Lignanes

Phyllanthin is widely used as hepatoprotective and antigenotoxic and inhibit function of P-gp.

Natural glycoside

Deoxypodophyllotoxin shows cytotoxic , antineoplastic, antitumor, insecticidal, anti-angiogenic, vascular disrupting, insecticidal, antiviral, and anti-inflammatory activities. Deoxypodophyllotoxin induces G2 /M cell-cycle arrest followed by apoptosis through multiple cellular processes, involving the activation of ATM, upregulation of p53 and Bax, activation of caspase-3 and -7, and accumulation of PTEN resulting in the inhibition of the Akt pathway. Deoxypodophyllotoxin maybe applicable to treat hyperpigmentation, it decreases UV-induced skin pigmentation of brown guinea pigs.

Epimagnolin A is a lignan obtained from the flower buds of Magnolia fargesii, which is traditionally used in Asian medicine for treating headache and nasal

Oxygen-heterocyclic compound

Fargesin is a naturally occurring compound that is a bioactive constituent of Magnolia flowers. It is derived from the dried buds of Magnolia fargesii, a plant traditionally used in herbal medicine. The compound exhibits a mode of action that involves anti-inflammatory and anti-allergic properties. It operates through the inhibition of the release of pro-inflammatory mediators, thereby reducing inflammation and allergic responses. Fargesin finds its applications primarily in the management of sinusitis and other respiratory tract ailments. Its anti-inflammatory effects make it a valuable molecule in reducing nasal congestion, sinus pressure, and other symptoms associated with rhinitis and sinus infections. Given its natural origin and targeted action, Fargesin is of interest in the development of treatments that aim to alleviate allergic and inflammation-related conditions without the side effects commonly associated with synthetic drugs. Researchers are exploring its potential uses in broader therapeutic contexts, contributing to a growing body of literature on botanical extracts in medical science.

Dehydropodophyllotoxin is a lignan compound, which is derived from the roots and rhizomes of the plant genus Podophyllum. It exhibits its activity primarily as an inhibitor of microtubule assembly. Microtubules are essential components of the cell cytoskeleton, playing a critical role in cell division and intracellular transport. By interfering with microtubule dynamics, dehydropodophyllotoxin disrupts mitosis, leading to cell cycle arrest and potential apoptosis in rapidly dividing cancer cells. This compound has garnered interest in the field of oncology due to its potential antitumor properties. Researchers are exploring its application in the development of chemotherapeutic agents aimed at various types of cancer. Although its precise molecular mechanisms are still under investigation, the ability of dehydropodophyllotoxin to inhibit microtubule formation represents a promising avenue for cancer treatment strategies. Scientists continue to study its pharmacokinetics and therapeutic efficacy in order to better understand its role and optimize its application in clinical settings.

Carboxylic acid with additional oxygen functions

4'-Demethylpodophyllotoxin is a lignan derivative, which is sourced primarily from the roots and rhizomes of the plant species Podophyllum. This compound is a refined version of podophyllotoxin, a well-known precursor in the synthesis of anticancer drugs. The primary mode of action of 4'-Demethylpodophyllotoxin involves the inhibition of microtubule assembly, thereby disrupting the mitotic spindle formation essential for cell division. This mechanism leads to cell cycle arrest and apoptosis in rapidly dividing cells, highlighting its potential in antitumor therapies. The compound finds extensive application in the development of chemotherapeutic agents, particularly in targeting various carcinomas. It is of significant interest in oncology research due to its structural similarity to other clinically effective antineoplastic agents. Furthermore, ongoing studies aim to enhance its therapeutic index and specificity through various modifications, making 4'-Demethylpodophyllotoxin a promising candidate in the quest for novel cancer treatments.

Ether phenol

Applications A metabolite of Tamoxifen (T006000), a nonsteroidal estrogen antagonist of interest in the treatment of some forms of breast cancer. Tamoxifen is a Protein Kinase C inhibitor, and induces apoptosis in human malignant glioma cell lines. References Brandt, S., et al.: Anticancer Res., 23, 223 (2003), Coller, J., et al.: Br. J. Clin. Pharmacol., 57, 105 (2004), Parte, P., et al.: Drug Metab. Dispos., 33, 1446 (2005),