Sucres du squelette et nucléobases

Fluorouracil is a pyrimidine-based chemotherapy drug that inhibits DNA synthesis by inhibiting the activity of the enzyme thymidylate synthase, thereby preventing the production of thymine nucleotides. Fluorouracil is used to treat cancers such as colorectal cancer and breast cancer. It is also used as adjuvant therapy for head and neck cancer. Fluorouracil works by binding to the enzyme dihydrofolate reductase, which is required for the synthesis of DNA precursors. This binding prevents the formation of tetrahydrofolate, which is essential for cell division. The main side effects are myelosuppression and gastrointestinal toxicities, which can be reduced or prevented with appropriate doses (lowering dose) or discontinuation (in case of gastrointestinal toxicity).

Adenine sulphate is a nucleotide that is involved in the formation of DNA and RNA. Adenine sulphate is synthesized from adenosine triphosphate and sulfuric acid. It has been shown to be an important component of DNA polymerase, which is responsible for the production of RNA and DNA. Adenine sulphate also plays a role in the development of insect resistance in plants and tissue culture cells. Adenine sulphate levels have been found to be reduced in patients with orotic aciduria, a condition characterized by high levels of orotic acid in the urine. The decreased adenine sulfate levels are thought to be due to an imbalance between adenosine diphosphate, which inhibits adenylosuccinate lyase (ADSL), and sulfite oxidase (SOX) activity. ADSL converts adenosine diphosphate into adenosinethiol disulfide, while SOX converts sulfite into hydrogen sulfide

Cy5-DBCO, a NIR red dye with absorption at 646 nm and emission at 670 nm, is not ideal for staining permeabilized cells due to high background.

Please enquire for more information about N2-Isobutyryl-7’-t-butyldimethylsilyloxy-N-trityl-morpholino guanosine including the price, delivery time and more detailed product information at the technical inquiry form on this page

1-Acetyluracil is a nucleophile molecule that contains the uracil residue. It is transferred to an organic molecule through the acetonitrile transfer reaction, which occurs in both animals and organisms. 1-Acetyluracil is found in ribosomes and possesses a functional group that can be modified by cellular enzymes. 1-Acetyluracil has been shown to be able to modify the peptidyl transferase activity of ribosomes in eukaryotes.

Please enquire for more information about 2’-O-Acetyl-5’-O-(p-toluoyl)-3’-deoxy-3’-fluoro-5-methyluridine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 1,3-Diethyl-6-aminouracil including the price, delivery time and more detailed product information at the technical inquiry form on this page

7-(2-Hydroxypropyl)guanine (7-HPG) is a nucleoside analogue that is used for the treatment of liver cancer. It is an alkylating agent, which reacts with cellular DNA to form crosslinks and inhibits DNA synthesis. 7-HPG is given intravenously and targets liver cells, as well as other tissues such as the pancreas and lung. The short-term exposure of 7-HPG in animals has not been found to cause any carcinogenic effects. This drug also has a neutral pH, making it suitable for use in patients who have difficulty tolerating acidic drugs. The repair mechanism of 7-HPG may be due to the cell type specificity or short duration of exposure.

Please enquire for more information about N3-(2-Allyloxy)ethyluridine including the price, delivery time and more detailed product information at the technical inquiry form on this page

1) Non-toxicity: belong to flower-stem dye, easy to biodegrade, no carcinogenic toxicity.

Pyrimidine nucleobase; allosteric regulator and coenzyme for reactions