Sucres du squelette et nucléobases

Please enquire for more information about 5-(Benzyloxy)-2-thiouracil including the price, delivery time and more detailed product information at the technical inquiry form on this page

7-Methyladenine is a nitrogen-containing compound that has been shown to cause an increase in renal blood flow. It is also a synthetic estrogen. 7-Methyladenine is mainly metabolized by methylation, and it can be detected in urine samples. This substance has been shown to have a direct effect on cardiac contractility and blood pressure. 7-Methyladenine also has the ability to stimulate the growth of cells and tissues, as well as being able to inhibit the synthesis of certain proteins.

8-Chloroguanine is a carcinogen that has been shown to cause cancer in laboratory animals. It is a reactive compound with a hydroxyl group and a hydrogen bond that can react with DNA, leading to the formation of 8-chloroadenine (8-CAD) and 8-chloroguanine (8-CG). These compounds are then converted into hypochlorous acid, which has been shown to be an inflammatory agent. The analytical method for quantifying 8-chloroguanine can be done by electrochemical impedance spectroscopy. This method has been used in model studies of inflammatory diseases.

Please enquire for more information about 8-(4-Chlorophenylthio)adenine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 2’,3’,5’-Tri-O-benzoyl-4’-thiouridine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 6-Amino-5-nitro-2-thio-uracil including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 2’-Deoxy-2’-fluoro-N3-(2S)-[2-(tert-butoxy-carbonyl)amino-3-carbonyl]propyluridine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 2’-Deoxy-2’-fluoro-N3-(4-hydroxybenzyl)-beta-D-arabinouridine including the price, delivery time and more detailed product information at the technical inquiry form on this page

7-Deaza-2-mercaptoadenine is a synthetic molecule that has been shown to be effective in vivo as an antibacterial agent against Gram-negative pathogens. It has been shown to have a comparable efficacy to the comparator, pleuromutilin. 7-Deaza-2-mercaptoadenine also showed activity against experimental infection with methicillin resistant Staphylococcus aureus (MRSA) and Clostridium difficile, which were not affected by comparator. 7-Deaza-2-mercaptoadenine is active against Gram negative bacteria by inhibiting protein synthesis through the inhibition of bacterial ribosomes.

5-Methylcytosine hydrochloride salt is a metabolite of cytosine that occurs naturally in the body. It is used as an inhibitor of DNA methylation to study the effect of this process on gene expression. 5-Methylcytosine hydrochloride salt has been shown to inhibit the production of growth factors, such as insulin-like growth factor 1, and radiation energy. It also causes oxidative damage to DNA and inhibits the oxidation of urea nitrogen in lettuce. The matrix effect may interfere with the analysis of 5-methylcytosine hydrochloride salt by spectrometry.

Please enquire for more information about N3-2-Furfuryluridine including the price, delivery time and more detailed product information at the technical inquiry form on this page

6-Amino-5-nitroso-2-thiouracil is a water molecule that has been synthesized and characterized by the kinetic method. It has an intense absorption line at 514 nm and can be used as a marker for technetium. 6-Amino-5-nitroso-2-thiouracil is also a ligand, which is a chemical that binds to metal ions in order to form coordination complexes. 6-Amino-5-nitroso-2-thiouracil is formed by the reaction of chloramine with ammonia, as well as other reactions involving chlorine atoms. 6Amino - 5 nitroso - 2 thiouracil can be used as a chelate ring, which is a type of ligand that contains both nitrogen and sulfur atoms. Bleomycin, a five membered ring molecule, reacts with 6 amino - 5 nitroso - 2 thiouracil to

Please enquire for more information about 3’,5’-Di-O-acetyl-2’-chloro-2’-deoxyuridine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 9-(3-Deoxy-3-fluoro-beta-D-ribofuranosyl)-6-(pyridine-4-yl)purine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 5’-C-Methyl-5-fluorouridine including the price, delivery time and more detailed product information at the technical inquiry form on this page

6-(Dimethylamino)-9-(4-Methylbenzyl)-2-(Trifluoromethyl)-9H-Purine is an antiviral agent that inhibits the replication of rhinovirus and other serotypes. It is a lipophilic compound that has optimum activity at concentrations of 0.1 to 10 μg/mL. 6-(Dimethylamino)-9-(4-Methylbenzyl)-2-(Trifluoromethyl)-9H-Purine binds to the active site of the viral polymerase, preventing the enzyme from adding nucleotides to the growing DNA strand. This drug has been shown to be effective against serotype A and B rhinoviruses in vitro and in vivo, as well as serotype C in vitro. 6-(Dimethylamino)-9-(4-Methylbenzyl)-2-(Trifluoromethyl)-9H-Purine also has antiv

Please enquire for more information about Xanthine-13C15N2 including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 1-[6-Phosphono-2-O-methyl-beta-D-ribo-hexofuranosyl]uracil including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about Paraxanthine hydrochloride including the price, delivery time and more detailed product information at the technical inquiry form on this page

A non-specific inhibitor of cAMP and cGMP phosphodiesterases (PDEs) with IC50 values between 2 and 50 µM. 2-isobutyl-1-methylxanthine (IBMX) has also been found to inhibit phenylephrine-induced 5-HT release by neuroendocrine epithelial cells and IBMX-mediated increase in cAMP and upregulation of Ca2+ channels promotes neuronal differentiation. Additionally IBMX stimulates secretion of thyroid hormones, resulting in cAMP-mediated activation of glycogenolysis and reduced glycogen storage.

5-Acetylamino-6-formylamino-3-methyluracil is an analysis method that can be used to determine the effectiveness of certain contraceptives. This drug has shown a potential to interact with other drugs, such as caffeine and amphetamines. It is also used to measure the enzyme activities of polymorphic human erythrocytes. 5-Acetylamino-6-formylamino-3-methyluracil is used in the preparation of blood samples for DNA sequencing and polymerase chain reaction (PCR) amplification. The concentration of intracellular calcium ions in humans has been shown to increase when this drug is administered, which leads to hyperproliferative diseases like cancer or HIV infection.

Please enquire for more information about 2’-Deoxy-2’-fluoro-N3-(propyn-2-yl)-beta-D-arabinouridine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Cy2 is a cyanine dye used for labeling amino-groups in oligonucleotides, peptides, and proteins (λ excitation: 488 nm; λ emission: 520 nm).

6-Bromopurine is a purine nucleoside that is synthesized from 6-chloropurine and pyrimidine. It can be used as an anti-cancer agent because of its ability to bind to the DNA helix, thereby inhibiting RNA synthesis. 6-Bromopurine also has a high affinity for protozoan parasites such as Plasmodium vivax, Pneumocystis carinii, and Leishmania donovani. The pharmacokinetic properties of this drug are not well understood, but it is thought to be metabolized in the liver by hydroxylation or deamination. 6-Bromopurine can be synthesized efficiently through the reaction between pyridine and 2-aminophenol with a yield of about 65%.

Applications Used in the preparation of pyrrolotriazines.

9-Benzyl-2,6-dichloro-9H-purine is a synthetic nucleoside that has been shown to be an effective antiviral agent. It has been used in the synthesis of cross-coupling reactions. The yields of this compound have been found to be high with the use of a solid-phase synthesis. 9-Benzyl-2,6-dichloro-9H-purine is not immunogenic and does not cause any toxicity issues when administered in animals or humans. This compound is being studied for its possible use as an adjuvant for vaccines.

Please enquire for more information about 1,3-Diethyl-8-phenylxanthine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Cy5.5 cadaverine is commonly used in biomolecular labeling, fluorescence imaging and other fluorescence biological analysis.

6-Amino-5-nitrouracil is a synthetic chemical that inhibits the growth of the hepatitis virus. It has been shown to inhibit glutamic dehydrogenase in human liver cells and overlaps with nitro groups on purines in the viral genome. 6-Amino-5-nitrouracil also interacts with uridine phosphorylase, which is an enzyme that converts uridine into cytosine, and this inhibition prevents DNA synthesis. The nitro group on 6-amino-5-nitrouracil can be oxidized by halogens to form a reactive oxygen species, which destroys the viral ribonucleic acid (RNA).

1,3-Didecanoyl-2-(6-(5-fluorouracil-1-yl)carbonylamino)hexanoylglyceride (FURAC) is a prodrug that is converted to 5-fluorouracil in vivo. FURAC binds to the mitochondrial membrane and induces fission, which leads to an increase in potassium ion release and oxidative stress. This drug has been shown to have psychotic effects in animals, as well as anticancer properties for certain cells. It also induces DNA methylation and inhibition of histone acetylation. FURAC has hypotensive activity due to its ability to inhibit the renin-angiotensin system; this activity may be mediated by its ability to inhibit angiotensin II formation by blocking the conversion of angiotensin I into angiotensin II.

Please enquire for more information about 3’-Azido-3’-deoxy-5-azauridine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 1-(5-O-Methoxytrityl-2-deoxy-beta-D-xylofuranosyl)uracil including the price, delivery time and more detailed product information at the technical inquiry form on this page

5-Aminouracil is a pyrimidine nucleoside that is used in the treatment of cancer, psoriasis and other autoimmune disorders. 5-Aminouracil is a prodrug that undergoes intracellular transformation to become an inhibitor of DNA synthesis. It promotes apoptosis by inhibiting the production of RNA and protein synthesis, leading to cell death. 5-Aminouracil has been shown to be effective against malignant cells in tissue culture as well as various types of cancer cells. A study using hydrogen bonding interactions showed that 5-aminouracil binds to the ribosomal protein L10 and inhibits its function in the polymerase chain reaction (PCR). Molecular docking studies have also shown that this drug can bind with redox potentials in both the active site and ligand binding site of human topoisomerase II alpha, which may lead to inhibition of enzyme activity or cell death.

5-Benzyl-1-(2-hydroxyethoxymethyl)uracil is a cytostatic drug that has been shown to inhibit the growth of cancer cells by inhibiting the enzyme activities necessary for DNA replication and transcription. This compound has been found to be effective in treating metastatic colorectal cancer in experimental models, as well as skin cancers in mice. 5-Benzyl-1-(2-hydroxyethoxymethyl)uracil is also an inhibitor of HIV infection, which may be due to its ability to block the synthesis of uridine. The symptoms that are caused by this drug are not yet known.

Please enquire for more information about 3’-Deoxy-3’-flluoro-3-deazauridine including the price, delivery time and more detailed product information at the technical inquiry form on this page

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Applications Modified nucleotide, essential for normal cell growth in some bacterial species. This compound is also able to chelate several metal ions. References Ikeuchi, Y., et al.: Mol. Cell, 21, 97 (2006), Odani, A., et al.: J. Inorg. Biochem., 101, 727 (2007), Wohlgamuth-Benedum, J., et al.: J. Biol. Chem., 284, 23947 (2009),

Please enquire for more information about 5-Cyanouracil-1-yl acetic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about N3-(4-Nitrobenzyl)uridine including the price, delivery time and more detailed product information at the technical inquiry form on this page

1,3,6-Trimethyl uracil is a dihydro derivative of uracil. It is a proton acceptor and has been studied for use as an inhibitor in transfer reactions. 1,3,6-Trimethyl uracil has also been shown to be effective in the inhibition of the reaction between phosphorus oxychloride and methyl proton. The hydration of 1,3,6-trimethyl uracil occurs at low temperatures and the hydrated form has been observed by infrared spectroscopy. This compound can be prepared from iodopyrimidine by treatment with phosphorus oxychloride and methyl proton.

Please enquire for more information about 1-(beta-D-Xylofuranosyl)-5-methyluracil including the price, delivery time and more detailed product information at the technical inquiry form on this page

1,3-Dipropylxanthine is a congener of caffeine. It is a nonselective adenosine receptor antagonist that binds to the adenosine receptors in the kidney. 1,3-Dipropylxanthine has been shown to increase renal blood flow and increase urine output. This drug may be used as a mobilisation agent for patients who are bedridden or have limited mobility. It should not be given to patients with heart disease or high blood pressure. 1,3-Dipropylxanthine has also been shown to inhibit the binding of pyrimido [1,2-a]benzimidazole (PPIM) and furyl derivatives to the adenosine receptor.

Dithiazanine iodide (Netocyd) is a benzothiazole.

CY5-YNE (Sulfo-Cyanine5-alkyne) is a reactive dye for the labeling of amino-groups in oligonucleotides, peptides, and proteins.

Please enquire for more information about 3’-O-Methyl-4-deoxyuridine including the price, delivery time and more detailed product information at the technical inquiry form on this page