.Formule :C23H20Cl2N4O2SDegré de pureté :99.28% - 99.83%Couleur et forme :SolidMasse moléculaire :487.4Olorinab
CAS :Olorinab (APD 371) (APD 371) is a highly potent, selective and fully efficacious cannabinoid receptor type 2 (CB2) agonist. With an EC50 of 6.2 nM for hCB2.Formule :C18H23N5O3Degré de pureté :97.13% - 97.67%Couleur et forme :SolidMasse moléculaire :357.41BAY 38-7271
CAS :BAY 38-7271: potent neuroprotective, selective CB1/CB2 agonist, Ki of 1.85 nM (CB1) & 5.96 nM (CB2).Formule :C20H21F3O5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :430.44
