Sucres du squelette et nucléobases

Please enquire for more information about 6-Methoxy-9-(beta-D-5-methylribofuranosyl)-9H-purine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 1,3-Dibutyl-5,6-diaminouracil including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 2-Amino-6-chloro-9-(3-deoxy-2-O-acetyl-5-O-benzoyl-beta-D-ribofuanosyl)-9H-purine including the price, delivery time and more detailed product information at the technical inquiry form on this page

9-[[2-Benzyloxy-1-(benzyloxymethyl)-ethoxy]-methyl]-6-chloroguanine (BZEG) is a molecular probe that has been used to detect viruses in acute phase. It can also increase the severity of an infection caused by coxsackievirus. BZEG is also able to neutralize virus and prevent replication. This compound has been shown to bind with high affinity to viral nucleic acid, causing it to precipitate, which allows for its detection by immunofluorescence staining. 9-[[2-Benzyloxy-1-(benzyloxymethyl)-ethoxy]-methyl]-6-chloroguanine has been used as an antimicrobial agent against bacteria such as Staphylococcus aureus and Pseudomonas aeruginosa.

Stability Hygroscopic Applications 5-Hydroxymethyl-2’-deoxyuridine acts as a biomarker for the diagnosis for oxidative stress in humans. Used as a diagnostic to for propensitiy for the development of breast cancer. References McAnulty, L. et al.: App. Physiol. Nutr. Metab., 36, 976 (2011); Djuric Z. et al.: Cancer Epidemiol. Biomarkers. Prev., 10, 147 (2001); Frenkel, K. et al.: 7, 49, (1998);

O6-[4-(Trifluoroacetamidomethyl)benzyl]guanine is a modified nucleoside that is an inhibitor of microRNAs (miRNAs). It can be used as a therapeutic agent for the treatment of cancer. O6-[4-(Trifluoroacetamidomethyl)benzyl]guanine is orally bioavailable and has shown tumor inhibition in invertebrate models. It is stable in vivo and has been shown to inhibit the activity of miRNA-1, miRNA-2, and miRNA-29b. This molecule also provides optimal orientation for highlighting through its large size, which makes it suitable for use with electron microscopy.

Please enquire for more information about 1,3-Dibenzyl-5-fluorouracil including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 1-(Ethyl-3-carboxypropyl)-3,7-dimethylxanthine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about N6-Benzoyl-3'-deoxy-5'-O-DMT-cytosine-2'-O-succinoyl-long chain alkylamino-CPG including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 3’,5’-Di-O-acetyl-2’-azido-2’-deoxy-5-methyluridine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Sulfo-Cyanine5, a Cy5 analog, is compatible with common fluorescent tools like imagers and microscopes.

Please enquire for more information about N6-Isopentenyladenine-9-glucoside including the price, delivery time and more detailed product information at the technical inquiry form on this page

Applications A useful intermediate in the synthesis of 1-substituted adenines. References Laufer, S., et al.: J. Med. Chem., 48, 710 (2005), Lambertucci, C., et al.: Bioorg. Med. Chem., 17, 2812 (2009),

Bis(trimethylsilyl)cytosine is an immunosuppressive agent that binds to the immunodeficient acceptor. It has been shown to be active against a number of viruses, including HIV-1 and HSV-1. Bis(trimethylsilyl)cytosine also inhibits the activity of purine and pyrimidine nucleotide synthesis, although it does not inhibit the activity of adenosine deaminase or ribonucleotide reductase. This compound has been shown to stimulate the immune system in mice with a deficiency in T cells by reducing the expression of genes that are responsible for cytokines such as IL-4 and IL-10.

Please enquire for more information about 2’-Deoxy-2’-fluoro-N3-[(pyrid-4-yl)methyl]uridine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 2’-O-Acetyl-5’-O-benzoyl-3’-Deoxy-3’-alpha-C-methyl-5-fluorouridine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 2’-Deoxy-2’-fluoro-N3-(3-aminopropyl)uridine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Applications 5-O-Trityl-2,3’-anhydrothymidine (cas# 25442-42-6) is a compound useful in organic synthesis.

Please enquire for more information about 3,5-Bis-O-(2,4-dichlorobenzyl)guanosine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 2’-Deoxy-2’-fluoro-N3-[(pyrid-2-yl)methyl]uridine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Sulfo-Cyanine 3 is an alternative dye primarily used for labeling peptides and oligos in replacing Cy4 that was originally developed by GE Healthcare.

9-[(4-fluoro)-3-hydroxymethylbutyl]guanine (9FHBG) is a small molecule that has been shown to have antitumor activity. It is an optical imaging probe and can be used for the detection of subcutaneous tumors by monitoring for the accumulation of 9FHBG in tumor tissue. This compound has also been shown to have biological properties, such as being a hyperproliferative disease model system, which may make it useful for in vitro assays. 9FHBG binds to DNA polymerase and inhibits DNA synthesis, thereby leading to cell death. The binding affinity of 9FHBG was determined using monoclonal antibodies and optical imaging probes. The pharmacokinetics of this drug have been studied in humans and mice with breast cancer models.

Please enquire for more information about 3’,5’-Bis-O-benzoyl-2’-Deoxy-2’-fluoro-4-deoxy-arabinouridine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 3’-beta-Azido-2’,3’-dideoxy-5-fluorouridine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Impurity Acicclovir EP Impurity L Applications N2,9-Diacetylguanine (Acicclovir EP Impurity L) is used to synthesize acyclic analogues of deoxyguanosine. References Martin, J. C., et al.: J Med Chem. 26, 759 (1983)

Please enquire for more information about 2-Aminopurine-9-beta-D-(2’-deoxy-3’,5’-di-O-(p-toluoyl))riboside including the price, delivery time and more detailed product information at the technical inquiry form on this page

Applications A constituent of nucleic acids. It was isolated from yeast nucleic acid. References Parrou, J., et al.: Anal. Biochem., 248, 186 (1997), Phipps, A., et al.: Xenobiotica, 28, 527 (1998), Mohler, R., et al.: Anal. Chem., 78, 2700 (2006),

Cy5 cadaverine is commonly used in biomolecular labeling, fluorescence imaging and other fluorescence biological analysis.

6-Benzoylamino-9H-purine-9-acetic acid (BAPAA) is a high quality reagent that is used in the synthesis of complex compounds. It is also a useful intermediate in the preparation of fine chemicals, speciality chemicals, and research chemicals. 6-Benzoylamino-9H-purine-9-acetic acid is a versatile building block for the synthesis of novel compounds with desired biological activity. This compound is an excellent reaction component because it can be used to synthesize various chemical structures.

Please enquire for more information about 2’-Deoxy-2’-fluoro-N3-(2-furfuryl)uridine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Sulfo-Cyanine7: enhanced Cy7 analog, 23% better quantum yield, more photostable, ideal for NIR imaging.

Stability Hygroscopic Applications 2,4-Dithiouridine (cas# 13239-96-8) is a compound useful in organic synthesis.

Impurity Zidovudine EP Impurity C Applications Thymine (Zidovudine EP Impurity C) is a nitrogenous base component in the nucleic acid of DNA. References Keum, Y., et al.: App. Microbiol. Biotechnol., 80, 863 (2008); Redzic, Z., et al.: Neurochem. Res., 34, 566 (2009); Lanevskij, K., et al.: J. Pharm. Sci., 98, 122 (2009); Rajendar, B., et al.: Bioorg. Med. Chem., 17, 351 (2009);

3’-Deoxy-5-fluorouridine is a synthetic compound that is used as an anticancer drug. It has been shown to induce apoptosis in cancer cells through the modulation of polymerase, synthetase and other enzymes involved in DNA synthesis. 3’-Deoxy-5-fluorouridine also inhibits the activity of viral thymidylate synthase, which prevents the conversion of deoxyuridine triphosphate (dUTP) to thymidylate monophosphate (dTMP), preventing DNA replication and cell division. This chemical can be synthesized by reacting uracil with trifluoroacetic acid followed by saponification.

2-Amino-6-cyclopropylamino-9H-purine is a nucleoside analog that inhibits the replication of herpes simplex virus (HSV) in humans. It is an acyclic nucleoside phosphonate, which binds to the viral DNA polymerase and blocks the incorporation of deoxyribonucleotide triphosphates into the viral DNA during elongation. 2-Amino-6-cyclopropylamino-9H-purine has been shown to be safe and effective for treating HSV infections in humans, with no serious adverse effects. This drug can be administered orally or intravenously and is scalable for manufacture by chemical synthesis. The antiviral activity of 2-Amino-6-cyclopropylamino-9H-purine was evaluated using hybridization assays on tissue culture cells infected with HSV type 1 or HSV type 2.

IR 783 is a heptamethine cyanine fluorescent probe for in vivo imaging of tumor cells. It displays excitation/emission maxima of 633/780 nm, respectively.

Please enquire for more information about 2’-O-Acetyl-3’-deoxy-3’-fluoro-5’-O-(p-toluoyl)-6-azauridine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Sulfo-Cyanine 3 is an alternative dye primarily used for labeling peptides and oligos in replacing Cy6 that was originally developed by GE Healthcare.

For the quantitative enzymatic determination of uric acid in serum. Uric acid measurements are useful in the diagnosis of numerous renal and metabolic disorders. Uric acid is a substrate for the enzyme uricase. Uric acid is oxidized by oxygen in a reaction catalyzed by the enzyme uricase forming hydrogen peroxide and allantoin. Production of hydrogen peroxide can be assayed by 4-aminoantipyrine (4-AAP) in combination with 2-hydroxy-3,5-dichloro-benzenesulfonate (HDCBS) in the presence of horseradish peroxidase (HRP) through the production of an intensely red dye.

Applications O6-Methyl-2’-deoxyguanosine is a ubiquitous DNA lesion formed by xenobiotic carcinogens and endogenous methylating agent, S-adenosyl-L-methionine. A mutagenic adducts formed by a potent tobacco carcinogen, 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). References Patra, A., et al.: J. Biol. Chem., 291, 24304-24313 (2016); Gowda, A. S., et al.: Chem. Res. Toxicol., 29, 1894-1900 (2016)