Building Blocks

Versatile small molecule scaffold

2,2'-Bipyridine-4,4'-dicarboxaldehyde is a synthetic compound that can be used in the production of cyclic compounds. It is produced by the reaction of bipyridines with an aldehyde in the presence of an organic solvent. The high yield and low cost make this process very attractive for industrial use. The reaction product is neutralized with hydrochloric acid to give 2,2'-Bipyridine-4,4'-dicarboxylic acid.

Versatile small molecule scaffold

Applications 2-(3,4-Dihydroxyphenyl)ethyl-1,1-d2-amine HCl (CAS# 83008-33-7) is a useful isotopically labeled research compound.

7,8-Dihydroxyflavone

Versatile small molecule scaffold

7-Bromo-4-cyanoquinoline-n-oxide

Versatile small molecule scaffold

7-Chloro-2-methyl-3,4-dihydro-2H-1,4-benzoxazine

1,4-Cyclohexanedicarbohydrazide (1,4-CHD) is a sympathomimetic drug that is used as a decongestant. 1,4-CHD is metabolized to pseudoephedrine, which has been shown to have antihistaminic and vasoconstrictor properties. 1,4-CHD is not sedating and does not cross the blood brain barrier. It has been found to be effective in treating chronic bronchitis and asthma when taken orally. Pregnant women should not take this drug because it can lead to low birth weight infants or premature births. The safety of this drug during breastfeeding has not been established.

Versatile small molecule scaffold

6-(Trifluoromethyl)pyridine-2-carboxamide is a crystalline solid that has polymorphic properties.

Versatile small molecule scaffold

2-Phenylpyridine 1-Oxide

2-ethyl-6-methylpyridine

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Sodium 4-aminobenzenesulfonate is a salt of the sulfonate group. It is used as a chemical intermediate in the production of sodium citrate and zirconium oxide. Sodium 4-aminobenzenesulfonate has been shown to be chemically stable and can be used at high temperatures without decomposition. It reacts with sodium carbonate, water vapor, and glycol ethers to produce anhydrous sodium carbonate, hydrogen fluoride, and monosodium 4-aminobenzenesulfonate. The reaction mechanism is similar to that of the reaction between sodium hydroxide and hydrochloric acid. This product also has been shown to have a glomerular filtration rate of 43 ml/minute/1.73m2.

Versatile small molecule scaffold

Ethyl 1,3,5-trimethyl-1H-pyrazole-4-carboxylate

5-Ethynyl-1H-indole is a synthetic compound that has been shown to inhibit the enzyme p450, which is involved in the metabolism of dopamine. Dopamine is a neurotransmitter and hormone that regulates many functions including movement, emotional response, motivation, and sexual desire. It also plays an important role in the development of Parkinson's disease. 5-Ethynyl-1H-indole has also been shown to bind to nicotinic acetylcholine receptors (nAChR) at α7 nicotinic acetylcholine receptors. 5-Ethynyl-1H-indole is being studied as a potential cancer drug due to its antitumour activity. The anti-cancer effect may be related to its ability to inhibit enzymatic reactions involving acetylcholine or its ability to block acetylcholine from binding with its receptor on muscle cells.

tert-Butyl 3-(aminomethyl)-4-fluoropiperidine-1-carboxylate

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

1-(6-Methylpyridin-2-yl)ethanamine

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

2,3-Dichloro-4-methoxyphenol is a phenolic compound that is found in plants. It has been shown to inhibit the growth of plants by hydroxylation and inhibiting the synthesis of lignin. This can be achieved by applying 2,3-dichloro-4-methoxyphenol to the leaves of plants in a controlled manner. The herbicide is absorbed through the leaf surface and then transported to other parts of the plant. The herbicide can also be applied as a preplant treatment to control weeds and grasses before planting crops. 2,3-Dichloro-4-methoxyphenol is used on crops such as wheat, barley, oats, corn, rye, rice, sorghum and sugar cane. It has been shown to have low toxicity for humans when consumed orally and does not cause cancer or reproductive effects.

Versatile small molecule scaffold

Versatile small molecule scaffold

1-Cyclohex-1-en-1-ylpyrrolidine

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

C-176 is a human monoclonal antibody that binds to the death protein and neutralizes its activity. It also inhibits angiogenesis by inhibiting the proliferation of endothelial cells. C-176 has been shown to reduce blood pressure in animal models. The mechanism for this effect is not known, but it may be due to its ability to inhibit the production of proinflammatory cytokines, such as tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β), which are stimulators of endothelial cell proliferation. C-176 also has regulatory effects on T cells, B cells, natural killer cells, and macrophages. It inhibits the coagulation process by reducing platelet aggregation and thrombin formation. This drug is an inhibitor of single-stranded DNA binding proteins and can be used in radiation therapy or as a stimulator of bone marrow stem cells in patients undergoing chemotherapy. END>>

Versatile small molecule scaffold

Versatile small molecule scaffold

8-(4-Bromobenzyl)-2,5-dioxa-8-azaspiro[3.4]octane

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

2-[2-(4-tert-Butoxycarbonylpiperazin-1-yl)ethoxy]acetophenone

Versatile small molecule scaffold

Versatile small molecule scaffold

3-benzoyl-1H-pyrazole is an alkylsulfonyl halide that has a pyrazole ring on the left side of the molecule. It also has an alkoxy, benzoylpyrazole, and hydroxyl group attached to it. 3-benzoyl-1H-pyrazole inhibits target enzymes such as heterocycles, nitrogen nucleophiles, and dialkylamino. This compound inhibits herbicidal activity in plants by inhibiting enzymes such as fatty acid synthase or nitrate reductase. 3-benzoyl-1H-pyrazole has been shown to have synergistic effects when used with other herbicides such as 2,4-dichlorophenoxyacetic acid (2,4D).

1-[(4E)-5-(Dimethylamino)-3-oxopent-4-en-2-yl]-5-(trifluoromethyl)-1,2-dihydropyridin-2-one

Versatile small molecule scaffold

2-(Aminomethyl)-1,3-thiazole

Versatile small molecule scaffold

N-Benzylcinchoninium Chloride

Versatile small molecule scaffold

(2-Amino-benzothiazol-6-yl)-acetic acid dihydrochloride

(2-Oxomorpholin-4-yl)acetic acid

2-Chloro-1-cyclohexylethan-1-one is an enantiopure epoxide that can be synthesized from chloroketones and amines. It is used in the synthesis of chlorinating agents, such as chloramines and chlorocarbons, as well as in the preparation of carbamates. 2-Chloro-1-cyclohexylethan-1-one also has a kinetic effect on dehalogenase enzymes, which are involved in halogen metabolism. The chemical's chlorine atom can react with hydrogen chloride to form hydrogen chloride gas and hydrochloric acid. 2-Chloro-1-cyclohexylethan-1-one has been shown to be effective against nematodes, limiting their growth by inhibiting the synthesis of essential proteins needed for cell division. This chemical also reacts with chloride ions to form polymers that act as a protective barrier against insects. 2CCHE is a

Octamethyleneimine

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

3-Hydroxy-2H-pyran

Versatile small molecule scaffold

Ethyl 6-bromo-8-fluoro-2-(trifluoromethyl)imidazo[1,2-a]pyridine-3-carboxylate

Versatile small molecule scaffold

4,6-Dichloro-3-iodo-1H-pyrazolo[3,4-d]pyrimidine

Versatile small molecule scaffold

FPS-ZM1 is a small molecule drug with immunomodulatory and anti-inflammatory properties. It was originally synthesized as an inhibitor of the transcriptional regulator HMG-BOX, which is found in the promoters of genes involved in neuronal death, inflammation, and autoimmune diseases. FPS-ZM1 inhibits the transcriptional regulator HMG-BOX by binding to it, thereby preventing it from interacting with its DNA target. This inhibition leads to decreased expression of proinflammatory genes. The effects of FPS-ZM1 on inflammatory responses have been demonstrated in vitro and in vivo using human cells. In addition, FPS-ZM1 has been shown to inhibit Toll-like receptor (TLR) signaling pathways that are activated by lipopolysaccharide (LPS).

Versatile small molecule scaffold

Versatile small molecule scaffold

1-(Pyridin-4-yl)propan-1-amine

Versatile small molecule scaffold

2-Propylthio-5-trifluoromethylpyridine-3-boronic acid

Versatile small molecule scaffold

2-Methyl-octahydro-pyrrolo[3,4-c]pyrrole

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

2-Ethynyl-1-benzofuran is a ligand in organic chemistry that can react with an oxidant to form terminal alkynes. It has been shown to undergo hydrofunctionalization and stereocontrol, which are two of the most commonly studied reactions in organic chemistry. This compound is also used as a precursor for benzofurans, which are important organic compounds that have been studied extensively due to their structural diversity. 2-Ethynyl-1-benzofuran is synthesized from azides and aldehydes or triazoles, which can be obtained through advances in organic chemistry.

5-(4-Bromo-3,5-dimethylpyrazol-1-ylmethyl)-4-methyl-1,2,4-triazole-3-thiol

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

N-Methylisatoic anhydride is a versatile compound used in various industries. It is commonly employed in the production of polymers, cellulose derivatives, and detergents. This compound acts as a cationic hydrogenated pyrazole chloride, making it highly soluble in water and easily solubilized in various solvents. N-Methylisatoic anhydride is also utilized as an inhibitor for the synthesis of uridine monophosphate and cytidine monophosphate. Additionally, it finds applications as an electrode material due to its excellent conductivity properties. With its wide range of uses, N-Methylisatoic anhydride is a valuable compound for multiple industries.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

N,4,5-Trimethyl-1,3-thiazol-2-amine hydrobromide

Versatile small molecule scaffold

2-(Acetyloxy)-5-chlorobenzoic acid is a potent apoptotic agent that is being investigated for its potential use in the treatment of cancer. It has been shown to inhibit tumor growth and increase survival in animal models and has been assessed in human clinical trials. 2-(Acetyloxy)-5-chlorobenzoic acid induces apoptosis by inhibiting DNA synthesis, protein synthesis, or both. It also inhibits the activity of caspases, enzymes that are involved in tumor cell death. This compound may be used to treat Alzheimer's disease because it inhibits tau phosphorylation, which is an important marker for Alzheimer's disease pathology.