Iridioïdes

Globularin is a naturally occurring bioactive compound, which is an iridoid glycoside sourced primarily from the plant family Plantaginaceae. Its mode of action involves modulation of specific cellular signaling pathways, demonstrating antioxidant, anti-inflammatory, and potential anti-cancer properties in various in vitro and in vivo studies. Globularin’s primary uses and applications are in the fields of pharmacology and biochemistry, where it is extensively researched for its therapeutic potential. It has shown promise in mitigating oxidative stress and associated cellular damage, making it a candidate for studies focused on neuroprotection and chronic inflammatory conditions. Additionally, preliminary research suggests its efficacy in modulating cell proliferation and apoptosis, positioning it as a compound of interest in cancer research. Its role in traditional medicine as a component of herbal extracts also underscores its historical significance and warrants further scientific exploration.

Natural glycoside

Natural glycoside

Natural glycoside

Nuzhenide analytical standard provided with chromatographic purity, to be used as reference material for qualitative determination.

Loganin is a non-competitive inhibitor of BACE1 with IC50 of 47.97 μM an also inhibits AChE and BChE with IC50 values of 3.95 μM and 33.02 μM, respectively. Loganin has neuroprotective, anti-amnesic, anti-inflammatory and anti-shock effects, it also exhibits protective effects against hepatic injury and other diabetic complications associated with abnormal metabolic states and inflammation caused by oxidative stress and advanced glycation endproduct formation. Loganin can attenuate neuroinflammatory responses through the inactivation of NF-κB by NF-κB dependent inflammatory pathways and phosphorylation of MAPK in Aβ25-35-induced PC12 cells, and can protect against hydrogen peroxide-induced apoptosis by inhibiting phosphorylation of JNK, p38, and ERK 1/2 MAPKs in SH-SY5Y cells.

Euphroside is a bioactive glycoside, which is a compound derived from natural sources, typically found in certain medicinal plants. Its chemical structure consists of a sugar moiety bound to a non-sugar component, which influences its pharmacological activity. The mode of action of Euphroside is not fully elucidated, but it is believed to interact with biological pathways involving oxidative stress and inflammatory responses. This action is hypothesized to modulate cellular processes and physiological functions, potentially offering therapeutic benefits. Euphroside is primarily studied for its possible applications in biomedical and pharmacological fields, including anti-inflammatory and antioxidant therapies. Its potential to mitigate oxidative stress makes it a subject of interest for researchers looking into treatments for chronic diseases characterized by inflammation and cellular damage. Additionally, Euphroside might hold promise for further exploration in other therapeutic areas, depending on ongoing research outcomes. Its efficacy and safety are under continuous investigation, with a focus on understanding the underlying mechanisms and identifying possible clinical applications.

Catalposide is a bioactive iridoid glycoside, which is a naturally occurring compound sourced from various plant species, including those in the family Bignoniaceae. This compound is primarily extracted from the roots, leaves, and flowers of plants such as Catalpa and Rehmannia species. Catalposide exhibits its effects by modulating various cellular pathways, including the inhibition of pro-inflammatory cytokines and the modulation of oxidative stress mechanisms. Its mode of action involves the suppression of NF-kB activation and interference with inflammatory signaling cascades. The compound's potent anti-inflammatory and antioxidative properties make it of significant interest in the field of pharmacology and medicine. Catalposide is studied for its potential therapeutic applications in managing conditions such as arthritis, cardiovascular diseases, and neurodegenerative disorders. Its capability to mitigate oxidative stress also positions it as a promising candidate for research in aging-related diseases and conditions that require the protection of cellular components from oxidative damage.

Ajugol analytical standard provided with w/w absolute assay, to be used for quantitative titration.

Aucubin is an iridoid glycoside, which is a naturally occurring compound found primarily in certain medicinal plants such as Plantago species. This compound is extracted from these botanical sources and has been studied for its diverse biological activities. The mode of action of Aucubin involves modulation of various biochemical pathways, including anti-inflammatory and antioxidant mechanisms. Aucubin has been shown to inhibit the production of pro-inflammatory cytokines and reactive oxygen species, contributing to its protective effects at the cellular level. In scientific research, Aucubin is investigated for its potential applications in treating inflammatory conditions, hepatic disorders, and other diseases where oxidative stress is a contributing factor. Its role in liver protection, neuroprotection, and wound healing has garnered attention, making it a subject of interest for researchers exploring new therapeutic avenues. The ongoing exploration of Aucubin's pharmacological potential underscores its significance in the field of medicinal chemistry and natural product research.

Picroside I is a hepatoprotective agent which is reported to be antimicrobial and used against hepatitis B. It has antioxidant, and anti-inflammatory activities, it may be the valuable anti-invasive drug candidates for cancer therapy by suppressing Collagenases and Gelatinases. Picroside I can enhance basic fibroblast growth factor(bFGF)-, staurosporine- or dbc-mitogen-activated protein (MAP)-induced neurite outgrowth from PC12D cells.

Harpagoside analytical standard provided with w/w absolute assay, to be used for quantitative titration.

Morroniside is a naturally occurring secoiridoid glucoside, which is primarily derived from plants such as Cornus officinalis, commonly known as the Japanese cornel dogwood. This compound is isolated through meticulous extraction processes from the fruit of the plant, which has a long history in traditional medicine systems, especially in East Asia. The active mode of action of Morroniside is notably characterized by its potent antioxidant capabilities. It scavenges free radicals and mitigates oxidative stress, offering protective effects at the cellular level. Morroniside is predominantly utilized in scientific studies due to its promising therapeutic potential. It has shown efficacy in modulating neuroprotective pathways, thereby gaining interest in the context of neurological disorders, such as Alzheimer's disease and stroke. Additionally, its anti-inflammatory properties make it a compound of interest in studies targeting chronic inflammatory conditions. Overall, its multifaceted biochemical activities underline its potential role in advancing therapeutic strategies and warrant further investigation in clinical settings.

Natural glycoside

Natural glycoside

Amarogentin is an iridoid glycoside, which is a secondary metabolite found primarily in the roots of the Gentiana lutea plant and other Gentianaceae species. It is renowned for its extreme bitterness and is considered one of the most bitter natural compounds known. Its mode of action involves stimulation of taste receptors, promoting the release of digestive enzymes, and enhancing gastrointestinal motility. This compound is of great interest in pharmacological research due to its potential therapeutic applications. Amarogentin exhibits promising anti-microbial, anti-inflammatory, and hepatoprotective effects, making it a subject of investigation in various biomedical fields. Studies indicate that it may also have anticancer properties by inducing apoptosis in cancer cells and inhibiting tumor growth. Additionally, it's utilized in traditional medicine systems as a digestive stimulant and for treating fevers and gastrointestinal disorders. Due to its diverse biological activities, Amarogentin continues to be a focal point in research aiming to develop novel drug therapies, leverage its bitterness for appetite regulation, and explore its role in enhancing the efficacy of conventional treatments.

Natural glycoside

8-Epideoxyloganic acid offers pain relief, stabilizes bodily functions, reduces inflammation, and may inhibit ROS via NOX activity.

Applications Harpagoside is an iridoid glycoside along with with Harpagide (H105270), the potential to be strong anti-inflammatory agents providing the bulk of the observed effects from their plant origins. References Zhang, L. et al.: Bioorg Med. Chem., 19, 4882 (2011); Wen, B. et al.: J. Ethnopharm., 147, 503 (2013);

Melittoside may have antioxidant activity.

Natural glycoside

Hastatoside analytical standard provided with w/w absolute assay, to be used for quantitative titration.

Geniposide analytical standard provided with w/w absolute assay, to be used for quantitative titration.

Natural glycoside

Natural glycoside

Ajugol (Leonuride) shows some trypanocidal potential against Trypanosoma brucei rhodesiense (IC50 values 29.3-73.0 ug/ml).

Oxygen-heterocyclic compound

Natural glycoside

Agnuside has anti-arthritic activity, it also shows inhibition of vascular permeability and leukocyte migration in vivo.It inhibited an array of pro-inflammatory mediators (PGE(2) and LTB(4)) and T-cell-mediated cytokines (IL-2, TNF-α, IFN-γ, IL-4, IL-10, IL-17).

4'-o-Methyltaxifolin is a flavonoid compound, which is derived from natural plant sources, particularly from species within the Pinaceae family. This compound is often found as a constituent of various plant-based extracts and is known for its diverse biochemical activities. Its mode of action involves acting as an antioxidant, where it helps in scavenging free radicals, thereby reducing oxidative stress and potential cellular damage. Additionally, it can modulate various cellular pathways, contributing to its anti-inflammatory and possible anticancer activities. In scientific research and applications, 4'-o-Methyltaxifolin is extensively studied for its potential therapeutic effects, particularly in relation to cardiovascular health, neuroprotection, and anti-cancer properties. Its ability to interact with biological membranes and proteins makes it a subject of interest in drug development studies. By understanding the interactions and pathways modulated by this compound, researchers aim to explore new therapeutic avenues for treating diseases associated with oxidative stress and inflammation.

Anti-tumor agent; cytoskeleton disruptor

Harpagide analytical standard provided with w/w absolute assay, to be used for quantitative titration.

Natural glycoside

Ajugol is a natural compound, specifically an iridoid glycoside, which is primarily sourced from plants belonging to the Lamiaceae family. It is particularly abundant in species such as Ajuga decumbens and other related Ajuga species. As a secondary metabolite, Ajugol has attracted scientific interest due to its bioactive properties. The mode of action of Ajugol involves its interaction with various biochemical pathways, contributing to its potential anti-inflammatory, antioxidant, and hepatoprotective effects. These activities are primarily attributed to its ability to modulate oxidative stress and influence enzymatic activity related to inflammatory responses. Researchers are investigating the applications of Ajugol in various fields, including pharmacology and herbal medicine. It is being explored for its potential therapeutic uses in treating conditions associated with inflammation, liver dysfunction, and oxidative stress-related disorders. While comprehensive clinical studies are necessary to fully elucidate its efficacy and safety profiles, Ajugol remains a compound of significant interest due to its natural origin and promising biological activities.

GL3 analytical standard provided with chromatographic purity, to be used as reference material for qualitative determination.

Sarracenin is a natural product. Sarracenin shows cytotoxic activities against tumor cells.

Gentiopicroside analytical standard provided with w/w absolute assay, to be used for quantitative titration.

Natural glycoside

Picroside II has antioxidant, anti-inflammatory, immune regulatory, anti-virus and other pharmacological activities. It has potent anti-apoptotic activity against renal I/R injury by suppressing the TLR4/NF-κB signaling pathway, it can protect the ischemic kidney against renal fibrosis and improve the neurological function of rats upon cerebral ischemia reperfusion injury. Picroside II enhances nerve growth factor (NGF)-induced neurite outgrowth from PC12D cells by amplifying a down-stream step of MAP kinase in the NGF receptor-mediated intracellular MAP kinase-dependent signaling pathway.

Natural glycoside

Natural glycoside

Natural glycoside

Ajugol shows some trypanocidal potential against Trypanosoma brucei rhodesiense (IC50 values 29.3-73.0 ug/ml).

Natural glycoside

Natural glycoside

Natural glycoside

Geniposide, a major iridoid found in fruit, is widely used in Asian countries for its anti-inflammatory, and anti-apoptotic activities, the anti-apoptotic activities is due to its modulation of and -related factors (p53, Bax, Bcl-2 and Caspase-3) in LPS-induced mouse mastitis.

Shanzhiside methylester analytical standard provided with w/w absolute assay, to be used for quantitative titration.

Geniposidic acid is a bioactive compound, which is a naturally occurring iridoid glycoside. It is primarily sourced from the fruit of Gardenia jasminoides, a plant used in traditional medicine systems. This compound exhibits its mode of action by influencing various biochemical pathways, including anti-inflammatory, antioxidant, and hepatoprotective activities. It interacts with cellular signaling processes that affect enzyme regulation and immune responses. The uses and applications of Geniposidic acid are varied due to its therapeutic potential. It has been studied for its effects on inflammatory conditions and liver protection, showing promise in mitigating oxidative stress and cellular damage. Additionally, its role in modulating immune responses presents opportunities for its use in managing disorders related to immune system dysregulation. Further research is needed to fully explore and validate the clinical applications of Geniposidic acid, though its preliminary results are promising in the context of pharmacological and therapeutic investigations.