Hydrocarbures aromatiques polycycliques (HAP)

Applications 4,5-Methanochrysene shows moderate degree of carcinogenic activity. As a polycyclic aromatic hydrocarbon (PAH), it is considered as a pollutant. References Dunlap, C., et al.: Cancer Res., 3, 606(1943); Rice, J., et al.: Carcinogenesis, 9, 2275 (1988); Fabacher, D., et al.: Arch. Environ. Con. Tox., 21, 17 (1991)

Applications 5-Methylbenz[a]anthracene is a monomethylated polycyclic aromatic hydrocarbon with carcinogenic activity. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Majumdar, R. et al.: Mutat. Res. Lett., 175, 1 (1986); Smith, I.A. et al.: Int. J. Quant. Chem. Quant. Biol. Symp., 5, 311 (1978); Wislocki, P.G. et al.: Carcinogenesis, 3, 215 (1982);

Applications 1-Hydroxypyrene-d9 is found in humane urine after exposure to coal tar and a coal derived product. References Jongeneelen, F.J., et al.: Int. Arch. Occup. Environ. Health, 57, 47 (1985)

Applications Polycyclic aromatic hydrocarbons (PAHs) and their PAH-DNA adducts in lung tissues, and their ability to mutate the Ki-ras oncogene in PAH-induced tumors. Seven PAHs were studied: cyclopenta[cd]pyrene (CPP), benzo[a]pyrene (B[a]P), benzo[b]fluoranthene (B[b]F), dibenz[a,h]anthracene (DBA), 5-methylchrysene (5MC), benz[j]aceanthrylene (B[j]A), and dibenzo[a,l]pyrene (DB[a,l]P). References Nesnow, S., et al.: Cancer Lett., 73, 73 (1993), Herzog, C., et al.: Cancer Res., 54, 4007 (1994), Prahalad, A., et al.: Carcinogenesis, 18, 1955 (1997),