Hydrocarbures aromatiques polycycliques (HAP)

Applications 1,7-Dimethyl-phenanthrene is an environmental pollutant. References Benner, B., et al.: Environ. Sci. Technol., 29, 2382 (1995);

Applications 2-​Methylnaphthalene is a polycyclic aromatic hydrocarbon (PAH) that has been used as an indicator of smoke exposure in food and packaging materials. This compound is a contaminant of emerging concern (CECs) Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Johnston, J.J., et. al.: J. Agr. Food Chem., 42, 1954 (1994)

Stability Light Sensitive Applications 7H-Benzo[c]fluorene is a polycyclic aomatic hydrocarbon (PAH) with mutagenic activity. 7H-Benzo[c]fluorene is a major DNA adduct-forming component of coal tar. Recent studies suggest that 7H-Benzo[c]fluorene may be capable of inducing lung tumors. References Lavoie, E.L. et al.: Mutat. Res. Lett., 91, 167 (1981); Koganti, A. et al.: Carcinogenesis, 21, 1601 (2000); Weyand, E.H. et al.: Polycyc. Arom. Comp., 24, 1 (2004);

Stability Hygroscopic Applications 1,2,3,4-Tetrahydro-1-[(4-hydroxyphenyl)methyl]-hydrobromide-(1S)-6,7-isoquinolinediol has been used in the preparation of (-)-Higenamine (H325800) References Ho, C.L., Ko, J.L., Chen, C.M.: J. Chinese Biochem. Soc., 14, 94 (1985)

Applications Occurs in coal tar. Is formed during distillation of coal, in very small amount during distillation or pyrolysis of many fats and oils. Chrysene is one of the basic polycyclic aromatic hydrocarbon (PAH) which is toxic environmental pollutant and consistently exposed to sunlight. However, little information is available on its photogenotoxicity.  The objective of the present study was to analyze the effects of Chrysene, under environmental intensity of UVB (0.6 mW/cm2) in human skin epidermal cell line (HaCaT). Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Anderson, D., et al.: Mutat. Res., 307, 261 (1994), Diamond, S., et al.: Environ. Toxicol. Chem., 25, 3015 (2006), Fotakis, G., et al.: Toxicol. Lett., 160, 171 (2006),

Applications 2-Nitrodibenzothiophene is a nitrated polycyclic aromatic hydrocarbon (PAH). 2-Nitrodibenzothiophene is removed from coal by hydrogenation in Tetralin. References Watanabe, T. et al.: Mut. Res. Gen. Toxicol. Environ. Mutagen., 388, 67 (1997); Gundermann, K.D.: U. S. Environ. Prot. Agency, Off. Res. Dev., 133 (1976);

Applications A metabolite of Phenanthrene (P294800(P)), which is a polycyclic aromatic hydrocarbon; an environmental pollutant. References Boyland, E., et al.: Biochem. J., 84, 564 (1962); Hamada, S., et al.: Mutat. Res., 495, 127 (2001); Shimada, T., et al.: Drug Metab. Dispos., 29, 1176 (2001); Moennikes, O., et al.: Cancer Res., 64, 4707 (2004); Albig, A., et al.: Mol. Biol. Cell., 16, 609 (2005); Di Toro, D. et al.: Environ. Toxicol. Chem., 19, 1971 (2000); Vines, C. et al.: Aquat. Toxicol., 51, 225 (2000); Incardona, J. et al.: Toxicol. Appl. Pharmacol., 196, 191 (2004); Junghans, M., et al.: Aquat. Toxicol., 76, 93 (2006);

Applications 6-Ethylchrysene is a persistent organic pollutant (POP). It is a derivative of chrysene (C428000) which is considered as a carcinogen. References Bratberg, M., et al.: Chemosphere, 90, 2157 (2013); Hecht, S., et al.: J. Natl. Cancer Inst., 53, 1121 (1974)