Cannabinoïdes

EHP-101 is a PPARγ/CB2 dual agonist with anti-inflammatory properties, inhibits fat formation, and combats diet-related obesity.

Cannabidiolic acid analytical standard provided with w/w absolute assay, to be used for quantitative titration.

Applications PF 3845 is a selective fatty acid amide hydrolase (FAAH) inhibitor (Ki = 0.23 μM). Reduces inflammatory pain via a cannabinoid receptor-dependent mechanism. Highly efficacious and selective in vivo. Displays no activity at FAAH-2 (IC50 >10 μM). Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Ahn, et al.: Chem. Biol., 16, 411 (2009), Ahn, et al.: Expert. Opin. Drug Discov., 4 763 (2009),

Taranabant: potent CB1 receptor inverse agonist; inhibits agonists with 0.13 nM Ki in vitro.

Applications An analgesic compound which acts as a partial agonist at both the CB1 and CB2 cannabinoid receptors.Synthetic Cannabinoids References Wiley, J., et al.: J. Pharmacol., Exper. Ther., 285, 995 (1998), Aung, M., et al.: Drug and Alcohol Dependence, 60, 133 (2000),

CB1-IN-1 (DBPR211) is a peripherally restricted CB1R antagonist, for CB1R and CB2R with Ki of 0.3 nM and 21 nM,respectively.

CB1/2 agonist 3 is a competitive and potent CB1/CB2 agonist with high affinity for hCB1 and hCB2 and can be used to study neurological disorders.

1,2,3,9-Tetrahydro-4H-carbazol-4-one is a cyclic ketone compound, which can be synthesized through various organic reactions involving appropriate precursors. It is often derived from indole-based substrates through catalytic hydrogenation, allowing the formation of its stable tetrahydro structure with a retained core carbazole skeleton. This compound operates primarily through participation in various chemical transformations and as an intermediate in synthetic pathways. Its mode of action involves providing structural frameworks or functional groups for subsequent organic reactions, thus enabling further molecular diversification or elaboration in complex synthesis processes. 1,2,3,9-Tetrahydro-4H-carbazol-4-one finds utility in the pharmaceutical industry, particularly in the synthesis of biologically active compounds. It is frequently used as an intermediate in the production of medicinal agents and has applications in the development of drugs with various therapeutic targets. Owing to its versatile chemical nature, this compound is crucial for researchers focusing on sophisticated molecular architecture and drug development pathways.

Applications Nitrosobenzene (cas# 586-96-9) is a useful research chemical.

GFB-024 is a humanized antibody targeting CB1, which can be used to study obesity.

Cannabigerol analytical standard provided with w/w absolute assay, to be used for quantitative titration.

Pregnenolone monosulfate sodium salt is an neurosteroid, enhances NMDA receptor,CREB phosphorylation, TRPM3 channels, and may inhibit GABA A receptors.

Noladin ether (2-AG ether) is a cannabinoid CB1 receptor agonist.

Otenabant (CP-945598) has been investigated for the treatment of Obesity.

Applications (1H-Indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)methanone is the scaffold for UR-144, XLR11, and a number of additional synthetic CBs. The tetramethylcyclopropyl group typically confers selectivity for the peripheral CB2 receptor References Frost, J., et al.: J. Med. Chem., 53, 295 (2010); Uchiyama, N., et al.: Forensic Toxicol., 31, 223 (2013)

Applications 3-O-Methyl-d3 Quercetin is the labeled analogue of 3-O-Methyl Quercetin (M326545), a metabolite of the flavanoid Quercetin (Q509500) with inhibitory activity on lipopolysaccharide-induced activation of macrophage U937 cells. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Okoko, T. et al.: Food Chem. Toxicol., 47, 809 (2009); Duenas, M. et al.: Eur. Food Res. Technol., 232, 103 (2011); Marzouk, M. et al.: Phytochem., 52, 943 (1999)

Applications Isotope labelled 1-Butanol (n-Butyl Alcohol), a common chemical reagent used in biodiesel production. Also it has been used in the study the polarization of vapor-deposited 1-butanol films (1) as well as in the preparation of bioavailable CB1 antagonists (2) . Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.

CB1R antagonist 1 is a potent CB1R antagonist that can be used to study diseases related to the nervous system.

Applications AM-251 is a biarylpyrazole compound that acts as an inverse CB1 cannabinoid receptor agonist and a selective GPR55 agonist. References Kesser, C., et al.: Mol. Cell. Endocrinol., 302, 108 (2009), Araujo, J., et al.: Pharmacol., 83, 170 (2009), Malysz, J., et al.: Eur. J. Pharmacol., 603, 12 (2009),

Carboxylic acid with phenol function

Cannabinoid type 1 (CB1) receptor agonist. Anti-depressant activity demonstrated in vivo alone, as well as enhancing the effect of fluoxetine. In the brain, ACEA activates CB1 receptors expressed in the mitochondria of neuronal cells to elicit neuroprotective effects. This is mediated by inducing glycogen synthase kinase-3β (GSK-3β) phosphorylation and inhibiting the opening of mitochondrial permeability transition pore (MPTP). Sold by weight of solid

(±)-Ibipinabant ((±)-SLV319) has been used in trials studying the treatment of Obesity and Obesity and Type 2 Diabetes.

Applications 5-Fluoro ADB is an analog of fluoronatied ADB-PINACA an analog of AKB48 in which the adamantyl group has been replaced with 1-amino-3,3-dimethyl-1-oxobutan-2-yl (ADB). 5-Fluoro ADB is a synthetic cannabinoid.Synthetic Cannabinoids References Uchiyama, N., et al.: Forensic Toxicol., 30, 114 (2012)

Applications MDMB-CHMICA is an analogue of N-[(1S)-1-(Aminocarbonyl)-2-methylpropyl]-1-[(4-fluorophenyl)methyl]-1H-indazole-3-carboxamide (A603135), an indazole derivative developed as a CB1 receptor modulator used in the treatment of CB1-mediated diseases. Synthetic Cannabinoids References Nahoko, U., et al.: Forensic. Toxicol., 31, 93 (2013)

Applications A-836339, is a cannabinoid CB2 receptor-selective agonist; exhibits high potencies at CB(2) and selectivity over CB(1) receptors. Synthetic Cannabinoids. References Yao BB, et al. J Pharmacol Exp Ther. 2009 Jan;328(1):141-51. doi: 10.1124/jpet.108.145011. Epub 2008 Oct 17.

Applications Labelled JWH 250 (J211500). A new class of cannabimimetic indoles. JWH 250 acts as cannabinoid receptor 2 agonist. References Eissenstat, M., et al.: J. Med. Chem., 38, 3094 (1995), Showalter, V., et al.: J. Pharmacol. Exp. Ther., 278, 989 (1996), Huffman, J., Bioorg. Med. Chem., 13, 89 (2005),

Applications S-Methyl-3-thioacetaminophen is a metabolite of Acetaminophen (A161220), an analgesic and antipyretic agent used as a pain reliever to treat headache, muscle aches, and arthritis (1,2,3). References (1) McGill, M. R. and Jaeschke, H. Pharm Res. 30, 2174 (2013)(2) Fairbrother, J.E., et al.: Anal. Profiles Drug Subs., 3, 1 (1974) (3) Hinson, J.A., et al.: Rev. Biochem. Toxicol., 2, 103 (1980)

BAY 38-7271: potent neuroprotective, selective CB1/CB2 agonist, Ki of 1.85 nM (CB1) & 5.96 nM (CB2).

Applications (5Z,​8Z,​11Z,​14Z)​-5,​8,​11,​14-​Eicosatetraenoic Acid 2-​[[(1,​1-​Dimethylethoxy)​carbonyl]​amino]​ethyl Ester is an intermediate used in synthesizing O-Arachidonoyl ethanolamine hydrochloride (A765130), a partial agonist at CB1 receptor and a full agonist at CB2 receptor. O-Arachidonoyl ethanolamine hydrochloride can be isolated from constituent of human and rat brain. It can be used to prepare antimicrobial arachidonic acid derivative. References Kvasenkov, O. I. RU 2171610 C2 20010810 (2001); Sharir, H., et al.: J Neuroimmune Pharmacol. 7, 856 (2012)

CB2R agonist 2 (cis-17-para) is a CB2R agonist [1].

Applications Labelled JWH-398. JWH-398 is a synthetic cannabimimetic indole derivative that acts as both a cannabinoid receptor CB1 and CB2 agonist. References Hudson, S. et al.: J. Anal. Toxicol., 34, 252 (2010); Hudson, S. et al.: Drug Test. Anal., 3, 466 (2011);

Dehydroabiethylamine (NSC-2955) boosts liver CYP2B, blocks PDKs & cholesterol transport, and has anti-tumor effects.

Applications Methyl 1-(Cyclohexylmethyl)-1H-indazole-3-carboxylate is an intermediate in the synthesis of MDMB-CHMINACA (M203515), a synthetic cannabinoid with potential neurochemical effects at the CB1 receptor. References Banister, S. ET AL.: ACS Chem. Neurosci., 7, 1241 (2016);

Applications N-Boc-4-aminophenethylamine is used in the preparation of N-phenylethylindole carboxamides as SAR study of allosteric modulators of CB1 receptors. References Piscitelli, F., et al.: J. Med. Chem., 55, 5627 (2012)

MDA77 is a CB2 agonist with an EC50 value of 5.82 nM and exhibits no activity towards CB1.

TRPV1/CB2 agonist 1 (compound 41) is a dual agonist targeting hTRPV1 and CB2 receptors, with an EC50 value of 26.8 μM for hTRPV1. It is applicable in research related to the nervous system.

O-1602 is a novel GPR55 agonist, an atypical cannabinoid associated with the central nervous system and obesity, and is a candidate compound for the treatment

MRL-650 is an oral, selective CB1 agonist; IC50: CB1=7.5 nM, CB2=4100 nM; anorexigenic effects noted.

Applications Ethyl 2-oxopentanoate is used as a reagent to synthesize selective CB1 cannabinoid receptor antagonists. Ethyl 2-oxopentanoate is also used to synthesize derivatives of iminodiacid, an inhibitor of angiotensin converting enzyme. References Lange, J., et al.: J. Med. Chem., 48, 1823 (2005); Vincent, M., et al.: Tetrahedron Lett., 23, 1677 (2982)

Applications AM-1220 is a synthetic cannabimimetic indole derivative. AM-1220 acts as a potent and moderately selective agonist for the cannabinoid receptor CB1 with around 19 times the selectivity for CB1 over CB2 receptor. Synthetic cannabinoids References Jarbe, T.U.C. et al.: Psychopharmacology, 216, 355 (2011); D'Ambra, T.E. et al.: Bioorg. Med. Chem. Lett., 6, 17 (1996);

Applications rac-Acetaminophen Mercapturate-d5 (Major), is a labeled analogue and free acid of 3-(N-Acetyl-L-cystein-S-yl) Acetaminophen Disodium Salt (A172100), which is a metabolite of Acetaminophen (A161220). Acetaminophen is an analgesic and antipyretic agent used as a pain reliever to treat headache, muscle aches, and arthritis (1,2,3). References van der Hooft, J.,et al.: Metabolomics, 12, 1 (2016)

Applications Arachidonoyl p-Nitroaniline is a nitroaniline probe for FAAH activity.

Applications A labelled synthetic cannabinoid with antiemetic, antiglaucoma, and CNS activity. Antiemetic. Controlled substance (hallucinogen). References Rubin, A., et al.: Clin. Pharmacol. Ther., 22, 85 (1977), Stark, P., et al.: J. Pharmacol. Exp. Ther., 214, 124 (1980), Souter, R.W., et al.: Anal. Profiles Drug Subs., 10, 499 (1981), Ward, A., Drugs, 30, 127 (1985),