Molécules organiques diverses avec substitutions isotopiques

Applications N,N-Diisopropylamine-d14 Hydrochloride (cas# 1219803-88-9) is a compound useful in organic synthesis.

Applications Ethion-D20 is a labelled analogue of Ethion (E678305). Ethion is an organophosphate pesticide that is commonly used for crop protection against pests, such as mites and aphids. Ethion is highly toxic if ingested, as it can cause acute cyanosis and flaccid paralysis. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Comstock, E., et al.: Tex. Med., 63, 71 (1967); Dickinson, B.: J. Econ. Entomol., 51, 354 (1958); Riehl, L., et al.: J. Econ. Entomol., 52, 857 (1959)

Applications Isotope labelled Azaperone, a sedative or tranquilizer. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Heykants, et al.: Arzneim.-Forsch., 21, 982 (1971), Stresser, D., et al.: Drug Metab. Dispos., 28, 1440 (2000), Egnell, A., et al.: J. Pharmacol. Exp. Ther., 305, 1251 (2003), Wester, M., et al.: J. Biol. Chem., 279, 35630 (2004),

Applications Labelled Budesonide, a non-halogenated glucocorticoid related to triamcinolone hexacetonide. Used as an antiinflammatory agent. References Ryrfeldt., A., et a.: J. Steroid Biochem., 10, 317 (1979), Roth, G., et al.: J. Pharm. Sci., 69, 766 (1980), Clissold, S.P., et al.: Drugs, 28, 485 (1984),

Applications Nandrolone-13C2 Benzoate is the isotope analog of Nandrolone Benzoate. Nandrolone Benzoate is a steroid that has effect on gondatropin and muscles, which is derived from Nandrolone (an anabolic steroid). References Lerner, L.J., et al.: Endocrinology, 64, 1010 (1959); Gradeen, C., et al.: J. Anal. Toxicol., 14, 120 (1990); Teale, P., et al.: Biol. Mass Spectrom., 20, 109 (1991); Yamada, M., et al.: J. Pharm. Biomed. Anal., 45, 125 (2007); Yamada, M., et al.: J. Anal. Toxicol., 32, 387 (2008)

Applications Labelled Bisphenol F, a bisphenol derivative with antioxidant activities. Bisphenol F has been reported to exhibit estrogen agonistic properties. References Higashihara, N. et al.: Arch. Toxicol., 81, 825 (2007); Kanai, H. et al.: Int. J. Cancer, 93, 20 (2001); Pospisil, J. et al.: Kinet. Mech. Polyreacti.Int. Symp. Macromol. Chem. Prepr.,5, 383 (1969);

Applications An isotopically labelled analog of a serum lipid regulating agent used as an antihyperlipoproteinemic. References Kissebach, A.H., et al.: Atherosclerosis, 24, 199 (1976), Lewis, J.E., et al.: Pract. Cardiol., 9, 99 (1983), Rubins, H.B., et al.: N. Engl. J. Med., 341, 410 (1999)

Applications Isotope labelled analogue of D-arabinitol, a sugar alcohol. D-arabinitol was used as a diagnostic tool for the detection of fungal infections in neutropenic patients. References Salonen, J.H., et al.: Eur. J. Clin. Microbiol. Infect. Dis., 20, 179 (2001);

Applications Clothianidin-d3 (N-methyl-d3) (CAS# 1262776-24-8) is a useful isotopically labeled research compound. This compound can be used to detect trace levels of neonicotinoid insecticides in honey bee royal jelly using ultra-sound assisted liquid-liquid extraction-UHPLC/MS. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Giroud, B., et.al., Microchemical J., 151,104249,(2019);

Applications Clozapine-d4 can act as modulators of dopamine receptors, serotonin receptors, adrenergic receptors, acetylcholine receptors, and/or histamine receptors. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Gant, T. G., U.S. Pat. Appl. Publ. (2010), US 20100166887 A1, 20100701

Applications 2-Methylpropionic-2-d1 Acid (CAS# 19136-93-7) is a useful isotopically labeled research compound.

Applications Isotope labelled Vinclozolin (V314050), which is an agricultural fungicide which acts through an anti-androgenic mode of action, however is incapable of disrupting endocrine homeostasis (1). Affects male reproductive organs through increased gonad activity with spermatogenesis with deformities (2). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References 1. Flick, B. et al.: Arch. Toxicol. 2017 Apr;91(4):1941-1956.2. Watermann, B. et al.: J. Environ. Sci Health A Tox Hazard Subst Environ Eng. 2016 Nov 9;51(13):1111-20.

Applications Labelled Pyrovalerone (P997750). A CNS stimulant. Controlled substance (stimulant). References Stille, et al.: Arzneim.-Forsch., 13, 871 (1963), Michaelis, et al.: J. Med. Chem., 13, 497 (1970),