Antiparasitaires

Bitoscanate (PDITC) is used in the treatment of hookworms.

Kaempferol (Robigenin) is a natural flavonoid and an inverse agonist of ERRα and ERRγ.

CP-320626 is an effective human liver glycogen phosphorylase (GP) inhibitor with cholesterol-lowering activity, used in type 2 diabetes research.

Ipronidazole (RO-71554) is an orally effective antiprotozoal agent used to prevent and ameliorate histomoniasis in turkeys, commonly referred to as blackhead disease.

Applications Desethyl Chloroquine is the major product of the stereoselective human metabolism of Chloroquine, used for the therapy and prevention of malaria. It is a COVID19-related research product. References Essien, E., et al.: J. Pharm. Pharmacol., 38, 543 (1986), Akintonwa, A., et al.: Ther. Drug Monit., 10, 147 (1988), Boelaert, J., et al.: AIDS, 15, 2205 (2001), Basco, L., et al.: Antimicrob. Agents Chemother., 47, 1391 (2003),

Flubendazole is a benzimidazole anthelmintic with action on microtubule formation in parasites and is used for treating intestinal worms in humans and animals.

Arohynapene B is an anticoccidial compound that inhibits the growth of Eimeria parasites.

Parbendazole (SKF 29044) is a potent inhibitor of microtubule assembly(EC50 : 8.79 nM).Parbendazole is a carbamate ester-amine.

Hexadecylphosphocholine, better known as miltefosine, belongs to the group of phospholipids. The long alkyl chain and a polar group of a molecule proved to be essential for antitumor activity, especially to cure breast cancer cells. The apoptotic process takes place in the plasma membrane, where molecules are inserted and then influence signaling pathways. Moreover, during preclinical studies hexadecylphosphocholine (He-PC) found to be highly effective in inhibiting the growth of chemically induced rat mammary carcinomas, and even a high percentage of the tumors regressed completely. The He-PC has many more applications such as antifungal agent, antiprotozoal drug, protein kinase inhibitor or immunomodulator. Even though miltefosine was originally developed in the 1980s as an anti-cancer agent, new studies have demonstrated activity against Leishmania parasites and neoplastic cells, and due to broad spectrum of antimicrobial effects, it is recommended as a first line treatment for free-living amebae infections.

Applications 2-[[(4S)-4-[(7-chloro-4-quinolinyl)amino]pentyl]ethylamino]-ethanol is the (S) enantiomer of (R)-Hydroxychloroquine (C373710).

DHC curbs antibody and cell-mediated allergies, inhibits mitochondrial potential in macrophages, and has antinociceptive, anti-inflammatory effects.

Tinidazole is a nitroimidazole antibiotic with action on DNA synthesis disruption in anaerobic bacteria and protozoa and is used for treating infections like giardiasis, amebiasis, and trichomoniasis.

Oxysanguinarine (Hydroxysanguinarine) possesses antiplatelet aggregation activity, it has potential inhibitory properties against the dengue virus.

Crotamiton (Eurax) is an antipruritic and a scabicidal agent available as a lotion or cream for topical use only.

Applications 1-Chlorodecane is a reagent in the preparation of antimycobacterial agents. Also used in the synthesis of antimalarial atovaquone derivatives. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Pathak, A. et al.: Bioorg. Med. Chem., 21, 1685 (2013); El Hage, S. et al.: Eur. J. Med. Chem., 44, 4778 (2009);