Récepteur S1P
Les récepteurs de la sphingosine-1-phosphate (S1P) sont une famille de GPCR qui se lient à la molécule de signalisation lipidique sphingosine-1-phosphate. Ces récepteurs jouent des rôles critiques dans le trafic des cellules immunitaires, le développement vasculaire et le maintien de l'intégrité des barrières endothéliales. Les modulateurs des récepteurs S1P sont en cours de développement pour le traitement de la sclérose en plaques, du cancer et des maladies cardiovasculaires en raison de leur capacité à influencer les réponses immunitaires et la migration cellulaire. Chez CymitQuimica, nous offrons une variété de modulateurs de récepteurs S1P de haute qualité pour soutenir vos recherches en immunologie, oncologie et biologie vasculaire.
Produits appartenant à la catégorie "Récepteur S1P"
Trier par
41 produits dans cette catégorie.
TY-52156
CAS :TY-52156 is an effective and selective S1P3 receptor antagonist (Ki: 110 nM).Formule :C18H19Cl2N3ODegré de pureté :99.91%Couleur et forme :SolidMasse moléculaire :364.27Ref: TM-T17183
2mg40,00€5mg60,00€10mg87,00€25mg166,00€50mg298,00€100mg510,00€200mg683,00€1mL*10mM (DMSO)66,00€N,N-Dimethylsphingosine
CAS :N,N-Dimethylsphingosine,is a potent competitive SphK phosphorylation inhibitor.DMS is elevated in models of neuropathic pain by increasing IL-1β and MCP-1.Formule :C20H41NO2Degré de pureté :98%Couleur et forme :Clear Colorless To Faint Yellow Liquid/White To Off-White PowderMasse moléculaire :327.55S1p receptor agonist 1
CAS :S1p receptor agonist 1 (S1p-receptor-agonist-1) is an S1P receptor agonist.Formule :C23H24FN3O3Degré de pureté :99.07% - 99.90%Couleur et forme :SolidMasse moléculaire :409.45Ozanimod
CAS :Ozanimod (RPC-1063) (RPC1063) is a specific oral S1P Receptor 1 modulator.Formule :C23H24N4O3Degré de pureté :98.68% - 99.58%Couleur et forme :SolidMasse moléculaire :404.46Ref: TM-T6923
1mg48,00€5mg96,00€10mg144,00€25mg283,00€50mg454,00€100mg655,00€200mg929,00€500mg1.378,00€1mL*10mM (DMSO)96,00€GSK2018682
CAS :GSK2018682 is an agonist of sphingosine-1-phosphate receptor (s1p1) and (s1p5) agonist(pEC50s of 7.7 and 7.2,respectively).Formule :C22H21ClN4O4Degré de pureté :99.04%Couleur et forme :SolidMasse moléculaire :440.88W140 HBr
CAS :[(3S)-3-amino-4-(3-hexylanilino)-4-oxobutyl]phosphonic acid;hydrobromide is a S1P1 antagonist with Ki of 2.84 μM.Formule :C16H28BrN2O4PDegré de pureté :99.34%Couleur et forme :SoildMasse moléculaire :423.28Ref: TM-T60204
1mg115,00€2mg172,00€5mg255,00€10mg375,00€25mg562,00€50mg787,00€100mg1.074,00€1mL*10mM (DMSO)284,00€SK1-IN-1
CAS :SK1-IN-1 is a SPHK1 inhibitor (IC50: 58 nM), with potential anticancer activity, and can be used to study cancer and neurodegenerative diseases.Formule :C22H30N4O3Degré de pureté :98.72%Couleur et forme :SolidMasse moléculaire :398.5BMS-960
CAS :BMS-960 is an S1P agonist with potential anti-tumour activity for cancer research.Formule :C26H23F3N4O5Degré de pureté :97.74% - 99.28%Couleur et forme :SolidMasse moléculaire :528.48CYM-5541
CAS :CYM-5541 (ML249) is a selective and allosteric S1P3 receptor agonist.Formule :C19H28N2O2Degré de pureté :97.34% - 98.39%Couleur et forme :SolidMasse moléculaire :316.44Ref: TM-T3961
2mg38,00€5mg57,00€10mg92,00€25mg160,00€50mg254,00€100mg373,00€500mg873,00€1mL*10mM (DMSO)64,00€ASP-4058
CAS :ASP-4058: Safe, oral S1P1/S1P5 agonist; improves autoimmune encephalomyelitis in mice.Formule :C19H12F6N4O2Degré de pureté :99.5% - 99.51%Couleur et forme :SolidMasse moléculaire :442.31Siponimod
CAS :Siponimod (BAF312) modulates S1P1/S1P5 with EC50s of 0.39/0.98 nM; >1000x selectivity over S1P2-4.Formule :C29H35F3N2O3Degré de pureté :97.08% - 99.40%Couleur et forme :SolidMasse moléculaire :516.59Cenerimod
CAS :Cenerimod (ACT-334441) is an S1P1 agonist used in the study of murine experimental autoimmune encephalomyelitis (EAE) and murine scleroderma.Formule :C25H31N3O5Degré de pureté :97.43% - 99.97%Couleur et forme :SolidMasse moléculaire :453.53SphK1&2-IN-1
CAS :SphK1&2-IN-1 is a sphingosine kinase inhibitor with anti-inflammatory, antitumor and hemostatic effects.Formule :C14H14N2O3SDegré de pureté :99.27%Couleur et forme :SolidMasse moléculaire :290.34GLPG2938
CAS :GLPG2938 (1-(2-Ethoxy-6-(trifluoromethyl)pyridin-4-yl)-3-((5-methyl-6-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)pyridazin-3-yl)methyl)urea) is a potent andFormule :C20H19F6N7O2Degré de pureté :98.25%Couleur et forme :SolidMasse moléculaire :503.4Ref: TM-T9199
1mg84,00€5mg153,00€10mg264,00€25mg550,00€50mg792,00€100mg1.093,00€200mg1.454,00€1mL*10mM (DMSO)166,00€Vibozilimod
CAS :Vibozilimod (SCD-044) is S1P receptor-1 (S1PR1) agonist .Formule :C29H36ClN3O5Degré de pureté :99.47%Couleur et forme :SolidMasse moléculaire :542.07SAR-114137
CAS :SAR-114137 is a histone sphingomyelin kinase inhibitor used in the study of molluscum arteriosum and peripheral neuropathic pain.Formule :C25H34N4O7SDegré de pureté :100% - 99.57%Couleur et forme :SolidMasse moléculaire :534.63MHP
CAS :MHP (Methyl caprooyl tyrosinate) is an activator of sphingosine kinase (SPHK1), and significantly stimulates CAMP mRNA and protein production in KC.Formule :C16H23NO4Degré de pureté :98.58%Couleur et forme :SolidMasse moléculaire :293.36Ref: TM-T4658
1mg47,00€2mg64,00€5mg111,00€10mg188,00€25mg376,00€50mg563,00€100mg800,00€1mL*10mM (DMSO)127,00€CS 2100
CAS :CS 2100 (1-[[4-Ethyl-5-[5-(4-phenoxyphenyl)-1,2,4-oxadiazol-3-yl]-2-thienyl]methyl]-3-azetidinecarboxylic acid) is an S1P1 agonist.Formule :C25H23N3O4SDegré de pureté :98.13%Couleur et forme :SolidMasse moléculaire :461.53VPC 23019
CAS :VPC 23019 is a competitive antagonist at the S1P1 and S1P3 receptors (pKi= 7.86 and 5.93, respectively).Formule :C17H29N2O5PDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :372.4AMG-369
CAS :AMG-369 (AMG 247) is an S1P1/S1P5 dual agonist that delays the development of experimental autoimmune encephalomyelitis in rats.Formule :C26H22FN3O2SDegré de pureté :98.39% - 98.92%Couleur et forme :SolidMasse moléculaire :459.54Amgen-23
CAS :Amgen-23 is a selective and highly potent sphingosine kinase 1 (SPHK1) inhibitor that inhibits SPHK2 and can be used in anticancer research.Formule :C23H25Cl2N3O2SDegré de pureté :97.31%Couleur et forme :SolidMasse moléculaire :478.44Opaganib
CAS :Opaganib (ABC294640) is an orally active and specific sphingosine kinase-2 (SphK2) inhibitor (IC50: 60 μM).Formule :C23H25ClN2ODegré de pureté :98.86% - 99.85%Couleur et forme :SolidMasse moléculaire :380.91Ref: TM-T6750
1mg40,00€2mg52,00€5mg85,00€10mg124,00€25mg240,00€50mg415,00€100mg615,00€1mL*10mM (DMSO)87,00€Ponesimod
CAS :Ponesimod (ACT-128800) is an orally available sphingosine-1-phosphate receptor 1 (S1PR1, S1P1) agonist with potential immunomodulating activity.Formule :C23H25ClN2O4SDegré de pureté :98.22% - 99.42%Couleur et forme :SolidMasse moléculaire :460.97Ref: TM-T3258
1mg46,00€2mg59,00€5mg93,00€10mg131,00€25mg234,00€50mg404,00€100mg597,00€500mg1.283,00€1mL*10mM (DMSO)97,00€CYM-5520
CAS :CYM-5520 is a noncompetitive allosteric agonist of S1P2Formule :C21H19N3O2Degré de pureté :99.47%Couleur et forme :SolidMasse moléculaire :345.39Ref: TM-T22703
1mg48,00€2mg64,00€5mg94,00€10mg142,00€25mg250,00€50mg374,00€100mg557,00€1mL*10mM (DMSO)103,00€PF429242 dihydrochloride
CAS :PF429242 dihydrochloride can reversibly inhibit S1P (IC50 of 175 nM).Formule :C25H37Cl2N3O2Degré de pureté :98.67%Couleur et forme :SolidMasse moléculaire :482.49MP-A08
CAS :MP-A08 selectively inhibits SPHK1; targets SphK1 & SphK2 with Ki of 6.9 μM & 27 μM, respectively.Formule :C27H25N3O4S2Degré de pureté :98.04%Couleur et forme :SolidMasse moléculaire :519.64CYM5442
CAS :CYM5442 is an S1P agonist, targeting to Sphingosine.Formule :C23H27N3O4Degré de pureté :96.65% - 97.57%Couleur et forme :SolidMasse moléculaire :409.48SLM6031434 HCl
CAS :SLM6031434 HCl (SLM-6031434 HCl) is a SphK2 inhibitor that reduces LPS-induced TNF伪 and IL-1尾 production.Formule :C22H31ClF3N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :489.96Etrasimod
CAS :Etrasimod (APD334) is a specific and orally available antagonist of the sphingosine-1-phosphate-1 (S1P1) receptor (IC50: 1.88 nM in CHO cells).Formule :C26H26F3NO3Degré de pureté :99.17% - 99.77%Couleur et forme :SolidMasse moléculaire :457.48Ref: TM-TQ0227
1mg52,00€5mg111,00€10mg180,00€25mg243,00€50mg305,00€100mg424,00€1mL*10mM (DMSO)113,00€K6PC-5
CAS :K6PC-5 is a ceramide derivative that acts as an activator of sphingosine kinase 1 (SPHK1), inducing a swift and temporary rise in intracellular calcium levels.Formule :C19H37NO4Degré de pureté :98.55%Couleur et forme :SolidMasse moléculaire :343.5SK1-I hydrochloride
CAS :SK1-I hydrochloride is a selective and competitive SphK1 inhibitor and sphingosine analog ,anti-leukemic to inhibit tumor cell growth and promote apoptosis.Formule :C17H28ClNO2Degré de pureté :99.80%Couleur et forme :SolidMasse moléculaire :313.86TASP 0277308
CAS :NH2-UAMC1110 TFA is an aminobutoxy derivative of UAMC1110 used in the synthesis of FAPI-QS. UAMC1110 is a fibroblast activating protein (fap) inhibitor.Formule :C23H28Cl2N6O3SCouleur et forme :SolidMasse moléculaire :539.48LX-2931
CAS :LX-2931(LX-3305) is a sphingosine-1-phosphate cleavage enzyme (S1P) inhibitor for the treatment of rheumatoid arthritis.Formule :C9H15N3O5Degré de pureté :100% - 99.83%Couleur et forme :SolidMasse moléculaire :245.23SEW2871
CAS :SEW 2871 is an orally available, highly selective S1P1 agonist. It activates ERK, Akt and Rac signaling pathways and induces S1P1 internalization and recycling.Formule :C20H10F6N2OSDegré de pureté :99.62%Couleur et forme :White SolidMasse moléculaire :440.36CYM50374
CAS :CYM50374 inhibits Sphingosine-1-phosphate receptor 4 (S1P4 ) with an IC50 of µM.Formule :C19H19NO3SDegré de pureté :98.4% - 98.49%Couleur et forme :SolidMasse moléculaire :341.42Ref: TM-T27106
1mg333,00€5mg787,00€10mg1.074,00€25mg1.510,00€50mg1.882,00€100mg2.375,00€500mg4.655,00€ML-031
CAS :ML-031 activated S1P2 with an EC50 value of 1 μM in an S1P reporter assay.Formule :C19H20N2O3Degré de pureté :99.21%Couleur et forme :SolidMasse moléculaire :324.374-Deoxypyridoxine hydrochloride
CAS :4-Deoxypyridoxine HCl halts S1P breakdown by blocking SPL, reducing apoptosis in insulinoma cells like S1P.Formule :C8H12ClNO2Degré de pureté :99.86%Couleur et forme :White To Off White Crystalline PowderMasse moléculaire :189.64Amiselimod hydrochloride
CAS :Amiselimod hydrochloride (MT-1303 hydrochloride) is a sphingosine 1-phosphate receptor-1 (S1P1) modulator.Formule :C19H31ClF3NO3Degré de pureté :99.55%Couleur et forme :SolidMasse moléculaire :413.9Ref: TM-T10305
1mg38,00€2mg49,00€5mg80,00€10mg120,00€25mg215,00€50mg354,00€100mg512,00€200mg738,00€1mL*10mM (DMSO)88,00€Ozanimod hydrochloride
CAS :Ozanimod (RPC-1063) HCl is a selective S1P1/S1P5 modulator with high affinity, used in relapsing MS research.Formule :C23H25ClN4O3Degré de pureté :99.81%Couleur et forme :SolidMasse moléculaire :440.92Ref: TM-T62552
1mg66,00€5mg139,00€10mg202,00€25mg416,00€50mg652,00€100mg938,00€500mg1.872,00€1mL*10mM (DMSO)154,00€CYM50308
CAS :CYM50308 is a high affinity agonist of sphingosine-1-phosphate receptor 4 (S1P4-R) (EC50: 56 nM).Formule :C20H21F2N3O2SDegré de pureté :99.43% - 99.63%Couleur et forme :SolidMasse moléculaire :405.46Ref: TM-T15032
1mg62,00€5mg140,00€10mg202,00€25mg324,00€50mg455,00€100mg597,00€200mg842,00€500mg1.225,00€SLP9101555
SLP9101555 is a potent and selective sphingosine kinase 2 (SphK2) inhibitor with a Ki of 90 nM.SLP9101555 has a high affinity for SphK2, which is 200-foldFormule :C16H22BrClN2Degré de pureté :99%Couleur et forme :SolidMasse moléculaire :357.72Ref: TM-T63047
1mg333,00€5mg787,00€10mg1.074,00€25mg1.510,00€50mg1.882,00€100mg2.375,00€500mg4.655,00€1mL*10mM (DMSO)663,00€
