Antifongiques

Anti-fungal; lanosterol 14α-demethylase inhibitor

Neticonazole has anti-infective and anti-cancer effects, inhibits exosome secretion, and can be used to study Candida albicans infection of the skin.

2-Methyl-4-isothiazolin-3-one or MIT is a powerful antimicrobial and antifungal agent which is widely used in personal care products. It is also used in industrial applications as a preservative and antifouling agent.

Caulilexin C inhibits hACAT1 and hACAT2 at 100 µg/ml.

Bitertanol (KWG 0599) is a triazole fungicide. Bitertanol inhibits demethylation, disrupts membrane function, and prevents sterol synthesis.

Neticonazole Hydrochloride is an imidazole antifungal for the treatment of fungal skin infections.

Amphotericin A is a polyene macrolide antibiotic, which is derived primarily from the soil bacterium *Streptomyces nodosus*. This compound functions by binding to ergosterol, an essential component of fungal cell membranes. This binding creates pores in the membrane, increasing its permeability and ultimately leading to cell death. Unlike its more widely used counterpart Amphotericin B, Amphotericin A is less frequently utilized but is critical in the study and understanding of antifungal activity. While Amphotericin A itself is not commonly used for clinical applications due to its lower efficacy compared to Amphotericin B, it plays a significant role in research settings. Its primary utility is in the investigation of the structure-activity relationship of polyene antibiotics, contributing to the development and enhancement of antifungal therapies. Scientists utilize Amphotericin A to understand the mechanisms behind antifungal drug resistance and to design synthetic derivatives with improved therapeutic profiles and reduced toxicity.

Isavuconazonium sulfate is a prodrug converted to antifungal isavuconazole, inhibiting fungal enzyme CYP51 to disrupt cell membrane synthesis.

Griseofulvin is an antifungal drug used to treat several types of dermatophytosis (ringworm). This includes fungal infections of the nails, scalp and the skin when antifungal creams have not worked. It is suggested that it prevents nuclear acid production and fungal cell mitosis. Additionally, through binding to alpha and beta tubulin, it interferes with the function of the spindle and cytoplasmic microtubules. Griseofulvin is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

LW3 is an effective broad-spectrum antifungal compound.

1H-Indole, 3,3'-(2-thienylmethylene)bis[2-methyl- can be used as a broad-spectrum antimicrobial agent with inhibitory activity against Aspergillus niger

Sertaconazole is a broad-spectrum antifungal.

Terconazole is an azole antifungal agent with action on fungal cell membranes by inhibiting ergosterol biosynthesis and is used for treating vaginal yeast infections.