Hydrocarbures aromatiques polycycliques (HAP)

Applications A major metabolite of 2-nitrofluorene (NF). It exhibits a significant estrogenic activity. References Stresser, D., et al.: Drug Metab. Dispos., 26, 868 (1998), Charles, G., et al.: Toxicol. Sci., 55, 320 (2000), Raichurkar, A., et al.: J. Med. Chem., 46, 4419 (2003).

Applications 1,3,6-Trichloropyrene is a chlorinated polycyclic aromatic hydrocarbon and micropollutant found in the environment. References Puzyn, T., et al.: J. Environ. Sci. Heal. A., A38, 1761 (2003)

Applications 2,7-Diisopropylnaphthalene (cas# 40458-98-8) is a useful research chemical. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications 6-Methylquinoline, is a building block used for the synthesis of various pharmaceutical compounds, and biologically active compounds. It can be used for the preparation of pyranobenzopyrone compounds, having anti-norovirus activity. References Pokhrel, L., et al.: bioorg. Med. Chem. Lett., 22, 3480 (2012);

Applications 1,4-Dibromonaphthalene is used in the annelation of PAHs. Also used in the synthesis of novel, orally active dual NK1/NK2 antagonists. References Bernstein, P. et al.: Bioorg. Med. Chem. Lett., 11, 2769 (2001); Wegner, H. et al.: J. Org. Chem., 68, 883 (2003);

Applications 6-Nitrochrysene-d11 is an isotopically labelled form of 6-Nitrochrysene(N520220). 6-Nitrochrysene is a nitro-polycyclic aromatic hydrocarbon and a carcinogen selector. An environmental contaminant and a carcinogen. References Hu, S., et al.: J. Air Waste Manag. Assoc., 63, 984 (2013); Boyiri T., et al.: Carcinogenesis, 25, 637 (2004); Krieger, R. K., et al.:Proceedings, Annual Meeting - Air & Waste Management Association, 90, WP100A06 (1997);

Applications 3-Hydroxy Benzopyrene O-β-D-glucuronide is the glucuronide conjugate and metabolite of the carcinogen Benzopyrene (B205800). Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Bevan, D.R. et al.: Carcinogensis, 13, 403 (1992); Nishimoto, M. et al.: Xenobiotica, 22, 949 (1992);Zheng, Z. et al.: Drug Metab. Dispos., 30,397 (2002);

Applications Dibenzo[a,i]pyrene is a polycyclic aromatic hydrocarbon (PAH) with potent carcinogenic activity. Dibenzo[a,i]pyrene was shown to induce DNA adduction, tumorigenicity as well as Ki-ras oncogene mutations in strain A/J mouse lung. Dibenzo[a,i]pyrene has been shown to be present in cigarette smoke condensate and in automobile exhaust gas in small quantities. References Prahalad, A.K. et al.: Carcinogenesis, 18, 1955 (1997); Wynder, E.L. et al.: Nature, 192, 1092 (1961); Homburger, F. et al.: J. Nat. Cancer Inst., 44, 357 (1970);

Applications A 16-membered ring macrolide antibiotic with antimicrobial activity against a wide range of pathogens. Particularly used in the treatment of Mycoplasma infection. References Osono, T. et al.: J. Antibiot., 27, 366 (1974); Kuriaki, K. et al.: Jpn. J. Antibiot., 22, 232 (1969); Tan K. et al.: Zhonghua Yiyuamganranxue Zazhi, 16, 235 (2006);

Applications A metabolite of Benzopyrene (BaP), a carcinogenic component of tobacco smoke implicated in lung cancer. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References DiBiasio, K., et al.: Drug Metab. Dispos.,19, 227 (1991), Beach, J., et al.: J. Anal. Toxicol., 24, 670 (2000), Borman, S., et al.: Toxicol. Appl. Pharmacol., 167, 191 (2000), Tsai-Turton, M., et al.: Biol. Reprod., 77, 442 (2007),

Applications Phenanthrene derivative used to make fluorescent probes. References Panda, G., et al.: Bioorg. Med. Chem., 12, 5269 (2004), Panda, G., et al.: Eur. J. Med. Chem., 42, 410 (2007), Nakagawa-Goto, K., et al.: J. Med. Chem., 51, 3297 (2008),

Applications Mono[2-(perfluorohexyl)ethyl] phosphate is used to water- and grease-proof food packaging materials, and this chemical is a known precursor to perfluoroalkyl carboxylic acids (PFCAs) References Gebbink, Wouter A., Envir. Sci. and Pollution Res., 20(11), 7949-7958 (2013)

Applications 9,10-Dichlorophenanthrene is a chlorinated polycyclic aromatic hydrocarbon (Cl-PAH) found in the urban environment, known to display dioxin-like toxicity and mutagenicity. References Ma, J., et al.: Adv. Mat. Res., 610, 2989 (2013); Ma, J., et al.: Environ. Sci. Technol., 43, 643 (2009)

Applications Quizalofop-ethyl may have agricultural applications specifically in controlling plant diseases. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Watanabe, S., Jpn. Kokai Tokkyo Koho (2020) JP 2020125364 A

Applications Perylene has been used as an acceptor for pristine C70 to be used as a sensitizer for efficient triplet-triplet annihilation upconversion; which has shown improved stability under continuous laser irradiation compared to the benchmark Pt(II)-ocetaethylprphyrin. Perylene has also been used as a dopant representing blue fluorescent dye on a white-emitting polymer film. Dyes and metabolites. References Moor, K., et. al.: Chem. Commun., 49, 10829 (2013); Sakai, K., et. al.: J. Mater. Chem-C, 1, 7866 (2013)