ATM/ATR
Les inhibiteurs de l'ATM (Ataxia Telangiectasia Mutated) et de l'ATR (ATM and Rad3-related) ciblent des kinases clés impliquées dans la réponse aux dommages de l'ADN (DDR), activées en réponse aux cassures double brin de l'ADN et au stress de réplication. Ces inhibiteurs perturbent la capacité des kinases à détecter et réparer les dommages de l'ADN, ce qui peut entraîner une instabilité génomique accrue et la mort cellulaire, en particulier dans les cellules cancéreuses qui dépendent de mécanismes de réparation de l'ADN robustes pour survivre. Les inhibiteurs de l'ATM/ATR sont des outils cruciaux dans la recherche et la thérapie contre le cancer, notamment en combinaison avec des agents endommageant l'ADN. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de l'ATM/ATR de haute qualité pour soutenir vos recherches sur la réponse aux dommages de l'ADN, la biologie du cancer et le développement thérapeutique.
Produits appartenant à la catégorie "ATM/ATR"
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ATR-IN-21
CAS :ATR-IN-21, also known as compound 60, is a potent inhibitor of ATR, exhibiting an IC50 of less than 1000 nM [1].Formule :C23H27N7ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :417.51AZD0156
CAS :AZD0156 , an effective and specific inhibitors of ATM kinase, is potential antineoplastic activities and chemo-/radio-sensitizing.Formule :C26H31N5O3Degré de pureté :99.03% - 99.13%Couleur et forme :SolidMasse moléculaire :461.56Schisandrin B
CAS :Schisandrin B (Schisandrin B (Sch B)) has an antioxidant effect on rodent liver and heart.Formule :C23H28O6Degré de pureté :100% - 99.84%Couleur et forme :SolidMasse moléculaire :400.46Ref: TM-T2925
1mg42,00€5mg88,00€10mg127,00€25mg230,00€50mg414,00€100mg600,00€500mg1.254,00€1mL*10mM (DMSO)94,00€Berzosertib
CAS :Berzosertib (VE-822) is an ATR inhibitor (Ki<0.2 nM) that also inhibits ATM (Ki=34 nM). Berzosertib has antitumor activity. Cost-effective and quality-assured.Formule :C24H25N5O3SDegré de pureté :100% - 99.7%Couleur et forme :SolidMasse moléculaire :463.55Ref: TM-T2669
1mg35,00€5mg74,00€10mg92,00€25mg155,00€50mg225,00€100mg359,00€200mg525,00€500mg833,00€1mL*10mM (DMSO)77,00€ATR-IN-29
CAS :ATR-IN-29, a potent, orally active inhibitor of ATR kinase, exhibits an IC50 of 1 nM and demonstrates antiproliferative activity [1].Formule :C19H22N8ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :378.43Elimusertib
CAS :Elimusertib (BAY-1895344) is a potent, highly selective and orally available ATR inhibitor with an IC50 of 7 nM.Elimusertib shows potent anti-tumor efficacy inFormule :C20H21N7ODegré de pureté :98.72% - 99.84%Couleur et forme :SolidMasse moléculaire :375.43Ref: TM-T7318
1mg37,00€5mg79,00€10mg111,00€25mg216,00€50mg359,00€100mg562,00€500mg1.206,00€1mL*10mM (DMSO)87,00€PIK-93
CAS :PIK-93 is the first potent, synthetic PI4K inhibitor with IC50 of 19 nM; inhibits PI3Kα with IC50 of 39 nM.Formule :C14H16ClN3O4S2Degré de pureté :97.72%Couleur et forme :SolidMasse moléculaire :389.88Camonsertib
CAS :Camonsertib (RP-3500) is a novel, potent and selective ATR kinase inhibitor (ATRi) that exhibits potent antitumor effects with an IC50: 1.00 nM in biochemical assays.Cost-effective and quality-assured.Formule :C21H26N6O3Degré de pureté :98.15% - 99.6%Couleur et forme :SolidMasse moléculaire :410.47Ref: TM-T62083
1mg169,00€5mg416,00€10mg605,00€25mg944,00€50mg1.254,00€100mg1.730,00€1mL*10mM (DMSO)470,00€NU6027
CAS :NU6027 is a potent ATR/CDK inhibitor, inhibits CDK1/2, ATR and DNA-PK with Ki of 2.5 μM/1.3 μM, 0.4 μM and 2.2 μM, enter cells more readily than the 6-Formule :C11H17N5O2Degré de pureté :98.36%Couleur et forme :SolidMasse moléculaire :251.29ATR kinase-IN-3
CAS :ATRkinase-IN-3 (Compound I-G-28) is an inhibitor of the ATR protein kinase, exhibiting a Ki value ranging from 0.01 to 1 μM, and is utilized in cancer research.Formule :C24H27F2N9O2Couleur et forme :SolidMasse moléculaire :511.53Ceralasertib
CAS :Ceralasertib (AZD6738) is an ATR kinase inhibitor (IC50=1 nM) with selective and oral activity. Ceralasertib has antitumor activity. Cost effective and quality assured.Formule :C20H24N6O2SDegré de pureté :98% - 99.99%Couleur et forme :SolidMasse moléculaire :412.51CP-466722
CAS :CP-466722, an effective and reversible ATM inhibitor, does not inhibit ATR and PI3K or PIKK family members in cells.Formule :C17H15N7O2Degré de pureté :99.14% - 99.85%Couleur et forme :SolidMasse moléculaire :349.35GJ103 sodium salt
CAS :GJ103 sodium salt, a GJ072 analog, lowers surface tension, viscosity, and pH in aqueous solutions, aiding molecular movement.Formule :C16H13N4NaO3SDegré de pureté :99.70% - 99.91%Couleur et forme :SolidMasse moléculaire :364.36azd1390
CAS :AZD1390: Potent ATM inhibitor (IC50: 0.78 nM), >10,000-fold selectivity vs. PIKK enzymes.Formule :C27H32FN5O2Degré de pureté :97.41% - 99.38%Couleur et forme :SolidMasse moléculaire :477.57ATR kinase-IN-2
CAS :ATRkinase-IN-2 (Compound I-G-27) is an inhibitor of the ATR protein kinase, with a Ki value ranging from 0.01 to 1 μΜ. It is utilized in tumor research.Formule :C24H29F2N9O2Couleur et forme :SolidMasse moléculaire :513.54(S)-WSD0628
CAS :(S)-WSD0628 is the S isomer of WSD0628 and serves as an ATM inhibitor, effectively suppressing ATM phosphorylation in MCF-7 cells with an IC50 of less than 100 nM. This compound also demonstrates radiosensitizing activity and is capable of penetrating the blood-brain barrier.Formule :C23H23F2N5O2Couleur et forme :SolidMasse moléculaire :439.458AZ20
CAS :AZ20 is an effective and specific inhibitor of ATR kinase (IC50: 5 nM, in a cell-free assay), 8-fold selectivity over mTOR.Formule :C21H24N4O3SDegré de pureté :100.00% - 98.02%Couleur et forme :SolidMasse moléculaire :412.51KU-55933
CAS :KU-55933 (ATM Kinase Inhibitor) is an ATM inhibitor that is selective and ATP-competitive. KU-55933 has antitumor effects. Cost-effective and quality-assured.Formule :C21H17NO3S2Degré de pureté :100% - 99.80%Couleur et forme :SolidMasse moléculaire :395.49CGK733
CAS :CGK733 (CGK 733) is a potent and selective inhibitor of ATM/ATR.Formule :C23H18Cl3FN4O3SDegré de pureté :98% - 99.7%Couleur et forme :SolidMasse moléculaire :555.84Dactolisib
CAS :Dactolisib (BEZ235) is an orally bioavailable inhibitor of PI3K and mTOR (IC50s: 4 nM/5 nM/7 nM/75 nM, and 20.7 nM for p110α/p110γ/p110δ/p110β and mTOR).Formule :C30H23N5ODegré de pureté :97.64% - 99.85%Couleur et forme :SolidMasse moléculaire :469.54
