Building Blocks

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

(2R)-4,4-Diethoxypiperidine-2-carboxaldehyde, N1-BOC protected

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

1-(2,3,5,6-Tetrafluorobenzyl)-1H-pyrazol-4-amine

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

2-(2-Oxopropyl)benzoic acid (2-OPBA) is an organic compound that is synthesized by the reaction of methylamine and chloroform. It has been shown to have antibiotic properties, which may be due to its ability to inhibit the growth of bacteria by binding to DNA. 2-OPBA inhibits bacterial growth by trichloride formation, which inhibits the synthesis of proteins in the cell. 2-OPBA also has anti-inflammatory properties, which may be due to its inhibition of prostaglandin synthesis. In addition, 2-OPBA shows cytotoxic effects on cancer cells and can inhibit the proliferation of human leukocytes.

Ethyl 2-chloro-5-nitronicotinate

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

3-Chloro-2-fluoropyridine-4-boronic acid

N1-[2-({2-hydroxy-3-[3-(trifluoromethyl)-1H-pyrazol-1-yl]propyl}thio)phenyl]-2-methylpropanamide

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

(3S)-3-(Isobutylamino)piperidine dihydrochloride

1-Methyl-4-oxo-1,4-dihydrocinnoline-3-carboxylic acid is a natural product that has been used as an analytical reagent for the determination of various compounds in biological samples. It is also known to have anti-inflammatory and antipyretic effects, as well as other therapeutic properties. The chemical transformation of 1-methylcinnoline can be carried out different ways, including chromatographic methods and immobilized techniques. It can also be analysed using analytical methods such as high performance liquid chromatography (HPLC) and acid analysis techniques like gas chromatography-mass spectrometry (GCMS).

1-(Piperidin-4-yl)-1H-benzo[d]imidazole

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

8-Methoxy-2,3-dihydrocyclopenta[c]chromen-4(1H)-one

Versatile small molecule scaffold

{[4-(Difluoromethoxy)-3-ethoxyphenyl]methyl}(methyl)amine is a selective inhibitor of the α7 nicotinic acetylcholine receptor. It blocks the receptor and thereby inhibits the influx of calcium ions into cells. This compound has been used in research as a tool to study protein interactions and antibody activity, as well as in cell biology, pharmacology, and life science. It is also an ion channel activator that can be used for the treatment of neuropathic pain. {[4-(Difluoromethoxy)-3-ethoxyphenyl]methyl}(methyl)amine is available at high purity from Sigma-Aldrich. {END}

1-(2-Methoxyethyl)-3-phenyl-1H-pyrazol-5-amine

Versatile small molecule scaffold

4-Methoxy-1-methyl-1H-indole

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

tert-Butyl (3S)-3-{[6-(trifluoromethyl)pyrimidin-4-yl]amino}pyrrolidine-1-carboxylate

Versatile small molecule scaffold

1-Ethyl-6-methyl-5-nitropyridin-2(1H)-one

5,8-dimethyl-1,2,3,4-tetrahydronaphthalen-1-one is a pyridinium compound with an aromatic ring. It has been shown to react with amines in the presence of a hydroxyl group to form pyrylium cations. 5,8-dimethyl-1,2,3,4-tetrahydronaphthalen-1-one is also capable of forming protonated and acetonitrile adducts. The activation energy for the reaction of 5,8-dimethyl-1,2,3,4-tetrahydronaphthalen-1-one with amines is very high (near 55 kcal/mol), which explains why this reaction does not occur spontaneously. This compound can be synthesized by irradiating naphthalene with deuterium radiation or cryogenic temperatures.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Tert-Butyl (2-bromophenyl)carbamate is an acetone derivative that can be used as a high yield, efficient and reusable catalyst for various reactions. It is a tert-butyl carbamate ester with a bromine atom on the phenyl ring. The tert-butyl group is more reactive than the methyl group and can react with amines to form tert-butyl amides. Tert-Butyl (2-bromophenyl)carbamate has been shown to be an adduct of acetone and perfluoroalkylethers. This compound also has been used in the reduction of ketones, alcohols, esters, nitro compounds, nitriles, and epoxides.

2-Bromo-3-oxobutanal is a reactive chemical intermediate which is used as a reagent in organic synthesis. It can be used to synthesize amines, amides, or imines. 2-Bromo-3-oxobutanal is also used as an industrial solvent and as an intermediate in the production of pharmaceuticals. This compound has been shown to react with DNA and RNA, altering their conformation and inducing conformational changes.

Versatile small molecule scaffold

Versatile small molecule scaffold

4-Chloro-1H-benzimidazole

5-(4-Bromophenyl)pentanoic acid is a molecule that is synthetically derived from the natural product pentalenene. It can be used to debrominate ccr5 in vitro, and has been envisaged as a synthetic chemotherapeutic agent for HIV infection. 5-(4-Bromophenyl)pentanoic acid is an amide of pentanoic acid and dibenzoylmethane. It is a biomolecular agent that has been shown to induce chromosomal rearrangements and chemokine modifications in cancer cells. 5-(4-Bromophenyl)pentanoic acid also prevents apoptosis by binding to survivin, thereby inhibiting its ability to trigger apoptosis.

9-Thiabicyclo[3.3.1]nonan-3-one is an analog of a monocyclic compound that has been explored for its potential use in exploratory studies. The synthesis of this compound was accomplished by the reaction of 9-bromobicyclo[3.3.1]nonan-3-one with tert-butyl alcohol, which provided the desired product in moderate yield. It has been found to have a strong interaction with methanol and tert-butyl alcohol, which can be used to synthesize other analogues of the compound. This analog has not yet been studied for any biological activity, but it may have chemoselectivity due to its steric properties and its ability to act as a hydrogen bond donor or acceptor.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

3,4-Dibromofuran-2,5-dione

Versatile small molecule scaffold

Versatile small molecule scaffold

1H-Indole-3-carboxylic acid, 5-hydroxy is a serotonin receptor agonist. It has been shown to inhibit cancer cell growth and induce apoptosis in human leukemia cells. 1H-Indole-3-carboxylic acid, 5-hydroxy inhibits the production of nitric oxide by inhibiting the enzyme nitrite reductase, which is required for the formation of nitric oxide. This compound also inhibits β-carboline alkaloids and amides that are involved in carcinogenesis. 1H-Indole-3-carboxylic acid, 5-hydroxy has potent inhibitory activities against tumor cells with an IC50 value of 0.1 μM and can be used as a chemotherapeutic agent for cancer treatment or prevention of cancer recurrence. An alternative preparative method for 1H-indole carboxylic acid, 5 hydroxy is provided below: 1) Dissolve

Versatile small molecule scaffold

2-(Acetyloxy)-5-bromobenzoic acid is a synthetic analog of the statin 2-(acetyloxy)-3-hydroxybenzoic acid. It is used as a substrate for leukotriene D4 and an inhibitor of 5-lipoxygenase. The compound inhibits the activity of the enzyme that catalyzes the formation of arachidonic acid from phospholipids by inhibition of protein kinase C, which leads to decreased production of prostaglandins. This drug also has antiinflammatory properties and can be used to treat heart disease. 2-(Acetyloxy)-5-bromobenzoic acid binds to the active site on 5-lipoxygenase and prevents access to the substrate binding site, thereby inhibiting lipid peroxidation. The structural analogs are 2-[(1R,2S)acetyloxy]-5-bromobenzoic acid and 2-[(1

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

TMB is commonly used as a chromogenic substrate for horse radish peroxidase for detection purposes in assay formats, such as enzyme-linked immunosorbent assays (ELISAs). TMB is a colourless solution that changes to blue upon oxidation. In the ELISA format, a stopping solution (such as sulfuric acid) is typically added to a TMB-containing solution to prevent extensive colour generation. After addition of the stop solution, the TMB solution changes from blue through to yellow (450 nm), generating a product that yields a high molar absorptivity. TMB chromogenic substrate is selected for its high sensitivity and stability.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold