Sucres du squelette et nucléobases

Stability Hygroscopic Applications 6-Azauridine is can be applied in antiviral studies.

CY5 triethylamine salt is a water-soluble dye, Excitation (nm):649, Emission (nm): 670.

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Phosphoribosyltransferase inhibitor; photocytotoxic

5-Methoxyuracil is a labile, colorless and crystalline compound that occurs spontaneously in the presence of oxygen. It has a chemical structure similar to thiourea, with one methyl group substituted for the amino group on the heterocycle. 5-Methoxyuracil is used as a precursor for synthesis of thymine and uracil. It also acts as an antioxidant, preventing reactive oxygen species from causing cellular damage. 5-Methoxyuracil can be used in regenerative medicine to increase the production of messenger RNA (mRNA) and ribosomal RNA (rRNA). This drug is used as a prebiotic agent and can be synthetically produced by dimethylation of uridine followed by ethyl formate oxidation.

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2-Bromohypoxanthine is a fluorescent analogue of the naturally occurring nucleoside hypoxanthine. It is used as a marker for 2-bromoethoxyacetic acid (2BEA) in human serum and has been shown to be useful for prognosis of metastatic colorectal cancer. 2-Bromohypoxanthine binds to proteins that contain polyunsaturated fatty acids, such as leucovorin and fatty acids, and can be used as a diagnostic tool for detection of these proteins. 2-Bromohypoxanthine is also known to inhibit the proliferation of cancer cells by blocking the growth factor signaling pathway.

1-(3-Carboxypropyl)-3,7-dimethylxanthine is a drug that belongs to a class of drugs called multidrugs. It has been shown to inhibit the growth of endothelial cells by blocking the binding of tnf-α to its receptor on these cells. 1-(3-Carboxypropyl)-3,7-dimethylxanthine also inhibits cancer cell proliferation and has been shown to be effective in some human cancer models. This drug interacts with other molecules (e.g., proton) and can have significant effects on magnetic resonance spectroscopy assays as well as in humans.

8-Chloropurine is an anion of the molecule 8-chloropurine. It has a hydrogen peroxide group in its structure, which makes it reactive. 8-Chloropurine is acidic and can be used for analytical purposes. The 13C NMR spectroscopy analysis of 8-chloropurine has been shown to be able to differentiate between protonated molecules, such as acetonitrile and piperidine, and chloride ions. 8-Chloropurine has also been shown to react with acetonitrile and phosphorus oxychloride at different rates.

Stability Stable at RT Applications An intermediate used for the sythesis of xanthine derivatives. References Daly, J.W., et al.: J. Med. Chem., 28, 487 (1985), Erickson, R.H., et al.: J. Med. Chem., 34, 3405 (1991),

2,6-Diaminopurine hemisulfate salt is a fine chemical that can be used as a building block for research chemicals, reagents, and specialty chemicals. It has been shown to be useful in the synthesis of various types of complex compounds. 2,6-Diaminopurine hemisulfate salt is also versatile in the sense that it can be used as an intermediate in reactions or as a scaffold for chemical synthesis. This product has CAS number 69369-16-0.

6-Methylaminouracil is a drug that is used to treat bacterial infections. It has been shown to inhibit the growth of staphylococcus by inhibiting the synthesis of nucleic acids and proteins, which are required for cell division. 6-Methylaminouracil also inhibits the UV irradiation of subtilis and causes a bathochromic shift in the absorption spectrum. The photodestruction of 6-methylaminouracil has been observed in experiments with viologen and catalytic effect.

5-Bromocytosine is a nucleoside analog that inhibits the replication of RNA and DNA viruses. It binds to the 5-hydroxymethylcytosine residue in the viral dna duplexes, forming an acid complex. The reaction products are then cleaved by cellular enzymes, which leads to termination of the viral genetic material. 5-Bromocytosine can also be converted into a tautomeric form (5-bromouracil) by electron transfer. The vibrational frequencies of this tautomer are different from those of thymine, so it has been used for vibrational spectroscopy studies as well as FTIR spectroscopy studies.

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5-Azauracil is a glycosylase that specifically hydrolyzes the N-glycosidic bond in uridine. It is a potential anticancer agent that inhibits the growth of cancer cells by targeting intracellular targets and inhibiting enzyme activities. 5-Azauracil binds to nitrogen atoms in the enzyme active site, causing an alteration in the hydrogen bonding network and resulting in inhibition of enzyme activity. The reaction mechanism involves the formation of orotic acid as a product. 5-Azauracil also has been shown to inhibit x-ray diffraction data, which may be due to its ability to bind to an enzyme's metal cofactors such as iron or copper.

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1-(2'-Tetrahydrothienyl)-5 Fluorouracil-1-'1'-Dioxide (THTF) is an anti-cancer drug that is structurally related to 5-fluorouracil. It has been shown to be more resistant to oxidation and can be used in the treatment of skin cancer, cancer, and lymphocytic leukemia. THTF has been shown to inhibit the activity of oxidases, which are enzymes involved in the production of reactive oxygen species (ROS). This can lead to cell death by preventing DNA repair and oxidation of lipids. THTF has been shown to be effective against l1210 murine leukemia cells, but not human leukemia cells. The difference in sensitivity may be due to a different number of primers for PCR amplification or differences between the strains of mice used.

5-Bis(2-chloroethyl)aminouracil is a molecule that can be used to treat metastatic colorectal cancer. It has been shown to induce antibody responses in mice and to inhibit the growth of mouse monoclonal antibodies. 5-Bis(2-chloroethyl)aminouracil is used in the preparation of pharmaceuticals, including an effective chemotherapy for metastatic colorectal cancer. It also induces aminouracil synthesis in the mouse and is toxic to k562 cells, which are leukemia cells from a patient with acute myelocytic leukemia. 5-Bis(2-chloroethyl)aminouracil has also been shown to have anti-inflammatory properties and can be used as an agent against infectious diseases such as erythromycin resistant staphylococcus aureus (MRSA).

3-Deazaadenine is a purine nucleoside. It has been found to inhibit the growth of herpes simplex virus and other DNA viruses. 3-Deazaadenine inhibits viral DNA replication by interfering with the hydroxylation of deoxyguanosine, which is required for viral DNA synthesis. 3-Deazaadenine also has an inhibitory effect on the activity of human target enzymes such as dna polymerases, topoisomerases, and helicases. In vivo studies have shown that 3-deazaadenine can be used to treat herpes simplex virus infections in mice and rats.

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Applications Tris(trimethylsilyl)guanine is an intermediate used in the synthesis of 9-(2-Hydroxyethyl)guanine (H942035), which is an impurity of the antiviral agent Acyclovir (A192400). 9-(2-Hydroxyethyl)guanine is a nucleoside phosphotransferase acceptor. References Kamimura, A. et al.: Agric. Biol. Chem., 37, 2037 (1973);