mTOR
Les inhibiteurs de mTOR sont des composés qui inhibent l'activité de la Cible de la Rapamycine chez les Mammifères (mTOR), un régulateur central de la croissance cellulaire, de la prolifération, du métabolisme et de la survie. La voie mTOR est fréquemment altérée dans le cancer et d'autres maladies, ce qui en fait une cible critique pour l'intervention thérapeutique. Les inhibiteurs de mTOR sont largement utilisés dans la recherche liée au cancer, au vieillissement et aux troubles métaboliques. Chez CymitQuimica, nous proposons une variété d'inhibiteurs de mTOR pour soutenir vos recherches en transduction de signaux, oncologie et développement thérapeutique.
Produits appartenant à la catégorie "mTOR"
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PP121
CAS :PP-121 inhibits PDGFR, Hck, mTOR, VEGFR2, Src, Abl, and DNA-PK with IC50 values ranging from 2 to 60 nM.Formule :C17H17N7Degré de pureté :99.19% - 99.67%Couleur et forme :SolidMasse moléculaire :319.36DMH-25
CAS :DMH25 is a novel covalent and potent inhibitor of mTOR and shows in vivo antitumor activity against triple-negative breast cancer cells.Formule :C15H8Br3NO3Degré de pureté :99.26%Couleur et forme :SolidMasse moléculaire :489.94Ref: TM-T8569
1mg88,00€5mg170,00€10mg259,00€25mg425,00€50mg598,00€100mg810,00€200mg1.074,00€1mL*10mM (DMSO)212,00€25(R,S)-Ruscogenin
CAS :25(R,S)-Ruscogenin is able to regulate the PI3K/Akt/mTOR signalling pathway, and hinder the metastasis of hepatocellular carcinoma.Formule :C27H42O4Degré de pureté :99.32% - 99.89%Couleur et forme :SolidMasse moléculaire :430.62DS-7423
CAS :DS-7423: a dual PI3K/mTOR inhibitor; IC50s-PI3Kα: 15.6 nM, mTOR: 34.9 nM, PI3Kβ: 1,143 nM, PI3Kγ: 249 nM, PI3Kδ: 262 nM.Formule :C22H27F3N10O2Degré de pureté :99.68%Couleur et forme :SolidMasse moléculaire :520.51Ref: TM-T36083
1mg127,00€5mg283,00€10mg432,00€25mg707,00€50mg938,00€100mg1.378,00€1mL*10mM (DMSO)321,00€Cbz-B3A
CAS :Cbz-B3A is a potent inhibitor of mTORC1 signalling, inhibits phosphorylation of eIF4E-binding protein 1 (4EBP1) and blocks translation by 68%.Formule :C35H58N6O9Degré de pureté :98.63%Couleur et forme :SolidMasse moléculaire :706.87Palomid 529
CAS :Palomid 529 (SG 00529) has been used in trials studying the treatment of Age-Related Macular Degeneration.Formule :C24H22O6Degré de pureté :98.40% - 98.59%Couleur et forme :SolidMasse moléculaire :406.43PKCβ inhibitor 1
CAS :PKCβ inhibitor 1 (KUN79359)(KUN79359) is a potent, selective and ATP-competitive inhibitor of PKC isozymes(IC50s of 21 and 5 nM for human PKCβ1 and PKCβ2,Formule :C24H21N5O2Degré de pureté :99.33%Couleur et forme :SolidMasse moléculaire :411.46Ref: TM-T8376
1mg154,00€5mg424,00€10mg605,00€25mg920,00€50mg1.216,00€100mg1.673,00€200mg2.252,00€500µg93,00€1mL*10mM (DMSO)401,00€mTOR inhibitor 9b
CAS :mTOR inhibitor 9b is an enzyme inhibitor of protein kinase mTOR he phosphatidylinositol 3-kinase PIK3CA with IC50s of 0.76 nm and 1.262 µM, respectively.mTORFormule :C21H23N5O2SDegré de pureté :99.53%Couleur et forme :SoildMasse moléculaire :409.5SC99
CAS :SC99 inhibits JAK2-STAT3, reducing STAT3 genes, platelet activity, and has anti-myeloma, anti-thrombotic effects.Formule :C15H8Cl2FN3ODegré de pureté :99.56%Couleur et forme :SolidMasse moléculaire :336.15Ref: TM-T8719
1mg46,00€5mg93,00€10mg140,00€25mg240,00€50mg363,00€100mg452,00€200mg630,00€1mL*10mM (DMSO)99,00€KU-0060648
CAS :KU-0060648 is a dual inhibitor of DNA-PK and PI3Kα, PI3Kβ, PI3Kδ with IC50 of 8.6 nM and 4 nM, 0.5 nM, 0.1 nM respectively, less inhibition of PI3Kγ.Formule :C33H34N4O4SDegré de pureté :98.75%Couleur et forme :SolidMasse moléculaire :582.71WYE-687
CAS :WYE-687 is a selective mTOR inhibitor (IC50: 7 nM), over 100x more selective for mTOR than PI3Kα/γ, affecting mTORC1/pS6K and mTORC2/P-AKT(S473).Formule :C28H32N8O3Degré de pureté :98.98%Couleur et forme :SolidMasse moléculaire :528.61mTOR inhibitor-8
CAS :mTOR inhibitor-8 is an mTOR inhibitor and autophagy inducer with antiviral and antitumor activity for the study of non-small cell lung cancer.Formule :C24H19ClN4OSDegré de pureté :98.11%Couleur et forme :SolidMasse moléculaire :446.95Ref: TM-T36316
1mg52,00€5mg111,00€10mg180,00€25mg359,00€50mg588,00€100mg944,00€1mL*10mM (DMSO)116,00€Anti-Phospho-MTOR (Ser2448) Antibody (2K503)
Anti-Phospho-MTOR (Ser2448) Antibody (2K503) is an antibody targeting Phospho-MTOR (Ser2448). Anti-Phospho-MTOR (Ser2448) Antibody (2K503) can be used in ELISA, WB, IHC, IF.Couleur et forme :Odour LiquidSalidroside
CAS :Salidroside is a bioactive phenolic glycoside compound isolated from Rhodiola rosea and is a prolyl endopeptidase inhibitor.Cost-effective and quality-assured.Formule :C14H20O7Degré de pureté :97.81%Couleur et forme :Red-Brown Fine PowderMasse moléculaire :300.3ETP-46464
CAS :ETP-46464 is an effective and specific ATR inhibitor (IC50: 25 nM).Formule :C30H22N4O2Degré de pureté :97.76%Couleur et forme :SolidMasse moléculaire :470.52XL388
CAS :XL388 is a highly effective, specifc, ATP-competitive inhibitor of mTOR ( IC50: 9.9 nM), 1000-fold selectivity than the closely related PI3K kinases.Formule :C23H22FN3O4SDegré de pureté :99.39% - 99.53%Couleur et forme :SolidMasse moléculaire :455.5(+)-Usnic acid
CAS :(+)-Usnic acid (D-Usnic Acid) is a naturally occurring dibenzofuran derivative found in several lichen species.Formule :C18H16O7Degré de pureté :97.61%Couleur et forme :SolidMasse moléculaire :344.32Sapanisertib
CAS :Sapanisertib (INK 128) is an oral raptor-mTOR and rictor-mTOR inhibitor with potential cancer-fighting properties.Formule :C15H15N7ODegré de pureté :100% - 99.67%Couleur et forme :SolidMasse moléculaire :309.33Ref: TM-T1838
1mg40,00€2mg51,00€5mg85,00€10mg96,00€25mg160,00€50mg235,00€100mg350,00€500mg838,00€1mL*10mM (DMSO)88,00€GNE-490
CAS :GNE-490 is an effective inhibitor of pan-PI3K with IC50s of 3.5 nM, 25 nM, 5.2 nM, 15 nM for PI3Kα, PI3Kβ, PI3Kδ and PI3Kγ, respectively.Formule :C18H22N6O2SDegré de pureté :99.77%Couleur et forme :SolidMasse moléculaire :386.47Ref: TM-T22339
1mg85,00€2mg115,00€5mg188,00€10mg321,00€25mg509,00€50mg702,00€100mg932,00€200mg1.283,00€1mL*10mM (DMSO)205,00€GSK1059615
CAS :GSK1059615 has been used in trials studying the treatment of Lymphoma, Solid Tumours, Endometrial Cancer, Solid Tumor Cancer, and Metastatic Breast Cancer.Formule :C18H11N3O2SDegré de pureté :≥95% - ≥95%Couleur et forme :SolidMasse moléculaire :333.36
